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Volumn 42, Issue 12, 2003, Pages 3943-3949

The ligand effect on the hydrolytic reactivity of Zn(II) complexes toward phosphate diesters

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYPROPYL 2 NITROPHENYL PHOSPHATE; BIS(4 NITROPHENYL PHOSPHATE); LEWIS ACID; LIGAND; ORGANOPHOSPHATE; UNCLASSIFIED DRUG; ZINC COMPLEX; ZINC ION;

EID: 0037945185     PISSN: 00201669     EISSN: None     Source Type: Journal    
DOI: 10.1021/ic034139x     Document Type: Article
Times cited : (87)

References (45)
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    • Williams, N. H.; Takasaki, B.; Wall, M.; Chin, J. Acc. Chem. Res. 1999, 32, 485-493. Different half-life values for the hydrolysis of DNA and RNA have been reported in the literature and are discussed in the reference.
    • (1999) Acc. Chem. Res. , vol.32 , pp. 485-493
    • Williams, N.H.1    Takasaki, B.2    Wall, M.3    Chin, J.4
  • 3
    • 0000001528 scopus 로고    scopus 로고
    • (b) Cowan, J. A. Chem. Rev. 1998, 98, 1067-1087.
    • (1998) Chem. Rev. , vol.98 , pp. 1067-1087
    • Cowan, J.A.1
  • 4
    • 0001431264 scopus 로고    scopus 로고
    • (c) Wilcox, D. E. Chem. Rev. 1996, 96, 2435-2458.
    • (1996) Chem. Rev. , vol.96 , pp. 2435-2458
    • Wilcox, D.E.1
  • 30
    • 0004284088 scopus 로고
    • Coetzer, I. F., Ritchie, C. D., Eds.; Marcel Dekker: New York
    • Bates, R. G. Solute-Solvent Interactions; Coetzer, I. F., Ritchie, C. D., Eds.; Marcel Dekker: New York, 1969.
    • (1969) Solute-Solvent Interactions
    • Bates, R.G.1
  • 34
    • 0038424022 scopus 로고    scopus 로고
    • note
    • -4 due to the solubility problem of the system.
  • 43
    • 37049128024 scopus 로고
    • Kirby, A. J.; Younas, M. J. J. Chem. Soc. B 1970, 510-513. The value was assigned by the authors to a general base mechanism, but it is considerably lower than that usually found for general base reactions, see ref 20.
    • (1970) J. Chem. Soc. B , pp. 510-513
    • Kirby, A.J.1    Younas, M.J.2
  • 45
    • 0038424023 scopus 로고    scopus 로고
    • note
    • A possible different explanation for the small deuterium kinetic solvent isotope effect has been suggested by one of the reviewers: it involves the mutually opposite effects of a better general base ability of the metal bound OD and a lower acidity of the substrate OD group in a general base catalysis mechanism.


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