Betaine elevates ovarian antioxidant enzyme activities and demonstrates methyl donor effect in non-pregnant rats

International Journal of Peptide Research and Therapeutics

Volumn 18, Issue 3, 2012, Pages 281-290

  Alirezaei, Masoud ^a   Niknam, Parvin ^b   Jelodar, Gholamali ^b  

^a LORESTAN UNIVERSITY   (Iran)

^b SHIRAZ UNIVERSITY   (Iran)

Author keywords

Betaine; Ethanol; Ovarian antioxidant enzymes; Rat

Indexed keywords

BETAINE; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HOMOCYSTEINE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIET THERAPY; ENZYME ACTIVITY; ESTRUS CYCLE; FEMALE; INFERTILITY; LIPID PEROXIDATION; NONHUMAN; OXIDATION; OXIDATIVE STRESS; RAT; TISSUE PREPARATION;

ANIMALIA; RATTUS;

EID: 84867334108     PISSN: 15733149     EISSN: 15733904     Source Type: Journal    
DOI: 10.1007/s10989-012-9300-5     Document Type: Article

References (67)

1. Agarwal A, Prabakaran SA, Said TM (2005) Prevention of oxidative stress injury to sperm. J Androl 26(6):654-660
2. Alirezaei M, Saeb M, Javidnia K, Nazifi S, Khalighyan N, Saeb S (2010) Betaine reduction of hyperhomocysteinemia and enhancement of 5-hydroxyindoleacetic acid in ethanol-induced hyperhomocysteinemia in rabbits. Afr J Biochem Res 4(11): 246-254
3. Alirezaei M, Jelodar G, Niknam P, Ghayemi Z, Nazifi S (2011a) Betaine prevents ethanol-induced oxidative stress and reduces total homocysteine in the rat cerebellum. J Physiol Biochem 67:605-612
4. Alirezaei M, Saeb M, Javidnia K, Nazifi S, Saeb S (2011b) Hyperhomocysteinemia reduction in ethanol-fed rabbits by oral betaine. Comp Clin Pathol 21:1-7
5. Alirezaei M, Jelodar G, Ghayemi Z (2012a) Antioxidant defense of betaine against oxidative stress induced by ethanol in the rat testes. Int J Pept Res Ther doi:10.1007/s10989-012-9297-9
6. Alirezaei M, Kheradmand A, Heydari R, Tanideh N, Neamati S, Rashidipour M (2012b) Oleuropein protects against ethanolinduced oxidative stress and modulates sperm quality in the rat testis. Mediterr J Nutr Metab. doi:10.1007/s12349-011-0079-2
7. Barak AJ, Beckenhauer HC (1988) The influence of ethanol on hepatic transmethylation. Alcohol Alcohol 23(1):73-77
8. Barak AJ, Beckenhauer HC, Tuma DJ (1985) Ethanol feeding inhibits the activity of hepatic N5-methyltetrahydrofolate: homocysteine methyltransferase in the rat. IRCS Med Sci 13:760-761
9. Bleich S, Degner D, Sperling W, Bönsch D, Thürauf N, Kornhuber J (2004) Homocysteine as a neurotoxin in chronic alcoholism. Prog Neuropsychopharmacol Biol Psychiatry 28(3):453-464
10. Bo WJ, Krueger WA, Ruenen PK, Symmes SK (1982) Ethanolinduced alterations in the morphology and function of the rat ovary. Anat Rec 202(2):255-260
11. Chuffa LGA, Padovani CR, Martinez FE (2009) Ovarian structure and hormonal status of the UChA and UChB adult rats in response to ethanol. Maturitas 62(1):21-29
12. Claiborne A (1985) Catalase activity. In: Greenwald RA (ed) CRC hand book of methods for oxygen radical research, vol 1. CRC Press, Boca Raton, pp 283-284
13. Dinu D, Nechifor MT, Movileanu L (2006) Ethanol-induced alterations of the antioxidant defense system in rat kidney. J Biochem Mol Toxicol 19(6):386-395
14. Dupont I, Bodenez P, Berthou F, Simon B, Bardou LG, Lucas D (2000) Cytochrome P-450 2E1 activity and oxidative stress in alcoholic patients. Alcohol Alcohol 35(1):98-103
