Building a new heart from old parts: Stem cell turnover in the aging heart

Circulation Research

Volumn 107, Issue 11, 2010, Pages 1292-1294

  Porrello, Enzo R ^a   Olson, Eric N ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Aging myopathy; Gender; Humans; Myocyte renewal; Stem cells

Indexed keywords

AURORA B KINASE; HISTONE H3; KI 67 ANTIGEN;

AGING; APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; EDITORIAL; HEART DEVELOPMENT; HEART MUSCLE CELL; HUMAN; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; SENESCENCE; STEM CELL; TELOMERE; TOTIPOTENT STEM CELL;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; ANIMALS; HEART; HUMANS; MIDDLE AGED; MYOCYTES, CARDIAC; SEX FACTORS; STEM CELLS; YOUNG ADULT;

EID: 78650369403     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.235168     Document Type: Editorial

References (13)

1. Anversa P, Kajstura J, Leri A, Bolli R. Life and death of cardiac stem cells: A paradigm shift in cardiac biology. Circulation. 2006;113:1451-1463.
2. Oberpriller JO, Oberpriller JC. Response of the adult newt ventricle to injury. J Exp Zool. 1974;187:249-253.
3. Poss KD, Wilson LG, Keating MT. Heart regeneration in zebrafish. Science. 2002;298:2188-2190.
4. Hsieh PC, Segers VF, Davis ME, MacGillivray C, Gannon J, Molkentin JD, Robbins J, Lee RT. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nat Med. 2007;13:970-974.
5. Quaini F, Urbanek K, Beltrami AP, Finato N, Beltrami CA, Nadal-Ginard B, Kajstura J, Leri A, Anversa P. Chimerism of the transplanted heart. N Engl J Med. 2002;346:5-15.
6. Goldspink DF, Burniston JG, Tan LB. Cardiomyocyte death and the ageing and failing heart. Exp Physiol. 2003;88:447-458.
7. Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnabe-Heider F, Walsh S, Zupicich J, Alkass K, Buchholz BA, Druid H, Jovinge S, Frisen J. Evidence for cardiomyocyte renewal in humans. Science. 2009;324: 98-102.
8. Olivetti G, Giordano G, Corradi D, Melissari M, Lagrasta C, Gambert SR,Anversa P. Gender differences and aging: Effects on the human heart. J Am Coll Cardio. 1995;26:1068-1079.
9. Kajstura J, Urbanek K, Perl S, Hosoda T, Zheng H, Ogorek B, Ferreira- Martins J, Goichberg P, Rondon-Clavo C, Sanada F, D'Amario D, Rota M, Del Monte F, Orlic D, Tisdale J, Leri A, Anversa P. Cardiomyogenesis in the adult human heart. Circ Res. 2010;107:305-315.
10. Kajstura J, Gurusamy N, Ogorek B, Goichberg P, Rondon CC, Hosoda T, D'Amario D, Bardelli S, Beltrami AP, Cesselli D, Bussani R, Del Monte F, Quaini F, Rota M, Beltrami CA, Buccholz B, Leri A, Anversa P. Myocyte turnover in the aging human heart. Circ Res. 2010;107: 1374-1386.
11. Wong LS, van der Harst P, de Boer RA, Huzen J, van Gilst WH, van Veldhuisen DJ. Aging, telomeres and heart failure. Heart Fail Rev. 2010;15:479-486.
12. Soonpaa MH, Field LJ. Assessment of cardiomyocyte DNA synthesis in normal and injured adult mouse hearts. Am J Physiol. 1997;272(1 Pt 2): H220-H226.
13. Bergmann O, Zdunek S, Alkass K, Druid H, Bernard S, Frisen J. Identification of cardiomyocyte nuclei and assessment of ploidy for the analysis of cell turnover. Exp Cell Res. In press.