Transfection of a human glioblastoma cell line with liver-type glutaminase (LGA) down-regulates the expression of DNA-repair gene MGMT and sensitizes the cells to alkylating agents

Journal of Neurochemistry

Volumn 123, Issue 3, 2012, Pages 428-436

  Szeliga, Monika ^a   Zgrzywa, Agata ^b   Obara Michlewska, Marta ^a   Albrecht, Jan ^a  

^a MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^b WARSAW UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

carmustine; liver type glutaminase (LGA); O6 methylguanine DNA methyltransferase (MGMT); T98G glioblastoma cell line; temozolomide

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CARMUSTINE; GLUTAMINASE; LIVER TYPE GLUTAMINASE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; TEMOZOLOMIDE; UNCLASSIFIED DRUG;

ARTICLE; CELL ASSAY; CELL GROWTH; CELL SURVIVAL; CLONOGENIC ASSAY; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; DRUG SENSITIVITY; GENE; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC TRANSFECTION; GLIOBLASTOMA; GROWTH INHIBITION; HUMAN; HUMAN CELL; MGMT GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, ALKYLATING; BRAIN NEOPLASMS; CELL LINE, TUMOR; DNA MODIFICATION METHYLASES; DNA REPAIR; DNA REPAIR ENZYMES; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GLIOBLASTOMA; HUMANS; LIVER; TRANSAMINASES; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS;

EID: 84867332010     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2012.07917.x     Document Type: Article

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