Toxic effects of celastrol on embryonic development of zebrafish (Danio rerio)

Drug and Chemical Toxicology

Volumn 34, Issue 1, 2011, Pages 61-65

  Wang, Sifeng ^a   Liu, Kechun ^a   Wang, Ximing ^a   He, Qiuxia ^a   Chen, Xiqiang ^a  

^a QILU UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Celastrol; Developmental toxicity; Embryo; Zebrafish

Indexed keywords

CELASTROL;

ARTICLE; CONTROLLED STUDY; EMBRYO DEVELOPMENT; FERTILIZATION; IN VIVO STUDY; LC 50; NONHUMAN; PERICARDIUM; PHENOTYPE; SURVIVAL; TOXICITY TESTING; ZEBRA FISH;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; EMBRYO, NONMAMMALIAN; EMBRYONIC DEVELOPMENT; FEMALE; MALE; TOXICITY TESTS; TRIPTERYGIUM; TRITERPENES; ZEBRAFISH;

DANIO RERIO; TRIPTERYGIUM WILFORDII;

EID: 78649921943     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.3109/01480545.2010.494664     Document Type: Article

References (21)

1. Allison, A. C., Cacabelos, R., Lombardi, V. R., et al. (2001). Celastrol, a potent anti-oxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry 25:1341-1357.
2. David, A., Pancharatna, K. (2009). Developmental anomalies induced by non-selective COX inhibitor (ibuprofen) in zebrafish (Danio rerio). Environ Toxicol Pharm 27:390-395.
3. Fraysse, B., Mons, R., Garric, J. (2006). Development of a zebrafish 4-day embryo-larval bioassay to assess toxicity of chemicals. Ecotoxicol Environ Saf 63:253-267.
4. Haendel, M. A., Tilton, F., Bailey, G. S., et al. (2004). Developmental toxicity of the dithiocarbamate pesticide sodium metam in zebrafish. Toxicol Sci 81:390-400.
5. He, M. F., Liu, L., Ge, W., et al. (2009). Antiangiogenic activity of Tripterygium wilfordii and its terpenoids. J Ethnopharmacol 121:61-68.
6. Huang, Y., Zhou, Y., Fan, Y., et al. (2003). Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Cancer Lett 264:101-106.
7. Lam, C. S., Korzh, V., Strahle, U. (2005). Zebrafish embryos are susceptible to the dopaminergic neurotoxin, MPTP. Eur J Neurosci 21:1758-1762.
8. Milan, D. J., Peterson, T. A., Ruskin, J. N., et al. (2003). Drugs that induce repolarization abnormalities cause bradycardia in zebrafish. Circulation 107:1355-1358.
9. Nagel, R. (2002). DarT: The embryo test with the zebrafish, Danio rerio-a general model in ecotoxicology and toxicology. ALTEX 19 (Suppl 1):38-48.
10. Parng, C. (2005). In vivo zebrafish assays for toxicity testing. Curr Opin Drug Discov Dev 8:100-106.
11. Rubinstein, A. L. (2006). Zebrafish assays for drug toxicity screening. Exp Opin Drug Metab Toxicol 2:231-240.
12. Selderslaghs, I. W., Van Rompay, A. R., De Coen, W., et al. (2009). Development of a screening assay to identify teratogenic and embryotoxic chemicals using the zebrafish embryo. Reprod Toxicol 28:308-320.
13. Setty, A. R., Sigal, L. H. (2005). Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects. Semin Arthritis Rheum 34:773-784.
14. Strmac, M., Braunbeck, T. (1999). Effects of triphenyltin acetate on survival, hatching success, and liver ultrastructure of early life stages of zebrafish (Danio rerio). Ecotoxicol Environ Saf 44:25-39.
15. Strmac, M., Oberemm, A., Braunbeck, T., et al. (2002). Effects of sediment eluates and extracts from differently polluted small rivers on zebrafish embryos and larvae. J Fish Biol 61:24-38.
16. Wang, S. F., Liu, K. C. H., Wang, X. M., et al. (2009). Preliminary study on cardiotoxicity of celastrol to zebrafish embryo. Chin Pharmacol Bull 24:634-636.
17. Westerfield, M. (1995). The zebrafish book. Eugene, Oregon, USA: University of Oregon Press.
18. Wu, J. Y., Lin, C. Y., Lin, T. W., et al. (2007). Curcumin affects development of zebrafish embryo. Biol Pharm Bull 30:1336-1339.
19. Yang, H. J., Chen, D., Cui, Q. Z., et al. (2006). Celastrol, a triterpene extracted from the Chinese "thunder of god vine", is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res 66:4758-4765.
20. Yang, L. X., Yang, L., Ho, N. Y., et al. (2009). Zebrafish embryos as models for embryotoxic and teratological effects of chemicals. Reprod Toxicol 28:245-253.
21. Zhang, C. J., Willett, C., Fremgen, T. (2003). Zebrafish: an animal model for toxicological studies. Curr Protoc Toxicol Suppl 17:1-18.