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Volumn 32, Issue 3, 2012, Pages 221-227

Vorapaxar expands antiplatelet options which patients may benefit from thrombin receptor antagonism?

Author keywords

Antiplatelet therapy; Atherothrombosis; Vorapaxar

Indexed keywords

ACETYLSALICYLIC ACID; ATOPAXAR; CLOPIDOGREL; PLACEBO; PROTEINASE ACTIVATED RECEPTOR 1; RIVAROXABAN; THROMBIN RECEPTOR ANTAGONIST; VORAPAXAR;

EID: 84867619644     PISSN: 07209355     EISSN: None     Source Type: Journal    
DOI: 10.5482/HAMO-12-05-0006     Document Type: Review
Times cited : (9)

References (41)
  • 1
    • 37249068049 scopus 로고    scopus 로고
    • Platelet activation and atherothrombosis
    • Davi G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med 2007; 357: 2482-2494.
    • (2007) N Engl J Med , vol.357 , pp. 2482-2494
    • Davi, G.1    Patrono, C.2
  • 2
    • 84856158305 scopus 로고    scopus 로고
    • ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation
    • Hamm CW, Bassand JP, Agewall S et al. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J 2011; 32: 2999-3054.
    • (2011) Eur Heart J , vol.32 , pp. 2999-3054
    • Hamm, C.W.1    Bassand, J.P.2    Agewall, S.3
  • 3
    • 83155180256 scopus 로고    scopus 로고
    • ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention
    • Levine GN, Bates ER, Blankenship JC et al. 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention. Circulation 2011; 124: e574-e651.
    • (2011) Circulation 2011 , vol.124
    • Levine, G.N.1    Bates, E.R.2    Blankenship, J.C.3
  • 4
    • 79955760903 scopus 로고    scopus 로고
    • ACCF/AHA Focused Update Incorporated Into the ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction
    • Anderson JL, Adams CD, Antman EM et al. 2011 ACCF/AHA Focused Update Incorporated Into the ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction. Circulation. 2011; 123: e426-e579.
    • (2011) Circulation. 2011 , vol.123
    • Anderson, J.L.1    Adams, C.D.2    Antman, E.M.3
  • 5
    • 84855605824 scopus 로고    scopus 로고
    • Examination of the in vivo mechanisms of late drug-eluting stent thrombosis findings from optical coherence tomography and intravascular ultrasound imaging
    • Guagliumi G, Sirbu V, Musumeci G et al. Examination of the in vivo mechanisms of late drug-eluting stent thrombosis findings from optical coherence tomography and intravascular ultrasound imaging. JACC Cardiovasc Interv 2012; 5: 12-20.
    • (2012) JACC Cardiovasc Interv , vol.5 , pp. 12-20
    • Guagliumi, G.1    Sirbu, V.2    Musumeci, G.3
  • 6
    • 83655177669 scopus 로고    scopus 로고
    • Thrombin-receptor antagonist vorapaxar in acute coronary syndromes
    • Tricoci P, Huang Z, Held C et al. Thrombin-receptor antagonist vorapaxar in acute coronary syndromes. N Engl J Med 2012; 366: 20-33.
    • (2012) N Engl J Med , vol.366 , pp. 20-33
    • Tricoci, P.1    Huang, Z.2    Held, C.3
  • 7
    • 84859555815 scopus 로고    scopus 로고
    • Vorapaxar in the secondary prevention of atherothrombotic events
    • Morrow DA, Braunwald E, Bonaca MP et al. Vorapaxar in the secondary prevention of atherothrombotic events. N Engl J Med 2012; 366: 1404-1413.
    • (2012) N Engl J Med , vol.366 , pp. 1404-1413
    • Morrow, D.A.1    Braunwald, E.2    Bonaca, M.P.3
  • 8
    • 79952673992 scopus 로고    scopus 로고
    • Composition of coronary thrombus in acute myocardial infarction
    • Silvain J, Collet JP, Nagaswami C et al. Composition of coronary thrombus in acute myocardial infarction. J Am Coll Cardiol 2011; 57: 1359-1367.
    • (2011) J Am Coll Cardiol , vol.57 , pp. 1359-1367
    • Silvain, J.1    Collet, J.P.2    Nagaswami, C.3
  • 9
    • 34247190302 scopus 로고    scopus 로고
    • Platelet adhesion receptors and their ligands in mouse models of thrombosis
    • Denis CV, Wagner DD. Platelet adhesion receptors and their ligands in mouse models of thrombosis. Arterioscler Thromb Vasc Biol 2007; 27: 728-739.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 728-739
    • Denis, C.V.1    Wagner, D.D.2
  • 10
    • 13344295095 scopus 로고    scopus 로고
    • Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor
    • Savage B, Saldivar E, Ruggeri ZM. Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor. Cell 1996; 84: 289-297.
    • (1996) Cell , vol.84 , pp. 289-297
    • Savage, B.1    Saldivar, E.2    Ruggeri, Z.M.3
  • 11
    • 77956547060 scopus 로고    scopus 로고
    • Clopidogrel in acute coronary syndrome: implications of recent study findings
    • Duerschmied D, Bode C, Moser M. Clopidogrel in acute coronary syndrome: implications of recent study findings. Expert Rev Cardiovasc Ther 2010; 8: 1215-1229.
    • (2010) Expert Rev Cardiovasc Ther , vol.8 , pp. 1215-1229
    • Duerschmied, D.1    Bode, C.2    Moser, M.3
  • 12
    • 76349089295 scopus 로고    scopus 로고
    • Combination antithrombotic therapies
    • Gurbel PA, Tantry US. Combination antithrombotic therapies. Circulation 2010; 121: 569-583.
    • (2010) Circulation , vol.121 , pp. 569-583
    • Gurbel, P.A.1    Tantry, U.S.2
  • 13
    • 69649089173 scopus 로고    scopus 로고
    • Novel antiplatelet therapies following percutaneous coronary interventions
    • Ahrens I, Bode C. Novel antiplatelet therapies following percutaneous coronary interventions. Curr Opin Investig Drugs 2009; 10: 902-911.
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 902-911
    • Ahrens, I.1    Bode, C.2
  • 14
    • 77649207179 scopus 로고    scopus 로고
    • A 2-Step mechanism of arterial thrombus formation induced by human atherosclerotic plaques
    • Reininger AJ, Bernlochner I, Penz SM et al. A 2-Step mechanism of arterial thrombus formation induced by human atherosclerotic plaques. J Am Coll Cardiol 2010; 55: 1147-1158.
    • (2010) J Am Coll Cardiol , vol.55 , pp. 1147-1158
    • Reininger, A.J.1    Bernlochner, I.2    Penz, S.M.3
  • 15
    • 33750941414 scopus 로고    scopus 로고
    • The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis
    • Bergmeier W, Piffath CL, Goerge T et al. The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis. Proc Natl Acad Sci USA 2006; 103: 16900-16905.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 16900-16905
    • Bergmeier, W.1    Piffath, C.L.2    Goerge, T.3
  • 16
    • 17744381152 scopus 로고    scopus 로고
    • Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen
    • Nieswandt B, Brakebusch C, Bergmeier W et al. Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen. Embo J 2001; 20: 2120-2130.
    • (2001) Embo J , vol.20 , pp. 2120-2130
    • Nieswandt, B.1    Brakebusch, C.2    Bergmeier, W.3
  • 17
    • 67149093849 scopus 로고    scopus 로고
    • A shear gradient-dependent platelet aggregation mechanism drives thrombus formation
    • Nesbitt WS, Westein E, Tovar-Lopez FJ et al. A shear gradient-dependent platelet aggregation mechanism drives thrombus formation. Nat Med 2009; 15: 665-673.
    • (2009) Nat Med , vol.15 , pp. 665-673
    • Nesbitt, W.S.1    Westein, E.2    Tovar-Lopez, F.J.3
  • 18
    • 33748704252 scopus 로고    scopus 로고
    • Activation-independent platelet adhesion and aggregation under elevated shear stress
    • Ruggeri ZM, Orje JN, Habermann R et al. Activation-independent platelet adhesion and aggregation under elevated shear stress. Blood 2006; 108: 1903-1910.
    • (2006) Blood , vol.108 , pp. 1903-1910
    • Ruggeri, Z.M.1    Orje, J.N.2    Habermann, R.3
  • 19
    • 70350511423 scopus 로고    scopus 로고
    • CalDAGGEFI is at the nexus of calcium-dependent platelet activation
    • Stefanini L, Roden RC, Bergmeier W. CalDAGGEFI is at the nexus of calcium-dependent platelet activation. Blood 2009; 114: 2506-2514.
    • (2009) Blood , vol.114 , pp. 2506-2514
    • Stefanini, L.1    Roden, R.C.2    Bergmeier, W.3
  • 20
    • 52649163308 scopus 로고    scopus 로고
    • CalDAGGEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets
    • Cifuni SM, Wagner DD, Bergmeier W. CalDAGGEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets. Blood 2008; 112: 1696-1703.
    • (2008) Blood , vol.112 , pp. 1696-1703
    • Cifuni, S.M.1    Wagner, D.D.2    Bergmeier, W.3
  • 21
    • 4644221351 scopus 로고    scopus 로고
    • Cal-DAG-GEFI integrates signaling for platelet aggregation and thrombus formation