15. Ebisch IMW, Thomas CMG, Peters WHM, Braat DDM, Steegers-Theunissen RPM (2007) The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility. Hum Reprod update 13(2):163-174
16. Finkelstein JD (2007) Metabolic regulatory properties of S-Adenosylmethionine and S-Adenosylhomocysteine. Clin Chem Lab Med 45(12):1694-1699
17. Forges T, Monnier-Barbarino P, Alberto JM, Gueant-Rodriguez RM, Daval JL, Gueant JL (2007) Impact of folate and homocysteine metabolism on human reproductive health. Hum Reprod update 13(3):225-239
18. Ganesan B, Buddhan S, Anandan R, Sivakumar R, Anbinezhilan R (2010) Antioxidant defense of betaine against isoprenalineinduced myocardial infarction in rats. Mol Biol Rep 37(3):1319-1327
19. Golbahar J, Aminzadeh MA, Hamidi SA, Omrani GR (2005) Association of red blood cell 5-methyltetrahydrfoate folate with bone mineral density in postmenopausal Iranian women. Osteoporos Int 16(12):1894-1898
20. Greenfeld CR, Pepling ME, Babus JK, Furth PA, Flaws JA (2007) BAX regulates follicular endowment in mice. Reproduction 133(5):865-876
21. Hakim RB, Gray RH, Zacur H (1998) Alcohol and caffeine consumption and decreased fertility. Fertil Steril 70(4): 632-637
22. Harlap S, Shiono PH (1980) Alcohol, smoking, and incidence of spontaneous abortions in the first and second trimester. Lancet 316(8187):173-176
23. Hugues JN, Coste T, Perret G, Jayle MF, Sebaoun J, Modigliani E (1980) Hypothalamic pituitary ovarian function in thirty-one women with chronic alcoholism. Clin Endocrinol 12(6): 543-551
24. Husain K, Scott BR, Reddy SK, Somani SM (2001) Chronic ethanol and nicotine interaction on rat tissue antioxidant defense system. Alcohol 25(2):89-97
25. Ji C, Kaplowitz N (2003) Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology 124(5):1488-1499
26. Jozwik M, Wolczynski S, Szamatowicz M (1999) Oxidative stress markers in preovulatory follicular fluid in humans. Mol Hum Reprod 5(5):409-413
27. Kage DN, Malashetty VB, Seetharam YN, Suresh P, Patil SB (2009) Effect of ethanol extract of whole plant of Trichosanthes cucumerina var. cucumerina L. on gonadotropins, ovarian follicular kinetics and ooestrous cycle for screening of antifertility activity in albino rats. J Morphol 27(1):173-182
28. Karthikeyan G, Thachil A, Sharma S, Kalaivani M, Ramakrishnan L (2007) Elevated high sensitivity CRP levels in patients with mitral stenosis and left atrial thrombus. Int J Cardiol 122(3): 252-254
29. Kheradmand A, Alirezaei M, Asadian P, Alavi ER, Joorabi S (2009) Antioxidant enzyme activity and MDA level in the rat testis following chronic administration of ghrelin. Andrologia 41(6): 335-340
30. Kheradmand A, Alirezaei M, Birjandi M (2010) Ghrelin promotes antioxidant enzyme activity and reduces lipid peroxidation in the rat ovary. Regul Pept 162(1-3):84-89
31. Kheradmand A, Dezfoulian O, Alirezaei M, Rasoulian B (2012) Ghrelin modulates testicular germ cells apoptosis and proliferation in adult normal rats. Biochem Biophys Res Commun 419: 299-304
32. Kim HP, Roe JH, Chock PB, Yim MB (1999) Transcriptional activation of the human manganese superoxide dismutase gene mediated by tetradecanoylphorbol acetate. J Biol Chem 274(52): 37455-37460
