-
2
-
-
0037509990
-
Focal adhesion kinase: The first ten years
-
DOI 10.1242/jcs.00373
-
Parsons JT: Focal adhesion kinase: The first ten years. J Cell Sci 2003;116:1409- 1416. (Pubitemid 36527488)
-
(2003)
Journal of Cell Science
, vol.116
, Issue.8
, pp. 1409-1416
-
-
Parsons, J.T.1
-
4
-
-
0036229694
-
Networks and crosstalk: Integrin signalling spreads
-
DOI 10.1038/ncb0402-e65
-
Schwartz MA, Ginsberg MH: Networks and crosstalk: Integrin signaling spreads. Nat Cell Biol 2002;4:E65-E68. (Pubitemid 34308840)
-
(2002)
Nature Cell Biology
, vol.4
, Issue.4
-
-
Schwartz, M.A.1
Ginsberg, M.H.2
-
5
-
-
67651085772
-
Signal transduction by focal adhesion kinase in cancer
-
Zhao J, Guan J-L: Signal transduction by focal adhesion kinase in cancer. Cancer Metastasis Rev 2009;28:35-49.
-
(2009)
Cancer Metastasis Rev
, vol.28
, pp. 35-49
-
-
Zhao, J.1
Guan, J.-L.2
-
6
-
-
28544452713
-
Expression profiling of serous low malignant potential, low-grade, and high-grade tumors of the ovary
-
DOI 10.1158/0008-5472.CAN-05-2240
-
Bonome T, Lee JY, Park DC, Radonovich M, Pise-Masison C, Brady J, et al.: Expression profiling of serous low malignant potential, low-grade, and highgrade tumors of the ovary. Cancer Res 2005;65:10602-10612. (Pubitemid 41743756)
-
(2005)
Cancer Research
, vol.65
, Issue.22
, pp. 10602-10612
-
-
Bonome, T.1
Lee, J.-Y.2
Park, D.-C.3
Radonovich, M.4
Pise-Masison, C.5
Brady, J.6
Gardner, G.J.7
Hao, K.8
Wong, W.H.9
Barrett, J.C.10
Lu, K.H.11
Sood, A.K.12
Gershenson, D.M.13
Mok, S.C.14
Birrer, M.J.15
-
7
-
-
0034044795
-
Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: Correlation with preinvasive and invasive phenotypes
-
Cance WG, Harris JE, Iacocca MV, Roche E, Yang X, Chang J, et al.: Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: Correlation with preinvasive and invasive phenotypes. Clin Cancer Res 2000;6:2417-2423. (Pubitemid 30399210)
-
(2000)
Clinical Cancer Research
, vol.6
, Issue.6
, pp. 2417-2423
-
-
Cance, W.G.1
Harris, J.E.2
Iacocca, M.V.3
Roche, E.4
Yang, X.H.5
Chang, J.6
Simkins, S.7
Xu, L.H.8
-
8
-
-
33747061570
-
Up-regulation of focal adhesion kinase in non-small cell lung cancer
-
DOI 10.1016/j.lungcan.2006.06.001, PII S016950020600287X
-
Carelli S, Zadra G, Vaira V, Falleni M, Bottiglieri L, Nosotti M, et al.: Upregulation of focal adhesion kinase in non-small cell lung cancer. Lung Cancer 2006;53:263-271. (Pubitemid 44209282)
-
(2006)
Lung Cancer
, vol.53
, Issue.3
, pp. 263-271
-
-
Carelli, S.1
Zadra, G.2
Vaira, V.3
Falleni, M.4
Bottiglieri, L.5
Nosotti, M.6
Di Giulio, A.M.7
Gorio, A.8
Bosari, S.9
-
10
-
-
0031112814
-
FAK) in human colorectal carcinoma liver metastases: Independence from c-src or c-yes activation
-
Han NM, Fleming RY, Curley SA, Gallick GE: Overexpression of focal adhesion kinase (p125FAK) in human colorectal carcinoma liver metastases: Independence from c-src or c-yes activation. Ann Surg Oncol 1997;4:264-268. (Pubitemid 127725254)
-
(1997)
Annals of Surgical Oncology
, vol.4
, Issue.3
, pp. 264-268
-
-
Han, N.M.1
Declan Fleming, R.Y.2
Curley, S.A.3
Gallick, G.E.4
-
11
-
-
0029690892
-
Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer
-
Owens LV, Xu L, Dent GA, Yang X, Sturge GC, Craven RJ, et al.: Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer. Ann Surg Oncol 1996;3:100-105. (Pubitemid 126729497)
-
(1996)
Annals of Surgical Oncology
, vol.3
, Issue.1
, pp. 100-105
-
-
Owens, L.V.1
Xu, L.2
Dent, G.A.3
Yang, X.4
Sturge, G.C.5
Craven, R.J.6
Cance, W.G.7
-
12
-
-
0029795243
-
Focal adhesion kinase (pp125(FAK)) expression, activation and association with paxillin and p50(CSK) in human metastatic prostate carcinoma
-
DOI 10.1002/(SICI)1097-0215(19961009)68:2 <169::AID-IJC4>3.0.CO;2-W
-
Tremblay L, Hauck W, Aprikian AG, Begin LR, Chapdelaine A, Chevalier S: Focal adhesion kinase (pp125FAK) expression, activation and association with paxillin and p50 CSK in human metastatic prostate carcinoma. Int J Cancer 1996;68:164-171. (Pubitemid 26380117)