    • Crittenden JR, Bergmeier W, Zhang Y et al. Cal-DAG-GEFI integrates signaling for platelet aggregation and thrombus formation. Nat Med 2004; 10: 982-986.
    • (2004) Nat Med , vol.10 , pp. 982-986
    • Crittenden, J.R.1    Bergmeier, W.2    Zhang, Y.3
  • 22
    • 14644400415 scopus 로고    scopus 로고
    • Rap1b is required for normal platelet function and hemostasis in mice
    • Chrzanowska-Wodnicka M, Smyth SS, Schoenwaelder SM et al. Rap1b is required for normal platelet function and hemostasis in mice. J Clin Invest. 2005; 115: 680-687.
    • (2005) J Clin Invest , vol.115 , pp. 680-687
    • Chrzanowska-Wodnicka, M.1    Smyth, S.S.2    Schoenwaelder, S.M.3
  • 24
    • 78751696504 scopus 로고    scopus 로고
    • The kinetics of alphaIIbbeta3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy
    • Stolla M, Stefanini L, Roden RC et al. The kinetics of alphaIIbbeta3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy. Blood 2011; 117: 1005-1013.
    • (2011) Blood , vol.117 , pp. 1005-1013
    • Stolla, M.1    Stefanini, L.2    Roden, R.C.3
  • 25
    • 0034648757 scopus 로고    scopus 로고
    • Thrombin signalling and proteaseactivated receptors
    • Coughlin SR. Thrombin signalling and proteaseactivated receptors. Nature 2000; 407: 258-264.
    • (2000) Nature , vol.407 , pp. 258-264
    • Coughlin, S.R.1
  • 26
    • 0026035523 scopus 로고
    • Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
    • Vu TK, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991; 64: 1057-1068.
    • (1991) Cell , vol.64 , pp. 1057-1068
    • Vu, T.K.1    Hung, D.T.2    Wheaton, V.I.3    Coughlin, S.R.4
  • 27
    • 0035817822 scopus 로고    scopus 로고
    • Role of thrombin signalling in platelets in haemostasis and thrombosis
    • Sambrano GR, Weiss EJ, Zheng YW et al. Role of thrombin signalling in platelets in haemostasis and thrombosis. Nature 2001; 413: 74-78.
    • (2001) Nature , vol.413 , pp. 74-78
    • Sambrano, G.R.1    Weiss, E.J.2    Zheng, Y.W.3
  • 28
    • 0033613269 scopus 로고    scopus 로고
    • Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity
    • Andersen H, Greenberg DL, Fujikawa K et al. Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity. Proc Natl Acad Sci USA 1999; 96: 11189-11193.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 11189-11193
    • Andersen, H.1    Greenberg, D.L.2    Fujikawa, K.3
  • 29
    • 70549108948 scopus 로고    scopus 로고
    • Improving antiplatelet therapy for atherothrombotic disease: preclinical results with SCH 530348 the first oral thrombin receptor antagonist selective for PAR-1
    • Hildemann SK, Bode C. Improving antiplatelet therapy for atherothrombotic disease: preclinical results with SCH 530348, the first oral thrombin receptor antagonist selective for PAR-1. Hämostaseologie 2009; 29: 349-355.
    • (2009) Hämostaseologie , vol.29 , pp. 349-355
    • Hildemann, S.K.1    Bode, C.2
  • 30
    • 78149281431 scopus 로고    scopus 로고
    • SCH 602539 a protease-activated receptor-1 antagonist, inhibits thrombosis alone and in combination with cangrelor in a Folts model of arterial thrombosis in cynomolgus monkeys
    • Chintala M, Strony J, Yang B et al. SCH 602539, a protease-activated receptor-1 antagonist, inhibits thrombosis alone and in combination with cangrelor in a Folts model of arterial thrombosis in cynomolgus monkeys. Arterioscler Thromb Vasc Biol 2010; 30: 2143-2149.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 2143-2149
    • Chintala, M.1    Strony, J.2    Yang, B.3
  • 31
    • 61849180442 scopus 로고    scopus 로고
    • Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: a randomised, double-blind, placebo-controlled phase II study
    • Becker RC, Moliterno DJ, Jennings LK et al. Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: a randomised, double-blind, placebo-controlled phase II study. Lancet 2009; 373: 919-928.
    • (2009) Lancet , vol.373 , pp. 919-928
    • Becker, R.C.1    Moliterno, D.J.2    Jennings, L.K.3
  • 32
    • 77649207578 scopus 로고    scopus 로고
