Glutaminase: A multifaceted protein not only involved in generating glutamate

Neurochemistry International

Volumn 48, Issue 6-7, 2006, Pages 465-471

  Márquez, Javier ^a   López de la Oliva, Amada R ^a   Matés, José M ^a   Segura, Juan A ^a   Alonso, Francisco J ^a  

^a UNIVERSITY OF MÁLAGA   (Spain)

Author keywords

Glutamate; Glutaminase; Mitochondria; Neurones; Nucleus; PDZ proteins; Protein protein interaction

Indexed keywords

BRAIN ENZYME; GLUTAMIC ACID; GLUTAMINASE; MITOCHONDRIAL ENZYME; NITROGEN;

ARTICLE; BRAIN; ENERGY METABOLISM; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME SYNTHESIS; EVIDENCE BASED MEDICINE; EXPERIMENTATION; GENE SEQUENCE; MAMMAL CELL; MEDICAL RESEARCH; METABOLISM; NITROGEN METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MOTIF;

AMINO ACID MOTIFS; ANIMALS; BRAIN; GLUTAMIC ACID; GLUTAMINASE; HUMANS;

MAMMALIA;

EID: 33645854641     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2005.10.015     Document Type: Article

References (51)

1. Adams M.E., Mueller H.A., and Froehner S.C. In vivo requirement of the alpha-syntrophin PDZ domain for the sarcolemmal localization of nNOS and aquaporin-4. J. Cell. Biol. 155 (2001) 113-122
2. Ahn A.H., Freener C.A., Gussoni E., Yoshida M., Ozawa E., and Kunkel L.M. The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives. J. Biol. Chem. 271 (1996) 2724-2730
3. Aledo J.C., de Pedro E., Gómez-Fabre P.M., Núñez de Castro I., and Márquez J. Submitochondrial localization and membrana topography of Ehrlich ascitic tumour cell glutaminase. Biochim. Biophys. Acta 1323 (1997) 173-184
4. Aledo J.C., Gómez-Fabre P.M., Olalla L., and Márquez J. Identification of two human glutaminase loci and tissue-specific expression of the two related genes. Mamm. Genome 11 (2000) 1107-1110
5. Aoki C., Kaneko T., Starr A., and Pickel V.M. Identification of mitochondrial and non-mitochondrial glutaminase within select neurons and glia of rat forebrain by electron microscopic immunocytochemistry. J. Neurosci. Res. 28 (1991) 531-548
6. Batchelor A.H., Piper D.E., de la Brousse F.C., McKnight S.L., and Wolberger C. The structure of GABPalpha/beta: an ETS domain-ankyrin repeat heterodimer bound to DNA. Science 279 (1998) 1037-1041
7. Bateman A., Coin L., Durbin R., Finn R.D., Hollich V., Griffiths-Jones S., Khanna A., Marshall M., Moxon S., Sonnhammer E.L.L., Studholme D.J., Yeats C., and Eddy S.R. The Pfam protein families database. Nucleic Acids Res. 32 (2004) D138-D141
8. Bungard C.I., and McGivan J.D. Glutamine availability up-regulates expression of the amino acid transporter protein ASCT2 in HepG2 cells and stimulates the ASCT2 promoter. Biochem. J. 382 (2004) 27-32
9. Campos J.A., Aledo J.C., Segura J.A., Alonso F.J., Gómez-Fabre P.M., Núñez de Castro I., and Márquez J. Expression of recombinant human L-glutaminase in Escherichia coli: polyclonal antibodies production and immunological analysis of mouse tissues. Biochim. Biophys. Acta 1648 (2003) 17-23
10. Castell L., Vance C., Abbott R., Márquez J., and Eggleton P. Granule localization of glutaminase in human neutrophils and the consequence of glutamine utilization for neutrophil activity. J. Biol. Chem. 279 (2004) 13305-13310
11. Collingridge G.L., and Lester R.A.J. Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol. Rev. 40 (1989) 143-210
12. Curthoys N.P., and Watford M. Regulation of glutaminase activity and glutamine metabolism. Annu. Rev. Nutr. 15 (1995) 133-159
13. Elgadi K.M., Meguid R.A., Qian M., Souba W.W., and Abcouwer S.F. Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing. Physiol. Genomics 1 (1999) 51-62
