Na+ channel I-II loop mediates parallel genetic and phosphorylation- dependent gating changes

Circulation

Volumn 126, Issue 17, 2012, Pages 2042-2046

  Bers, Donald M ^a   Herren, Anthony W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; SODIUM CHANNEL NAV1.5;

CARDIOVASCULAR DISEASE; DOG; GENE MUTATION; GENETIC VARIABILITY; HEART ARRHYTHMIA; HEART FAILURE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; REVIEW; SUDDEN DEATH;

ANIMALS; ARRHYTHMIAS, CARDIAC; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; HUMANS; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL;

EID: 84867795118     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.112.140384     Document Type: Review

References (30)

1. Koval OM, Snyder JS, Wolf RM, Pavlovicz RE, Glynn P, Curran J, Leymaster ND, Dun W, Wright PJ, Cardona N, Qian L, Mitchell CC, Boyden PA, Binkley PF, Li C, Anderson ME, Mohler PJ, Hund TJ. Ca2/Calmodulin-dependent protein kinase II-based regulation of voltage-gated Na channel in cardiac disease. Circulation. 2012;126: 2084-2094.
2. Grant AO. Cardiac ion channels. Circ Arrhythm Electrophysiol. 2009;2: 185-194.
3. Wilde AA, Brugada R. Phenotypical manifestations of mutations in the genes encoding subunits of the cardiac sodium channel. Circ Res. 2011; 108:884-897.
4. Zimmer T, Surber R. Scn5a channelopathies-an update on mutations and mechanisms. Prog Biophys Mol Biol. 2008;98:120-136.
5. Tomaselli GF, Zipes DP. What causes sudden death in heart failure? Circ Res. 2004;95:754-763. (Pubitemid 39390577)
6. Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar DB, Moy CS, Mozaffarian D, Mussolino ME, Nichol G, Paynter NP, Soliman EZ, Sorlie PD, Sotoodehnia N, Turan TN, Virani SS, Wong ND, Woo D, Turner MB, American Heart Association Statistics C, Stroke Statistics S. Heart disease and stroke statistics-2012 update: a report from the American Heart Association. Circulation. 2012;125:e2-e220.
7. Abriel H. Cardiac sodium channel Nav1.5 and interacting proteins: physiology and pathophysiology. J Mol Cell Cardiol. 2010;48:2-11.
8. Meadows LS, Isom LL. Sodium channels as macromolecular complexes: implications for inherited arrhythmia syndromes. Cardiovasc Res. 2005; 67:448-458. (Pubitemid 41019552)
9. Wagner S, Dybkova N, Rasenack EC, Jacobshagen C, Fabritz L, Kirchhof P, Maier SK, Zhang T, Hasenfuss G, Brown JH, Bers DM, Maier LS. Ca2/calmodulin-dependent protein kinase II regulates cardiac Na channels. J Clin invest. 2006;116:3127-3138. (Pubitemid 44878627)
10. Hoch B, Meyer R, Hetzer R, Krause EG, Karczewski P. Identification and expression of delta-isoforms of the multifunctional Ca2/calmodulindependent protein kinase in failing and nonfailing human myocardium. Circ Res. 1999;84:713-721. (Pubitemid 29157339)
11. Ai X, Curran JW, Shannon TR, Bers DM, Pogwizd SM. Ca2/calmodulin- dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2 leak in heart failure. Circ Res. 2005;97:1314-1322.
12. Veldkamp MW, Viswanathan PC, Bezzina C, Baartscheer A, Wilde AA, Balser JR. Two distinct congenital arrhythmias evoked by a multidysfunctional Na channel. Circ Res. 2000;86:e91-e97.
13. Aiba T, Hesketh GG, Liu T, Carlisle R, Villa-Abrille MC, O'Rourke B, Akar FG, Tomaselli GF. Na channel regulation by Ca2/calmodulin and Ca2/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes. Cardiovasc Res. 2010;85:454-463.
14. Hund TJ, Koval OM, Li J, Wright PJ, Qian L, Snyder JS, Gudmundsson H, Kline CF, Davidson NP, Cardona N, Rasband MN, Anderson ME, Mohler PJ. A beta(iv)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice. J Clin Invest. 2010;120:3508-3519.
