-
1
-
-
0347318052
-
The AMP-activated protein kinase cascade-a unifying system for energy control
-
Carling D (2004) The AMP-activated protein kinase cascade-a unifying system for energy control. Trends Biochem Sci 29:18-24.
-
(2004)
Trends Biochem Sci
, vol.29
, pp. 18-24
-
-
Carling, D.1
-
2
-
-
33745225026
-
AMP-activated protein kinase - Development of the energy sensor concept
-
DOI 10.1113/jphysiol.2006.108944
-
Hardie DG, Hawley SA, Scott JW (2006) AMP-activated protein kinase-development of the energy sensor concept. J Physiol 574:7-15. (Pubitemid 43905792)
-
(2006)
Journal of Physiology
, vol.574
, Issue.1
, pp. 7-15
-
-
Hardie, D.G.1
Hawley, S.A.2
Scott, J.W.3
-
3
-
-
80052511813
-
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
-
Mihaylova MM, Shaw RJ (2011) The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 13:1016-1023.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 1016-1023
-
-
Mihaylova, M.M.1
Shaw, R.J.2
-
4
-
-
0036864358
-
Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase
-
DOI 10.1042/BST0301064
-
Hardie DG, Pan DA (2002) Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase. Biochem Soc Trans 30:1064-1070. (Pubitemid 36002407)
-
(2002)
Biochemical Society Transactions
, vol.30
, Issue.6
, pp. 1064-1070
-
-
Hardie, D.G.1
Pan, D.A.2
-
5
-
-
1842484296
-
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
-
DOI 10.1038/nature02440
-
Minokoshi Y, et al. (2004) AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428:569-574. (Pubitemid 38480541)
-
(2004)
Nature
, vol.428
, Issue.6982
, pp. 569-574
-
-
Minokoshi, Y.1
Alquier, T.2
Furukawa, H.3
Kim, Y.-B.4
Lee, A.5
Xue, B.6
Mu, J.7
Foufelle, F.8
Ferre, P.9
Birnbaum, M.J.10
Stuck, B.J.11
Kahn, B.B.12
-
6
-
-
33745199458
-
Developing a head for energy sensing: AMP-activated protein kinase as a multifunctional metabolic sensor in the brain
-
DOI 10.1113/jphysiol.2006.110122
-
Ramamurthy S, Ronnett GV (2006) Developing a head for energy sensing:AMP-activated protein kinase as a multifunctional metabolic sensor in the brain. J Physiol 574:85-93. (Pubitemid 43905799)
-
(2006)
Journal of Physiology
, vol.574
, Issue.1
, pp. 85-93
-
-
Ramamurthy, S.1
Ronnett, G.V.2
-
7
-
-
28144433884
-
Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate
-
Chang SC, Majerus PW (2006) Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate. Biochem Biophys Res Commun 339:209-216.
-
(2006)
Biochem Biophys Res Commun
, vol.339
, pp. 209-216
-
-
Chang, S.C.1
Majerus, P.W.2
-
8
-
-
38449092165
-
Inositol polyphosphate multikinase: Metabolic architect of nuclear inositides
-
Resnick Saiardi AC, Saiardi A (2008) Inositol polyphosphate multikinase: Metabolic architect of nuclear inositides. Front Biosci 13:856-866.
-
(2008)
Front Biosci
, vol.13
, pp. 856-866
-
-
Resnick Saiardi, A.C.1
Saiardi, A.2
-
9
-
-
77955294401
-
Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes
-
Tsui MM, York JD (2010) Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes. Adv Enzyme Regul 50:324-337.
-
(2010)
Adv Enzyme Regul
, vol.50
, pp. 324-337
-
-
Tsui, M.M.1
York, J.D.2
-
10
-
-
79951885087
-
Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB
-
Maag D, et al. (2011) Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB. Proc Natl Acad Sci USA 108:1391-1396.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 1391-1396
-
-
Maag, D.1
-
11
-
-
79551565620
-
Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase
-
Kim S, et al. (2011) Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase. Cell Metab 13:215-221.
