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Volumn 45, Issue 3, 2012, Pages 586-595

The path from skin to brain: Generation of functional neurons from fibroblasts

Author keywords

Cell fate reprogramming; Embryonic stem cells (ESCs); Fibroblasts; Induced neural stem cells (iNSCs); Induced neurons (iNs); Induced pluripotent stem cells (iPSCs); Neurogenesis

Indexed keywords

ANIMAL; BRAIN; CYTOLOGY; FIBROBLAST; HUMAN; METABOLISM; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; PLURIPOTENT STEM CELL; REVIEW; SKIN;

EID: 84867471374     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-012-8277-6     Document Type: Article
Times cited : (32)

References (92)
  • 1
    • 0033638174 scopus 로고    scopus 로고
    • Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity
    • Kawasaki H et al (2000) Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. Neuron 28(1):31-40
    • (2000) Neuron , vol.28 , Issue.1 , pp. 31-40
    • Kawasaki, H.1
  • 2
    • 0034044317 scopus 로고    scopus 로고
    • Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells
    • Lee SH et al (2000) Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat Biotechnol 18 (6):675-679
    • (2000) Nat Biotechnol , vol.18 , Issue.6 , pp. 675-679
    • Lee, S.H.1
  • 3
    • 0030248408 scopus 로고    scopus 로고
    • Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro
    • Okabe S et al (1996) Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro. Mech Dev 59(1):89-102
    • (1996) Mech Dev , vol.59 , Issue.1 , pp. 89-102
    • Okabe, S.1
  • 4
    • 0034101804 scopus 로고    scopus 로고
    • Embryonic stem cell lines from human blastocysts: Somatic differentiation in vitro
    • Reubinoff BE et al (2000) Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat Biotechnol 18 (4):399-404
    • (2000) Nat Biotechnol , vol.18 , Issue.4 , pp. 399-404
    • Reubinoff, B.E.1
  • 5
    • 0031890165 scopus 로고    scopus 로고
    • Neural differentiation of rhesus embryonic stem cells
    • discussion 156-7
    • Thomson JA, Marshall VS, Trojanowski JQ (1998) Neural differentiation of rhesus embryonic stem cells. APMIS 106(1):149-156, discussion 156-7
    • (1998) APMIS , vol.106 , Issue.1 , pp. 149-156
    • Thomson, J.A.1    Marshall, V.S.2    Trojanowski, J.Q.3
  • 6
    • 67650260099 scopus 로고    scopus 로고
    • Ethical and policy issues surrounding the donation of cryopreserved and fresh embryos for human embryonic stem cell research
    • Cohen CB (2009) Ethical and policy issues surrounding the donation of cryopreserved and fresh embryos for human embryonic stem cell research. Stem Cell Rev 5(2):116-122
    • (2009) Stem Cell Rev , vol.5 , Issue.2 , pp. 116-122
    • Cohen, C.B.1
  • 7
    • 75149134338 scopus 로고    scopus 로고
    • The roles of glycosphingolipids in the proliferation and neural differentiation of mouse embryonic stem cells
    • Jung JU et al (2009) The roles of glycosphingolipids in the proliferation and neural differentiation of mouse embryonic stem cells. Exp Mol Med 41(12):935-945
    • (2009) Exp Mol Med , vol.41 , Issue.12 , pp. 935-945
    • Jung, J.U.1
  • 8
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126(4):663-676
    • (2006) Cell , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 9
