Cellular Ras partly mediates gap junction closure by the polyoma virus middle tumor antigen

Cancer Letters

Volumn 103, Issue 1, 1996, Pages 99-106

  Brownell, Heather L ^a   Whitfield, James F ^b   Raptis, Leda ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

c Ras; Intercellular communication; mT; Polyoma virus

Indexed keywords

COMPLEMENTARY DNA; RAS PROTEIN; TUMOR ANTIGEN;

ANIMAL CELL; ARTICLE; CELL COMMUNICATION; CELL JUNCTION; CONTROLLED STUDY; FIBROBLAST; GENE EXPRESSION; MOUSE; NONHUMAN; POLYOMA VIRUS; PRIORITY JOURNAL; VIRUS CELL TRANSFORMATION;

EID: 0029926074     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(96)04187-0     Document Type: Article

References (26)

1. Anderson, S.K., Stankova, J. and Roder, J.C. (1989) Decreased p21 levels in anti-sense ras transfectants augments NK sensitivity. Mol. Immunol., 26, 985-991.
2. Azarnia, R. and Loewenstein, W.R. (1987) Polyomavirus middle t antigen downregulates junctional cell-to-cell communication. Mol. Cell. Biol., 7, 946-950.
3. Bennett, M.V.L., Barrio, L.C., Bargiello, T.A., Spray, D.C., Hertzberg, E. and Saez, J.C. (1991) Gap junctions: new tools, new answers, new questions. Neuron, 6, 305-320.
4. Bignami, M., Rosa, S., Falcone, G., Tato, F., Katoh, F. and Yamasaki, H. (1988) Specific viral oncogenes cause differential effects on cell-to-cell communication, relevant to the suppression of the transformed phenotype by normal cells. Mol. Carcinogen., 1, 67-75.
5. Boguski, M.S. and McCormick, F. (1993) Proteins regulating Ras and its relatives. Nature, 366, 643-654.
6. Capon, D.J., Chen, E.Y., Levinson, A.D., Seeburg, P.H. and Goeddel, D.V. (1983) Complete nucleotide sequence of the T24 human bladder carcinoma oncogene and its normal homologue. Nature, 302, 33-37.
7. Cooper, G.H. (1995) Oncogenes. Jones and Bartlett, Boston, MA.
8. De Feijter, A.W., Trosko, J.E., Krizman, D.B., Lebovitz, R.M. and Lieberman, M.W. (1992) Correlation of increased levels of Ha-ras T24 protein with extent of loss of gap junction function in rat liver epithelial cells. Mol. Carcinogen., 5, 205-212.
9. el-Fouly, M.H., Trosko, J.E., Chang, C.C. and Warren, S.T. (1989) Potential role of the human Ha-ras oncogene in the inhibition of gap junctional intercellular communication. Mol. Carcinogen., 2, 131-135.
10. Hu, M.C.T. and Davidson, N. (1990) A combination of derepression of the lac operator-repressor system with positive induction by glucocorticoid and metal ions provides a high-level-inducible gene expression system based on the human metallothionein-IIa promoter. Mol. Cell. Biol., 10, 6141-6151.
11. Johnson, R.G. and E.L. Hertzberg (1988) Introduction: gap junctions and the control of cell growth. In: Modern Cell Biology, Vol. 7, Gap Junctions. Editors: E.L. Hertzberg and R.G. Johnson. Alan R. Liss, New York, pp. 393-396.
12. Loewenstein, W.R. (1987) The cell-to-cell channel of gap Junctions. Cell, 48, 725-726.
13. Lowy, D.R. and Willumsen, B.M. (1993) Function and regulation of ras. Annu. Rev. Biochem., 62, 851-891.
14. Morgenstern, J.P. and Land, H. (1990) Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging line. Nucleic Acids Res., 18, 3587-3596.
15. Raptis, L., Brownell, H.L., Firth, K.L. and MacKenzie, L.W. (1994) A novel technique for the study of intercellular, junctional communication; electroporation of adherent cells on a partly conductive slide. DNA Cell Biol., 13, 963-975.
16. Raptis, L., Lamfrom, H. and Benjamin, T.L. (1985) Regulation of cellular phenotype and expression of polyomavirus middle T antigen in rat fibroblasts. Mol. Cell. Biol., 5, 2476-2486.
17. Raptis, L., Marcellus, R., Corbley, M.J., Krook, A., Whitfield, J., Anderson, S.K. and Haliotis, T. (1991) Cellular ras gene activity is required for full neoplastic transformation by polyomavirus. J. Virol., 65, 5203-5210.
18. Reznikoff, C.A., Brankow, D.W. and Heidelberger, C. (1973) Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division. Cancer Res., 33, 3231-3238.
19. Ruch, R.J., Madhukar, B.V., Trosko, J.E. and Klaunig, J.E. (1993) Reversal of ras-induced inhibition of gap-junctional intercellular communication, transformation and tumorigenesis by lovastatin. Mol. Carcinogen., 7, 50-59.
20. Southern, P.J. and Berg, P. (1982) Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J. Mol. Appl. Genet., 1, 327-341.
21. Stagg, R.B. and Fletcher, W.H. (1990) The hormone-induced regulation of contact-dependent cell-cell communication by phosphorylation. Endocr. Rev., 11, 302-325.
22. Trimble, W.S., Johnson, P.W., Hozumi, N. and Roder, J.C. (1986) Inducible cellular transformation by a metallothionein-ras hybrid oncogene leads to natural killer cell susceptibility. Nature, 321, 782-784.
23. Wagner, R.W. and Nishikura, K. (1988) Cell cycle expression of RNA duplex unwindase activity in mammalian cells. Mol. Cell. Biol., 8, 770-777.
24. Whitfield, J.F. (1995) Calcium, Cell Cycles and Cancer. CRC Press, Boca Raton, FL.
25. Yamasaki, H. (1991) Aberrant expression and function of gap junctions during carcinogenesis. Environ. Health Perspect., 93, 191-197.
26. Yanisch-Perron, C., Vieira, J. and Messing, J. (1985) Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene, 33, 103-119.