Chicken DT40 cells stably transfected with the rat P2X7 receptor ion channel: A system suitable for the study of purine receptor-mediated cell death

Biochemical Pharmacology

Volumn 66, Issue 3, 2003, Pages 415-424

  Hillman, Kate A ^a   Harada, Hitoshi ^b   Chan, Choong M ^a   Townsend Nicholson, Andrea ^a,c   Moss, Stephen E ^a,d   Miyamoto, Kengo ^b   Suketa, Yasunobu ^b   Burnstock, Geoffrey ^a   Unwin, Robert J ^a   Dunn, Philip M ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY OF SHIZUOKA   (Japan)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Apoptosis; ATP; Caspase; Cell death; Lymphocyte; P2X receptor

Indexed keywords

ADENOSINE TRIPHOSPHATE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CALCIUM; CASPASE 3; CASPASE INHIBITOR; DIBENZOYL ADENOSINE TRIPHOSPHATE; DNA; DNA FRAGMENT; FURA 2; ION CHANNEL; MANGANESE; PHOSPHATIDYLSERINE; PURINE P2 RECEPTOR; PURINE P2X RECEPTOR; PURINE RECEPTOR; PURINERGIC RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CALCIUM TRANSPORT; CELL CLONE; CELL DEATH; CELL LINE; CELL MEMBRANE; CHICKEN; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CLEAVAGE; DRUG POTENCY; GENETIC MANIPULATION; GENETIC TRANSFECTION; LYMPHOCYTE; MODEL; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SPECTROFLUOROMETRY; STUDY; VOLTAGE CLAMP; WESTERN BLOTTING;

EID: 0042196282     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(03)00286-7     Document Type: Article

References (45)

