ET-743: More than an innovative mechanism of action

Anti-Cancer Drugs

Volumn 13, Issue SUPPL. 1, 2002, Pages

  Scotto, Kathleen W ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

Anti tumor agents; DNA repair; Ecteinascidin 743; Minor groove binders; Natural products; Transcriptional control

Indexed keywords

ANTINEOPLASTIC AGENT; DNA; DNA DEPENDENT PROTEIN KINASE; RNA POLYMERASE II; TRABECTEDIN; 1,3 DIOXOLANE DERIVATIVE; ALKYLATING AGENT; ISOQUINOLINE DERIVATIVE; TETRAHYDROISOQUINOLINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; BREAST CARCINOMA; CONFERENCE PAPER; CYTOTOXICITY; DNA BINDING; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME ACTIVITY; EXCISION REPAIR; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; LUNG NON SMALL CELL CANCER; MELANOMA; MISMATCH REPAIR; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROSTATE CARCINOMA; SOFT TISSUE SARCOMA; SOLID TUMOR; DRUG SCREENING; REVIEW;

ANTINEOPLASTIC AGENTS, ALKYLATING; DIOXOLES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMAN; ISOQUINOLINES; HUMANS; TETRAHYDROISOQUINOLINES;

EID: 0036270039     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (12)

1. Progress in the acquisition of new marine-derived anticancer compounds: Development of ecteinascidin-743 (ET-743)
2. Ecteinascidin 743: A minor groove alkylator that bends DNA towards the major groove
3. Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways
4. Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair
5. The inefficiency of incisions of ecteinascidin 743-DNA adducts by the UvrABC nuclease and the unique structural feature of the DNA adducts can be used to explain the repair-dependent toxicities of this antitumor agent
6. P-glycoproteins and multidrug resistance
7. Interference of transcriptional activation by the antineoplastic drug ET-743
8. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
9. Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action
10. Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation
11. Sensitivity of soft tissue sarcoma cell lines to chemotherapeutic agents: Identification of ecteinascidin-743 as a potent cytotoxic agent
12. Sequence-dependent enhancement of cytotoxicity produced by ecteinascidin 743 (ET-743) with doxorubicin or paclitaxel in soft tissue sarcoma cells