Electrophilic assistance to the cleavage of an RNA model phopshodiester via specific and general base-catalyzed mechanisms

Journal of Organic Chemistry

Volumn 77, Issue 20, 2012, Pages 9110-9119

  Corona Martínez, David Octavio ^a   Gomez Tagle, Paola ^b   Yatsimirsky, Anatoly K ^b  

^a UNIVERSIDAD DE SONORA   (Mexico)

^b Universidad Nacional Autonoma de Mexico Facultad de Quimica   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AQUEOUS DMSO; BINDING CONSTANT; COFACTORS; DEUTERIUM ISOTOPE EFFECT; DIANIONS; GENERAL BASE; GUANIDINIUM; LEWIS ACID; MECHANISTIC PROBES; MODEL SUBSTRATES; PURE WATER; REACTION PATHS; RIBOZYMES; TRANSITION STATE; TRANSITION-STATE BINDING;

CATALYSIS; CATALYSTS; DEUTERIUM; ENZYMES; POSITIVE IONS; RATE CONSTANTS; RNA;

REACTION KINETICS;

2 HYDROXYPROPYL 4 NITROPHENYL PHOSPHATE; CALCIUM; DEUTERIUM; DIMETHYL SULFOXIDE; LITHIUM; MAGNESIUM; NUCLEASE; PHOSPHATE; PHOSPHORANE DERIVATIVE; RIBOZYME; SODIUM; UNCLASSIFIED DRUG; WATER;

ARTICLE; BINDING SITE; CATALYSIS; CHEMICAL REACTION; ELECTROPHILICITY; KINETICS; PKA; PROTON TRANSPORT; RNA CLEAVAGE; SOLVENT EFFECT; SPECTROPHOTOMETRY; THERMODYNAMICS; TRANSESTERIFICATION;

CALCIUM; CATALYSIS; COBALT; ESTERS; ETHYLENEDIAMINES; GUANIDINE; MAGNESIUM; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; RNA; SODIUM;

EID: 84867707667     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo301649u     Document Type: Article

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