Melatonin administration attenuates depressed immune functions after trauma-hemorrhage

Journal of Surgical Research

Volumn 63, Issue 1, 1996, Pages 256-262

  Wichmann, Matthias W ^a,d   Zellweger, René ^a   Demaso, Catherine M ^a   Ayala, Alfred ^a,b,d   Chaudry, Irshad H ^a,c,d  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b Rhode Island Hospital ^*  (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; INTERLEUKIN 1; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 6; LYMPHOKINE; MELATONIN; MONOKINE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; BODY WEIGHT; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DRUG BLOOD LEVEL; HEMORRHAGIC SHOCK; IMMUNE DEFICIENCY; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; SOFT TISSUE INJURY; SPLEEN CELL; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0029970106     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1996.0257     Document Type: Conference Paper

References (32)

1. Maestroni, G. J. M., and Pierpaoli, W. Pharmacological control of the hormonally mediated immune-response. In R. Ader (Ed.), Psychoneuroimmunology. New York: Academic Press, 1981. Pp. 405-425.
2. Maestroni, G. J. M., Conti, A., and Pierpaoli, W. Role of the pineal gland in immunity. Circadian synthesis and release of melatonin modulates the antibody response and antagonizes the immunosuppressive effect of corticosterone. J. Neuroimmunol. 13: 19, 1986.
3. Maestroni, G. J. M., Conti, A., and Pierpaoli, W. The pineal gland and the circadian opiatergic immunoregulatory role of melatonin. Ann. NY Acad. Sci. 496: 67, 1987.
4. Becker, J., Veit, G., Handgretinger, A., Attanasio, A., Bruchett, G., Treuner, I., Niethammer, D., and Gupta, D. Circadian variations in the immunomodulatory role of the pineal gland. Neuroendocrinology Letts. 10: 65, 1988.
5. Maestroni, G. J. M., Conti, A., and Pierpaoli, W. Role of the pineal gland in immunity. III. Melatonin antagonizes the immunosuppressive effect of acute stress via an opiatergic mechanism. Immunology 63: 465, 1988.
6. 125I] melatonin by partially purified membranes of rat thymus. J. Neuroimmunol. 45: 121, 1993.
7. Lopez-Gonzalez, M. A., Calvo, J. R., Segura, J. J., and Guerrero, J. M. Characterization of melatonin binding sites in human peripheral blood neutrophils. Biotechnol. Ther. 4: 253, 1993.
8. Lopez-Gonzalez, M. A., Calvo, J. R., Osuna, C., and Guerrero, J. M. Interaction of melatonin with human lymphocytes: Evidence for binding sites coupled to potentiation of cyclic AMP stimulated by vasoactive intestinal peptide and activation of cyclic GMP. J. Pineal Res. 12: 97, 1992.
9. O'Benar, J. D., Hannon, J. P., Peterson, J. L., and Bossone, C. A. Beta-endorphin, ACTH, and cortisol response to hemorrhage in conscious pigs. Am. J. Physiol. 252: R953, 1987.
10. Chaudry, I. H., Ayala, A., Ertel, W., and Stephan, R. N. Editorial Review. Hemorrhage and resuscitation: Immunological Aspects. Am. J. Physiol. 259: R663, 1990.
11. Ayala, A., Lehman, D. L., Herdon, C. D., and Chaudry, I. H. Mechanism of enhanced susceptibility to sepsis following hemorrhage. Arch. Surg. 129: 1172, 1994.
12. Stephan, R. N., Kupper, T. S., Geha, A. S., Baue, A. S., and Chaudry, I. H. Hemorrhage without tissue trauma produces immunosuppression and enhances susceptibility to sepsis. Arch. Surg. 122: 62, 1987.
13. Chaudry, I. H., and Ayala, A. Immunological Aspects of Hemorrhage, Austin, TX: Medical Intelligence Unit; R. G. Landes Company, 1992.