33. Kinney A, Kline J, Kelly A, Reuss ML, Levin B (2007) Smoking, alcohol and caffeine in relation to ovarian age during the reproductive years. Hum Reprod 22(4):1175-1185
34. Krueger WA, Bo WJ, Kevin Rudeen P (1982) Female reproduction during chronic ethanol consumption in rats. Pharmacol Biochem Behav 17(4):629-631
35. Li SY, Gomelsky M, Duan J, Zhang Z, Gomelsky L, Zhang X, Epstein PN, Ren J (2004) Overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene prevents acetaldehyde-induced cell injury in human umbilical vein endothelial cells. J Biol Chem 279(12):11244-11252
36. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193(1):265-275
37. Margolin Y, Aten RF, Behrman HR (1990) Antigonadotropic and antisteroidogenic actions of peroxide in rat granulosa cells. Endocrinology 127(1):245-250
38. Masella R, Vari R, D'Archivio M, Di Benedetto R, Matarrese P, Malorni W, Scazzocchio B, Giovannini C (2004) Extra virgin olive oil biophenols inhibit cell-mediated oxidation of LDL by increasing the mRNA transcription of glutathione-related enzymes. J Nutr 134(4):785-791
39. Mates JM (2000) Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology 153(1):83-104
40. Mello NK, Bree MP, Mendelson JH, Ellingboe J, King NW, Sehgal P (1983) Alcohol self-Administration disrupts reproductive function in female macaque monkeys. Science 221(4611):677-679
41. Mello NK, Mendelson JH, Teoh SK (1993) Overview of the effects of alcohol on the neuroendocrine function in women. Alcohol and the endocrine system. National Institute on Alcohol Abuse and Alcoholism Research monograph 23:139-169
42. Millian NS, Garrow TA (1998) Human betaine-homocysteine methyltransferase is a zinc metalloenzyme. Arch Biochem Biophys 356(1):93-98
43. Neamati S, Alirezaei M, Kheradmand A (2011) Ghrelin acts as an antioxidant agent in the rat kidney. Int J Pept Res Ther 17:239-245
44. Nicotera TM, Notaro J, Notaro S, Schumer J, Sandberg AA (1989) Elevated superoxide dismutase in Bloom's syndrome: a genetic condition of oxidative stress. Cancer Res 49(19):5239-5243
45. Paszkowski T, Traub AI, Robinson SY, McMaster D (1995) Selenium dependent glutathione peroxidase activity in human follicular fluid. Clin Chim Acta 236(2):173-180
46. Petrie L, Duthie SJ, Rees WD, McConnell JML (2002) Serum concentrations of homocysteine are elevated during early pregnancy in rodent models of fetal programming. Br J Nutr 88(05):471-477
47. Pettersson P, Ellsinger BM, Sjoberg C, Bjorntorp P (1990) Fat distribution and steroid hormones in women with alcohol abuse. J Int Med 228(4):311-316
48. Rees WD, Wilson FA, Maloney CA (2006) Sulfur amino acid metabolism in pregnancy: the impact of methionine in the maternal diet. J Nutr 136(6):1701S-1705S
49. Rodriguez C, Mayo JC, Sainz RM, Antolinn I, Herrera F, Martin V, Reiter RJ (2004) Regulation of antioxidant enzymes: a significant role for melatonin. J Pineal Res 36(1):1-9
50. Rueda BR, Tilly KI, Hansen TR, Hoyer PB, Tilly JL (1995) Expression of superoxide dismutase, catalase and glutathione peroxidase in the bovine corpus luteum: evidence supporting a role for oxidative stress in luteolysis. Endocrine 3(3):227-232