1. Zheng L.M., Zychlinsky A., Liu C.C., Ojcius D.M., Young J.D.E. Extracellular ATP as a trigger for apoptosis or programmed cell death. J. Cell Biol. 112:1991;279-288.
2. Chow S.C., Kass G.E., Orrenius S. Purines and their roles in apoptosis. Neuropharmacology. 36:1997;1149-1156.
3. 2Y purinoceptors? Pharmacol. Ther. 64:1994;445-475.
4. Zhang F.L., Luo L., Gustafson E., Palmer K., Qiao X., Fan X., Yang S., Laz T.M., Bayne M., Monsma F. Jr. P2Y(13): identification and characterization of a novel Galphai-coupled ADP receptor from human and mouse. J. Pharmacol. Exp. Ther. 301:2002;705-713.
5. 3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels. EMBO J. 17:1998;3016-3028.
6. 2 purinoceptors. J. Gen. Physiol. 113:1999;695-720.
7. 2 receptor: estimates based on methanethiosulfonate block at T336C. Mol. Pharmacol. 56:1999;973-981.
8. 2, an ATP-gated ion channel. Biochem. Biophys. Res. Commun. 240:1997;618-622.
9. 2 purinoceptors by divalent cations. J. Physiol. (London). 522:2000;199-214.
10. 7). Science. 272:1996;735-738.
11. 7. Cloning and expression of a human cDNA. J. Biol. Chem. 272:1997;5482-5486.
12. Valera S., Hussy N., Evans R.J., Adani N., North R.A., Surprenant A., Buell G. A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP. Nature. 371:1994;516-519.
13. Hansen M.A., Barden J.A., Balcar V.J., Keay K.A., Bennett M.R. Structural motif and characteristics of the extracellular domain of P2X receptors. Biochem. Biophys. Res. Commun. 236:1997;670-675.
14. 7 receptor signalling complex. EMBO J. 20:2001;6347-6358.
15. 7 receptor C-terminus. J. Biol. Chem. 277:2002;34017-34023.
16. + RNA from murine macrophages. Mol. Pharmacol. 44:1993;93-101.
17. 7 channel. Am. J. Physiol. 275:1998;C1224-C1231.
18. 7 purinoceptor in mouse NTW8 microglial cells. Br. J. Pharmacol. 121:1997;1429-1437.
19. 7 receptor. J. Physiol. (London). 519:1999;335-346.
20. 7-like cytolytic pore in human skin fibroblasts. Am. J. Physiol. 277:1999;C755-C765.
21. 7 purinergic receptor stimulation activate a common cytolytic pore. Am. J. Physiol. 277:1999;C766-C776.
22. Murgia M., Pizzo P., Steinberg T.H., Di Virgilio F. Characterization of the cytotoxic effect of extracellular ATP in J774 mouse macrophages. Biochem. J. 288:1992;897-901.
23. Zanovello P., Bronte V., Rosato A., Pizzo P., Di Virgilio F. Responses of mouse lymphocytes to extracellular ATP. II. Extracellular ATP causes cell type-dependent lysis and DNA fragmentation. J. Immunol. 145:1990;1545-1550.
24. Ferrari D., Los M., Bauer M.K., Vandenabeele P., Wesselborg S., Schulze-Osthoff K. P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death. FEBS Lett. 447:1999;71-75.
25. 2-purinergic receptors. Am. J. Physiol. 263:1992;F374-F383.
26. Harada H., Chan C.M., Loesch A., Unwin R.J., Burnstock G. Induction of proliferation and apoptotic cell death via P2Y and P2X receptors, respectively, in rat glomerular mesangial cells. Kidney Int. 57:2000;949-958.
27. Buerstedde J.M., Takeda S. Increased ratio of targeted to random integration after transfection of chicken B cell lines. Cell. 67:1991;179-188.
28. 2+ influx in B cells. Curr. Biol. 9:1999;1403-1406.
29. + channels by gallamine and a novel bis-quaternary quinolinium cyclophane, UCL 1530. Br. J. Pharmacol. 117:1996;35-42.
30. Hamill O.P., Marty A., Neher E., Sakmann B., Sigworth F.J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 391:1981;85-100.
31. Koopman G., Reutelingsperger C.P., Kuijten G.A., Keehnen R.M., Pals S.T., van Oers M.H. Annexin-V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood. 84:1994;1415-1420.
32. Murgia M., Hanau S., Pizzo P., Rippa M., Di Virgilio F. Oxidised ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor. J. Biol. Chem. 268:1993;8199-8203.
33. Thompson E.B. Special topic: apoptosis. Annu. Rev. Physiol. 60:1998;525-532.
34. Fadok V.A., Voelker D.R., Campbell P.A., Cohen J.J., Bratton D.L., Henson P.M. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J. Immunol. 148:1992;2207-2216.
35. 7 ATP receptor. J. Biol. Chem. 274:1999;33206-33208.
36. Chiozzi P., Murgia M., Falzoni S., Ferrari D., Di Virgilio F. Role of the purinergic P2Z receptor in spontaneous cell death in J774 macrophage cultures. Biochem. Biophys. Res. Commun. 218:1996;176-181.
37. Ferrari D., Chiozzi P., Falzoni S., Dal Susino M., Collo G., Buell G., Di Virgilio F. ATP-mediated cytotoxicity in microglial cells. Neuropharmacology. 36:1997;1295-1301.
38. 7 receptor-dependent apoptosis of dendritic cells. Am. J. Physiol. 276:1999;C1139-C1147.
39. Bianchi B.R., Lynch K.J., Touma E., Niforatos W., Burgard E.C., Alexander K.M., Park H.S., Yu H., Metzger R., Kowaluk E., Jarvis M.F., van Biessen T. Pharmacological characterization of recombinant human and rat P2X receptor subtypes. Eur. J. Pharmacol. 376:1999;127-138.
40. Nuttle L.C., Dubyak G.R. Differential activation of cation channels and non-selective pores by macrophage P2Z purinergic receptors expressed in Xenopus oocytes. J. Biol. Chem. 269:1994;13988-13996.
41. Ding J., Takano T., Gao S., Han W., Noda C., Yanagi S., Yamamura H. Syk is required for the activation of Akt survival pathway in B cells exposed to oxidative stress. J. Biol. Chem. 275:2000;30873-30877.
42. Pogue S.L., Kurosaki T., Bolen J., Herbst R. B cell antigen receptor-induced activation of Akt promotes B cell survival and is dependent on Syk kinase. J. Immunol. 165:2000;1300-1306.
43. Salvesen G.S., Dixit V.M. Caspases: intracellular signaling by proteolysis. Cell. 91:1997;443-446.
44. Zoetewij J.P., van de Water B., de Bont H.J., Nagelkerke J.F. The role of a purinergic P2Z receptor in calcium-dependent cell killing of isolated rat hepatocytes by extracellular adenosine triphosphate. Hepatology. 23:1996;858-865.
45. 2+-dependent apoptosis. Proc. Natl. Acad. Sci. U.S.A. 99:2002;8054-8059.