Ca++/CaMKII switches nociceptor-sensitizing stimuli into desensitizing stimuli

Journal of Neurochemistry

Volumn 123, Issue 4, 2012, Pages 589-601

  Hucho, Tim ^a,b   Suckow, Vanessa ^a   Joseph, Elizabeth K ^c   Kuhn, Julia ^a,d   Schmoranzer, Jan ^d,e   Dina, Olayinka A ^c   Chen, Xiaojie ^c   Karst, Matthias ^f   Bernateck, Michael ^f   Levine, Jon D ^c   Ropers, Hans Hilger ^a  

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^b UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d FREIE UNIVERSITÄT BERLIN   (Germany)

^e Universitätsmedizin   (Germany)

^f HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

CaMKII; hyperalgesia; pain; peripheral nociceptive neuron; protein kinase C epsilon; sensitization signaling

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; CELL PROTEIN; EPAC PROTEIN; INOSITOL TRISPHOSPHATE; PROTEIN KINASE C EPSILON; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL CULTURE; CELL MEMBRANE; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LOCALIZATION; IN VIVO STUDY; MALE; NERVE CELL; NERVE FIBER C; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NOCICEPTIVE STIMULATION; NONHUMAN; PAIN RECEPTOR; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; SENSITIZATION; SIGNAL TRANSDUCTION; STIMULUS RESPONSE;

ADRENERGIC BETA-AGONISTS; ANALYSIS OF VARIANCE; ANIMALS; CALCIUM; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELLS, CULTURED; CYCLIC AMP; ELECTRIC STIMULATION; ENZYME INHIBITORS; GANGLIA, SPINAL; HYPERALGESIA; INOSITOL 1,4,5-TRISPHOSPHATE; ISOPROTERENOL; MALE; NERVE FIBERS; NEURONS; NOCICEPTORS; PAIN THRESHOLD; PROTEIN KINASE C-EPSILON; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RYANODINE; SIGNAL TRANSDUCTION; THIONUCLEOTIDES; TRPV CATION CHANNELS; URIDINE TRIPHOSPHATE;

EID: 84867579270     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2012.07920.x     Document Type: Article

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