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K et al (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131(5):861-872
    • (2007) Cell , vol.131 , Issue.5 , pp. 861-872
    • Takahashi, K.1
  • 10
    • 50149098605 scopus 로고    scopus 로고
    • Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons
    • Dimos JT et al (2008) Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science 321(5893):1218-1221
    • (2008) Science , vol.321 , Issue.5893 , pp. 1218-1221
    • Dimos, J.T.1
  • 11
    • 79952420882 scopus 로고    scopus 로고
    • Analysis of differential proteomes of induced pluripotent stem cells by protein-based reprogramming of fibroblasts
    • Jin J et al (2011) Analysis of differential proteomes of induced pluripotent stem cells by protein-based reprogramming of fibroblasts. J Proteome Res 10(3):977-989
    • (2011) J Proteome Res , vol.10 , Issue.3 , pp. 977-989
    • Jin, J.1
  • 12
    • 50549089957 scopus 로고    scopus 로고
    • Disease-specific induced pluripotent stem cells
    • Park IH et al (2008) Disease-specific induced pluripotent stem cells. Cell 134(5):877-886
    • (2008) Cell , vol.134 , Issue.5 , pp. 877-886
    • Park, I.H.1
  • 13
    • 79961131135 scopus 로고    scopus 로고
    • Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons
    • Qiang L et al (2011) Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons. Cell 146(3):359-371
    • (2011) Cell , vol.146 , Issue.3 , pp. 359-371
    • Qiang, L.1
  • 14
    • 80053900492 scopus 로고    scopus 로고
    • Direct lineage conversion of terminally differentiated hepatocytes to functional neurons
    • Marro S et al (2011) Direct lineage conversion of terminally differentiated hepatocytes to functional neurons. Cell Stem Cell 9 (4):374-382
    • (2011) Cell Stem Cell , vol.9 , Issue.4 , pp. 374-382
    • Marro, S.1
  • 15
    • 78751703892 scopus 로고    scopus 로고
    • Direct conversion of C. elegans germ cells into specific neuron types
    • Tursun B et al (2011) Direct conversion of C. elegans germ cells into specific neuron types. Science 331(6015):304-308
    • (2011) Science , vol.331 , Issue.6015 , pp. 304-308
    • Tursun, B.1
  • 16
    • 0000522160 scopus 로고
    • Human skin fibroblasts in vitro differentiate along a terminal cell lineage
    • Bayreuther K et al (1988) Human skin fibroblasts in vitro differentiate along a terminal cell lineage. Proc Natl Acad Sci U S A 85 (14):5112-5116
    • (1988) Proc Natl Acad Sci U S A , vol.85 , Issue.14 , pp. 5112-5116
    • Bayreuther, K.1
  • 17
    • 18844392836 scopus 로고    scopus 로고
    • Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues
    • Hochedlinger K et al (2005) Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell 121(3):465-477
    • (2005) Cell , vol.121 , Issue.3 , pp. 465-477
    • Hochedlinger, K.1
  • 18
    • 34848874100 scopus 로고    scopus 로고
    • Oct4 expression is not required for mouse somatic stem cell self-renewal
    • Lengner CJ et al (2007) Oct4 expression is not required for mouse somatic stem cell self-renewal. Cell Stem Cell 1(4):403-415
    • (2007) Cell Stem Cell , vol.1 , Issue.4 , pp. 403-415
    • Lengner, C.J.1
  • 19
    • 42049123664 scopus 로고    scopus 로고
    • The pluripotency regulator Oct4: A role in somatic stem cells?
