Cholinesterase inhibition and alterations of hepatic metabolism by oral acute and repeated chlorpyrifos administration to mice

Toxicology

Volumn 234, Issue 1-2, 2007, Pages 90-102

  Cometa, Maria Francesca ^a   Buratti, Franca Maria ^a   Fortuna, Stefano ^a   Lorenzini, Paola ^a   Volpe, Maria Teresa ^a   Parisi, Laura ^a   Testai, Emanuela ^a   Meneguz, Annarita ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Chlorpyrifos; Cholinesterase; Metabolism; Mouse; Oral acute and repeated toxicity; Organophosphate insecticides

Indexed keywords

CARBOXYLESTERASE; CHLORPYRIFOS; CHOLINESTERASE; GLUTATHIONE; LIVER ENZYME; ORGANOPHOSPHATE INSECTICIDE; XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; COGNITION; CONTROLLED STUDY; DETOXIFICATION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME INHIBITION; EXPOSURE; IN VIVO STUDY; LD 50; LIPID METABOLISM; LIVER MICROSOME; LONG TERM EXPOSURE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ACETYLCHOLINESTERASE; ADMINISTRATION, ORAL; ANIMALS; BRAIN; CHLORPYRIFOS; CHOLINESTERASE INHIBITORS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; HYDROXYLATION; LIVER; MALE; MICE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; PYRIDONES; TESTOSTERONE; WEIGHT LOSS;

ANIMALIA; MUS; MUS MUSCULUS; RATTUS;

EID: 34047110668     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2007.02.008     Document Type: Article

References (54)

