Melatonin prevents hemorrhagic shock-induced liver injury in rats through an Akt-dependent HO-1 pathway

Journal of Pineal Research

Volumn 53, Issue 4, 2012, Pages 410-416

  Hsu, Jun Te ^a   Kuo, Chia Jung ^a   Chen, Tsung Hsing ^a   Wang, Frank ^a   Lin, Chun Jun ^a   Yeh, Ta Sen ^a   Hwang, Tsann Long ^a   Jan, Yi Yin ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Akt; hemorrhagic shock; HO 1; inflammation; liver injury; melatonin

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPASE 3; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT 1; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT 3; HEME OXYGENASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MALONALDEHYDE; MAMMALIAN TARGET OF RAPAMYCIN; MELATONIN; MYELOPEROXIDASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WORTMANNIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FLUID RESUSCITATION; HEMORRHAGIC SHOCK; LAPAROTOMY; LIVER INJURY; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PROTEIN EXPRESSION; RAT; SHAM PROCEDURE; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ALANINE TRANSAMINASE; ANDROSTADIENES; ANIMALS; ASPARTATE AMINOTRANSFERASES; CASPASE 3; CYTOKINES; CYTOPROTECTION; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; HEME OXYGENASE (DECYCLIZING); INFLAMMATION MEDIATORS; LIVER; LIVER DISEASES; MALE; MALONDIALDEHYDE; MELATONIN; PEROXIDASE; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SHOCK, HEMORRHAGIC; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84867744314     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2012.01011.x     Document Type: Article

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