15. Ashpole NM, Herren AW, Ginsburg KS, Brogan JD, Johnson DE, Cummins TR, Bers DM, Hudmon A. Ca2/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites. J Biol Chem. 2012;287:19856-19869.
16. Anderson ME, Brown JH, Bers DM. CaMKII in myocardial hypertrophy and heart failure. J Mol Cell Cardiol. 2011;51:468-473.
17. Tsuji Y, Hojo M, Voigt N, El-Armouche A, Inden Y, Murohara T, Dobrev D, Nattel S, Kodama I, Kamiya K. Ca2-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm. Circulation. 2011;123:2192-2203.
18. Zhang R, Khoo MS, Wu Y, Yang Y, Grueter CE, Ni G, Price EE Jr, Thiel W, Guatimosim S, Song LS, Madu EC, Shah AN, Vishnivetskaya TA, Atkinson JB, Gurevich VV, Salama G, Lederer WJ, Colbran RJ, Anderson ME. Calmodulin kinase II inhibition protects against structural heart disease. Nature Med. 2005;11:409-417. (Pubitemid 40562331)
19. Papadatos GA, Wallerstein PM, Head CE, Ratcliff R, Brady PA, Benndorf K, Saumarez RC, Trezise AE, Huang CL, Vandenberg JI, Colledge WH, Grace AA. Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene SCN5A. Proc Natl Acad Sci U S A. 2002;99:6210-6215. (Pubitemid 34493291)
20. Remme CA, Verkerk AO, Nuyens D, van Ginneken AC, van Brunschot S, Belterman CN, Wilders R, van Roon MA, Tan HL, Wilde AA, Carmeliet P, de Bakker JM, Veldkamp MW, Bezzina CR. Overlap syndrome of cardiac sodium channel disease in mice carrying the equivalent mutation of human SCN5A-1795insd. Circulation. 2006;114: 2584-2594. (Pubitemid 44967341)
21. Clancy CE, Tateyama M, Kass RS. Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome. J Clin Invest. 2002;110:1251-1262. (Pubitemid 35285751)
22. Grandi E, Puglisi JL, Wagner S, Maier LS, Severi S, Bers DM. Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials. Biophys J. 2007;93: 3835-3847. (Pubitemid 350223802)
23. Maltsev VA, Reznikov V, Undrovinas NA, Sabbah HN, Undrovinas A. Modulation of late sodium current by Ca2, calmodulin, and CaMKII in normal and failing dog cardiomyocytes: Similarities and differences. Am J Physiol Heart Circ Physiol. 2008;294:H1597-H1608. (Pubitemid 351490589)
24. Valdivia CR, Chu WW, Pu J, Foell JD, Haworth RA, Wolff MR, Kamp TJ, Makielski JC. Increased late sodium current in myocytes from a canine heart failure model and from failing human heart. J Mol Cell Cardiol. 2005;38:475-483. (Pubitemid 40331938)
25. Wagner S, Ruff HM, Weber SL, Bellmann S, Sowa T, Schulte T, Anderson ME, Grandi E, Bers DM, Backs J, Belardinelli L, Maier LS. Reactive oxygen species-activated Ca/calmodulin kinase IIdelta is required for late INa augmentation leading to cellular Na and Ca overload. Circ Res. 2011;108:555-565.
26. Belardinelli L, Shryock JC, Fraser H. Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine. Heart. 2006;92 Suppl 4:iv6-iv14. (Pubitemid 43974036)
27. Grant AO, Carboni MP, Neplioueva V, Starmer CF, Memmi M, Napolitano C, Priori S. Long QT syndrome, brugada syndrome, and conduction system disease are linked to a single sodium channel mutation. J Clin Invest. 2002;110:1201-1209. (Pubitemid 35215901)
28. van Oort RJ, McCauley MD, Dixit SS, Pereira L, Yang Y, Respress JL, Wang Q, De Almeida AC, Skapura DG, Anderson ME, Bers DM, Wehrens XH. Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation. 2010;122:2669-2679.
29. Pogwizd SM, Bers DM. Cellular basis of triggered arrhythmias in heart failure. Trends Cardiovasc Med. 2004;14:61-66. (Pubitemid 38340848)
30. Robison AJ, Bartlett RK, Bass MA, Colbran RJ. Differential modulation of Ca2/calmodulin-dependent protein kinase II activity by regulated interactions with n-methyl-d-aspartate receptor nr2b subunits and alphaactinin. J Biol Chem. 2005;280:39316-39323. (Pubitemid 41713887)