-
(2011)
Cell Metab
, vol.13
, pp. 215-221
-
-
Kim, S.1
-
12
-
-
3042818799
-
Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
-
DOI 10.1101/gad.1199104
-
Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL (2004) Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev 18:1533-1538. (Pubitemid 38868905)
-
(2004)
Genes and Development
, vol.18
, Issue.13
, pp. 1533-1538
-
-
Corradetti, M.N.1
Inoki, K.2
Bardeesy, N.3
DePinho, R.A.4
Guan, K.-L.5
-
13
-
-
42949139481
-
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
-
DOI 10.1016/j.molcel.2008.03.003, PII S109727650800169X
-
Gwinn DM, et al. (2008) AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 30:214-226. (Pubitemid 351626684)
-
(2008)
Molecular Cell
, vol.30
, Issue.2
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
14
-
-
33646582664
-
Hypothalamic mTOR signaling regulates food intake
-
DOI 10.1126/science.1124147
-
Cota D, et al. (2006) Hypothalamic mTOR signaling regulates food intake. Science 312:927-930. (Pubitemid 43727328)
-
(2006)
Science
, vol.312
, Issue.5775
, pp. 927-930
-
-
Cota, D.1
Proulx, K.2
Blake, S.K.A.3
Kozma, S.C.4
Thomas, G.5
Woods, S.C.6
Seeley, R.J.7
-
15
-
-
63449109316
-
Critical role for hypothalamic mTOR activity in energy balance
-
Mori H, et al. (2009) Critical role for hypothalamic mTOR activity in energy balance. Cell Metab 9:362-374.
-
(2009)
Cell Metab
, vol.9
, pp. 362-374
-
-
Mori, H.1
-
16
-
-
0026058687
-
Metabolism of pro-luteinizing hormone-releasing hormone in immortalized hypothalamic neurons
-
Wetsel WC, Mellon PL, Weiner RI, Negro-Vilar A (1991) Metabolism of pro-luteinizing hormone-releasing hormone in immortalized hypothalamic neurons. Endocrinology 129:1584-1595.
-
(1991)
Endocrinology
, vol.129
, pp. 1584-1595
-
-
Wetsel, W.C.1
Mellon, P.L.2
Weiner, R.I.3
Negro-Vilar, A.4
-
17
-
-
0345107247
-
Complexes between the LKB1 tumor suppressor, STRAD alpha/ beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
-
Hawley SA, et al. (2003) Complexes between the LKB1 tumor suppressor, STRAD alpha/ beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2:28.
-
(2003)
J Biol
, vol.2
, pp. 28
-
-
Hawley, S.A.1
-
18
-
-
10744230065
-
LKB1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade
-
DOI 10.1016/j.cub.2003.10.031
-
Woods A, et al. (2003) LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol 13:2004-2008. (Pubitemid 37425212)
-
(2003)
Current Biology
, vol.13
, Issue.22
, pp. 2004-2008
-
-
Woods, A.1
Johnstone, S.R.2
Dickerson, K.3
Leiper, F.C.4
Fryer, L.G.D.5
Neumann, D.6
Schlattner, U.7
Wallimann, T.8
Carlson, M.9
Carling, D.10
-
19
-
-
0346102907
-
1 subunit AMP allosteric regulatory site
-
DOI 10.1110/ps.03340004
-
Adams J, et al. (2004) Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site. Protein Sci 13:155-165. (Pubitemid 38021150)
-
(2004)
Protein Science
, vol.13
, Issue.1
, pp. 155-165
-
-
Adams, J.1
Chen, Z.-P.2
Van Denderen, B.J.W.3
Morton, C.J.4
Parker, M.W.5
Witters, L.A.6
Stapleton, D.7
Kemp, B.E.8
-
20
-
-
0034654362
-
Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding
-
DOI 10.1042/0264-6021:3460659
-
Cheung PC, Salt IP, Davies SP, Hardie DG, Carling D (2000) Characterization of AMPactivated protein kinase gamma-subunit isoforms and their role in AMP binding. Biochem J 346(Pt 3):659-669. (Pubitemid 30171026)
-
(2000)
Biochemical Journal
, vol.346
, Issue.3
, pp. 659-669
-
-
Cheung, P.C.F.1
Salt, I.P.2
Davies, S.P.3
Hardie, D.G.4
Carling, D.5
-
21
-
-
23044432463
-
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase
-
DOI 10.1016/j.cmet.2005.05.009, PII S155041310500166X
-
Hawley SA, et al. (2005) Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab 2:9-19. (Pubitemid 43239821)