1. Aldridge J.E., Levin E.D., Seidler F.J., and Slotkin T.A. Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression. Environ. Health. Perspect. 113 (2005) 527-531
2. Aldridge W.N. The esterases: perspectives and problems. Chem. Biol. Interact. 87 (1993) 5-13
3. Beach J.R., Spurgeon A., Stephens R., Heafield T., Calvert I.A., Levy L.S., and Harrington J.M. Abnormalities on neurological examination among sheep farmers exposed to organophosphorous pesticides. Occup. Environ. Med. 53 (1996) 520-525
4. Berkowitz G.S., Wetmur J.G., Birman-Deych E., Obel J., Lapinski R.H., Godbold J.H., Holzman I.R., and Wolff M.S. In utero pesticide exposure, maternal paraoxonase activity, and head circumference. Environ. Health Perspect. 112 (2004) 388-391
5. Bignami G., Rosic N., Michalek H., Milosevic M., and Gatti G.L. Behavioral toxicity of anticholinesterase agents: Methodological, neurochemical, and neuropsychological aspects. In: Weiss B., and Laties V.G. (Eds). Behavioral Toxicology (1975), Plenum Press, New York 155-215
6. Buratti F.M., Volpe M.T., Fabrizi L., Meneguz A., Vittozzi L., and Testai E. Kinetic parameters of OPT pesticide desulfuration by c-DNA expressed human CYPs. Environ. Toxicol. Pharmacol. (2002) 181-190
7. Buratti F.M., Volpe M.T., Meneguz A., Vittozzi L., and Testai E. CYP-specific bioactivation of four organophosphorothioate pesticides by human liver microsomes. Toxicol. Appl. Pharmacol. 186 (2003) 143-154
8. Chambers J.E., and Chambers H.W. Time course of inhibition of acetylcholinesterase and aliesterases following parathion and paraoxon exposures in rats. Toxicol. Appl. Pharmacol. 103 (1990) 420-429
9. Clegg D.J., and van Gemert M. Determination of the reference dose for chlorpyrifos: proceedings of an expert panel. J. Toxicol. Environ. Health B Crit. Rev. 2 (1999) 211-255
10. Cochran R.C., Kishiyama J., Aldous C., Carr Jr. W.C., and Pfeifer K.F. Chlorpyrifos: hazard assessment based on a review of the effects of short-term and long-term exposure in animals and humans. Food Chem. Toxicol. 33 (1995) 165-172
11. Cole T.B., Walter B.J., Shih D.M., Tward A.D., Lusis A.J., Timchalk C., Richter R.J., Costa L.G., and Furlong C.E. Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism. Pharmacogenet. Genomics 15 (2005) 589-598
12. Costa L.G., Li W.F., Richter R.J., Shih D.M., Lusis A., and Furlong C.E. The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism. Chem. Biol. Interact. 119-120 (1999) 429-438
13. Ellman G.L. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82 (1959) 70-77
14. Ellman G.L., Courtney K.D., Andres Jr. V., and Feather-Stone R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7 (1961) 88-95
15. Eskenazi B., Bradman A., and Castorina R. Exposures of children to organophosphate pesticides and their potential adverse health effects. Environ. Health Perspect. 107 Suppl. 3 (1999) 409-419
16. FQPA, 1996. US Food Quality Protection Act, Public Law No. 104-170.
17. Gurunathan S., Robson M., Freeman N., Buckley B., Roy A., Meyer R., Bukowski J., and Lioy P.J. Accumulation of chlorpyrifos on residential surfaces and toys accessible to children. Environ. Health Perspect. 106 (1998) 9-16
18. Halpert J., Hammond D., and Neal R.A. Inactivation of purified rat liver cytochrome P-450 during the metabolism of parathion (diethyl p-nitrophenyl phosphorothionate). J. Biol. Chem. 255 (1980) 1080-1089
19. Huang Y.S., and Sultatos L.G. Glutathione-dependent biotransformation of methyl parathion by mouse liver in vitro. Toxicol. Lett. 68 (1993) 275-284
20. Jamal G.A., Hansen S., and Julu P.O. Low level exposures to organophosphorus esters may cause neurotoxicity. Toxicology 181-182 (2002) 23-33
21. Karanth S., Liu J., Mirajkar N., and Pope C. Effects of acute chlorpyrifos exposure on in vivo acetylcholine accumulation in rat striatum. Toxicol. Appl. Pharmacol. 216 (2006) 150-156
22. Karanth S., and Pope C. Carboxylesterase and A-esterase activities during maturation and aging: relationship to the toxicity of chlorpyrifos and parathion in rats. Toxicol. Sci. 58 (2000) 282-289
23. Karanth S., and Pope C. Age-related effects of chlorpyrifos and parathion on acetylcholine synthesis in rat striatum. Neurotoxicol. Teratol. 25 (2003) 599-606
24. Li W.F., Furlong C.E., and Costa L.G. Paraoxonase protects against chlorpyrifos toxicity in mice. Toxicol. Lett. 76 (1995) 219-226
25. Liu J., Chakraborti T., and Pope C. In vitro effects of organophosphorus anticholinesterases on muscarinic receptor-mediated inhibition of acetylcholine release in rat striatum. Toxicol. Appl. Pharmacol. 178 (2002) 102-108
26. Liu J., and Pope C.N. Effects of chlorpyrifos on high-affinity choline uptake and [3H]hemicholinium-3 binding in rat brain. Fundam. Appl. Toxicol. 34 (1996) 84-90
27. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
