Mind the gap; Regulation of gap junctional, intercellular communication by the src oncogene product and its effectors

Anticancer Research

Volumn 32, Issue 10, 2012, Pages 4245-4250

  Geletu, Mulu ^a   Trotman Grant, Aaron ^a   Raptis, Leda ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Cx43; Gap junctional intercellular communication; Src oncogene

Indexed keywords

CONNEXIN 43; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C GAMMA; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; RAF PROTEIN; RAS PROTEIN; STAT3 PROTEIN;

CELL COMMUNICATION; DOWN REGULATION; EPITHELIUM CELL; FIBROBLAST; GAP JUNCTION; HUMAN; MALIGNANT TRANSFORMATION; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SHORT SURVEY; SRC ONCOGENE;

ANIMALS; CELL COMMUNICATION; CONNEXIN 43; GAP JUNCTIONS; HUMANS; MICE; PHOSPHORYLATION; RATS; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TYROSINE;

EID: 84867794024     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (54)

1. Aleshin A and Finn RS: SRC: a century of science brought to the clinic. Neoplasia 12: 599-607, 2010.
2. Anagnostopoulou A, Vultur A, Arulanandam R, Cao J, Turkson J, Jove R, Kim JS, Glenn M, Hamilton AD and Raptis L: Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells. Cancer Lett 242: 120-132, 2006. (Pubitemid 44485298)
3. Atkinson MM and Sheridan JD: Altered junctional permeability between cells transformed by v-ras, v-mos, or v-src. American Journal of Physiology 255: C674-C683, 1988.
4. Azarnia R and Loewenstein WR: Polyomavirus middle t antigen downregulates junctional cell-to-cell communication. Mol Cell Biol 7: 946-950, 1987. (Pubitemid 17004564)
5. Bao X, Reuss L and Altenberg GA: Regulation of purified and reconstituted connexin 43 hemichannels by protein kinase C-mediated phosphorylation of Serine 368. J Biol Chem 279:20058-20066, 2004. (Pubitemid 38623450)
6. Bhattacharjee R, Kaneda M, Nakahama K and Morita I: The steady-state expression of connexin43 is maintained by the PI3K/Akt in osteoblasts. Biochem Biophys Res Commun 382:440-444, 2009.
7. Bromberg JF, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C and Darnell JE Jr.: Stat3 as an oncogene. Cell 98: 295-303, 1999. (Pubitemid 29380565)
8. Brownell HL, Narsimhan R, Corbley MJ, Mann VM, Whitfield JF, and Raptis L: Ras is involved in gap junction closure in mouse fibroblasts or preadipocytes but not in differentiated adipocytes. DNA & Cell Biol 15: 443-451, 1996.
9. Brownell HL, Whitfield JF and Raptis L: Cellular Ras partly mediates gap junction closure by the polyoma virus middle Tumor antigen. Cancer Lett 103: 99-106, 1996. (Pubitemid 26125170)
10. Crow DS, Beyer EC, Paul DL, Kobe SS and Lau AF: Phosphorylation of connexin43 gap junction protein in uninfected and rous sarcoma virus-transformed mammalian fibroblasts. Mol Cell Biol 10: 1754-1763, 1990.
11. Cruciani V, Husoy T and Mikalsen SO: Pharmacological evidence for system-dependent involvement of protein kinase C isoenzymes in phorbol ester-suppressed gap junctional communication. Exp Cell Res 268: 150-161, 2001. (Pubitemid 32744646)
12. Doble BW, Ping P and Kardami E: The epsilon subtype of protein kinase C is required for cardiomyocyte connexin-43 phosphorylation. Circ Res 86: 293-301, 2000. (Pubitemid 30108823)
13. Frank DA: STAT3 as a central mediator of neoplastic cellular transformation. Cancer Lett 251: 199-210, 2007.
14. Geletu M, Chaize C, Arulanandam R, Vultur A, Kowolik C, Anagnostopoulou A, Jove R and Raptis L: Stat3 activity is required for gap junctional permeability in normal epithelial cells and fibroblasts. DNA & Cell Biol 28: 319-327, 2009.
15. Germain D and Frank DA: Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy. Clin Cancer Res 13: 5665-5669, 2007. (Pubitemid 47583890)
