UDP-glucuronic acid binds first and the aglycone substrate binds second to form a ternary complex in UGT1A9-catalyzed reactions, in both the presence and absence of bovine serum albumin

Drug Metabolism and Disposition

Volumn 40, Issue 11, 2012, Pages 2192-2203

  Manevski, Nenad ^a   Yli Kauhaluoma, Jari ^a   Finel, Moshe ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

1 NAPHTHOL BETA DEXTRO GLUCURONIDE; 1 NAPHTHOL DERIVATIVE; AGLYCONE; BOVINE SERUM ALBUMIN; ENTACAPONE; GLUCURONOSYLTRANSFERASE 1A9; HYMECROMONE; HYMECROMONE GLUCURONIDE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCURONIC ACID;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CATALYSIS; CHEMICAL BINDING; COMPETITIVE INHIBITION; COMPLEX FORMATION; CONCEPTUAL FRAMEWORK; CONTROLLED STUDY; DISSOCIATION CONSTANT; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; EQUILIBRIUM CONSTANT; GLUCURONIDATION; INSECT CELL; INSECT CELL MEMBRANE; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MEMBRANE BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE STUDY;

ANIMALS; CATALYSIS; CELL MEMBRANE; GLUCURONOSYLTRANSFERASE; HUMANS; HYMECROMONE; INSECTS; KINETICS; NAPHTHOLS; SERUM ALBUMIN, BOVINE; URIDINE DIPHOSPHATE GLUCURONIC ACID;

EID: 84867681989     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.047746     Document Type: Article

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