Inositol polyphosphate multikinase: An emerging player for the central action of AMP-activated protein kinase

Biochemical and Biophysical Research Communications

Volumn 421, Issue 1, 2012, Pages 1-3

  Dailey, Megan J ^a   Kim, Seyun ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

AMPK; Energy homeostasis; Food intake; IPMK

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CALMODULIN DEPENDENT PROTEIN KINASE KINASE BETA; CHLORIDE CHANNEL; GLUCOSE; GLUCOSE TRANSPORTER; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INOSITOL; INOSITOL POLYPHOSPHATE; INOSITOL POLYPHOSPHATE MULTIKINASE; LIVER KINASE B1; MAMMALIAN TARGET OF RAPAMYCIN; POTASSIUM CHANNEL; PROTEIN KINASE; UNCLASSIFIED DRUG;

ANOREXIA NERVOSA; BODY WEIGHT; DEPHOSPHORYLATION; DRUG TARGETING; EATING DISORDER; ENERGY METABOLISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SUBUNIT; FOOD INTAKE; HUMAN; HYPOTHALAMUS; LIVER; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUTRIENT; OBESITY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SHORT SURVEY; SIGNAL TRANSDUCTION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ARCUATE NUCLEUS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE; EATING; ENERGY METABOLISM; GLUCOSE; HUMANS; INOSITOL; MICE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR);

EID: 84860345097     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.04.010     Document Type: Short Survey

References (19)

1. Kahn B.B., Alquier T., Carling D., Hardie D.G. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 2005, 1:15-25.
2. Blanco Martinez de Morentin P., Gonzalez C.R., Saha A.K., Martins L., Dieguez C., Vidal-Puig A., Tena-Sempere M., Lopez M. Hypothalamic AMP-activated protein kinase as a mediator of whole body energy balance. Rev. Endocr. Metab. Disord. 2011, 12:127-140.
3. Minokoshi Y., Alquier T., Furukawa N., Kim Y.B., Lee A., Xue B., Mu J., Foufelle F., Ferre P., Birnbaum M.J., Stuck B.J., Kahn B.B. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 2004, 428:569-574.
4. Andersson U., Filipsson K., Abbott C.R., Woods A., Smith K., Bloom S.R., Carling D., Small C.J. AMP-activated protein kinase plays a role in the control of food intake. J. Biol. Chem. 2004, 279:12005-12008.
5. Hawley S.A., Davison M., Woods A., Davies S.P., Beri R.K., Carling D., Hardie D.G. Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. J. Biol. Chem. 1996, 271:27879-27887.
6. Scott J.W., Hawley S.A., Green K.A., Anis M., Stewart G., Scullion G.A., Norman D.G., Hardie D.G. CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. J. Clin. Invest. 2004, 113:274-284.
7. Xiao B., Sanders M.J., Underwood E., Heath R., Mayer F.V., Carmena D., Jing C., Walker P.A., Eccleston J.F., Haire L.F., Saiu P., Howell S.A., Aasland R., Martin S.R., Carling D., Gamblin S.J. Structure of mammalian AMPK and its regulation by ADP. Nature 2011, 472:230-233.
8. Hardie D.G. Sensing of energy and nutrients by AMP-activated protein kinase. Am. J. Clin. Nutr. 2011, 93:891S-896.
9. Hawley S.A., Pan D.A., Mustard K.J., Ross L., Bain J., Edelman A.M., Frenguelli B.G., Hardie D.G. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab. 2005, 2:9-19.
10. Bang S., Kim S., Dailey M.J., Chen Y., Moran T.H., Snyder S.H., Kim S.F. AMP-activated protein kinase is physiologically regulated by inositol polyphosphate multikinase. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:616-620.
11. Holub B.J. Metabolism and function of myo-inositol and inositol phospholipids. Annu. Rev. Nutr. 1986, 6:563-597.
12. Chakraborty A., Kim S., Snyder S.H. Inositol pyrophosphates as mammalian cell signals. Sci. Signal. 2011, 4:re1.
13. Maag D., Maxwell M.J., Hardesty D.A., Boucher K.L., Choudhari N., Hanno A.G., Ma J.F., Snowman A.S., Pietropaoli J.W., Xu R., Storm P.B., Saiardi A., Snyder S.H., Resnick A.C. Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:1391-1396.
14. Bechet J., Grenson M., Wiame J.M. Mutations affecting repressibility of arginine biosynthetic enzymes in Saccharomyces cerevisiae. Eur. J. Biochem. 1970, 12:31.
15. Odom A.R., Stahlberg A., Wente S.R., York J.D. A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control. Science 2000, 287:2026-2029.
16. Kim S., Kim S.F., Maag D., Maxwell M.J., Resnick A.C., Juluri K.R., Chakraborty A., Koldobskiy M.A., Cha S.H., Barrow R., Snowman A.M., Snyder S.H. Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase. Cell Metab. 2011, 13:215-221.
17. Claret M., Smith M.A., Knauf C., Al-Qassab H., Woods A., Heslegrave A., Piipari K., Emmanuel J.J., Colom A., Valet P., Cani P.D., Begum G., White A., Mucket P., Peters M., Mizuno K., Batterham R.L., Giese K.P., Ashworth A., Burcelin R., Ashford M.L., Carling D., Withers D.J. Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice. Diabetes 2011, 60:735-745.
18. Fioramonti X., Contie S., Song Z., Routh V.H., Lorsignol A., Penicaud L. Characterization of glucosensing neuron subpopulations in the arcuate nucleus: integration in neuropeptide Y and pro-opio melanocortin networks?. Diabetes 2007, 56:1219-1227.
19. Song Z., Levin B.E., McArdle J.J., Bakhos N., Routh V.H. Convergence of pre- and postsynaptic influences on glucosensing neurons in the ventromedial hypothalamic nucleus. Diabetes 2001, 50:2673-2681.