    • Lengner CJ, Welstead GG, Jaenisch R (2008) The pluripotency regulator Oct4: a role in somatic stem cells? Cell Cycle 7(6):725-728
    • (2008) Cell Cycle , vol.7 , Issue.6 , pp. 725-728
    • Lengner, C.J.1    Welstead, G.G.2    Jaenisch, R.3
  • 20
    • 0037547198 scopus 로고    scopus 로고
    • POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors
    • Looijenga LH et al (2003) POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors. Cancer Res 63 (9):2244-2250
    • (2003) Cancer Res , vol.63 , Issue.9 , pp. 2244-2250
    • Looijenga, L.H.1
  • 21
    • 0034028901 scopus 로고    scopus 로고
    • Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
    • Niwa H, Miyazaki J, Smith AG (2000) Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 24(4):372-376
    • (2000) Nat Genet , vol.24 , Issue.4 , pp. 372-376
    • Niwa, H.1    Miyazaki, J.2    Smith, A.G.3
  • 22
    • 34547180496 scopus 로고    scopus 로고
    • Oct-4 expression in adult human differentiated cells challenges its role as a pure stem cell marker
    • Zangrossi S et al (2007) Oct-4 expression in adult human differentiated cells challenges its role as a pure stem cell marker. Stem Cells 25(7):1675-1680
    • (2007) Stem Cells , vol.25 , Issue.7 , pp. 1675-1680
    • Zangrossi, S.1
  • 23
    • 0037227099 scopus 로고    scopus 로고
    • Multipotent cell lineages in early mouse development depend on SOX2 function
    • Avilion AA et al (2003) Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev 17(1):126-140
    • (2003) Genes Dev , vol.17 , Issue.1 , pp. 126-140
    • Avilion, A.A.1
  • 24
    • 25144525014 scopus 로고    scopus 로고
    • Core transcriptional regulatory circuitry in human embryonic stem cells
    • Boyer LA et al (2005) Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122(6):947-956
    • (2005) Cell , vol.122 , Issue.6 , pp. 947-956
    • Boyer, L.A.1
  • 25
    • 21744444920 scopus 로고    scopus 로고
    • Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells
    • Chew JL et al (2005) Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol 25(14):6031-6046
    • (2005) Mol Cell Biol , vol.25 , Issue.14 , pp. 6031-6046
    • Chew, J.L.1
  • 26
    • 34249876564 scopus 로고    scopus 로고
    • Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells
    • Masui S et al (2007) Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. Nat Cell Biol 9(6):625-635
    • (2007) Nat Cell Biol , vol.9 , Issue.6 , pp. 625-635
    • Masui, S.1
  • 27
    • 33645381936 scopus 로고    scopus 로고
    • The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
    • Loh YH et al (2006) The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet 38(4):431-440
    • (2006) Nat Genet , vol.38 , Issue.4 , pp. 431-440
    • Loh, Y.H.1
  • 28
    • 21644434480 scopus 로고    scopus 로고
    • Transcriptional regulation of nanog by OCT4 and SOX2
    • Rodda DJ et al (2005) Transcriptional regulation of nanog by OCT4 and SOX2. J Biol Chem 280(26):24731-24737
    • (2005) J Biol Chem , vol.280 , Issue.26 , pp. 24731-24737
    • Rodda, D.J.1
  • 29
    • 0037459050 scopus 로고    scopus 로고
    • Transcriptional profiling of Kruppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation
    • Chen X et al (2003) Transcriptional profiling of Kruppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation. J Mol Biol 326(3):665-677
    • (2003) J Mol Biol , vol.326 , Issue.3 , pp. 665-677
    • Chen, X.1
  • 30
    • 30144440248 scopus 로고    scopus 로고
    • The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene
    • Rowland BD, Bernards R, Peeper DS (2005) The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Nat Cell Biol 7(11):1074-1082
    • (2005) Nat Cell Biol , vol.7 , Issue.11 , pp. 1074-1082
    • Rowland, B.D.1    Bernards, R.2    Peeper, D.S.3
  • 31
    • 49649101156 scopus 로고    scopus 로고
    • Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells
    • Wei D et al (2008) Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells. Cancer Res 68(12):4631-4639
    • (2008) Cancer Res , vol.68 , Issue.12 , pp. 4631-4639
    • Wei, D.1
  • 32
    • 84864151293 scopus 로고    scopus 로고
    • Krüppel-like factor 4 function as a tumor suppressor in cervical carcinoma
    • doi:10.1002/cncr.26698
    • Yang W-T, Zheng P-S (2011) Krüppel-like factor 4 function as a tumor suppressor in cervical carcinoma. Cancer. doi:10.1002/cncr.26698
    • (2011) Cancer
    • Yang, W.-T.1    Zheng, P.-S.2
  • 33
    • 0037462796 scopus 로고    scopus 로고
    • Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage
    • Yoon HS, Chen X, Yang VW (2003) Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage. J Biol Chem 278(4):2101-2105
    • (2003) J Biol Chem , vol.278 , Issue.4 , pp. 2101-2105
    • Yoon, H.S.1    Chen, X.2    Yang, V.W.3
  • 34
  • 35
    • 0031806044 scopus 로고    scopus 로고
    • The molecular role of Myc in growth and transformation: Recent discoveries lead to new insights
    • Facchini LM, Penn LZ (1998) The molecular role of Myc in growth and transformation: recent discoveries lead to new insights. FASEB J 12(9):633-651
    • (1998) FASEB J , vol.12 , Issue.9 , pp. 633-651
    • Facchini, L.M.1    Penn, L.Z.2
  • 36
    • 0030995824 scopus 로고    scopus 로고
    • Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F
    • Leone G et al (1997) Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature 387(6631):422-426
    • (1997) Nature , vol.387 , Issue.6631 , pp. 422-426
    • Leone, G.1
  • 38
    • 77956214743 scopus 로고    scopus 로고
    • Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells
    • Urbach A et al (2010) Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells. Cell Stem Cell 6(5):407-411
    • (2010) Cell Stem Cell , vol.6 , Issue.5 , pp. 407-411
    • Urbach, A.1
  • 39
    • 78149488365 scopus 로고    scopus 로고
    • A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells
    • Marchetto MC et al (2010) A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell 143(4):527-539
    • (2010) Cell , vol.143 , Issue.4 , pp. 527-539
    • Marchetto, M.C.1
  • 40
    • 79955602167 scopus 로고    scopus 로고
    • Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation
    • Cheung AY et al (2011) Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation. Hum Mol Genet 20(11):2103-2115
    • (2011) Hum Mol Genet , vol.20 , Issue.11 , pp. 2103-2115
    • Cheung, A.Y.1
  • 41
    • 80052419902 scopus 로고    scopus 로고
    • Parkinson's disease induced pluripotent stem cells with triplication of the alpha-synuclein locus
    • Devine MJ et al (2011) Parkinson's disease induced pluripotent stem cells with triplication of the alpha-synuclein locus. Nat Commun 2:440
    • (2011) Nat Commun , vol.2 , pp. 440
    • Devine, M.J.1
  • 42
    • 79952258224 scopus 로고    scopus 로고
    • Somatic coding mutations in human induced pluripotent stem cells
    • Gore A et al (2011) Somatic coding mutations in human induced pluripotent stem cells. Nature 471(7336):63-67
    • (2011) Nature , vol.471 , Issue.7336 , pp. 63-67
    • Gore, A.1
  • 43
    • 79955479900 scopus 로고    scopus 로고
    • Human induced pluripotent stem cells: The past, present, and future
    • Hussein SM, Nagy K, Nagy A (2011) Human induced pluripotent stem cells: the past, present, and future. Clin Pharmacol Ther 89 (5):741-745
    • (2011) Clin Pharmacol Ther , vol.89 , Issue.5 , pp. 741-745
    • Hussein, S.M.1    Nagy, K.2    Nagy, A.3
  • 44
    • 79551677421 scopus 로고    scopus 로고
    • Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines
    • Bock C et al (2011) Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines. Cell 144(3):439-452
    • (2011) Cell , vol.144 , Issue.3 , pp. 439-452
    • Bock, C.1
  • 45
    • 79551665440 scopus 로고    scopus 로고
    • A functionally characterized test set of human induced pluripotent stem cells
