Neural stem cell-based dual suicide gene delivery for metastatic brain tumors

Cancer Gene Therapy

Volumn 19, Issue 11, 2012, Pages 796-801

  Wang, C ^a,b   Natsume, A ^a   Lee, H J ^c,d   Motomura, K ^a   Nishimira, Y ^a   Ohno, M ^a   Ito, M ^a   Kinjo, S ^a   Momota, H ^a   Iwami, K ^a   Ohka, F ^a   Wakabayashi, T ^a   Kim, S U ^c,d  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b China Scholarship Council   (China)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d Chung Ang University College of Medicine   (South Korea)

Author keywords

dual suicide genes; metastatic brain tumors; neural stem cells

Indexed keywords

CYTOSINE DEAMINASE; FLUCYTOSINE; GANCICLOVIR; THYMIDINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN METASTASIS; BYSTANDER EFFECT; CANCER CELL; CANCER MODEL; CANCER SURVIVAL; CELL LINE; COMMON CAROTID ARTERY; CONTROLLED STUDY; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENETIC ENGINEERING; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CANCER; MOUSE; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; SUICIDE GENE; TUMOR VOLUME;

ADMINISTRATION, INTRAVENOUS; ANIMALS; ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; BYSTANDER EFFECT; CAROTID ARTERIES; CELL MOVEMENT; CELL SURVIVAL; CYTOSINE DEAMINASE; FLUCYTOSINE; GANCICLOVIR; GENE TRANSFER TECHNIQUES; GENES, TRANSGENIC, SUICIDE; GENETIC ENGINEERING; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; KAPLAN-MEIER ESTIMATE; LUNG NEOPLASMS; MICE; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; NEURAL STEM CELLS; PRODRUGS; SIMPLEXVIRUS; THYMIDINE KINASE;

ANIMALIA; SIMPLEXVIRUS;

EID: 84867748652     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2012.63     Document Type: Article

References (26)

1. Delattre JY, Krol G, Thaler HT, Posner JB. Distribution of brain metastases. Arch Neurol 1988; 45: 741-744.
2. Yazawa K, Fisher WE, Brunicardi FC. Current progress in suicide gene therapy for cancer. World J Surg 2002; 26: 783-789.
3. Niculescu-Duvaz I, Springer CJ. Introduction to the background, principles, and state of the art in suicide gene therapy. Mol Biotechnol 2005; 30: 71-88.
4. Egami T, Ohuchida K, Miyoshi K, Mizumoto K, Onimaru M, Toma H et al. Che-motherapeutic agents potentiate adenoviral gene therapy for pancreatic cancer. Cancer Sci 2009; 100: 722-729.
5. Shimato S, Natsume A, Takeuchi H, Wakabayashi T, Fujii M, Ito M et al. Human neural stem cells target and deliver therapeutic gene to experimental leptome-ningeal medulloblastoma. Gene Therapy 2007; 14: 1132-1142.
6. Ito S, Natsume A, Shimato S, Ohno M, Kato T, Chansakul P et al. Human neural stem cells transduced with IFN-beta and cytosine deaminase genes intensify bystander effect in experimental glioma. Cancer Gene Ther 17: 299-306.
7. Vermes A, van Der Sijs H, Guchelaar HJ. Flucytosine: correlation between toxicity and pharmacokinetic parameters. Chemotherapy 2000; 46: 86-94.
8. Vermes A, Guchelaar HJ, Dankert J. Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions. J Antimicrob Chemother 2000; 46: 171-179.
9. Kievit E, Bershad E, Ng E, Sethna P, Dev I, Lawrence TS et al. Superiority of yeast over bacterial cytosine deaminase for enzyme/prodrug gene therapy in colon cancer xenografts. Cancer Res 1999; 59: 1417-1421.
10. Miller WH, Miller RL. Phosphorylation of acyclovir (acycloguanosine) monopho-sphate by GMP kinase. J Biol Chem 1980; 255: 7204-7207.
11. Uckert W, Kammertons T, Haack K, Qin Z, Gebert J, Schendel DJ et al. Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo. Hum Gene Ther 1998; 9: 855-865.
12. Lee HJ, Kim KS, Kim EJ, Lee KH, Choi HB, Park IH et al. Brain transplantation of human neural stem cells promotes functional recovery in mouse intracerebral hemorrhage stroke model. Stem Cells 2007; 25: 211-224.
13. Kim SU, Nagai A, Nakagawa E, Choi HB, Bang JH, Lee HJ et al. Production and characterization of immortal human neural stem cell line with multipotent differentiation property. Methods Mol Biol 2008; 438: 103-121.
14. Gutova M, Najbauer J, Chen MY, Potter PM, Kim SU, Aboody KS. Therapeutic targeting of melanoma cells using neural stem cells expressing carboxylesterase, a CPT-11 activating enzyme. Curr Stem Cell Res Ther 5: 273-276.
15. Kim YG, Bi W, Feliciano ES, Drake RR, Stambrook PJ. Ganciclovir-mediated cell killing and bystander effect is enhanced in cells with two copies of the herpes simplex virus thymidine kinase gene. Cancer Gene Ther 2000; 7: 240-246.
16. Rogulski KR, Wing MS, Paielli DL, Gilbert JD, Kim JH, Freytag SO. Double suicide gene therapy augments the antitumor activity of a replication-competent lytic adenovirus through enhanced cytotoxicity and radiosensitization. Hum Gene Ther 2000; 11: 67-76.
17. Toda M, Martuza RL, Rabkin SD. Combination suicide/cytokine gene therapy as adjuvants to a defective herpes simplex virus-based cancer vaccine. Gene Therapy 2001; 8: 332-339.
18. Kim SU. Neural stem cell-based gene therapy for brain tumors. Stem Cell Rev 7: 130-140.
19. Aboody KS, Brown A, Rainov NG, Bower KA, Liu S, Yang W et al. Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci USA 2000; 97: 12846-12851.
20. Aboody KS, Najbauer J, Danks MK. Stem and progenitor cell-mediated tumor selective gene therapy. Gene Therapy 2008; 15: 739-752.
21. Muller FJ, Snyder EY, Loring JF. Gene therapy: can neural stem cells deliver? Nat Rev Neurosci 2006; 7: 75-84.
22. Tang Y, Shah K, Messerli SM, Snyder E, Breakefield X, Weissleder R. In vivo tracking of neural progenitor cell migration to glioblastomas. Hum Gene Ther 2003; 14: 1247-1254.
23. Joo KM, Park IH, Shin JY, Jin J, Kang BG, Kim MH et al. Human neural stem cells can target and deliver therapeutic genes to breast cancer brain metastases. Mol Ther 2009; 17: 570-575.
24. Kim SU, Jeung EB, Kim YB, Cho MH, Choi KC. Potential tumor-tropic effect of genetically engineered stem cells expressing suicide enzymes to selectively target invasive cancer in animal models. Anticancer Res 31: 1249-1258.
25. Ushio Y, Chernik NL, Shapiro WR, Posner JB. Metastatic tumor of the brain: development of an experimental model. Ann Neurol 1977; 2: 20-29.
26. Springer CJ, Niculescu-Duvaz I. Prodrug-activating systems in suicide gene therapy. J Clin Invest 2000: 105; 1161-1167.