Development of an isotope labeling ultra-high performance liquid chromatography mass spectrometric method for quantification of acylglycines in human urine

Analytica Chimica Acta

Volumn 750, Issue , 2012, Pages 161-172

  Stanislaus, Avalyn ^a   Guo, Kevin ^a   Li, Liang ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Acylglycines; Endogenous metabolites; Isotope labeling; Liquid chromatography; Metabolomics; Tandem mass spectrometry

Indexed keywords

ACYL-COA ESTER; ACYLGLYCINES; ANALYTES; AUTOSAMPLERS; BODY MASS INDEX; CALIBRATION CURVES; CALIBRATION STANDARD; DETECTION SENSITIVITY; ENDOGENOUS CONCENTRATION; FREEZE/THAW CYCLES; HEALTHY INDIVIDUALS; HIGH SENSITIVITY; HUMAN URINE; INBORN ERRORS OF METABOLISMS; INTERNAL STANDARDS; ION DETECTION; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LOWER LIMIT OF QUANTITATIONS; MATRIX APPROACH; MATRIX EFFECTS; METABOLOMICS; MULTIPLE REACTION MONITORING; RELATIVE ERRORS; ROOM TEMPERATURE; SPECTROMETRIC METHODS; STANDARD ADDITION; TANDEM MASS SPECTROMETRY; ULTRA-HIGH PERFORMANCE; URINE SAMPLE;

BROMINE COMPOUNDS; CALIBRATION; CHROMATOGRAPHY; DETOXIFICATION; DIAGNOSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES;

BODY FLUIDS;

2 FUROYLGLYCINE; 2 METHYLBUTYRYLGLYCINE; 3 METHYLCROTONYLGLYCINE; 4 HYDROXYPHENYLACETYLGLYCINE; ACYLGLYCINE DERIVATIVE; BUTYRYLGLYCINE; GLUTARYLGLYCINE; GLYCINE DERIVATIVE; HEPTANOYLGLYCINE; HEXANOYLGLYCINE; ISOBUTYRYLGLYCINE; ISOVALERYLGLYCINE; OCTANOYLGLYCINE; PHENYLACETYLGLYCINE; PHENYLPROPIONYLGLYCINE; PROPIONYLGLYCINE; SUBERYLGLYCINE; TIGLYLGLYCINE; UNCLASSIFIED DRUG; VALERYLGLYCINE;

ADULT; ARTICLE; CALIBRATION; CONTROLLED STUDY; CREATININE URINE LEVEL; FEMALE; HUMAN; HUMAN EXPERIMENT; ISOTOPE LABELING; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MALE; MASS SPECTROMETRY; METABOLOMICS; NORMAL HUMAN; PRIORITY JOURNAL; QUALITY CONTROL; REPRODUCIBILITY; SENSITIVITY ANALYSIS; SIGNAL NOISE RATIO; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS; URINE LEVEL;

ADULT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; GLYCINE; HUMANS; ISOTOPE LABELING; MALE; TANDEM MASS SPECTROMETRY; TEMPERATURE;

EID: 84867336670     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2012.05.006     Document Type: Article

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