    • Safety and exploratory efficacy of the novel thrombin receptor (PAR-1) antagonist SCH530348 for non-ST-segment elevation acute coronary syndrome
    • Goto S, Yamaguchi T, Ikeda Y et al. Safety and exploratory efficacy of the novel thrombin receptor (PAR-1) antagonist SCH530348 for non-ST-segment elevation acute coronary syndrome. J Atheroscler Thromb 2010; 17: 156-164.
    • (2010) J Atheroscler Thromb , vol.17 , pp. 156-164
    • Goto, S.1    Yamaguchi, T.2    Ikeda, Y.3
  • 33
    • 58649088469 scopus 로고    scopus 로고
    • Protease-activated receptors in cardiovascular health and diseases
    • Shah R. Protease-activated receptors in cardiovascular health and diseases. Am Heart J 2009; 157: 253-262.
    • (2009) Am Heart J , vol.157 , pp. 253-262
    • Shah, R.1
  • 34
    • 0032514474 scopus 로고    scopus 로고
    • A dual thrombin receptor system for platelet activation
    • Kahn ML, Zheng YW, Huang W et al. A dual thrombin receptor system for platelet activation. Nature 1998; 394: 690-694.
    • (1998) Nature , vol.394 , pp. 690-694
    • Kahn, M.L.1    Zheng, Y.W.2    Huang, W.3
  • 35
    • 79959999841 scopus 로고    scopus 로고
    • Oral administration of the thrombin receptor antagonist E5555 (atopaxar) attenuates intimal thickening following balloon injury in rats
    • Kogushi M, Matsuoka T, Kuramochi H et al. Oral administration of the thrombin receptor antagonist E5555 (atopaxar) attenuates intimal thickening following balloon injury in rats. Eur J Pharmacol 2011; 666: 158-164.
    • (2011) Eur J Pharmacol , vol.666 , pp. 158-164
    • Kogushi, M.1    Matsuoka, T.2    Kuramochi, H.3
  • 36
    • 85027951718 scopus 로고    scopus 로고
    • Randomized trial of atopaxar in the treatment of patients with coronary artery disease: the lessons from antagonizing the cellular effect of Thrombin-Coronary Artery Disease Trial
    • Wiviott SD, Flather MD, O'Donoghue ML et al. Randomized trial of atopaxar in the treatment of patients with coronary artery disease: the lessons from antagonizing the cellular effect of Thrombin-Coronary Artery Disease Trial. Circulation 2011; 123: 1854-1863.
    • (2011) Circulation , vol.123 , pp. 1854-1863
    • Wiviott, S.D.1    Flather, M.D.2    O'Donoghue, M.L.3
  • 37
    • 85058720552 scopus 로고    scopus 로고
    • The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA*CER) trial: study design and rationale
    • The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA*CER) trial: study design and rationale. Am Heart J 2009; 158: 327-334 e4.
    • (2009) Am Heart J , vol.158
  • 38
    • 68949156886 scopus 로고    scopus 로고
    • Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: design and rationale for the Thrombin-Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2 degrees P)-TIMI 50 trial
    • Morrow DA, Scirica BM, Fox KA et al. Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: design and rationale for the Thrombin-Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2 degrees P)-TIMI 50 trial. Am Heart J 2009; 158: 335-341 e3.
    • (2009) Am Heart J , vol.158
    • Morrow, D.A.1    Scirica, B.M.2    Fox, K.A.3
  • 40
    • 80054767005 scopus 로고    scopus 로고
    • Upstream use of small-molecule glycoprotein iib/iiia inhibitors in patients with non-ST-segment elevation acute coronary syndromes: a systematic overview of randomized clinical trials
    • Tricoci P, Newby LK, Hasselblad V et al. Upstream use of small-molecule glycoprotein iib/iiia inhibitors in patients with non-ST-segment elevation acute coronary syndromes: a systematic overview of randomized clinical trials. Circ Cardiovasc Qual Outcomes 2011; 4: 448-458.
    • (2011) Circ Cardiovasc Qual Outcomes , vol.4 , pp. 448-458
    • Tricoci, P.1    Newby, L.K.2    Hasselblad, V.3
  • 41
    • 84862907587 scopus 로고    scopus 로고
    • Rivaroxaban in patients with a recent acute coronary syndrome
    • Mega JL, Braunwald E, Wiviott SD et al. Rivaroxaban in patients with a recent acute coronary syndrome. N Engl J Med 2012; 366: 9-19.
    • (2012) N Engl J Med , vol.366 , pp. 9-19
    • Mega, J.L.1    Braunwald, E.2    Wiviott, S.D.3


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