    • Boulting GL et al (2011) A functionally characterized test set of human induced pluripotent stem cells. Nat Biotechnol 29(3):279-286
    • (2011) Nat Biotechnol , vol.29 , Issue.3 , pp. 279-286
    • Boulting, G.L.1
  • 46
    • 33751239783 scopus 로고    scopus 로고
    • Self-renewal of embryonic stem cells by a small molecule
    • Chen S et al (2006) Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci U S A 103(46):17266-17271
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.46 , pp. 17266-17271
    • Chen, S.1
  • 47
    • 0347717672 scopus 로고    scopus 로고
    • Dedifferentiation of lineage-committed cells by a small molecule
    • Chen S et al (2004) Dedifferentiation of lineage-committed cells by a small molecule. J Am Chem Soc 126(2):410-411
    • (2004) J Am Chem Soc , vol.126 , Issue.2 , pp. 410-411
    • Chen, S.1
  • 48
    • 58049192815 scopus 로고    scopus 로고
    • Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors
    • Li Wet al (2009) Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell 4(1):16-19
    • (2009) Cell Stem Cell , vol.4 , Issue.1 , pp. 16-19
    • Wet Al., L.1
  • 49
    • 77952360137 scopus 로고    scopus 로고
    • Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules
    • Xu Y et al (2010) Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc Natl Acad Sci U S A 107(18):8129-8134
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.18 , pp. 8129-8134
    • Xu, Y.1
  • 50
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • Yu J et al (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318(5858):1917-1920
    • (2007) Science , vol.318 , Issue.5858 , pp. 1917-1920
    • Yu, J.1
  • 51
    • 56549127713 scopus 로고    scopus 로고
    • Guidelines and techniques for the generation of induced pluripotent stem cells
    • Maherali N, Hochedlinger K (2008) Guidelines and techniques for the generation of induced pluripotent stem cells. Cell Stem Cell 3 (6):595-605
    • (2008) Cell Stem Cell , vol.3 , Issue.6 , pp. 595-605
    • Maherali, N.1    Hochedlinger, K.2
  • 52
    • 48149107133 scopus 로고    scopus 로고
    • Wnt signaling promotes reprogramming of somatic cells to pluripotency
    • Marson A et al (2008) Wnt signaling promotes reprogramming of somatic cells to pluripotency. Cell Stem Cell 3(2):132-135
    • (2008) Cell Stem Cell , vol.3 , Issue.2 , pp. 132-135
    • Marson, A.1
  • 53
    • 44349170450 scopus 로고    scopus 로고
    • The ground state of embryonic stem cell selfrenewal
    • Ying QL et al (2008) The ground state of embryonic stem cell selfrenewal. Nature 453(7194):519-523
    • (2008) Nature , vol.453 , Issue.7194 , pp. 519-523
    • Ying, Q.L.1
  • 54
    • 46949085597 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
    • Huangfu D et al (2008) Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol 26(7):795-797
    • (2008) Nat Biotechnol , vol.26 , Issue.7 , pp. 795-797
    • Huangfu, D.1
  • 55
    • 44349103591 scopus 로고    scopus 로고
    • A combined chemical and genetic approach for the generation of induced pluripotent stem cells
    • Shi Y et al (2008) A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell 2 (6):525-528
    • (2008) Cell Stem Cell , vol.2 , Issue.6 , pp. 525-528
    • Shi, Y.1
  • 56
    • 79961173182 scopus 로고    scopus 로고
    • Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions
    • Ambasudhan R et al (2011) Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions. Cell Stem Cell 9(2):113-118
    • (2011) Cell Stem Cell , vol.9 , Issue.2 , pp. 113-118
    • Ambasudhan, R.1
  • 57
    • 79960854285 scopus 로고    scopus 로고
    • Induction of human neuronal cells by defined transcription factors
    • Pang ZP et al (2011) Induction of human neuronal cells by defined transcription factors. Nature 476(7359):220-223
    • (2011) Nature , vol.476 , Issue.7359 , pp. 220-223
    • Pang, Z.P.1
  • 58
    • 79959951387 scopus 로고    scopus 로고
    • Direct conversion of human fibroblasts to dopaminergic neurons
