Acute pulmonary toxicity of acrolein in rats-underlying mechanism

Toxicology Letters

Volumn 104, Issue 3, 1999, Pages 189-194

  Arumugam, N ^a   Sivakumar, V ^a   Thanislass, J ^a   Sadasivan Pillai, K ^c   Niranjali Devaraj, S ^b   Devaraj, H ^a  

^a Unit of Biochemistry   (India)

^b UNIVERSITY OF MADRAS   (India)

^c Fredrick Institute of Plant Protection and Toxicology India   (India)

Author keywords

Acrolein; Antioxidant enzymes; Lipid peroxidation; Lung

Indexed keywords

ACROLEIN; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CATALASE; DIPEPTIDYL CARBOXYPEPTIDASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LACTATE DEHYDROGENASE; LACTIC ACID; PROTEIN;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOPATHOLOGY; LIPID PEROXIDATION; LUNG INJURY; LUNG LAVAGE; LUNG TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ACROLEIN; ACUTE DISEASE; ANIMALS; ASCORBIC ACID; GLUTATHIONE; LIPID PEROXIDATION; LUNG; LUNG DISEASES; MALE; OXIDATION-REDUCTION; RATS; RATS, WISTAR; SULFHYDRYL COMPOUNDS; VITAMIN E;

EID: 0033060707     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(98)00370-1     Document Type: Article

References (32)

1. Adams J.D. Jr., Klaidman L.K. Acrolein-induced oxygen radical formation. Free Radical Biol. Med. 15:1993;187-193.
2. Babiuk C., Steinhagen W.H., Barrow C.S. Sensory irritation response to inhaled aldehydes after formaldehyde pretreatment. Toxicol. Appl. Pharmacol. 79:1985;143-149.
3. Baker S.B., Summerson W.H. The colorimetric determination of lactic acid in biological materials. J. Biol. Chem. 138:1941;535-554.
4. Beauchamp R.O. Jr., Andjelkovich D.A., Kligerman A.D., Morgan K.T., Heck H.D. A critical review of the literature on acrolein toxicity. Crit. Rev. Toxicol. 14:1985;309-380.
5. Beers R.F., Seizer I.W. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J. Biol. Chem. 115:1952;133-140.
6. Costa D.L., Kutzman R.S., Lehmann J.R., Drew R.T. Altered lung function and structure in the rat after sub-chronic exposure to acrolein. Am. Rev. Respir. Dis. 133:1986;286-291.
7. Cushman D.W., Cheung H.S. Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochem. Pharmacol. 20:1971;1637-1648.
8. Desai I.D. Vitamin E analysis methods for animal tissues. Methods Enzymol. 105:1984;138-147.
9. EHC, 1992. Environmental Health Criteria 127: Acrolein. World Health Organization, Geneva.
10. Feron V.J., Kruysee A., Til H.P., Immel H.R. Reported exposure to acrolein vapor: Subacute studies in hamsters, rats and rabbits. Toxicology. 9:1978;47-57.
11. Halliwell B., Gutteridge J.M.C. Role of free radicals and catalytic metal ions in human disease: an over view. Methods Enzymol. 186:1990;1-85.
12. Hollinger M.A., Patwell S.W., Zuckerman J.E., Gorin A.B., Parsons G., Giri S.N. Effect of paraquat on serum angiotensin converting. Am. Rev. Respir. Dis. 121:1980;795-798.
13. Klein R.A. The detection of oxidation in liposome preparations. Biochim. Biophys. Acta. 210:1970;486-489.
14. Kutzman R.S., Popenoe E.A., Schmaeler M., Drew R.T. Changes in rat lung structure and composition as a result of subchronic exposure to acrolein. Toxicology. 34:1985;139-151.
15. Lagrue G., Branellec A., Lebargy F. Toxicology of tobacco. Rev. Prat. 43:1993;1203-1207.
16. Lam C.W., Casanova M., Heck Hd.'A. Depletion of nasal mucosal glutathione by acrolein and enhancement of formaldehyde-induced DNA-protein cross-linking by simultaneous exposure to acrolein. Arch. Toxicol. 58:1985;67-71.
17. Linhart I., Frantik E., Vodickova L., Vosmanska M., Smejkal J., Mitera J. Biotransformation of acrolein in rat: excretion of mercapturic acids after inhalation and intraperitoneal injection. Toxicol. Appl. Pharmacol. 136:1996;155-160.
18. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
19. Martensson J., Lai J.C.K., Meister A. High-affinity transport of glutathione is part of a multicomponent system essential for mitochondrial function. Proc. Natl. Acad. Sci. U.S.A. 87:1990;7185-7189.
20. McNulty M.J., Heck Hd.'A., Casanova-Schmitz M. Depletion of glutathione in rat respirating mucosa by inhaled acrolein. Fed. Proc. 43:1984;575.
21. Misra H.P., Fridovich I. The role of superoxide anion in the autooxidation of epinephrine and the simple assay for superoxide dismutase. J. Biol. Chem. 247:1972;3170-3175.
22. Moron M.S., Defierre J.W., Mannervik K.B. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim. Biophys. Acta. 582:1979;67-74.
23. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95:1979;351-358.
24. Omaye S.T., Turnbull J.D., Sauberlich H.E. Selected methods for the determination of ascorbic acids in animal cells, tissues, and fluids. Methods Enzymol. 62:1979;3-11.
25. Parent R.A., Caravello H.E., Long J.E. Two-year toxicity and carcinogenicity study of acrolein in rats. J. Appl. Toxicol. 12:1992;131-139.
26. Pompella A., Romani A., Benedetti A., Comporti M. Loss of membrane protein thiols and lipid peroxidation in allyl alcohol hepatotoxicity. Biochem. Pharmacol. 41:1991;1255-1259.
27. Rotruck J.T., Pope A.L., Ganther H.E., Swanson A.B., Hafeman D.G., Hoekstra W.G. Selenium: biochemical role as a component of glutathione peroxidase purification and assay. Science. 179:1973;588-590.
28. Sedlak J., Lindsay R.H. Estimation of total, protein bound, and non-protein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem. 25:1968;192-205.
29. Smith L.J. Lung damage induced by butylated hydroxytoluene in mice: Biochemical, cellular and morphologic characterization. Am. Rev. Respir. Dis. 130:1984;895-904.
30. Thanislass J., Raveendran M., Devaraj H. Buthionine-sulfoximine induced glutathione depletion: its effect on antioxidants, lipid peroxidation and calcium homeostasis in the lung. Biochem. Pharmacol. 50:1995;229-234.
31. Wacker W.E.C., Ulmer D.D., Vallee B.L. Metalloenzymes and myocardial infarction. II. Malic and lactic dehydrogenase activities and zinc concentrations in serum. New Engl. J. Med. 255:1956;449-454.
32. Zitting A., Heinonen T. Decrease of reduced glutathione in isolated rat hepatocytes caused by acrolein, acrylonitrile, and the thermal degradation products of styrene copolymers. Toxicology. 17:1980;333-341.