-
1
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med. 2005; 353: 123-132.
-
(2005)
N Engl J Med.
, vol.353
, pp. 123-132
-
-
Shepherd, F.A.1
Rodrigues Pereira, J.2
Ciuleanu, T.3
-
2
-
-
27544503230
-
Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
-
Thatcher N, Chang A, Parikh P, et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet. 2005; 366: 1527-1537.
-
(2005)
Lancet.
, vol.366
, pp. 1527-1537
-
-
Thatcher, N.1
Chang, A.2
Parikh, P.3
-
3
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med. 2009; 361: 947-957.
-
(2009)
N Engl J Med.
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
-
4
-
-
4444344330
-
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
-
Pao W, Miller V, Zakowski M, et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A. 2004; 101: 13306-13311.
-
(2004)
Proc Natl Acad Sci U S A.
, vol.101
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
-
5
-
-
34648815009
-
Lung cancer in never smokers - A different disease
-
Sun S, Schiller JH, Gazdar AF,. Lung cancer in never smokers-a different disease. Nat Rev Cancer. 2007; 7: 778-790.
-
(2007)
Nat Rev Cancer.
, vol.7
, pp. 778-790
-
-
Sun, S.1
Schiller, J.H.2
Gazdar, A.F.3
-
6
-
-
34547154349
-
P38 MAP-kinases pathway regulation, function and role in human diseases
-
Cuenda A, Rousseau S,. p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim Biophys Acta. 2007; 1773: 1358-1375.
-
(2007)
Biochim Biophys Acta.
, vol.1773
, pp. 1358-1375
-
-
Cuenda, A.1
Rousseau, S.2
-
7
-
-
67749117934
-
Signal integration by JNK and p38 MAPK pathways in cancer development
-
Wagner EF, Nebreda AR,. Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer. 2009; 9: 537-549.
-
(2009)
Nat Rev Cancer.
, vol.9
, pp. 537-549
-
-
Wagner, E.F.1
Nebreda, A.R.2
-
8
-
-
35648935982
-
Suppression of p53-dependent senescence by the JNK signal transduction pathway
-
Das M, Jiang F, Sluss HK, et al. Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proc Natl Acad Sci U S A. 2007; 104: 15759-15764.
-
(2007)
Proc Natl Acad Sci U S A.
, vol.104
, pp. 15759-15764
-
-
Das, M.1
Jiang, F.2
Sluss, H.K.3
-
9
-
-
20344386238
-
Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling
-
Emerling BM, Platanias LC, Black E, Nebreda AR, Davis RJ, Chandel NS,. Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling. Mol Cell Biol. 2005; 25: 4853-4862.
-
(2005)
Mol Cell Biol.
, vol.25
, pp. 4853-4862
-
-
Emerling, B.M.1
Platanias, L.C.2
Black, E.3
Nebreda, A.R.4
Davis, R.J.5
Chandel, N.S.6
-
10
-
-
34249314755
-
P38 mitogen-activated protein kinase pathway is involved in protein kinase Calpha-regulated invasion in human hepatocellular carcinoma cells
-
Hsieh YH, Wu TT, Huang CY, Hsieh YS, Hwang JM, Liu JY,. p38 mitogen-activated protein kinase pathway is involved in protein kinase Calpha-regulated invasion in human hepatocellular carcinoma cells. Cancer Res. 2007; 67: 4320-4327.
-
(2007)
Cancer Res.
, vol.67
, pp. 4320-4327
-
-
Hsieh, Y.H.1
Wu, T.T.2
Huang, C.Y.3
Hsieh, Y.S.4
Hwang, J.M.5
Liu, J.Y.6
-
11
-
-
34547809513
-
P38alpha and p38delta mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells
-
Junttila MR, Ala-Aho R, Jokilehto T, et al. p38alpha and p38delta mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells. Oncogene. 2007; 26: 5267-5279.
-
(2007)
Oncogene.
, vol.26
, pp. 5267-5279
-
-
Junttila, M.R.1
Ala-Aho, R.2
Jokilehto, T.3
-
12
-
-
34248152719
-
MAP-ing glioma invasion: Mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival
-
Demuth T, Reavie LB, Rennert JL, et al. MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival. Mol Cancer Ther. 2007; 6: 1212-1222.
-
(2007)
Mol Cancer Ther.
, vol.6
, pp. 1212-1222
-
-
Demuth, T.1
Reavie, L.B.2
Rennert, J.L.3
-
13
-
-
33845982933
-
Involvement of p38alpha mitogen-activated protein kinase in lung metastasis of tumor cells
-
Matsuo Y, Amano S, Furuya M, et al. Involvement of p38alpha mitogen-activated protein kinase in lung metastasis of tumor cells. J Biol Chem. 2006; 281: 36767-36775.
-
(2006)
J Biol Chem.
, vol.281
, pp. 36767-36775
-
-
Matsuo, Y.1
Amano, S.2
Furuya, M.3
-
14
-
-
34249807348
-
P38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
-
Ventura JJ, Tenbaum S, Perdiguero E, et al. p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation. Nat Genet. 2007; 39: 750-758.