16. Gonzalez E and McGraw TE: The Akt kinases: isoform specificity in metabolism and cancer. Cell Cycle 8: 2502-2508, 2009.
17. Gould KL, Woodgett JR, Cooper JA, Buss JE, Shalloway D, and Hunter T: Protein kinase C phosphorylates pp60c-src at a novel site. Cell 42: 849-857, 1985.
18. Grammatikakis N, Vultur A, Ramana CV, Siganou A, Schweinfest CW and Raptis L: The role of Hsp90N, a new member of the Hsp90 family, in signal transduction and neoplastic transformation. J Biol Chem 277: 8312-8320, 2002. (Pubitemid 34968291)
19. Griner EM and Kazanietz MG: Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer 7: 281-294, 2007. (Pubitemid 46480971)
20. Hung W and Elliott B: Co-operative effect of c-Src tyrosine kinase and Stat3 in activation of hepatocyte growth factor expression in mammary carcinoma cells. J Biol Chem 276:12395-12403, 2001.
21. Ito S, Hyodo T, Hasegawa H, Yuan H, Hamaguchi M and Senga T: PI3K/Akt signaling is involved in the disruption of gap junctional communication caused by v-Src and TNF-alpha. Biochem Biophys Res Commun 400: 230-235, 2010.
22. Ito S, Ito Y, Senga T, Hattori S, Matsuo S and Hamaguchi M: v-Src requires Ras signaling for the suppression of gap junctional intercellular communication. Oncogene 25: 2420-2424, 2006.
23. Kanemitsu MY, Jiang W and Eckhart W: Cdc2-mediated phosphorylation of the gap junction protein, connexin43, during mitosis. Cell Growth Differ 9: 13-21, 1998. (Pubitemid 28049523)
24. Katakowski M, Buller B, Wang X, Rogers T and Chopp M: Functional microRNA is transferred between glioma cells. Cancer Res 70: 8259-8263, 2010.
25. Lampe PD, Kurata WE, Warn-Cramer BJ and Lau AF: Formation of a distinct connexin43 phosphoisoform in mitotic cells is dependent upon p34cdc2 kinase. J Cell Sci 111(Pt 6):833-841, 1998. (Pubitemid 28163891)
26. Lampe PD, TenBroek EM, Burt JM, Kurata WE, Johnson RG and Lau AF: Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication. J Cell Biol 149: 1503-1512, 2000. (Pubitemid 30437622)
27. Lin D, Boyle DL, and Takemoto DJ: IGF-I-induced phosphorylation of connexin 43 by PKCgamma: regulation of gap junctions in rabbit lens epithelial cells. Invest Ophthalmol Vis Sci 44: 1160-1168, 2003. (Pubitemid 36297836)
28. Lin D, Zhou J, Zelenka PS and Takemoto DJ: Protein kinase Cgamma regulation of gap junction activity through caveolin-1-containing lipid rafts. Invest Ophthalmol Vis Sci 44: 5259-5268, 2003. (Pubitemid 37475397)
29. Lin R, Martyn KD, Guyette CV, Lau AF and Warn-Cramer BJ: v-Src tyrosine phosphorylation of connexin43: regulation of gap junction communication and effects on cell transformation. Cell Commun Adhes 13: 199-216, 2006. (Pubitemid 44256249)
30. Lin R, Warn-Cramer BJ, Kurata WE and Lau AF: v-Src phosphorylation of connexin 43 on Tyr247 and Tyr265 disrupts gap junctional communication. J Cell Biol 154: 815-827, 2001. (Pubitemid 34292962)
31. Loewenstein WR and Kanno Y: Intercellular communication and the control of tissue growth: lack of communication between cancer cells. Nature 209: 1248-1249, 1966.
32. Manning BD and Cantley LC: AKT/PKB signaling: navigating downstream. Cell 129: 1261-1274, 2007. (Pubitemid 46962095)
33. Pahujaa M, Anikin M and Goldberg GS: Phosphorylation of connexin43 induced by Src: regulation of gap junctional communication between transformed cells. Exp Cell Res 313:4083-4090, 2007. (Pubitemid 350087051)
34. Park DJ, Wallick CJ, Martyn KD, Lau AF, Jin C and Warn-Cramer BJ: Akt phosphorylates Connexin43 on Ser373, a "mode-1"binding site for 14-3-3. Cell Commun Adhes 14: 211-226, 2007.
35. Raptis L, Brownell HL, Firth KL and MacKenzie LW: A novel technique for the study of intercellular, junctional communication; electroporation of adherent cells on a partly conductive slide. DNA & Cell Biol 13: 963-975, 1994. (Pubitemid 24376828)
