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Volumn 287, Issue 43, 2012, Pages 36222-36228

Suppressor of fused (Sufu) mediates the effect of parathyroid hormone-like hormone (Pthlh) on chondrocyte differentiation in the growth plate

Author keywords

[No Author keywords available]

Indexed keywords

CHONDROCYTE DIFFERENTIATION; CHONDROCYTES; GROWTH PLATE; HEDGEHOG SIGNALING; HYPERTROPHIC CHONDROCYTES; LONG BONE; MOLECULAR SWITCHES; PROTEIN LEVEL; UP-REGULATION;

EID: 84867765157     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.382275     Document Type: Article
Times cited : (14)

References (33)
  • 1
    • 0033950445 scopus 로고    scopus 로고
    • Indian Hedgehog coordinates endochondral bone growth and morphogenesis via Parathyroid Hormone related-Protein-dependent and -independent pathways
    • Karp, S. J., Schipani, E., St-Jacques, B., Hunzelman, J., Kronenberg, H., and McMahon, A. P. (2000) Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone-related protein-dependent and -independent pathways. Development 127, 543-548 (Pubitemid 30093402)
    • (2000) Development , vol.127 , Issue.3 , pp. 543-548
    • Karp, S.J.1    Schipani, E.2    St-Jacques, B.3    Hunzelman, J.4    Kronenberg, H.5    McMahon, A.P.6
  • 4
    • 0034747252 scopus 로고    scopus 로고
    • BMP and lhh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation
    • Minina, E., Wenzel, H. M., Kreschel, C., Karp, S., Gaffield, W., McMahon, A. P., and Vortkamp, A. (2001) BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation. Development 128, 4523-4534 (Pubitemid 33130432)
    • (2001) Development , vol.128 , Issue.22 , pp. 4523-4534
    • Minina, E.1    Wenzel, H.M.2    Kreschel, C.3    Karp, S.4    Gaffield, W.5    McMahon, A.P.6    Vortkamp, A.7
  • 5
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • Kronenberg, H. M. (2003) Developmental regulation of the growth plate. Nature 423, 332-336
    • (2003) Nature , vol.423 , pp. 332-336
    • Kronenberg, H.M.1
  • 6
    • 0035691559 scopus 로고    scopus 로고
    • Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation
    • Long, F., Zhang, X. M., Karp, S., Yang, Y., and McMahon, A. P. (2001) Genetic manipulation of Hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development 128, 5099-5108 (Pubitemid 34086893)
    • (2001) Development , vol.128 , Issue.24 , pp. 5099-5108
    • Long, F.1    Zhang, X.M.2    Karp, S.3    Yang, Y.4    McMahon, A.P.5
  • 7
    • 46749111932 scopus 로고    scopus 로고
    • Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy
    • DOI 10.1242/dev.018044
    • Mak, K. K., Kronenberg, H. M., Chuang, P. T., Mackem, S., and Yang, Y. (2008) Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy. Development 135, 1947-1956 (Pubitemid 351943359)
    • (2008) Development , vol.135 , Issue.11 , pp. 1947-1956
    • Mak, K.K.1    Kronenberg, H.M.2    Chuang, P.-T.3    Mackem, S.4    Yang, Y.5
  • 8
    • 27644584608 scopus 로고    scopus 로고
    • Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused
    • DOI 10.1242/dev.02021
    • Cooper, A. F., Yu, K. P., Brueckner, M., Brailey, L. L., Johnson, L., McGrath, J. M., and Bale, A. E. (2005) Cardiac and CNS defects in a mouse with targeted disruption of Suppressor of fused. Development 132, 4407-4417 (Pubitemid 41576701)
    • (2005) Development , vol.132 , Issue.19 , pp. 4407-4417
    • Cooper, A.F.1    Yu, K.P.2    Brueckner, M.3    Brailey, L.L.4    Johnson, L.5    McGrath, J.M.6    Bale, A.E.7
  • 9
    • 31744451535 scopus 로고    scopus 로고
    • Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian hedgehog signaling pathway
    • DOI 10.1016/j.devcel.2005.12.013, PII S1534580706000050
    • Svärd, J., Henricson, K. H., Persson-Lek, M., Rozell, B., Lauth, M., Bergström, A., Ericson, J., Toftgård, R., and Teglund, S. (2006) Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev. Cell 10, 187-197 (Pubitemid 43174952)