-
(2007)
Nat Genet.
, vol.39
, pp. 750-758
-
-
Ventura, J.J.1
Tenbaum, S.2
Perdiguero, E.3
-
15
-
-
1442274808
-
P38 MAP kinase: A convergence point in cancer therapy
-
Olson JM, Hallahan AR,. p38 MAP kinase: a convergence point in cancer therapy. Trends Mol Med. 2004; 10: 125-129.
-
(2004)
Trends Mol Med.
, vol.10
, pp. 125-129
-
-
Olson, J.M.1
Hallahan, A.R.2
-
16
-
-
48249091704
-
Mitogen-activated protein kinase activation in lung adenocarcinoma: A comparative study between ever smokers and never smokers
-
Mountzios G, Planchard D, Besse B, et al. Mitogen-activated protein kinase activation in lung adenocarcinoma: a comparative study between ever smokers and never smokers. Clin Cancer Res. 2008; 14: 4096-4102.
-
(2008)
Clin Cancer Res.
, vol.14
, pp. 4096-4102
-
-
Mountzios, G.1
Planchard, D.2
Besse, B.3
-
17
-
-
0036010518
-
Selective p38 activation in human non-small cell lung cancer
-
Greenberg AK, Basu S, Hu J, et al. Selective p38 activation in human non-small cell lung cancer. Am J Respir Cell Mol Biol. 2002; 26: 558-564.
-
(2002)
Am J Respir Cell Mol Biol.
, vol.26
, pp. 558-564
-
-
Greenberg, A.K.1
Basu, S.2
Hu, J.3
-
18
-
-
33748435058
-
DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy
-
Olaussen KA, Dunant A, Fouret P, et al. DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy. N Engl J Med. 2006; 355: 983-991.
-
(2006)
N Engl J Med.
, vol.355
, pp. 983-991
-
-
Olaussen, K.A.1
Dunant, A.2
Fouret, P.3
-
19
-
-
33847107236
-
DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer
-
Zheng Z, Chen T, Li X, Haura E, Sharma A, Bepler G,. DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer. N Engl J Med. 2007; 356: 800-808.
-
(2007)
N Engl J Med.
, vol.356
, pp. 800-808
-
-
Zheng, Z.1
Chen, T.2
Li, X.3
Haura, E.4
Sharma, A.5
Bepler, G.6
-
20
-
-
67650361229
-
The NER proteins are differentially expressed in ever smokers and in never smokers with lung adenocarcinoma
-
Planchard D, Domont J, Taranchon E, et al. The NER proteins are differentially expressed in ever smokers and in never smokers with lung adenocarcinoma. Ann Oncol. 2009; 20: 1257-1263.
-
(2009)
Ann Oncol.
, vol.20
, pp. 1257-1263
-
-
Planchard, D.1
Domont, J.2
Taranchon, E.3
-
21
-
-
0035988959
-
Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer
-
Lord RV, Brabender J, Gandara D, et al. Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer. Clin Cancer Res. 2002; 8: 2286-2291.
-
(2002)
Clin Cancer Res.
, vol.8
, pp. 2286-2291
-
-
Lord, R.V.1
Brabender, J.2
Gandara, D.3
-
22
-
-
0030924833
-
Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site
-
Young PR, McLaughlin MM, Kumar S, et al. Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site. J Biol Chem. 1997; 272: 12116-12121.
-
(1997)
J Biol Chem.
, vol.272
, pp. 12116-12121
-
-
Young, P.R.1
McLaughlin, M.M.2
Kumar, S.3
-
23
-
-
19644367000
-
Activation and signaling of the p38 MAP kinase pathway
-
Zarubin T, Han J,. Activation and signaling of the p38 MAP kinase pathway. Cell Res. 2005; 15: 11-18.
-
(2005)
Cell Res.
, vol.15
, pp. 11-18
-
-
Zarubin, T.1
Han, J.2
-
24
-
-
1242295291
-
UVA-mediated activation of signaling pathways involved in skin tumor promotion and progression
-
Bachelor MA, Bowden GT,. UVA-mediated activation of signaling pathways involved in skin tumor promotion and progression. Semin Cancer Biol. 2004; 14: 131-138.
-
(2004)
Semin Cancer Biol.
, vol.14
, pp. 131-138
-
-
Bachelor, M.A.1
Bowden, G.T.2
-
25
-
-
34447121976
-
EGFR activation results in enhanced cyclooxygenase-2 expression through p38 mitogen-activated protein kinase-dependent activation of the Sp1/Sp3 transcription factors in human gliomas
-
Xu K, Shu HK,. EGFR activation results in enhanced cyclooxygenase-2 expression through p38 mitogen-activated protein kinase-dependent activation of the Sp1/Sp3 transcription factors in human gliomas. Cancer Res. 2007; 67: 6121-6129.
-
(2007)
Cancer Res.