28. Melnyk L.J., Berry M.R., Sheldon L.S., Freeman N.C., Pellizzari E.D., and Kinman R.N. Dietary exposure of children in lead-laden environments. J. Expo. Anal. Environ. Epidemiol. 10 (2000) 723-731
29. Meneguz A., Bisso G.M., and Michalek H. Age-related changes in acetylcholinesterase and its molecular forms in various brain areas of rats. Neurochem. Res. 17 (1992) 785-790
30. Michalek H., Pintor A., Fortuna S., and Bisso G.M. Effects of diisopropylfluorophosphate on brain cholinergic systems of rats at early developmental stages. Fundam. Appl. Toxicol. 5 (1985) S204-S212
31. Moser V.C., McCormick J.P., Creason J.P., and MacPhail R.C. Comparison of chlordimeform and carbaryl using a functional observational battery. Fundam. Appl. Toxicol. 11 (1988) 189-206
32. Nostrandt A.C., Padilla S., and Moser V.C. The relationship of oral chlorpyrifos effects on behavior, cholinesterase inhibition, and muscarinic receptor density in rat. Pharmacol. Biochem. Behav. 58 (1997) 15-23
33. Omura T., and Sato R. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem. 239 (1964) 2370-2378
34. Oyama V.I., and Eagle H. Measurement of cell growth in tissue culture with a phenol reagent (folin-ciocalteau). Proc. Soc. Exp. Biol. Med. 91 (1956) 305-307
35. Pope C.N. Organophosphorus pesticides: do they all have the same mechanism of toxicity?. J. Toxicol. Environ. Health B Crit. Rev. 2 (1999) 161-181
36. Pope C.N., Chakraborti T.K., Chapman M.L., and Farrar J.D. Long-term neurochemical and behavioral effects induced by acute chlorpyrifos treatment. Pharmacol. Biochem. Behav. 42 (1992) 251-256
37. Pope C.N., Chakraborti T.K., Chapman M.L., Farrar J.D., and Arthun D. Comparison of in vivo cholinesterase inhibition in neonatal and adult rats by three organophosphorothioate insecticides. Toxicology 68 (1991) 51-61
38. Ray D.E. Chronic effects of low level exposure to anticholinesterases-a mechanistic review. Toxicol. Lett. 102-103 (1998) 527-533
39. Ray D.E. Pesticide neurotoxicity in Europe: real risks and perceived risks. Neurotoxicology 21 (2000) 219-221
40. Ricceri L., Markina N., Valanzano A., Fortuna S., Cometa M.F., Meneguz A., and Calamandrei G. Developmental exposure to chlorpyrifos alters reactivity to environmental and social cues in adolescent mice. Toxicol. Appl. Pharmacol. 191 (2003) 189-201
41. Ricceri L., Venerosi A., Capone F., Cometa M.F., Lorenzini P., Fortuna S., and Calamandrei G. Developmental neurotoxicity of organophosphorous pesticides: fetal and neonatal exposure to chlorpyrifos alters sex-specific behaviors at adulthood in mice. Toxicol. Sci. 93 (2006) 105-113
42. Richards P., Johnson M., Ray D., and Walker C. Novel protein targets for organophosphorus compounds. Chem. Biol. Interact. 119-120 (1999) 503-511
43. Richardson R.J. Assessment of the neurotoxic potential of chlorpyrifos relative to other organophosphorus compounds: a critical review of the literature. J. Toxicol. Environ. Health 44 (1995) 135-165
44. Sanchez-Amate M.C., Flores P., and Sanchez-Santed F. Effects of chlorpyrifos in the plus-maze model of anxiety. Behav. Pharmacol. 12 (2001) 285-292
45. Sanchez-Santed F., Canadas F., Flores P., Lopez-Grancha M., and Cardona D. Long-term functional neurotoxicity of paraoxon and chlorpyrifos: behavioural and pharmacological evidence. Neurotoxicol. Teratol. 26 (2004) 305-317
46. Sanwald P., Blankson E.A., Dulery B.D., Schoun J., Huebert N.D., and Dow J. Isocratic high-performance liquid chromatographic method for the separation of testosterone metabolites. J. Chromatogr. B Biomed. Appl. 672 (1995) 207-215
47. Shih D.M., Gu L., Xia Y.R., Navab M., Li W.F., Hama S., Castellani L.W., Furlong C.E., Costa L.G., Fogelman A.M., and Lusis A.J. Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis. Nature 394 (1998) 284-287
48. Sultatos L.G. Mammalian toxicology of organophosphorus pesticides. J. Toxicol. Environ. Health 43 (1994) 271-289
49. Talcott R.E. Hepatic and extrahepatic malathion carboxylesterases. Assay and localization in the rat. Toxicol. Appl. Pharmacol. 47 (1979) 145-150
50. Tang J., Cao Y., Rose R.L., Brimfield A.A., Dai D., Goldstein J.A., and Hodgson E. Metabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse, and rat liver microsomes. Drug Metab. Dispos. 29 (2001) 1201-1204
51. Testai E., and Vittozzi L. Biochemical alterations elicited in rat liver microsomes by oxidation and reduction products of chloroform metabolism. Chem. Biol. Interact. 59 (1986) 157-171
52. Won Y.K., Liu J., Olivier Jr. K., Zheng Q., and Pope C.N. Age-related effects of chlorpyrifos on acetylcholine release in rat brain. Neurotoxicology 22 (2001) 39-48
53. Zhang H., Liu J., and Pope C.N. Age-related effects of chlorpyrifos on muscarinic receptor-mediated signaling in rat cortex. Arch. Toxicol. 75 (2002) 676-684
54. Zheng Q., Olivier K., Won Y.K., and Pope C.N. Comparative cholinergic neurotoxicity of oral chlorpyrifos exposures in preweanling and adult rats. Toxicol. Sci. 55 (2000) 124-132