Rhein induces apoptosis of human gastric cancer SGC-7901 cells via an intrinsic mitochondrial pathway

Brazilian Journal of Medical and Biological Research

Volumn 45, Issue 11, 2012, Pages 1052-1059

  Li, Yiwen ^a   Xu, Yuqing ^a   Lei, Bo ^a   Wang, Wenxiu ^a   Ge, Xin ^b   Li, Jingrui ^b  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b Second Hospital of Heilongjiang Province   (China)

Author keywords

Apoptosis; Flow cytometry; MTT; Rhein, SGC 7901 cells; TUNEL

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANNEXIN; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 9; CYTOCHROME C; FLUORESCEIN ISOTHIOCYANATE; MESSENGER RNA; PROCASPASE 3; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; RHEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELL VIABILITY; CELLULAR PARAMETERS; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INTRINSIC MITOCHONDRIAL PATHWAY; MOLECULAR MECHANICS; NICK END LABELING; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RELATIVE CELL VIABILITY; RNA ANALYSIS; RNA ISOLATION; SIGNAL TRANSDUCTION; STOMACH CANCER; WESTERN BLOTTING;

ANTHRAQUINONES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; FLOW CYTOMETRY; HUMANS; IN SITU NICK-END LABELING; MEMBRANE POTENTIAL, MITOCHONDRIAL; REAL-TIME POLYMERASE CHAIN REACTION; STOMACH NEOPLASMS;

EID: 84867545808     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2012007500125     Document Type: Article

References (36)

