Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 4, 2011, Pages 1391-1396

  Maag, David ^a   Maxwell, Micah J ^a   Hardesty, Douglas A ^b   Boucher, Katie L ^b   Choudhari, Namrata ^b   Hanno, Adam G ^b   Ma, Jenny F ^b   Snowman, Adele S ^a   Pietropaoli, Joseph W ^a   Xu, Risheng ^a   Storm, Phillip B ^b   Saiardi, Adolfo ^c   Snyder, Solomon H ^a   Resnick, Adam C ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Cancer; Signal transduction

Indexed keywords

INOSITOL PHOSPHATE; INOSITOL POLYPHOSPHATE; INOSITOL POLYPHOSPHATE MULTIKINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PROTEIN KINASE B; PROTEIN P110; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GROWTH STIMULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANDROSTADIENES; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CELLS, CULTURED; EMBRYO, MAMMALIAN; ENZYME ACTIVATION; FEMALE; FIBROBLASTS; HEK293 CELLS; HUMANS; IMMUNOBLOTTING; INOSITOL PHOSPHATES; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, BIOLOGICAL; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTO-ONCOGENE PROTEINS C-AKT;

EID: 79951885087     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1017831108     Document Type: Article

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