14. Erecinska M., and Silver I.A. Metabolism and role of glutamate in mammalian brain. Prog. Neurobiol. 35 (1990) 245-296
15. Fonnum F. Glutamate: a neurotransmitter in mammalian brain. J. Neurochem. 42 (1984) 1-11
16. Gómez-Fabre P.M., Aledo J.C., del Castillo-Olivares A., Alonso F.J., Núñez de Castro I., Campos J.A., and Márquez J. Molecular cloning, sequencing and expression studies of the human breast cancer cell glutaminase. Biochem. J. 345 (2000) 365-375
17. Heery D.M., Kalkhoven E., Hoare S., and Parker M.G. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387 (1997) 733-736
18. Hozumi Y., Ito T., Nakano T., Nakagawa T., Aoyagi M., Kondo H., and Goto K. Nuclear localization of diacylglycerol kinase zeta in neurons. Eur. J. Neurosci. 18 (2003) 1448-1457
19. Hsueh Y.P., Wang T.F., Yang F.C., and Sheng M. Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2. Nature 404 (2000) 298-302
20. Jeffery C.J. Moonlighting proteins. Trends Biochem. Sci. 24 (1999) 8-11
21. Jeffery C.J. Moonlighting proteins: old proteins learning new tricks. Trends Genet. 19 (2003) 415-417
22. Kanamori M., Sandy P., Marzinotto S., Benetti R., Kai C., Hayashizaki Y., Schneider C., and Suzuki H. The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells. J. Biol. Chem. 278 (2003) 38758-38764
23. Kausalya P.J., Phua D.C., and Hunziker W. Association of ARVCF with zonula occludens (ZO)-1 and ZO-2: binding to PDZ-domain proteins and cell-cell adhesion regulate plasma membrane and nuclear localization of ARVCF. Mol. Biol. Cell 15 (2004) 5503-5515
24. Kornau H.C., Schenker L.T., Kennedy M.B., and Seeburg P.H. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science 269 (1995) 1737-1740
25. Kovacevic Z., and McGivan J.D. Mitochondrial metabolism of glutamine and glutamate and its physiological significance. Physiol. Rev. 63 (1983) 547-605
26. Krebs H.A. The synthesis of glutamine from glutamate and ammonia, and the enzymatic hydrolysis of glutamine in animal tissues. Biochem. J. 29 (1935) 1951-1969
27. Kvamme E. Enzymes of cerebral glutamine metabolism. In: Häussinger D., and Sies H. (Eds). Glutamine Metabolism in Mammalian Tissues (1984), Springer-Verlag, Berlin 32-48
28. Laake J.H., Slyngstad T.A., Haug F.M., and Ottersen O.P. Glutamine from glial cells is essential for the maintenance of the nerve terminal pool of glutamate: immunogold evidence from hippocampal slice cultures. J. Neurochem. 65 (1995) 871-881
29. Laake J.H., Takumi Y., Eidet J., Torgner I.A., Roberg B., Kvamme E., and Ottersen O.P. Postembedding immunogold labelling reveals subcellular localization and pathway-specific enrichment of phosphate activated glutaminase in rat cerebellum. Neuroscience 88 (1999) 1137-1151
30. Lobo C., Ruiz-Bellido M.A., Aledo J.C., Márquez J., Núñez de Castro I., and Alonso F.J. Inhibition of glutaminase expression by antisense mRNA decreases growth and tumourigenicity of tumour cells. Biochem. J. 348 (2000) 257-261
31. Meertens L.M., Miyata K.S., Cechetto J.D., Rachubinski R.A., and Capone J.P. A mitochondrial ketogenic enzyme regulates its gene expression by association with the nuclear hormone receptor PPARα. EMBO J. 17 (1998) 6972-6978
32. Nicklas W.J., Zeevalk G., and Hyndman A. Interactions between neurons and glia in glutamate/glutamine compartmentation. Biochem. Soc. Trans. 15 (1987) 208-210
33. Norenberg M.D., and Martínez-Hernández A. Fine structural localization of glutamine synthetase in astrocytes of rat brain. Brain Res. 161 (1979) 303-310
