Neutrophil-selective CD18 silencing using RNA interference in vivo

Blood

Volumn 111, Issue 7, 2008, Pages 3591-3598

  Cullere, Xavier ^a   Lauterbach, Michael ^a   Tsuboi, Naotake ^a   Mayadas, Tanya N ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALGRANULIN A; CD18 ANTIGEN; LEUKOCYTE ADHESION DEFICIENCY TYPE I; MICRORNA; UNCLASSIFIED DRUG; ABC TRANSPORTER; ABCC11 PROTEIN, HUMAN;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE SILENCING; GENETIC MANIPULATION; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; LEUKOCYTE ADHESION DEFICIENCY; MACROPHAGE; MONOCYTE; MOUSE; NEUTROPHIL; NEUTROPHILIA; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RNA INTERFERENCE; SPLENOMEGALY; TRANSGENIC MOUSE; ANIMAL; ANTIBODY SPECIFICITY; CELL LINE; CELL MOTION; DISEASE MODEL; GENETICS; HUMAN; IMMUNOLOGY; PATHOLOGY; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD18; ATP-BINDING CASSETTE TRANSPORTERS; CELL DIFFERENTIATION; CELL LINE; CELL MOVEMENT; DISEASE MODELS, ANIMAL; HUMANS; IMMUNITY, NATURAL; LEUKOCYTE-ADHESION DEFICIENCY SYNDROME; MICE; MICE, TRANSGENIC; MICRORNAS; MONOCYTES; NEUTROPHILS; ORGAN SPECIFICITY; PROMOTER REGIONS (GENETICS); RNA INTERFERENCE; SPLENOMEGALY; T-LYMPHOCYTES;

EID: 43549114589     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2007-12-127837     Document Type: Article

References (42)

