Ligand electronic properties modulate tau filament binding site density

Biophysical Chemistry

Volumn 170, Issue , 2012, Pages 25-33

  Cisek, Katryna ^a   Jensen, Jordan R ^a   Honson, Nicolette S ^a   Schafer, Kelsey N ^a   Cooper, Grace L ^a   Kuret, Jeff ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Computational chemistry; Dispersion force; Ligand binding; Polarizability; Tau protein

Indexed keywords

1 IODO 2,5 BIS( 3 HYDROXYCARBONYL 4 METHOXY)STYRYLBENZENE; 2 [ 2 [ 4 (DIMETHYLAMINO)PHENYL]ETHENYL] 6 METHOXYBENZOTHIAZOLE; 2 [[ 4 (DIMETHYLAMINO)PHENYL]AZO] 6 METHOXYBENZOTHIAZOLE; BENZENE DERIVATIVE; BENZOTHIAZOLE DERIVATIVE; DIRECT YELLOW 7; LIGAND; TAU PROTEIN; THIOFLAVINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DENSITY FUNCTIONAL THEORY; DENSITY GRADIENT; ELECTRON; ELECTRON TRANSPORT; IN VITRO STUDY; ISOTOPE LABELING; LIGAND BINDING; MOLECULAR ELECTRONICS; MOLECULAR PROBE; NEUROFILAMENT; POLARIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN LOCALIZATION; QUANTUM MECHANICS;

BENZOTHIAZOLES; BINDING SITES; ELECTRONS; FLUORESCENT DYES; HUMANS; LIGANDS; QUANTUM THEORY; RECOMBINANT PROTEINS; TAU PROTEINS; THIAZOLES;

EID: 84867301510     PISSN: 03014622     EISSN: 18734200     Source Type: Journal    
DOI: 10.1016/j.bpc.2012.09.001     Document Type: Article

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