, vol.67
, pp. 6121-6129
-
-
Xu, K.1
Shu, H.K.2
-
26
-
-
0034213138
-
P38 MAP kinases: Beyond the stress response
-
Nebreda AR, Porras A,. p38 MAP kinases: beyond the stress response. Trends Biochem Sci. 2000; 25: 257-260.
-
(2000)
Trends Biochem Sci.
, vol.25
, pp. 257-260
-
-
Nebreda, A.R.1
Porras, A.2
-
27
-
-
33846811520
-
P38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis
-
Dolado I, Swat A, Ajenjo N, De Vita G, Cuadrado A, Nebreda AR,. p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis. Cancer Cell. 2007; 11: 191-205.
-
(2007)
Cancer Cell.
, vol.11
, pp. 191-205
-
-
Dolado, I.1
Swat, A.2
Ajenjo, N.3
De Vita, G.4
Cuadrado, A.5
Nebreda, A.R.6
-
28
-
-
33846846493
-
A radical role for p38 MAPK in tumor initiation
-
Kennedy NJ, Cellurale C, Davis RJ,. A radical role for p38 MAPK in tumor initiation. Cancer Cell. 2007; 11: 101-103.
-
(2007)
Cancer Cell.
, vol.11
, pp. 101-103
-
-
Kennedy, N.J.1
Cellurale, C.2
Davis, R.J.3
-
29
-
-
0036174516
-
Cellular N-Ras promotes cell survival by downregulation of Jun N-terminal protein kinase and p38
-
Wolfman JC, Palmby T, Der CJ, Wolfman A,. Cellular N-Ras promotes cell survival by downregulation of Jun N-terminal protein kinase and p38. Mol Cell Biol. 2002; 22: 1589-1606.
-
(2002)
Mol Cell Biol.
, vol.22
, pp. 1589-1606
-
-
Wolfman, J.C.1
Palmby, T.2
Der, C.J.3
Wolfman, A.4
-
30
-
-
2542458262
-
P38 MAPK activation selectively induces cell death in K-ras-mutated human colon cancer cells through regulation of vitamin D receptor
-
Qi X, Tang J, Pramanik R, et al. p38 MAPK activation selectively induces cell death in K-ras-mutated human colon cancer cells through regulation of vitamin D receptor. J Biol Chem. 2004; 279: 22138-22144.
-
(2004)
J Biol Chem.
, vol.279
, pp. 22138-22144
-
-
Qi, X.1
Tang, J.2
Pramanik, R.3
-
31
-
-
33645052711
-
Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features
-
Tam IY, Chung LP, Suen WS, et al. Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features. Clin Cancer Res. 2006; 12: 1647-1653.
-
(2006)
Clin Cancer Res.
, vol.12
, pp. 1647-1653
-
-
Tam, I.Y.1
Chung, L.P.2
Suen, W.S.3
-
32
-
-
70349443682
-
Lung cancer in never smokers: Molecular profiles and therapeutic implications
-
Rudin CM, Avila-Tang E, Harris CC, et al. Lung cancer in never smokers: molecular profiles and therapeutic implications. Clin Cancer Res. 2009; 15: 5646-5661.
-
(2009)
Clin Cancer Res.
, vol.15
, pp. 5646-5661
-
-
Rudin, C.M.1
Avila-Tang, E.2
Harris, C.C.3
-
33
-
-
0032927651
-
Phorbol ester exposure activates an AP-1-mediated increase in ERCC-1 messenger RNA expression in human ovarian tumor cells
-
Li Q, Zhang L, Tsang B, Gardner K, Bostick-Bruton F, Reed E,. Phorbol ester exposure activates an AP-1-mediated increase in ERCC-1 messenger RNA expression in human ovarian tumor cells. Cell Mol Life Sci. 1999; 55: 456-466.
-
(1999)
Cell Mol Life Sci.
, vol.55
, pp. 456-466
-
-
Li, Q.1
Zhang, L.2
Tsang, B.3
Gardner, K.4
Bostick-Bruton, F.5
Reed, E.6
-
34
-
-
0038757747
-
The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair
-
Hayakawa J, Depatie C, Ohmichi M, Mercola D,. The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair. J Biol Chem. 2003; 278: 20582-20592.
-
(2003)
J Biol Chem.
, vol.278
, pp. 20582-20592
-
-
Hayakawa, J.1
Depatie, C.2
Ohmichi, M.3
Mercola, D.4
-
35
-
-
33947211351
-
GATA-1 is essential in EGF-mediated induction of nucleotide excision repair activity and ERCC1 expression through ERK2 in human hepatoma cells
-
Andrieux LO, Fautrel A, Bessard A, Guillouzo A, Baffet G, Langouet S,. GATA-1 is essential in EGF-mediated induction of nucleotide excision repair activity and ERCC1 expression through ERK2 in human hepatoma cells. Cancer Res. 2007; 67: 2114-2123.
-
(2007)
Cancer Res.
, vol.67
, pp. 2114-2123
-
-
Andrieux, L.O.1
Fautrel, A.2
Bessard, A.3
Guillouzo, A.4
Baffet, G.5
Langouet, S.6
|