Treatment of Autoimmune Inflammation by a TLR7 Ligand Regulating the Innate Immune System

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Hayashi, Tomoko ^a   Yao, Shiyin ^a   Crain, Brian ^a   Chan, Michael ^a   Tawatao, Rommel I ^a   Gray, Christine ^a   Vuong, Linda ^a   Lao, Fitzgerald ^a   Cottam, Howard B ^a   Carson, Dennis A ^a   Corr, Maripat ^b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1V136; 9 BENZYL 8 HYDROXY 2 (2 METHOXYETHOXY)ADENINE; CD11B ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 17; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEOLIPID PROTEIN; TOLL LIKE RECEPTOR 7; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALITIS; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CONTROLLED STUDY; DEMYELINATION; DENDRITIC CELL; DESENSITIZATION; DISEASE SEVERITY; FEMALE; INFLAMMATORY CELL; INNATE IMMUNITY; INTERFERON PRODUCTION; LOW DRUG DOSE; MICROGLIA; MONONUCLEAR CELL; MOUSE; NONHUMAN; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SPLEEN CELL; T LYMPHOCYTE; TH1 CELL; TH17 CELL; TH2 CELL; UPREGULATION;

ADENINE; ANIMALS; ANTIGEN-PRESENTING CELLS; CELLS, CULTURED; CHEMOKINES; CYTOKINES; DENDRITIC CELLS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; IMMUNITY, INNATE; IMMUNOSUPPRESSIVE AGENTS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICROGLIA; NEUTROPHIL INFILTRATION; SPINAL CORD; T-LYMPHOCYTES; TOLL-LIKE RECEPTOR 7;

EID: 84867628506     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045860     Document Type: Article

References (47)