    • Pfisterer U et al (2011) Direct conversion of human fibroblasts to dopaminergic neurons. Proc Natl Acad Sci U S A 108(25):10343-10348
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.25 , pp. 10343-10348
    • Pfisterer, U.1
  • 59
    • 80052295767 scopus 로고    scopus 로고
    • Conversion of mouse and human fibroblasts into functional spinal motor neurons
    • Son EY et al (2011) Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell Stem Cell 9(3):205-218
    • (2011) Cell Stem Cell , vol.9 , Issue.3 , pp. 205-218
    • Son, E.Y.1
  • 60
    • 80051684096 scopus 로고    scopus 로고
    • MicroRNA-mediated conversion of human fibroblasts to neurons
    • Yoo AS et al (2011) MicroRNA-mediated conversion of human fibroblasts to neurons. Nature 476(7359):228-231
    • (2011) Nature , vol.476 , Issue.7359 , pp. 228-231
    • Yoo, A.S.1
  • 61
    • 77649162059 scopus 로고    scopus 로고
    • Direct conversion of fibroblasts to functional neurons by defined factors
    • Vierbuchen T et al (2010) Direct conversion of fibroblasts to functional neurons by defined factors. Nature 463(7284):1035-1041
    • (2010) Nature , vol.463 , Issue.7284 , pp. 1035-1041
    • Vierbuchen, T.1
  • 62
    • 4744350000 scopus 로고    scopus 로고
    • Conserved POU binding DNA sites in the Sox2 upstream enhancer regulate gene expression in embryonic and neural stem cells
    • Catena R et al (2004) Conserved POU binding DNA sites in the Sox2 upstream enhancer regulate gene expression in embryonic and neural stem cells. J Biol Chem 279(40):41846- 41857
    • (2004) J Biol Chem , vol.279 , Issue.40 , pp. 41846-41857
    • Catena, R.1
  • 63
    • 65549110335 scopus 로고    scopus 로고
    • Different transcription factors regulate nestin gene expression during P19 cell neural differentiation and central nervous system development
    • Jin Z et al (2009) Different transcription factors regulate nestin gene expression during P19 cell neural differentiation and central nervous system development. J Biol Chem 284(12):8160-8173
    • (2009) J Biol Chem , vol.284 , Issue.12 , pp. 8160-8173
    • Jin, Z.1
  • 64
    • 0037099207 scopus 로고    scopus 로고
    • Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons
    • Sugitani Y et al (2002) Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons. Genes Dev 16(14):1760-1765
    • (2002) Genes Dev , vol.16 , Issue.14 , pp. 1760-1765
    • Sugitani, Y.1
  • 65
    • 0031172193 scopus 로고    scopus 로고
    • MASH1 maintains competence for BMP2-induced neuronal differentiation in post-migratory neural crest cells
    • Lo L, Sommer L, Anderson DJ (1997) MASH1 maintains competence for BMP2-induced neuronal differentiation in post-migratory neural crest cells. Curr Biol 7(6):440-450
    • (1997) Curr Biol , vol.7 , Issue.6 , pp. 440-450
    • Lo, L.1    Sommer, L.2    Anderson, D.J.3
  • 66
    • 0036467664 scopus 로고    scopus 로고
    • Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity
    • Parras CM et al (2002) Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity. Genes Dev 16(3):324-338
    • (2002) Genes Dev , vol.16 , Issue.3 , pp. 324-338
    • Parras, C.M.1
  • 67
    • 0030736423 scopus 로고    scopus 로고
    • Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system
    • Kim JG et al (1997) Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system. J Neurosci Res 50(2):272-290
    • (1997) J Neurosci Res , vol.50 , Issue.2 , pp. 272-290
    • Kim, J.G.1
  • 68
    • 1242284406 scopus 로고    scopus 로고
    • Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells
    • Nielsen JA et al (2004) Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells. Mol Cell Neurosci 25(1):111-123
    • (2004) Mol Cell Neurosci , vol.25 , Issue.1 , pp. 111-123
    • Nielsen, J.A.1
  • 69
    • 80051674431 scopus 로고    scopus 로고
    • Direct generation of functional dopaminergic neurons from mouse and human fibroblasts