1. Jemal A, Thomas A, Murray T, Thun M. Cancer statistics, 2002. CA Cancer J Clin 2002; 52: 23-47.
2. Thun, MJ, DeLancey, JO, Center MM, Jemal A, Ward EM. The global burden of cancer: priorities for prevention. Carcinogenesis 2010; 31: 100-110.
3. Lin S, Li JJ, Fujii M, Hou DX. Rhein inhibits TPA-induced activator protein-1 activation and cell transformation by blocking the JNK-dependent pathway. Int J Oncol 2003; 22: 829-833.
4. Huang Q, Lu G, Shen HM, Chung MC, Ong CN. Anti-cancerproperties of anthraquinones from rhubarb. Med Res Rev 2007; 27: 609-630.
5. Miccadei S, Pulselli R, Floridi A. Effect of lonidamine and rhein on the phosphorylation potential generated by respiring rat liver mitochondria. Anticancer Res 1993; 13: 1507-1510.
6. Delpino A, Paggi MG, Gentile PF, Castiglione S, Bruno T, Benass M, et al. Protein synthetic activity and adenylate energy charge in Rhein-treated cultured human glioma cells. Cancer Biochem Biophys 1992; 12: 241-252.
7. Castiglione S, Fanciulli M, Bruno T, Evangelista M, Del Carlo C, Paggi MG, et al. Rhein inhibits glucose uptake in Ehrlich ascites tumor cells by alteration of membrane-associated functions. Anticancer Drugs 1993; 4: 407-414.
8. Lai WW, Yang JS, Lai KC, Kuo CL, Hsu CK, Wang CK, et al. Rhein induced apoptosis through the endoplasmic reticulum stress, caspase- and mitochondria-dependent pathways in SCC-4 human tongue squamous cancer cells. In Vivo 2009; 23: 309-316.
9. Chen YY, Chiang SY, Lin JG, Yang JS, Ma YS, Liao CL, et al. Emodin, aloe-emodin and rhein induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells. Anticancer Res 2010; 30: 945-951.
10. Chen YY, Chiang SY, Lin JG, Ma YS, Liao CL, Weng SW, et al. Emodin, aloe-emodin and rhein inhibit migration and invasion in human tongue cancer SCC-4 cells through the inhibition of gene expression of matrix metalloproteinase-9. Int J Oncol 2010; 36: 1113-1120.
11. Aviello G, Rowland I, Gill CI, Acquaviva AM, Capasso F, McCann M, et al. Anti-proliferative effect of rhein, an anthraquinone isolated from Cassia species, on Caco-2 human adenocarcinoma cells. J Cell Mol Med 2010; 14: 2006-2014.
12. Lin YJ, Zhen YS. Rhein lysinate suppresses the growth of breast cancer cells and potentiates the inhibitory effect of Taxol in athymic mice. Anticancer Drugs 2009; 20: 65-72.
13. Lin ML, Chung JG, Lu YC, Yang CY, Chen SS. Rhein inhibits invasion and migration of human nasopharyngeal carcinoma cells in vitro by down-regulation of matrix metalloproteinases-9 and vascular endothelial growth factor. Oral Oncol 2009; 45: 531-537.
14. 2+ on rhein-induced apoptosis in A-549 human lung cancer cells. Anticancer Res 2009; 29: 309-318.
15. Shi P, Huang Z, Chen G. Rhein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma BEL-7402 cells. Am J Chin Med 2008; 36: 805-813.
16. 2+ on rhein-induced apoptosis in human cervical cancer Ca Ski cells. Anticancer Res 2007; 27: 379-389.
17. Lin S, Fujii M, Hou DX. Rhein induces apoptosis in HL-60 cells via reactive oxygen species-independent mitochondrial death pathway. Arch Biochem Biophys 2003; 418: 99-107.
18. Kuo PL, Hsu YL, Ng LT, Lin CC. Rhein inhibits the growth and induces the apoptosis of Hep G2 cells. Planta Med 2004; 70: 12-16.
19. Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature 2001; 411: 342-348.
20. Kaufmann SH, Earnshaw WC. Induction of apoptosis by cancer chemotherapy. Exp Cell Res 2000; 256: 42-49.
21. Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA, Newmeyer DD, et al. Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol 1999; 144: 281-292.
22. Lee HJ, Lee HJ, Lee EO, Ko SG, Bae HS, Kim CH, et al. Mitochondria-cytochrome C-caspase-9 cascade mediates isorhamnetin-induced apoptosis. Cancer Lett 2008; 270: 342-353.
23. Baell JB, Huang DC. Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs. BiochemPharmacol 2002; 64: 851-863.
24. Goodsell DS. The molecular perspective: Bcl-2 and apoptosis. Stem Cells 2002; 20: 355-356.
25. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 1997; 275: 1132-1136.
26. Sedlak TW, Oltvai ZN, Yang E, Wang K, Boise LH, Thompson CB, et al. Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc Natl Acad Sci U S A 1995; 92: 7834-7838.
27. Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993; 74: 609-619.
28. Mantena SK, Baliga MS, Katiyar SK. Grape seed proanthocyanidins induce apoptosis and inhibit metastasis of highly metastatic breast carcinoma cells. Carcinogenesis 2006; 27: 1682-1691.
29. Green DR, Reed JC. Mitochondria and apoptosis. Science 1998; 281: 1309-1312.
30. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997; 91: 479-489.
31. Hengartner MO. The biochemistry of apoptosis. Nature 2000; 407: 770-776.
32. Thornberry NA, Lazebnik Y. Caspases: enemies within. Science 1998; 281: 1312-1316.
33. Dvorakova K, Payne CM, Landowski TH, Tome ME, Halperin DS, Dorr RT. Imexon activates an intrinsic apoptosis pathway in RPMI8226 myeloma cells. Anticancer Drugs 2002; 13: 1031-1042.
34. Hess CJ, Berkhof J, Denkers F, Ossenkoppele GJ, Schouten JP, Oudejans JJ, et al. Activated intrinsic apoptosis pathway is a key related prognostic parameter in acute myeloid leukemia. J Clin Oncol 2007; 25: 1209-1215.
35. Heo SK, Yun HJ, Park WH, Park SD. Rhein inhibits TNFalpha-induced human aortic smooth muscle cell proliferation via mitochondrial-dependent apoptosis. J Vasc Res 2009; 46: 375-386.
36. 2+-dependent mitochondrial death pathway in human nasopharyngeal carcinoma cells. Anticancer Res 2007; 27: 3313-3322.