    • (2006) Developmental Cell , vol.10 , Issue.2 , pp. 187-197
    • Svard, J.1    Henricson, K.H.2    Persson-Lek, M.3    Rozell, B.4    Lauth, M.5    Bergstrom, A.6    Ericson, J.7    Toftgard, R.8    Teglund, S.9
  • 10
    • 69249245332 scopus 로고    scopus 로고
    • Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
    • Chen, M. H., Wilson, C. W., Li, Y. J., Law, K. K., Lu, C. S., Gacayan, R., Zhang, X., Hui, C. C., and Chuang, P. T. (2009) Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 23, 1910-1928
    • (2009) Genes Dev. , vol.23 , pp. 1910-1928
    • Chen, M.H.1    Wilson, C.W.2    Li, Y.J.3    Law, K.K.4    Lu, C.S.5    Gacayan, R.6    Zhang, X.7    Hui, C.C.8    Chuang, P.T.9
  • 12
    • 80051536284 scopus 로고    scopus 로고
    • Kif7 promotes Hedgehog signaling in growth plate chondrocytes by restricting the inhibitory function of Sufu
    • Hsu, S. H., Zhang, X., Yu, C., Li, Z. J., Wunder, J. S., Hui, C. C., and Alman, B. A. (2011) Kif7 promotes Hedgehog signaling in growth plate chondrocytes by restricting the inhibitory function of Sufu. Development 138, 3791-3801
    • (2011) Development , vol.138 , pp. 3791-3801
    • Hsu, S.H.1    Zhang, X.2    Yu, C.3    Li, Z.J.4    Wunder, J.S.5    Hui, C.C.6    Alman, B.A.7
  • 13
    • 34247163680 scopus 로고    scopus 로고
    • PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms
    • DOI 10.1016/j.ydbio.2007.01.031, PII S0012160607000784
    • Mau, E., Whetstone, H., Yu, C., Hopyan, S., Wunder, J. S., and Alman, B. A. (2007) PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3-dependent manner utilizing Hedgehog ligand-dependent and -independent mechanisms. Dev. Biol. 305, 28-39 (Pubitemid 46589405)
    • (2007) Developmental Biology , vol.305 , Issue.1 , pp. 28-39
    • Mau, E.1    Whetstone, H.2    Yu, C.3    Hopyan, S.4    Wunder, J.S.5    Alman, B.A.6
  • 14
    • 79953858623 scopus 로고    scopus 로고
    • Dual phosphorylation of Suppressor of fused (Sufu) by PKA and GSK3β regulates its stability and localization in the primary cilium
    • Chen, Y., Yue, S., Xie, L., Pu, X. H., Jin, T., and Cheng, S. Y. (2011) Dual phosphorylation of Suppressor of fused (Sufu) by PKA and GSK3β regulates its stability and localization in the primary cilium. J. Biol. Chem. 286, 13502-13511
    • (2011) J. Biol. Chem. , vol.286 , pp. 13502-13511
    • Chen, Y.1    Yue, S.2    Xie, L.3    Pu, X.H.4    Jin, T.5    Cheng, S.Y.6
  • 15
    • 0033533714 scopus 로고    scopus 로고
    • Mouse suppressor of fused is a negative regulator of Sonic hedgehog signaling and alters the subcellular distribution of Gli1
    • DOI 10.1016/S0960-9822(99)80482-5
    • Ding, Q., Fukami, S., Meng, X., Nishizaki, Y., Zhang, X., Sasaki, H., Dlugosz, A., Nakafuku, M., and Hui, C. (1999) Mouse Suppressor of fused is a negative regulator of Sonic hedgehog signaling and alters the subcellular distribution of Gli1. Curr. Biol. 9, 1119-1122 (Pubitemid 29504483)
    • (1999) Current Biology , vol.9 , Issue.19 , pp. 1119-1122
    • Ding, Q.1    Fukami, S.-I.2    Meng, X.3    Nishizaki, Y.4    Zhang, X.5    Sasaki, H.6    Dlugosz, A.7    Nakafuku, M.8    Hui, C.-C.9
  • 16
    • 67651152911 scopus 로고    scopus 로고
    • Gli2 and p53 cooperate to regulate IGFBP-3-mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors
    • Ho, L., Stojanovski, A., Whetstone, H., Wei, Q. X., Mau, E., Wunder, J. S., and Alman, B. (2009) Gli2 and p53 cooperate to regulate IGFBP-3-mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors. Cancer Cell 16, 126-136
    • (2009) Cancer Cell , vol.16 , pp. 126-136
    • Ho, L.1    Stojanovski, A.2    Whetstone, H.3    Wei, Q.X.4    Mau, E.5    Wunder, J.S.6    Alman, B.7
  • 18
    • 33244463281 scopus 로고    scopus 로고
    • GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis
    • DOI 10.1242/dev.02220