36. Raptis L and Firth KL: Electrode assemblies used for electroporation of cultured cells. In: Electroporation protocols (Li S ed). Humana Press, pp. 58-73, 2008.
37. Roberts PJ and Der CJ: Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 26: 3291-3310, 2007. (Pubitemid 46763022)
38. Shah MM, Martinez AM and Fletcher WH: The connexin43 gap junction protein is phosphorylated by protein kinase A and protein kinase C: in vivo and in vitro studies. Mol Cell Biochem 238: 57-68, 2002. (Pubitemid 35023529)
39. Shen Y, Khusial PR, Li X, Ichikawa H, Moreno AP and Goldberg GS: SRC utilizes Cas to block gap junctional communication mediated by connexin43. J Biol Chem 282:18914-18921, 2007. (Pubitemid 47100169)
40. Solan JL and Lampe PD: Connexin 43 in LA-25 cells with active v-src is phosphorylated on Y247, Y265, S262, S279/282, and S368 via multiple signaling pathways. Cell Commun Adhes 15: 75-84, 2008.
41. Steinman RA, Wentzel A, Lu Y, Stehle C and Grandis JR: Activation of Stat3 by cell confluence reveals negative regulation of Stat3 by cdk2. Oncogene 22: 3608-3615, 2003. (Pubitemid 36765320)
42. Su HW, Yeh HH, Wang SW, Shen MR, Chen TL, Kiela PR, Ghishan FK and Tang MJ: Cell confluence-induced activation of signal transducer and activator of transcription-3 (Stat3) triggers epithelial dome formation via augmentation of sodium hydrogen exchanger-3 (NHE3) expression. J Biol Chem 282: 9883-9894, 2007. (Pubitemid 47104639)
43. Swenson LI, Piwnica-Worms H, McNamee H and Paul DL: Tyrosine phosphorylation of the gap junction protein connexin43 is required for the pp60v-src-induced inhibition of communication. Cell Regul 1: 989-1002, 1990.
44. TenBroek EM, Lampe PD, Solan JL, Reynhout JK and Johnson RG: Ser364 of connexin43 and the up-regulation of gap junction assembly by cAMP. J Cell Biol 155: 1307-1318, 2001. (Pubitemid 34286279)
45. Theiss C, Mazur A, Meller K and Mannherz HG: Changes in gap junction organization and decreased coupling during induced apoptosis in lens epithelial and NIH-3T3 cells. Exp Cell Res 313: 38-52, 2007. (Pubitemid 44958452)
46. Vinken M, Vanhaecke T, Papeleu P, Snykers S, Henkens T and Rogiers V: Connexins and their channels in cell growth and cell death. Cell Signal 18: 592-600, 2006. (Pubitemid 43113290)
47. Vultur A, Arulanandam R, Turkson J, Niu G, Jove R and Raptis L: Stat3 is required for full neoplastic transformation by the Simian Virus 40 Large Tumor antigen. Molecular Biology of the Cell 16: 3832-3846, 2005. (Pubitemid 41077091)
48. Vultur A, Cao J, Arulanandam R, Turkson J, Jove R, Greer P, Craig A, Elliott BE and Raptis L: Cell to cell adhesion modulates Stat3 activity in normal and breast carcinoma cells. Oncogene 23: 2600-2616, 2004. (Pubitemid 38586314)
49. Wagner LM, Saleh SM, Boyle DJ and Takemoto DJ: Effect of protein kinase Cgamma on gap junction disassembly in lens epithelial cells and retinal cells in culture. Mol Vis 8: 59-66, 2002. (Pubitemid 36153591)
50. Warn-Cramer BJ, Lampe PD, Kurata WE, Kanemitsu MY, Loo LW, Eckhart W and Lau AF: Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein. J Biol Chem 271: 3779-3786, 1996. (Pubitemid 26065698)
51. White TW and Paul DL: Genetic diseases and gene knockouts reveal diverse connexin functions. Annu Rev Physiol 61: 283-310, 1999. (Pubitemid 29143172)
52. Yu H, Pardoll D and Jove R: STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 9: 798-809, 2009.
53. Zhang Y, Turkson J, Carter-Su C, Smithgall T, Levitzki A, Kraker A, Krolewski JJ, Medveczky P and Jove R: Activation of Stat3 in v-Src transformed fibroblasts requires cooperation of Jak1 kinase activity. J Biol Chem 275: 24935-24944, 2000. (Pubitemid 30626601)
54. Zhou L, Kasperek EM and Nicholson BJ: Dissection of the molecular basis of pp60(v-src) induced gating of connexin 43 gap junction channels. J Cell Biol 144: 1033-1045, 1999. (Pubitemid 29238976)