-
(2005)
Cell Metabolism
, vol.2
, Issue.1
, pp. 9-19
-
-
Hawley, S.A.1
Pan, D.A.2
Mustard, K.J.3
Ross, L.4
Bain, J.5
Edelman, A.M.6
Frenguelli, B.G.7
Hardie, D.G.8
-
22
-
-
23044437445
-
2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells
-
DOI 10.1016/j.cmet.2005.06.005, PII S1550413105001701
-
Woods A, et al. (2005) Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab 2:21-33. (Pubitemid 43239822)
-
(2005)
Cell Metabolism
, vol.2
, Issue.1
, pp. 21-33
-
-
Woods, A.1
Dickerson, K.2
Heath, R.3
Hong, S.-P.4
Momcilovic, M.5
Johnstone, S.R.6
Carlson, M.7
Carling, D.8
-
23
-
-
0029561919
-
5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2Calpha and native bovine protein phosphatase-2A(C)
-
DOI 10.1016/0014-5793(95)01368-7
-
Davies SP, Helps NR, Cohen PT, Hardie DG (1995) 5′-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC. FEBS Lett 377:421-425. (Pubitemid 26027159)
-
(1995)
FEBS Letters
, vol.377
, Issue.3
, pp. 421-425
-
-
Davies, S.P.1
Helps, N.R.2
Cohen, P.T.W.3
Hardie, D.G.4
-
24
-
-
0028812135
-
Glucose-induced stimulation of human insulin-receptor mRNA and tyrosine kinase activity in cultured cells
-
Hauguel-de-Mouzon S, Mrejen C, Alengrin F, Van OE (1995) Glucose-induced stimulation of human insulin-receptor mRNA and tyrosine kinase activity in cultured cells. Biochem J 305(Pt 1):119-124.
-
(1995)
Biochem J
, vol.305
, Issue.PART 1
, pp. 119-124
-
-
Hauguel-de-Mouzon, S.1
Mrejen, C.2
Alengrin, F.3
Van, O.E.4
-
25
-
-
57349165885
-
High glucose promotes retinal endothelial cell migration through activation of Src, PI3K/Akt1/eNOS, and ERKs
-
Huang Q, Sheibani N (2008) High glucose promotes retinal endothelial cell migration through activation of Src, PI3K/Akt1/eNOS, and ERKs. Am J Physiol Cell Physiol 295: C1647-C1657.
-
(2008)
Am J Physiol Cell Physiol
, vol.295
-
-
Huang, Q.1
Sheibani, N.2
-
26
-
-
79954986877
-
Caveolin-1 and integrin β1 regulate embryonic stem cell proliferation via p38 MAPK and FAK in high glucose
-
Lee SH, Lee YJ, Park SW, Kim HS, Han HJ (2011) Caveolin-1 and integrin β1 regulate embryonic stem cell proliferation via p38 MAPK and FAK in high glucose. J Cell Physiol 226:1850-1859.
-
(2011)
J Cell Physiol
, vol.226
, pp. 1850-1859
-
-
Lee, S.H.1
Lee, Y.J.2
Park, S.W.3
Kim, H.S.4
Han, H.J.5
-
27
-
-
0038433304
-
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
-
DOI 10.1016/S1097-2765(03)00220-X
-
Garami A, et al. (2003) Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell 11:1457-1466. (Pubitemid 36776533)
-
(2003)
Molecular Cell
, vol.11
, Issue.6
, pp. 1457-1466
-
-
Garami, A.1
Zwartkruis, F.J.T.2
Nobukuni, T.3
Joaquin, M.4
Roccio, M.5
Stocker, H.6
Kozma, S.C.7
Hafen, E.8
Bos, J.L.9
Thomas, G.10
-
28
-
-
0043127125
-
Rheb GTpase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
DOI 10.1101/gad.1110003
-
Inoki K, Li Y, Xu T, Guan KL (2003) Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 17:1829-1834. (Pubitemid 36944560)
-
(2003)
Genes and Development
, vol.17
, Issue.15
, pp. 1829-1834
-
-
Inoki, K.1
Li, Y.2
Xu, T.3
Guan, K.-L.4
-
29
-
-
79251587803
-
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
-
Egan DF, et al. (2011) Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 331:456-461.
-
(2011)
Science
, vol.331
, pp. 456-461
-
-
Egan, D.F.1
-
30
-
-
28844433635
-
Medicine: The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
-
DOI 10.1126/science.1120781
-
Shaw RJ, et al. (2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310:1642-1646. (Pubitemid 41780780)
-
(2005)
Science
, vol.310
, Issue.5754
, pp. 1642-1646
-
-
Shaw, R.J.1
Lamia, K.A.2
Vasquez, D.3
Koo, S.-H.4
Bardeesy, N.5
DePinho, R.A.6
Montminy, M.7
Cantley, L.C.8
|