    • Caiazzo M et al (2011) Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature 476 (7359):224-227
    • (2011) Nature , vol.476 , Issue.7359 , pp. 224-227
    • Caiazzo, M.1
  • 70
    • 79953881831 scopus 로고    scopus 로고
    • Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency
    • Anokye-Danso F et al (2011) Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell 8(4):376-388
    • (2011) Cell Stem Cell , vol.8 , Issue.4 , pp. 376-388
    • Anokye-Danso, F.1
  • 71
    • 77949903674 scopus 로고    scopus 로고
    • MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors
    • Delaloy C et al (2010) MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors. Cell Stem Cell 6(4):323-335
    • (2010) Cell Stem Cell , vol.6 , Issue.4 , pp. 323-335
    • Delaloy, C.1
  • 72
    • 34547212309 scopus 로고    scopus 로고
    • The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing
    • Makeyev EV et al (2007) The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Mol Cell 27(3):435-448
    • (2007) Mol Cell , vol.27 , Issue.3 , pp. 435-448
    • Makeyev, E.V.1
  • 73
    • 79957855262 scopus 로고    scopus 로고
    • Reprogramming of mouse and human cells to pluripotency using mature microRNAs
    • Miyoshi N et al (2011) Reprogramming of mouse and human cells to pluripotency using mature microRNAs. Cell Stem Cell 8 (6):633-638
    • (2011) Cell Stem Cell , vol.8 , Issue.6 , pp. 633-638
    • Miyoshi, N.1
  • 74
    • 79955780736 scopus 로고    scopus 로고
    • Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells
    • Subramanyam D et al (2011) Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol 29(5):443-448
    • (2011) Nat Biotechnol , vol.29 , Issue.5 , pp. 443-448
    • Subramanyam, D.1
  • 75
    • 34147157651 scopus 로고    scopus 로고
    • The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development
    • Visvanathan J et al (2007) The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development. Genes Dev 21(7):744-749
    • (2007) Genes Dev , vol.21 , Issue.7 , pp. 744-749
    • Visvanathan, J.1
  • 76
    • 64049095014 scopus 로고    scopus 로고
    • A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination
    • Zhao C et al (2009) A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination. Nat Struct Mol Biol 16(4):365-371
    • (2009) Nat Struct Mol Biol , vol.16 , Issue.4 , pp. 365-371
    • Zhao, C.1
  • 77
    • 33745480963 scopus 로고    scopus 로고
    • Specific microRNAs modulate embryonic stem cell-derived neurogenesis
    • Krichevsky AM et al (2006) Specific microRNAs modulate embryonic stem cell-derived neurogenesis. Stem Cells 24(4):857-864
    • (2006) Stem Cells , vol.24 , Issue.4 , pp. 857-864
    • Krichevsky, A.M.1
  • 78
    • 65349085532 scopus 로고    scopus 로고
    • MicroRNA-124: Micromanager of neurogenesis
    • Papagiannakopoulos T, Kosik KS (2009) MicroRNA-124: micromanager of neurogenesis. Cell Stem Cell 4(5):375-376
    • (2009) Cell Stem Cell , vol.4 , Issue.5 , pp. 375-376
    • Papagiannakopoulos, T.1    Kosik, K.S.2
  • 79
    • 0027482675 scopus 로고
    • Short-term synaptic plasticity is altered in mice lacking synapsin i
    • Rosahl TW et al (1993) Short-term synaptic plasticity is altered in mice lacking synapsin I. Cell 75(4):661-670
    • (1993) Cell , vol.75 , Issue.4 , pp. 661-670
    • Rosahl, T.W.1
  • 80
    • 0031019926 scopus 로고    scopus 로고
    • Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses
    • Schiavo G et al (1997) Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses. Proc Natl Acad Sci U S A 94(3):997-1001
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.3 , pp. 997-1001
    • Schiavo, G.1
  • 81
    • 84859535900 scopus 로고    scopus 로고
    • How to remake a fibroblast into a neural stem cell
    • Zhou Q, Tripathi P (2012) How to remake a fibroblast into a neural stem cell. Cell Stem Cell 10(4):347-348
    • (2012) Cell Stem Cell , vol.10 , Issue.4 , pp. 347-348