14. Swain, S. L., Weinberg, A. D., English, M., and Huston, G. IL-4 directs the development of Th2-like helper effectors. J. Immunol. 145: 3796, 1990.
15. Zellweger, R., Ayala, A., DeMaso, C. M., and Chaudry, I. H. Trauma-hemorrhage causes prolonged depression in cellular immunity. Shock 4: 149, 1995.
16. Maestroni, G. M. The immunoneuroendocrine role of melatonin: Mini-review. J. Pineal Res. 14: 1, 1993.
17. Schmand, J. F., Ayala, A., Morrison, M. H., and Chaudry, I. H. Dextran 70 administration following trauma and hemorrhagic shock does not impair cellular immune functions. J. Crit. Care 9: 244, 1994.
18. Ayala, A., Perrin, M. M., Wagner, M. A., and Chaudry, I. H. Enhanced susceptibility to sepsis following simple hemorrhage: Depression of Fc and C3b receptor mediated phagocytosis. Arch. Surg. 125: 70, 1990.
19. Ihle, J. N., Keller, J., Greenberger, J. S., Henderson, L., Yetter, R. A., and Morse, H. C. Phenotypic characteristics of cell lines requiring IL-3 for growth. J. Immunol. 129: 1377, 1982.
20. Meldrum, D. R., Ayala, A., Perrin, M. M., Ertel, W., and Chaudry, I. H. Diltiazem restores IL-2, IL-3, IL-6 and IFN-gamma synthesis and decreases susceptibility to sepsis following hemorrhage. J. Surg. Res. 51: 158, 1991.
21. Mizel, S. B. Production and quantitation of lymphocyte-activating factor (interleukin 1). In H. B. Herscowitz, H. T. Holden, J. A. Bellanti, and A. Ghaffar (Eds.), Manual of Macrophage Methodology. New York: Marcel Dekker, Inc., 1981. Pp. 407-441.
22. Ertel, W., Morrison, M. H., Ayala, A., and Chaudry, I. H. Chloroquine attenuates hemorrhagic shock induced suppression of Kupffer cell antigen presentation and MHC class II antigen expression through blockade of tumor necrosis factor and prostaglandin release. Blood 78: 1781, 1991.
23. Hültner, L., Szöts, H., Welle, M., Van Snick, J., Moeller, J., and Dörmer, P. Mouse bone marrow-derived interleukin 3-dependent mast cells and autonomous sublines produce interleukin 6. Immunology 67: 408, 1989.
24. Vaughan, G. M. New sensitive serum melatonin radioimmunoassay employing the Kennaway G280 antibody: Syrian hamster morning adrenergic response. J. Pineal Res. 15: 88, 1993.
25. Harkema, J. M., Singh, G., Wang, P., and Chaudry, I. H. Pharmacologic agents in the treatment of ischemia, hemorrhagic shock, and sepsis. J. Crit. Care 7: 189, 1992.
26. Fang, J-M., and Dubocovich, M. L. Activation of melatonin receptor sites retarded the depletion of norepinephrine following inhibition of synthesis in the C3H/HeN mouse hypothalamus. J. Neuroimmunol. 55: 76, 1990.
27. Goto, M., and Ebihara, S. The influence of different light intensities on pineal melatonin content in the retinal degenerate C3H mouse and the normal CBA mouse. Neurosci. Letts. 3: 267, 1990.
28. Poon, A. M. S., Liu, Z. M., Pang, C. S., Brown, G. M., and Pang, S. F. Evidence for a direct action of melatonin on the immune system. Biol. Signals 3: 107, 1994.
29. + cells to release opioid agonist(s) with immunoenhancing and anti-stress properties. J. Neuroimmunol. 28: 167, 1990.
30. Stankov, B., Gervasoni, M., Scaglione, F., Perego, R., Cova, D., Marabini, L., and Fraschini, F. Primary pharmaco-toxicological evaluation of 2-iodomelatonin, a potent melatonin agonist. Life Sci. 53: 1357, 1993.
31. Jan, J. E., Espezel, H., and Appleton, R. E. The treatment of sleep disorders with melatonin. Dev. Med. Child Neurol. 36: 97, 1994.
32. Reiter, R. J. Melatonin: The chemical expression of darkness. Mol. Cell Endocrinol. 79: C153, 1991.