51. Schwahn BC, Laryea MD, Chen Z, Melnyk S, Pogribny I, Garrow T, James SJ, Rozen R (2004) Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency. Biochem J 382(Pt 3):831
52. Sehirli O, Sener E, Sener G, Cetinel S, Erzik C, Yegen BC (2008) Ghrelin improves burn-induced multiple organ injury by depressing neutrophil infiltration and the release of pro-inflammatory cytokines. Peptides 29(7):1231-1240
53. Slow S, Lever M, Chambers ST, George PM (2009) Plasma dependent and independent accumulation of betaine in male and female rat tissues. Physiol Res 58:403-410
54. Song Z, Zhou Z, Chen T, Hill D, Kang J, Barve S, McClain C (2003) S-Adenosylmethionine (SAMe) protects against acute alcohol induced hepatotoxicity in mice. J Nutr Biochem 14(10): 591-597
55. Subbarao KV, Richardson JS, Ang LC (1990) Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro. J Neurochem 55(1):342-345
56. Sugino N, Takiguchi S, Kashida S, Takayama H, Yamagata Y, Nakamura Y, Kato H (1999) Suppression of intracellular superoxide dismutase activity by antisense oligonucleotides causes inhibition of progesterone production by rat luteal cells. Biol Reprod 61(4):1133-1138
57. Sunden SLF, Renduchintala MS, Park EI, Miklasz SD, Garrow TA (1997) Betaine-homocysteine methyltransferase expression in porcine and human tissues and chromosomal localization of the human gene. Arch Biochem Biophys 345(1):171-174
58. Tremellen K (2008) Oxidative stress and male infertility-A clinical perspective. Hum Reprod Update 14(3):243-259
59. Trisolini C, Minoia G, Manca R, Rizzo A, Robbe D, Valentini L, Sciorsci RL (2008) Plasma homocysteine levels in cycling, pregnant, and spayed bitches. Anim Reprod Sci 108(1):29-36
60. Tsai-Turton M, Luderer U (2006) Opposing effects of glutathione depletion and follicle-stimulating hormone on reactive oxygen species and apoptosis in cultured preovulatory rat follicles. Endocrinology 147(3):1224-1236
61. Valimaki M, Pelkonen R, Salaspuro M, Harkonenen M, Hirvonen E, Ylikahri R (1984) Sex hormones in amenorrheic women with alcoholic liver disease. J Clin Endocrinol Metab 59(1):133-138
62. Valimaki MJ, Laitinen K, Tiitinen A, Steman UH, Ylostao P (1995) Gonadal function and morphology in non-cirrhotic female alcoholics. Acta Obstet Gynecol Scand 74(6):462-466
63. Van Thiel DH, Gavaler JS, Lester R, Sherins RJ (1978) Alcoholinduced ovarian failure in the rat. J Clin Invest 61(3):624
64. Wallace JMW, Bonham MP, Strain JJ, Duffy EM, Robson PJ, Ward M, McNulty H, Davidson PW, Myers GJ, Shamlaye CF (2008) Homocysteine concentration, related B vitamins, and betaine in pregnant women recruited to the Seychelles Child Development Study. Am J Clin Nutr 87(2):391-397
65. Yao P, Li K, Song F, Zhou S, Sun X, Zhang X, Nussler AK, Liu L (2007) Heme oxygenase-1 upregulated by Ginkgo biloba extract: potential protection against ethanol-induced oxidative liver damage. Food Chem Toxicol 45(8):1333-1342
66. Yoo HY, Chang MS, Rho HM (1999) The activation of the rat copper/zinc superoxide dismutase gene by hydrogen peroxide through the hydrogen peroxide-responsive element and by paraquat and heat shock through the same heat shock element. J Biol Chem 274(34):23887-23892
67. Zeisel SH, Mar MH, Howe JC, Holden JM (2003) Concentrations of choline-containing compounds and betaine in common foods. J Nutr 133(5):1302-1307