34. Olalla L., Aledo J.C., Bannenberg G., and Márquez J. The C-terminus of human glutaminase L mediates association with PDZ domain-containing proteins. FEBS Lett. 488 (2001) 116-122
35. Olalla L., Gutiérrez A., Campos J.A., Khan Z.U., Alonso F., Segura J.A., Márquez J., and Aledo J.C. Nuclear localization of L-glutaminase in mammalian brain. J. Biol. Chem. 277 (2002) 38939-38944
36. Palaiologos G., Hertz L., and Schousboe A. Evidence that aspartate aminotransferase activity and ketodicarboxylate carrier function are essential for biosynthesis of transmitter glutamate. J. Neurochem. 51 (1988) 317-320
37. Pérez-Gómez C., Campos-Sandoval J.A., Alonso F.J., Segura J.A., Manzanares E., Ruiz-Sánchez P., González M.E., Márquez J., and Matés J.M. Co-expression of glutaminase K and L isoenzymes in human tumour cells. Biochem. J. 386 (2005) 535-542
38. Pérez-Gómez C., Matés J.M., Gómez-Fabre P.M., del Castillo-Olivares A., Alonso F.J., and Márquez J. Genomic organization and transcriptional analysis of the human L-glutaminase gene. Biochem. J. 370 (2003) 771-784
39. Ponting C.P., Phillips C., Davies K.E., and Blake D.J. PDZ domains: targeting signalling molecules to sub-membranous sites. Bioessays 19 (1997) 469-479
40. Porter L.D., Ibrahim H., Taylor L., and Curthoys N.P. Complexity and species variation of the kidney-type glutaminase gene. Physiol. Genomics 9 (2002) 57-66
41. Poulat F., Barbara P.S., Desclozeaux M., Soullier S., Moniot B., Bonneaud N., Boizet B., and Berta P. The human testis determining factor SRY binds a nuclear factor containing PDZ protein interaction domains. J. Biol. Chem. 272 (1997) 7167-7172
42. Reynaud C., Fabre S., and Jalinot P. The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element. J. Biol. Chem. 275 (2000) 33962-33968
43. Roberg B., Torgner I.A., and Kvamme E. The orientation of phosphate activated glutaminase in the inner mitochondrial membrane of synaptic and non-synaptic rat brain mitochondria. Neurochem. Int. 27 (1995) 367-376
44. Sachdev S., Hoffmann A., and Hannink M. Nuclear localization of IkappaB alpha is mediated by the second ankyrin repeat: the IkappaB alpha ankyrin repeats define a novel class of cis-acting nuclear import sequences. Mol. Cell. Biol. 18 (1998) 2524-2534
45. Sedgwick S.G., and Smerdon S.J. The ankyrin repeat: a diversity of interactions on a common structural framework. Trends Biochem. Sci. 24 (1999) 311-316
46. Shapiro R.A., Farrell L., Srinivasan M., and Curthoys N.P. Isolation, characterization, and in vitro expression of a cDNA that encodes the kidney isoenzyme of the mitochondrial glutaminase. J. Biol. Chem. 266 (1991) 18792-18796
47. Smith E.M., and Watford M. Molecular cloning of a cDNA for rat hepatic glutaminase. Sequence similarity to kidney-type glutaminase. J. Biol. Chem. 265 (1990) 10631-10636
48. Szeliga M., Sidoryk M., Matyja E., Kowalczyk P., and Albrecht J. Lack of expression of the liver-type glutaminase (LGA) mRNA in human malignant gliomas. Neurosci. Lett. 374 (2005) 171-173
49. Turner A., and McGivan J.D. Glutaminase isoform expression in cell lines derived from human colorectal adenomas and carcinomas. Biochem. J. 370 (2003) 403-408
50. Waagepetersen H.S., Qu H., Sonnewald U., Shimamoto K., and Schousboe A. Role of glutamine and neuronal glutamate uptake in glutamate homeostasis and synthesis during vesicular release in cultured glutamatergic neurons. Neurochem. Int. 47 (2005) 92-102
51. Zhang A., Yeung P.L., Li C.W., Tsai S.C., Dinh G.K., Wu X., Li H., and Chen J.D. Identification of a novel family of ankyrin repeats containing cofactors for p160 nuclear receptor coactivators. J. Biol. Chem. 279 (2004) 33799-33805