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The role of the active site Zn in the catalytic mechanism of the GH38 Golgi α-mannosidase II: implications from noeuromycin inhibition
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Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates
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The relation of three-dimensional structure to biosynthesis in the N-linked oligosaccharides
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Probing the substrate specificity of Golgi alpha-mannosidase II by use of synthetic oligosaccharides and a catalytic nucleophile mutant
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Golgi alpha-mannosidase II cleaves two sugars sequentially in the same catalytic site
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Shah N., Kuntz D.A., Rose D.R. Golgi alpha-mannosidase II cleaves two sugars sequentially in the same catalytic site. Proc Natl Acad Sci USA 2008, 105:9570-9575.
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Functionalized pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: optimizing the fit to the active site
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Fiaux H., Kuntz D.A., Hoffman D., Janzer R.C., Gerber-Lemaire S., Rose D.R., Juillerat-Jeanneret L. Functionalized pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: optimizing the fit to the active site. Bioorg Med Chem 2008, 16:7337-7346.
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A combined STD-NMR/molecular modeling protocol for predicting the binding modes of the glycosidase inhibitors kifunensine and salacinol to Golgi alpha-mannosidase II
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Wen X., Yuan Y., Kuntz D.A., Rose D.R., Pinto B.M. A combined STD-NMR/molecular modeling protocol for predicting the binding modes of the glycosidase inhibitors kifunensine and salacinol to Golgi alpha-mannosidase II. Biochemistry 2005, 44:6729-6737.
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Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives
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Synthesis, enzymatic activity, and X-ray crystallography of an unusual class of amino acids
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Structural investigation of the binding of 5-substituted swainsonine analogues to Golgi alpha-mannosidase II
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Kuntz D.A., Nakayama S., Shea K., Hori H., Uto Y., Nagasawa H., Rose D.R. Structural investigation of the binding of 5-substituted swainsonine analogues to Golgi alpha-mannosidase II. Chembiochem 2010, 11:673-680.
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Binding of sulfonium-ion analogues of di-epi-swainsonine and 8-epi-lentiginosine to Drosophila Golgi alpha-mannosidase II: the role of water in inhibitor binding
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Kumar N.S., Kuntz D.A., Wen X., Pinto B.M., Rose D.R. Binding of sulfonium-ion analogues of di-epi-swainsonine and 8-epi-lentiginosine to Drosophila Golgi alpha-mannosidase II: the role of water in inhibitor binding. Proteins 2008, 71:1484-1496.
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5-Thio-d-glycopyranosylamines and their amidinium salts as potential transition-state mimics of glycosyl hydrolases: synthesis, enzyme inhibitory activities, X-ray crystallography, and molecular modeling
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Kavlekar L.M., Kuntz D.A., Wen X., Johnston B.D., Svensson B., Rose D.R., Pinto B.M. 5-Thio-d-glycopyranosylamines and their amidinium salts as potential transition-state mimics of glycosyl hydrolases: synthesis, enzyme inhibitory activities, X-ray crystallography, and molecular modeling. Tetrahedron: Asymmetry 2005, 16:1035-1046.
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Structural basis of the inhibition of Golgi alpha-mannosidase II by mannostatin A and the role of the thiomethyl moiety in ligand-protein interactions
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