    • Zhou, Q.1    Tripathi, P.2
  • 82
    • 84859555919 scopus 로고    scopus 로고
    • Direct conversion of fibroblasts into stably expandable neural stem cells
    • Thier M et al (2012) Direct conversion of fibroblasts into stably expandable neural stem cells. Cell Stem Cell 10(4):473-479
    • (2012) Cell Stem Cell , vol.10 , Issue.4 , pp. 473-479
    • Thier, M.1
  • 83
    • 84862777308 scopus 로고    scopus 로고
    • Direct reprogramming of fibroblasts into neural stem cells by defined factors
    • HanDWet al (2012) Direct reprogramming of fibroblasts into neural stem cells by defined factors. Cell Stem Cell 10(4):465-472
    • (2012) Cell Stem Cell , vol.10 , Issue.4 , pp. 465-472
    • Han, D.W.1
  • 84
    • 79956357347 scopus 로고    scopus 로고
    • Direct reprogramming of mouse fibroblasts to neural progenitors
    • Kim J et al (2011) Direct reprogramming of mouse fibroblasts to neural progenitors. Proc Natl Acad Sci 108(19):7838-7843
    • (2011) Proc Natl Acad Sci , vol.108 , Issue.19 , pp. 7838-7843
    • Kim, J.1
  • 85
    • 34547657665 scopus 로고    scopus 로고
    • Hot spots of retroviral integration in human CD34+ hematopoietic cells
    • Cattoglio C et al (2007) Hot spots of retroviral integration in human CD34+ hematopoietic cells. Blood 110(6):1770-1778
    • (2007) Blood , vol.110 , Issue.6 , pp. 1770-1778
    • Cattoglio, C.1
  • 86
    • 0022380768 scopus 로고
    • The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
    • Adams JM et al (1985) The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 318(6046):533-538
    • (1985) Nature , vol.318 , Issue.6046 , pp. 533-538
    • Adams, J.M.1
  • 87
    • 0023854161 scopus 로고
    • The e mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early. B cells
    • Harris AWet al (1988) The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early. B cells J Exp Med 167(2):353-371
    • (1988) J Exp Med , vol.167 , Issue.2 , pp. 353-371
    • Awet Al., H.1
  • 88
    • 0022497717 scopus 로고
    • Consequences of widespread deregulation of the c-myc gene in transgenic mice: Multiple neoplasms and normal development
    • Leder A et al (1986) Consequences of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasms and normal development. Cell 45(4):485-495
    • (1986) Cell , vol.45 , Issue.4 , pp. 485-495
    • Leder, A.1
  • 89
    • 0028373224 scopus 로고
    • Use of transgenic mice to study myc family gene function in normal mammalian development and in cancer
    • Morgenbesser SD, DePinho RA (1994) Use of transgenic mice to study myc family gene function in normal mammalian development and in cancer. Semin Cancer Biol 5(1):21-36
    • (1994) Semin Cancer Biol , vol.5 , Issue.1 , pp. 21-36
    • Morgenbesser, S.D.1    Depinho, R.A.2
  • 90
    • 33745108790 scopus 로고    scopus 로고
    • Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration
    • Montini E et al (2006) Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration. Nat Biotechnol 24(6):687-696
    • (2006) Nat Biotechnol , vol.24 , Issue.6 , pp. 687-696
    • Montini, E.1
  • 91
    • 69249232195 scopus 로고    scopus 로고
    • An efficient and reversible transposable system for gene delivery and lineagespecific differentiation in human embryonic stem cells
    • Lacoste A, Berenshteyn F, Brivanlou AH (2009) An efficient and reversible transposable system for gene delivery and lineagespecific differentiation in human embryonic stem cells. Cell Stem Cell 5(3):332-342
    • (2009) Cell Stem Cell , vol.5 , Issue.3 , pp. 332-342
    • Lacoste, A.1    Berenshteyn, F.2    Brivanlou, A.H.3
  • 92
    • 77958536106 scopus 로고    scopus 로고
    • Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA
    • Warren L et al (2010) Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7(5):618-630
    • (2010) Cell Stem Cell , vol.7 , Issue.5 , pp. 618-630
    • Warren, L.1


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