1. Galli-Taliadoros LA, Sedgwick JD, Wood SA, Korner H. Gene knock-out technology: a methodological overview for the interested novice. J Immunol Methods. 1995;181:1-15.
2. Hutvagner G. Zamore PD. AmicroRNA in a multiple-turnover RNAi enzyme complex. Science. 2002;297:2056-2060.
3. Llave G, Xie Z, Kasschau KD, Garrington JC. Cleavage of Scarecrow-like rnRNAtargets directed by a class of Arabidopsis miRNA. Science. 2002;297:2053-2056.
4. Meister G, Landthaler M, PatkaniowskaA, Dorsett Y, Teng G, Tuschl T. Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol Cell. 2004;15:185-197.
5. Yekta S, Shih IH, Bartel DP. MicroRNA-directed cleavage of HOXB8 mRNA. Science. 2004;304: 594-596.
6. Jackson RJ, Standart N. How do microRNAs regulate gene expression. Sci STKE. 2007;2007(367):re1.
7. Valencia-Sanchez MA, Liu J. Hannon GJ, Parker R. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev. 2006;20: 515-524.
8. Filipowicz W, Jaskiewicz L Kolb FA, Pillai RS. Posttranscriptional gene silencing by siRNAs and miRNAs. Curr Opin Struct Biol. 2005;15:331 -341.
9. Du G, Yonekubo J, Zeng Y, Osisami M, Frohman MA. Design of expression vectors for RNA interference based on miRNAs and RNAsplicing. FEBS J. 2006;273:5421-5427.
10. Carmell MA, Zhang L Conklin DS, Hannon GJ, RosenquistTA. Germline transmission of RNAi in mice. Nat Struct Biol. 2003;10:91-92.
11. Xia XG, Zhou H, Xu Z. Promises and challenges in developing RNAi as a research tool and therapy for eurodegenerative diseases. Neurodegener Dis. 2005;2:220-231.
12. Xia XG, Zhou H, Samper E, Melov S, Xu Z. Pol ll-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice. PLoS Genet. 2006;2:e10.
13. Rao MK, Pham J, Imam JS, et al. Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis. Genes Dev. 2006;20:147-152.
14. Lagasse E, Weissman lL. bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages. J Exp Med. 1994;179:1047-1052.
15. Anderson DC, Schmalsteig FC, Finegold MJ. et al. The severe and moderate phenotypes of heritable Mac-1, LFA-1 deficiency: their quantitative definition and relation to leukocyte dysfunction and clinical features. J Infect Dis. 1985;152:668-689.
16. Wilson RW, Ballantyne CM, Wayne Smith C, et al. Gene targeting yields a CD18-mutant mouse for study of inflammation. J Immunol. 1993;151: 1571-1578.
17. Scharffetter-Kochanek K, Lu H, Norman K, et al. Spontaneous skin ulceration and defective T-cell function in CD18 null mice. J Exp Med. 1998;188: 119-131.
18. Bullard DC, Scharffetter-Kochanek K, McArthur MJ, et al. A polygenic mouse model of psoriasiform skin disease in GD18-deficient mice. Proc Natl Acad Sci USA.1996;93:2116-2121.
19. Peters T, Sindrilaru A, Wang H, et al. CD18 in monogenic and polygenic inflammatory processes of the skin. J Investig Dermatol Symp Proc. 2006; 11:7-15.
20. Lagasse E, Weissman IL. Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op/op mice. Cell. 1997;89:1021-1031.
21. Wu H, Prince JE, Brayton CR et al. Host resistance of CD18 knockout mice against systemic infection with Listeria monocytogenes. Infect Immun. 2003;71:5986-5993.
22. Movahedi M, Entezari N, Pourpak Z, et al. Clinical and laboratory findings in Iranian patients with leukocyte adhesion deficiency (study of 15 cases). J Clin Immunol. 2007;27:302-307.
23. Tsai S, Collins SJ. A dominant negative retinoic acid receptor blocks neutrophil differentiation at the promyelocyte stage. Proc Natl Acad Sci U S A. 1993;90:7153-7157.
24. Hirahashi J. Mekala D, Van Ziffle J, et al. Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Immunity. 2006;25:271-283.
25. Tang T, Rosenkranz A, Assmann KJM, et al. A role for Mac-1 (GD11 b/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained FCγ receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis. J Exp Med. 1997;186:1853-1863.
26. Utomo A, Cullere X, Glogauer M, Swat W, Mayadas TN. Vav proteins in neutrophils are required for Fc{gamma}R-mediated signaling to Rac GT-Pases and nicotinamide adenine dinucleotide phosphate oxidase component p40(phox). J Immunol. 2006:177:6388-6397.
27. Mizgerd JP, Kubo H, Kutkoski GJ, et al. Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient mice. J Exp Med. 1997;186: 1357-1364.
28. Coxon A, Cullere X, Knight S, et al. FcgammaRIII mediates neutrophil recruitment to immune complexes: a mechanism for neutrophil accumulation in immune-mediated inflammation. Immunity. 2001;14:693-704.
29. Anderson DC, Springer TA. Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins. Ann Rev Med. 1987;38:175-194.
30. Peer D, Zhu P, Carman CV Lieberman J, Shimaoka M. Selective gene silencing in activated lymphocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1. Proc Natl Acad Sci U SA. 2007;104:4095-4100.
31. Schmidt-Supprian M, Rajewsky K. Vagaries of conditional gene targeting. Nat Immunol. 2007;8: 665-668.
32. Jaiswal S, Traver D, Miyamoto T, Akashi K, Lagasse E, Weissman IL. Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias. Proc Natl Acad Sci USA. 2003;100:10002-10007.
33. Odink K, Cerletti N, Brüggen J. et al. Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis. Nature. 1987;330:80-82.
34. Zwadlo G, Bruggen J, Gerhards G, Schlegel R, Sorg C. Two calcium-binding proteins associated with specific stages of myeloid cell differentiation are expressed by subsets of macrophages in inflammatory tissues. Clin Exp Immunol. 1988;72: 510-515.
35. Lagasse E, Clerc RG. Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiation. Mol Cell Biol. 1988;8:2402-2410.
36. Nelson PT De Planell-Saguer M, Lamprinaki S, et al. A novel monoclonal antibody against human Argonaute proteins reveals unexpected characteristics of miRNAs in human blood cells. RNA. 2007;13:1787-1792.
37. Grabbe S, Varga G, Beissert S, et al. Beta2 integrins are required for skin homing of primed T cells but not for priming naive T cells. J Clin Invest. 2002:109:183-192.
38. Weinmann P, Gaehtgens P, Walzog B. Bcl-Xr and Bax-α-mediated regulation of apoptosis of human neutrophilis via caspase-3. Blood. 1999;93:3106- 3115.
39. Forlow SB, Schurr JR, Kolls JK, Bagby GJ, Schwarzenberger PO. Ley K. Increased granulopoiesis through interleukin-17 and granulocyte colony-stimulating factor in leukocyte adhesion molecule-deficient mice. Blood. 2001:98:3309- 3314.
40. Horwitz BH, Mizgerd JP, Scott ML, Doerschuk CM. Mechanisms of granulocytosis in the absence of CD18. Blood. 2001 ;97:1578-1583.
41. Etzioni A, Doerschuk CM, Harlan JM. Of man and mouse: leukocyte and endothelial adhesion molecule deficiencies. Blood. 1999;94:3281-3288.
42. Ott MG, Seger R, Stein S, Siler U, Hoelzer D, Grez M. Advances in the treatment of chronic granulomatous disease by gene therapy. Curr Gene Ther. 2007;7:155-161.