Late sodium current inhibition alone with ranolazine is sufficient to reduce ischemia- and cardiac glycoside-induced calcium overload and contractile dysfunction mediated by reverse-mode sodium/calcium exchange

Journal of Pharmacology and Experimental Therapeutics

Volumn 343, Issue 2, 2012, Pages 325-332

  Soliman, Daniel ^a   Wang, Lianguo ^a   Hamming, Kevin S C ^a   Yang, Wei ^a   Fatehi, Mohammad ^a   Carter, Christian C ^a   Clanachan, Alexander S ^a   Light, Peter E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; LIDOCAINE; OUABAIN; RANOLAZINE; SODIUM CALCIUM EXCHANGE 1.1 PROTEIN; SODIUM CALCIUM EXCHANGE PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CARDIOTOXICITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HEART CONTRACTION; HEART LEFT VENTRICLE WALL; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART VENTRICLE OVERLOAD; IC 50; MALE; MYOCARDIAL DISEASE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; REPERFUSION INJURY; SODIUM CALCIUM EXCHANGE; SODIUM CURRENT;

ACETANILIDES; ANIMALS; ANIMALS, NEWBORN; CALCIUM; CALCIUM SIGNALING; CARDIAC GLYCOSIDES; ELECTROPHYSIOLOGICAL PROCESSES; ENZYME INHIBITORS; ISCHEMIA; LIDOCAINE; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION INJURY; PATCH-CLAMP TECHNIQUES; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNEL BLOCKERS; SODIUM-CALCIUM EXCHANGER; TRANSFECTION; VENTRICULAR DYSFUNCTION, LEFT;

EID: 84867625920     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.112.196949     Document Type: Article

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