Identification and validation of a novel lead compound targeting 4-diphosphocytidyl-2-C-methylerythritol synthetase (IspD) of mycobacteria

European Journal of Pharmacology

Volumn 694, Issue 1-3, 2012, Pages 45-52

  Gao, Peng ^a   Yang, Yanhui ^b   Xiao, Chunling ^b   Liu, Yishuang ^b   Gan, Maoluo ^b   Guan, Yan ^b   Hao, Xueqin ^b   Meng, Jianzhou ^b   Zhou, Shuang ^b   Chen, Xiaojuan ^b   Cui, Jiafei ^b  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

4 diphosphocytidyl 2 C methyl d erythritol synthase (CDP MEP synthase, IspD); Antituberculosis activity; DMB (Domiphen bromide); Inhibitor; Target

Indexed keywords

4 DIPHOSPHOCYTIDYL 2 C METHYLERYTHRITOL SYNTHETASE; BACTERIAL ENZYME; DOMIPHEN BROMIDE; ISONIAZID; KANAMYCIN; RIFAMPICIN; TETRACYCLINE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL CELL WALL; BACTERIAL GROWTH; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG TARGETING; ENZYME INHIBITION; ENZYME REGULATION; ESSENTIAL GENE; GENE SILENCING; GROWTH INHIBITION; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; MYCOBACTERIUM; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; VALIDATION PROCESS;

DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, BACTERIAL; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; KINETICS; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; OXIDOREDUCTASES; QUATERNARY AMMONIUM COMPOUNDS; REPRODUCIBILITY OF RESULTS;

EID: 84867336808     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.08.012     Document Type: Article

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