1. Sospedra M, Martin R, (2005) Immunology of multiple sclerosis. Annu Rev Immunol 23: 683-747.
2. Lee J, Chuang TH, Redecke V, She L, Pitha PM, et al. (2003) Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A 100: 6646-6651.
3. Lee J, Wu CC, Lee KJ, Chuang TH, Katakura K, et al. (2006) Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A 103: 1828-1833.
4. Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, et al. (2002) Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 3: 196-200.
5. Kurimoto A, Ogino T, Ichii S, Isobe Y, Tobe M, et al. (2004) Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities. Bioorg Med Chem 12: 1091-1099.
6. Hayashi T, Gray CS, Chan M, Tawatao RI, Ronacher L, et al. (2009) Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7. Proc Natl Acad Sci U S A 106: 2764-2769.
7. Simpson JE, Newcombe J, Cuzner ML, Woodroofe MN, (1998) Expression of monocyte chemoattractant protein-1 and other beta-chemokines by resident glia and inflammatory cells in multiple sclerosis lesions. J Neuroimmunol 84: 238-249.
8. Merson TD, Binder MD, Kilpatrick TJ, (2010) Role of cytokines as mediators and regulators of microglial activity in inflammatory demyelination of the CNS. Neuromolecular Med 12: 99-132.
9. O'Connor KC, Bar-Or A, Hafler DA, (2001) The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesis. J Clin Immunol 21: 81-92.
10. Kuchroo VK, Anderson AC, Waldner H, Munder M, Bettelli E, et al. (2002) T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire. Annu Rev Immunol 20: 101-123.
11. Hayashi T, Yao S, Crain B, Chan M, Cottam HB, et al. (2012) Mast Cell-Mediated Inhibition of Abdominal Neutrophil Inflammation by a PEGylated TLR7 Ligand. Mediators of Inflammation 2012. PMID: 22619481, PMCID: PMC3348532.
12. Domingues HS, Mues M, Lassmann H, Wekerle H, Krishnamoorthy G, (2010) Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. PLoS One 5: e15531.
13. Weiner HL, (2004) Multiple sclerosis is an inflammatory T-cell-mediated autoimmune disease. Arch Neurol 61: 1613-1615.
14. Bruck W, (2005) The pathology of multiple sclerosis is the result of focal inflammatory demyelination with axonal damage. J Neurol 252 (Suppl 5): v3-9.
15. Cyster JG, (2005) Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu Rev Immunol 23: 127-159.
16. Hess DC, Abe T, Hill WD, Studdard AM, Carothers J, et al. (2004) Hematopoietic origin of microglial and perivascular cells in brain. Exp Neurol 186: 134-144.
17. Kennedy DW, Abkowitz JL, (1997) Kinetics of central nervous system microglial and macrophage engraftment: analysis using a transgenic bone marrow transplantation model. Blood 90: 986-993.
18. Butchi NB, Du M, Peterson KE, (2010) Interactions between TLR7 and TLR9 agonists and receptors regulate innate immune responses by astrocytes and microglia. Glia 58: 650-664.
19. Weiner HL, (2008) A shift from adaptive to innate immunity: a potential mechanism of disease progression in multiple sclerosis. J Neurol 255 (Suppl 1): 3-11.
20. Fearon DT, Locksley RM, (1996) The instructive role of innate immunity in the acquired immune response. Science 272: 50-53.
21. Prinz M, Garbe F, Schmidt H, Mildner A, Gutcher I, et al. (2006) Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis. J Clin Invest 116: 456-464.
22. Marta M, Andersson A, Isaksson M, Kampe O, Lobell A, (2008) Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis. Eur J Immunol 38: 565-575.
23. Touil T, Fitzgerald D, Zhang GX, Rostami A, Gran B, (2006) Cutting Edge: TLR3 stimulation suppresses experimental autoimmune encephalomyelitis by inducing endogenous IFN-beta. J Immunol 177: 7505-7509.
24. Ito T, Amakawa R, Kaisho T, Hemmi H, Tajima K, et al. (2002) Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets. J Exp Med 195: 1507-1512.
25. Caron G, Duluc D, Fremaux I, Jeannin P, David C, et al. (2005) Direct stimulation of human T cells via TLR5 and TLR7/8: flagellin and R-848 up-regulate proliferation and IFN-gamma production by memory CD4+ T cells. J Immunol 175: 1551-1557.
26. Krieg AM, Vollmer J, (2007) Toll-like receptors 7, 8, and 9: linking innate immunity to autoimmunity. Immunol Rev 220: 251-269.
27. Lombardi V, Van Overtvelt L, Horiot S, Moingeon P, (2009) Human dendritic cells stimulated via TLR7 and/or TLR8 induce the sequential production of Il-10, IFN-gamma, and IL-17A by naive CD4+ T cells. J Immunol 182: 3372-3379.
28. Jack CS, Arbour N, Manusow J, Montgrain V, Blain M, et al. (2005) TLR signaling tailors innate immune responses in human microglia and astrocytes. J Immunol 175: 4320-4330.
29. Farina C, Krumbholz M, Giese T, Hartmann G, Aloisi F, et al. (2005) Preferential expression and function of Toll-like receptor 3 in human astrocytes. J Neuroimmunol 159: 12-19.
30. Forward NA, Furlong SJ, Yang Y, Lin TJ, Hoskin DW, (2010) Signaling through TLR7 enhances the immunosuppressive activity of murine CD4+CD25+ T regulatory cells. J Leukoc Biol 87: 117-125.
31. Dann A, Poeck H, Croxford AL, Gaupp S, Kierdorf K, et al. (2012) Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS. Nat Neurosci 15: 98-106.
32. Zhang X, Jin J, Tang Y, Speer D, Sujkowska D, et al. (2009) IFN-beta1a inhibits the secretion of Th17-polarizing cytokines in human dendritic cells via TLR7 up-regulation. J Immunol 182: 3928-3936.
33. Cavaillon JM, Adrie C, Fitting C, Adib-Conquy M, (2005) Reprogramming of circulatory cells in sepsis and SIRS. J Endotoxin Res 11: 311-320.
34. Milo R, Panitch H, (2011) Combination therapy in multiple sclerosis. J Neuroimmunol 231: 23-31.
35. Purdon CH, Azzi CG, Zhang J, Smith EW, Maibach HI, (2004) Penetration enhancement of transdermal delivery-current permutations and limitations. Crit Rev Ther Drug Carrier Syst 21: 97-132.
36. Chang YC, Madkan V, Cook-Norris R, Sra K, Tyring S, (2005) Current and potential uses of imiquimod. South Med J 98: 914-920.
37. Craft N, Bruhn KW, Nguyen BD, Prins R, Lin JW, et al. (2005) The TLR7 agonist imiquimod enhances the anti-melanoma effects of a recombinant Listeria monocytogenes vaccine. J Immunol 175: 1983-1990.
38. Dumitru CD, Antonysamy MA, Gorski KS, Johnson DD, Reddy LG, et al. (2009) NK1.1+ cells mediate the antitumor effects of a dual Toll-like receptor 7/8 agonist in the disseminated B16-F10 melanoma model. Cancer Immunol Immunother 58: 575-587.
39. Dummer R, Hauschild A, Becker JC, Grob JJ, Schadendorf D, et al. (2008) An exploratory study of systemic administration of the toll-like receptor-7 agonist 852A in patients with refractory metastatic melanoma. Clin Cancer Res 14: 856-864.
40. Fleming CJ, Bryden AM, Evans A, Dawe RS, Ibbotson SH, (2004) A pilot study of treatment of lentigo maligna with 5% imiquimod cream. Br J Dermatol 151: 485-488.
41. Inglefield JR, Dumitru CD, Alkan SS, Gibson SJ, Lipson KE, et al. (2008) TLR7 agonist 852A inhibition of tumor cell proliferation is dependent on plasmacytoid dendritic cells and type I IFN. J Interferon Cytokine Res 28: 253-263.
42. Hayashi T, Rao SP, Takabayashi K, Van Uden JH, Kornbluth RS, et al. (2001) Enhancement of innate immunity against Mycobacterium avium infection by immunostimulatory DNA is mediated by indoleamine 2,3-dioxygenase. Infect Immun 69: 6156-6164.
43. Chan M, Hayashi T, Kuy CS, Gray CS, Wu CC, et al. (2009) Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates. Bioconjug Chem 20: 1194-1200.
44. Datta SK, Redecke V, Prilliman KR, Takabayashi K, Corr M, et al. (2003) A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells. J Immunol 170: 4102-4110.
45. Pollinger B, Krishnamoorthy G, Berer K, Lassmann H, Bosl MR, et al. (2009) Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. J Exp Med 206: 1303-1316.
46. Chan M, Hayashi T, Mathewson RD, Yao S, Gray C, et al. (2011) Synthesis and Characterization of PEGylated Toll Like Receptor 7 Ligands. Bioconjug Chem 22: 445-454.
47. Doran A, Obach RS, Smith BJ, Hosea NA, Becker S, et al. (2005) The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model. Drug Metab Dispos 33: 165-174.