    • Hu, M. C., Mo, R., Bhella, S., Wilson, C. W., Chuang, P. T., Hui, C. C., and Rosenblum, N. D. (2006) GLI3-dependent transcriptional repression of Gli1, Gli2, and kidney patterning genes disrupts renal morphogenesis. Development 133, 569-578 (Pubitemid 43273842)
    • (2006) Development , vol.133 , Issue.3 , pp. 569-578
    • Hu, M.C.1    Mo, R.2    Bhella, S.3    Wilson, C.W.4    Chuang, P.-T.5    Hui, C.-C.6    Rosenblum, N.D.7
  • 21
    • 0034681266 scopus 로고    scopus 로고
    • Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
    • Wang, B., Fallon, J. F., and Beachy, P. A. (2000) Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell 100, 423-434
    • (2000) Cell , vol.100 , pp. 423-434
    • Wang, B.1    Fallon, J.F.2    Beachy, P.A.3
  • 22
  • 23
    • 34548566067 scopus 로고    scopus 로고
    • Cyclin D1 as a target for the proliferative effects of PTH and PTHrP in early osteoblastic cells
    • DOI 10.1359/jbmr.070328
    • Datta, N. S., Pettway, G. J., Chen, C., Koh, A. J., and McCauley, L. K. (2007) CyclinD1 as a target for the proliferative effects ofPTHand PTHrP in early osteoblastic cells. J. Bone Miner. Res. 22, 951-964 (Pubitemid 351339717)
    • (2007) Journal of Bone and Mineral Research , vol.22 , Issue.7 , pp. 951-964
    • Datta, N.S.1    Pettway, G.J.2    Chen, C.3    Koh, A.J.4    McCauley, L.K.5
  • 24
    • 0035710746 scopus 로고    scopus 로고
    • -ΔΔCT method
    • DOI 10.1006/meth.2001.1262
    • Livak, K. J., and Schmittgen, T. D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCt method. Methods 25, 402-408 (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 25
    • 50349096522 scopus 로고    scopus 로고
    • Primary culture and phenotyping of murine chondrocytes
    • Gosset, M., Berenbaum, F., Thirion, S., and Jacques, C. (2008) Primary culture and phenotyping of murine chondrocytes. Nat. Protoc. 3, 1253-1260
    • (2008) Nat. Protoc. , vol.3 , pp. 1253-1260
    • Gosset, M.1    Berenbaum, F.2    Thirion, S.3    Jacques, C.4
  • 27
    • 0036696005 scopus 로고    scopus 로고
    • The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C
    • Guo, J., Chung, U. I., Kondo, H., Bringhurst, F. R., and Kronenberg, H. M. (2002) The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C. Dev. Cell 3, 183-194
    • (2002) Dev. Cell , vol.3 , pp. 183-194
    • Guo, J.1    Chung, U.I.2    Kondo, H.3    Bringhurst, F.R.4    Kronenberg, H.M.5
  • 28
    • 31744450041 scopus 로고    scopus 로고
    • Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms
    • DOI 10.1111/j.1432-0436.2005.00042.x
    • Barnfield, P. C., Zhang, X., Thanabalasingham, V., Yoshida, M., and Hui, C. C. (2005) Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms. Differentiation 73, 397-405 (Pubitemid 43922158)
    • (2005) Differentiation , vol.73 , Issue.8 , pp. 397-405
    • Barnfield, P.C.1    Zhang, X.2    Thanabalasingham, V.3    Yoshida, M.4    Hui, C.-C.5
  • 32
    • 84861998949 scopus 로고    scopus 로고
    • Small ubiquitin-like modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo
    • Han, L., Pan, Y., and Wang, B. (2012) Small ubiquitin-like modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo. J. Biol. Chem. 287, 20483-20489
    • (2012) J. Biol. Chem. , vol.287 , pp. 20483-20489
    • Han, L.1    Pan, Y.2    Wang, B.3
  • 33
    • 84865240334 scopus 로고    scopus 로고
    • Transcriptomic and proteomic analyses in bone tumor cells: Deciphering parathyroid hormone- Related protein regulation of the cell cycle and apoptosis
    • Mak, I. W., Turcotte, R. E., and Ghert, M. (2012) Transcriptomic and proteomic analyses in bone tumor cells: deciphering parathyroid hormone- related protein regulation of the cell cycle and apoptosis. J. Bone Miner. Res. 27, 1976-1991
    • (2012) J. Bone Miner. Res. , vol.27 , pp. 1976-1991
    • Mak, I.W.1    Turcotte, R.E.2    Ghert, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.