Turning Back the Cardiac Regenerative Clock: Lessons From the Neonate

Trends in Cardiovascular Medicine

Volumn 22, Issue 5, 2012, Pages 128-133

  Mahmoud, Ahmed I ^a   Porrello, Enzo R ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIAC REGENERATION; CELL PROLIFERATION; EMBRYO DEVELOPMENT; HEART DEVELOPMENT; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HUMAN; NEWBORN; NONHUMAN; PERINATAL DEVELOPMENT; PRIORITY JOURNAL; REGENERATION; REVIEW; VERTEBRATE;

ADULT; AMPHIBIANS; ANIMALS; ANIMALS, NEWBORN; BIOLOGICAL EVOLUTION; CELL LINEAGE; CELL PROLIFERATION; HEART; HEART INJURIES; HUMANS; INFANT, NEWBORN; MAMMALS; MICE; MYOCYTES, CARDIAC; PHYLOGENY; REGENERATION; REGENERATIVE MEDICINE; ZEBRAFISH;

EID: 84867383549     PISSN: 10501738     EISSN: 18732615     Source Type: Journal    
DOI: 10.1016/j.tcm.2012.07.008     Document Type: Review

References (55)

1. Ahuja P., Sdek P., MacLellan W.R. Cardiac myocyte cell cycle control in development, disease, and regeneration. Physiol Rev 2007, 87:521-544.
2. Beltrami A.P., Barlucchi L., Torella D., et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003, 114:763-776.
3. Beltrami A.P., Urbanek K., Kajstura J., et al. Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med 2001, 344:1750-1757.
4. Bergmann O., Bhardwaj R.D., Bernard S., et al. Evidence for cardiomyocyte renewal in humans. Science 2009, 324:98-102.
5. Bersell K., Arab S., Haring B., Kühn B. Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell 2009, 138:257-270.
6. Blau H.M., Pomerantz J.H. "Reevolutionary" regenerative medicine. JAMA 2011, 305:87-88.
7. Bonci D., Coppola V., Musumeci M., et al. The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities. Nat Med 2008, 14:1271-1277.
8. Botting K.J., Wang K.C., Padhee M., et al. Early origins of heart disease: Low birth weight and determinants of cardiomyocyte endowment. Clin Exp Pharmacol Physiol 2011, [Epub ahead of print].
9. Calin G.A., Dumitru C.D., Shimizu M., et al. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2002, 99. 15524-1552.
10. Chaudhry H.W., Dashoush N.H., Tang H., et al. Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium. J Biol Chem 2004, 279:35858-35866.
11. Choi W.Y., Poss K.D. Cardiac regeneration. Curr Top Dev Biol 2012, 100:319-344.
12. Chong J.J., Chandrakanthan V., Xaymardan M., et al. Adult cardiac-resident MSC-like stem cells with a proepicardial origin. Cell Stem Cell 2011, 9:527-540.
13. Delgado-Olguín P., Huang Y., Li X., et al. Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis. Nat Genet 2012, 44:343-347.
14. Di Stefano V., Giacca M., Capogrossi M.C., et al. Knockdown of cyclin-dependent kinase inhibitors induces cardiomyocyte re-entry in the cell cycle. J Biol Chem 2011, 286:8644-8654.
15. Drenckhahn J.D., Schwarz Q.P., Gray S., et al. Compensatory growth of healthy cardiac cells in the presence of diseased cells restores tissue homeostasis during heart development. Dev Cell 2008, 15:521-533.
16. Engel F.B., Hsieh P.C., Lee R.T., Keating M.T. FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction. Proc Natl Acad Sci U S A 2006, 103:15546-15551.
17. Engel F.B., Schebesta M., Duong M.T., et al. p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. Genes Dev 2005, 19:1175-1187.
18. Ferreira-Martins J., Ogórek B., Cappetta D., et al. Cardiomyogenesis in the developing heart is regulated by c-kit-positive cardiac stem cells. Circ Res 2012, 110:701-715.
19. Finnerty J.R., Wang W.X., Hébert S.S., et al. The miR-15/107 group of microRNA genes: Evolutionary biology, cellular functions, and roles in human diseases. J Mol Biol 2010, 402:491-509.
20. Flink I.L. Cell cycle reentry of ventricular and atrial cardiomyocytes and cells within the epicardium following amputation of the ventricular apex in the axolotl, Amblystoma mexicanum: Confocal microscopic immunofluorescent image analysis of bromodeoxyuridine-labeled nuclei. Anat Embryol (Berlin) 2002, 205:235-244.
21. Gupta V., Poss K.D. Clonally dominant cardiomyocytes direct heart morphogenesis. Nature 2012, 484:479-484.
22. Hsieh P.C., Segers V.F., Davis M.E., et al. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nat Med 2007, 13:970-974.
23. Hullinger T.G., Montgomery R.L., Seto A.G., et al. Inhibition of miR-15 protects against cardiac ischemic injury. Circ Res 2012, 110:71-81.
24. Jackson K.A., Majka S.M., Wang H., et al. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest 2001, 107:1395-1402.
25. Jopling C., Sleep E., Raya M., et al. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature 2010, 464:606-609.
26. Kajstura J., Gurusamy N., Ogorek B., et al. Myocyte turnover in the aging human heart. Circ Res 2010, 107:1374-1386.
27. Kikuchi K., Gupta V., Wang J., et al. tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration. Development 2011, 138:2895-2902.
28. Kikuchi K., Holdway J.E., Werdich A.A., et al. Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. Nature 2010, 464:601-605.
29. Kocabas F., Mahmoud A.I., Sosic D., et al. The hypoxic epicardial and subepicardial microenvironment. J Cardiovasc Transl Res 2012, 5:654-665.
30. Kubin T., Pöling J., Kostin S., et al. Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling. Cell Stem Cell 2011, 9:420-432.
31. Kühn B., del Monte F., Hajjar R.J., et al. Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Nat Med 2007, 13:962-969.
32. Laflamme M.A., Murry C.E. Heart regeneration. Nature 2011, 473:326-335.
33. Laugwitz K.L., Moretti A., Lam J., et al. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature 2005, 433:647-653.
34. Lepilina A., Coon A.N., Kikuchi K., et al. A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. Cell 2006, 127:607-619.
35. Li F., Wang X., Capasso J.M., Gerdes A.M. Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development. J Mol Cell Cardiol 1996, 28:1737-1746.
36. Li M., Naqvi N., Yahiro E., et al. c-kit is required for cardiomyocyte terminal differentiation. Circ Res 2008, 102:677-685.
37. Liu Q., Fu H., Sun F., et al. miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes. Nucleic Acids Res 2008, 36:5391-5404.
38. Oberpriller J.O., Oberpriller J.C. Response of the adult newt ventricle to injury. J Exp Zool 1974, 187:249-253.
39. Oberpriller J.O., Oberpriller J.C., Arefyeva A.M., et al. Nuclear characteristics of cardiac myocytes following the proliferative response to mincing of the myocardium in the adult newt, Notophthalmus viridescens. Cell Tissue Res 1988, 253:619-624.
40. Oh H., Bradfute S.B., Gallardo T.D., et al. Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction. Proc Natl Acad Sci U S A 2003, 100:12313-12318.
41. Pasumarthi K.B., Nakajima H., Nakajima H.O., et al. Targeted expression of cyclin D2 results in cardiomyocyte DNA synthesis and infarct regression in transgenic mice. Circ Res 2005, 96:110-118.
42. Porrello E.R., Johnson B.A., Aurora A.B., et al. miR-15 family regulates postnatal mitotic arrest of cardiomyocytes. Circ Res 2011, 109:670-679.
43. Porrello E.R., Mahmoud A.I., Simpson E., et al. Transient regenerative potential of the neonatal mouse heart. Science 2011, 331:1078-1080.
44. Porrello E.R., Olson E.N. Building a new heart from old parts: Stem cell turnover in the aging heart. Circ Res 2010, 107:1292-1294.
45. Poss K.D. Getting to the heart of regeneration in zebrafish. Semin Cell Dev Biol 2007, 18:36-45.
46. Poss K.D., Wilson L.G., Keating M.T. Heart regeneration in zebrafish. Science 2002, 298:2188-2190.
47. Reddien P.W., Sánchez Alvarado A. Fundamentals of planarian regeneration. Annu Rev Cell Dev Biol 2004, 20:725-757.
48. Sdek P., Zhao P., Wang Y., et al. Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes. J Cell Biol 2011, 194:407-423.
49. Small E.M., Olson E.N. Pervasive roles of microRNAs in cardiovascular biology. Nature 2011, 469:336-342.
50. Smith R.R., Barile L., Cho H.C., et al. Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation 2007, 115:896-908.
51. Soonpaa M.H., Kim K.K., Pajak L., et al. Cardiomyocyte DNA synthesis and binucleation during murine development. Am J Physiol 1996, 271:H2183-H2189.
52. Soonpaa M.H., Koh G.Y., Pajak L., et al. Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice. J Clin Invest 1997, 99:2644-2654.
53. Walsh S., Pontén A., Fleischmann B.K., Jovinge S. Cardiomyocyte cell cycle control and growth estimation in vivo-An analysis based on cardiomyocyte nuclei. Cardiovasc Res 2010, 86:365-373.
54. Wills A.A., Holdway J.E., Major R.J., Poss K.D. Regulated addition of new myocardial and epicardial cells fosters homeostatic cardiac growth and maintenance in adult zebrafish. Development 2008, 135:183-192.
55. Yin V.P., Lepilina A., Smith A., Poss K.D. Regulation of zebrafish heart regeneration by miR-133. Dev Biol 2012, 365:319-327.