-
(1996)
International Journal of Cancer
, vol.68
, Issue.2
, pp. 164-171
-
-
Tremblay, L.1
Hauck, W.2
Aprikian, A.G.3
Begin, L.R.4
Chapdelaine, A.5
Chevalier, S.6
-
13
-
-
33748364149
-
Focal adhesion kinasetargeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy
-
DOI 10.1158/1078-0432.CCR-06-0021
-
Halder J, Kamat AA, Landen CN, Jr., Han LY, Lutgendorf SK, Lin YG, et al.: Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy. Clin Cancer Res 2006;12:4916-4924. (Pubitemid 44338579)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.16
, pp. 4916-4924
-
-
Halder, J.1
Kamat, A.A.2
Landen Jr., C.N.3
Han, L.Y.4
Lutgendorf, S.K.5
Lin, Y.G.6
Merritt, W.M.7
Jennings, N.B.8
Chavez-Reyes, A.9
Coleman, R.L.10
Gershenson, D.M.11
Schmandt, R.12
Cole, S.W.13
Lopez-Berestein, G.14
Sood, A.K.15
-
14
-
-
36949015986
-
Role of focal adhesion kinase in human cancer: A potential target for drug discovery
-
DOI 10.2174/187152007784111296
-
Han EK-H, McGonigal T: Role of focal adhesion kinase in human cancer: A potential target for drug discovery. Anti-Cancer Agents Med Chem 2007;7:681- 684. (Pubitemid 350237772)
-
(2007)
Anti-Cancer Agents in Medicinal Chemistry
, vol.7
, Issue.6
, pp. 681-684
-
-
Han, E.K.-H.1
McGonigal, T.2
-
15
-
-
0037137847
-
CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase
-
DOI 10.1002/ijc.1605
-
Kohno M, Hasegawa H, Miyake M, Yamamoto T, Fujita S: CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase. Int J Cancer 2002;97:336-343. (Pubitemid 34049024)
-
(2002)
International Journal of Cancer
, vol.97
, Issue.3
, pp. 336-343
-
-
Kohno, M.1
Hasegawa, H.2
Miyake, M.3
Yamamoto, T.4
Fujita, S.5
-
16
-
-
36348933509
-
Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma
-
DOI 10.1158/0008-5472.CAN-07-2667
-
Halder J, Lin YG, Merritt WM, Spannuth WA, Nick AM, Honda T, et al.: Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma. Cancer Res 2007;67:10976-10983. (Pubitemid 350145927)
-
(2007)
Cancer Research
, vol.67
, Issue.22
, pp. 10976-10983
-
-
Halder, J.1
Lin, Y.G.2
Merritt, W.M.3
Spannuth, W.A.4
Nick, A.M.5
Honda, T.6
Kamat, A.A.7
Han, L.Y.8
Tae, J.K.9
Lu, C.10
Tari, A.M.11
Bornmann, W.12
Fernandez, A.13
Lopez-Berestein, G.14
Sood, A.K.15
-
17
-
-
40949152523
-
Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271
-
DOI 10.1158/0008-5472.CAN-07-5155
-
Roberts WG, Ung E, Whalen P, Cooper B, Hulford C, Autry C, et al.: Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF- 562,271. Cancer Res 2008;68:1935-1944. (Pubitemid 351416580)
-
(2008)
Cancer Research
, vol.68
, Issue.6
, pp. 1935-1944
-
-
Roberts, W.G.1
Ung, E.2
Whalen, P.3
Cooper, B.4
Hulford, C.5
Autry, C.6
Richter, D.7
Emerson, E.8
Lin, J.9
Kath, J.10
Coleman, K.11
Yao, L.12
Martinez-Alsina, L.13
Lorenzen, M.14
Berliner, M.15
Luzzio, M.16
Patel, N.17
Schmitt, E.18
LaGreca, S.19
Jani, J.20
Wessel, M.21
Marr, E.22
Griffor, M.23
Vajdos, F.24
more..
-
18
-
-
33748325882
-
Drug-target residence time and its implications for lead optimization
-
DOI 10.1038/nrd2082, PII NRD2082
-
Copeland RA, Pompliano DL, Meek TD: Drug-target residence time and its implications for lead optimization. Nat Rev Drug Discov 2006;5:730-739. (Pubitemid 44323700)
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, Issue.9
, pp. 730-739
-
-
Copeland, R.A.1
Pompliano, D.L.2
Meek, T.D.3
-
19
-
-
44049103958
-
Residence time of receptor - Ligand complexes and its effect on biological function
-
DOI 10.1021/bi8002023
-
Tummino PJ, Copeland RA: Residence time of receptor-ligand complexes and its effect on biological function. Biochemistry 2008;47:5481-5492. (Pubitemid 351711169)
-
(2008)
Biochemistry
, vol.47
, Issue.20
, pp. 5481-5492
-
-
Tummino, P.J.1
Copeland, R.A.2
-
20
-
-
58449084255
-
Label-free kinetic binding data as a decisive element in drug discovery
-
Andersson K, Karlsson R, Lofas S, Franklin G, Hamalainen MD: Label-free kinetic binding data as a decisive element in drug discovery. Expert Opin Drug Discov 2006;1:439-446.
-
(2006)
Expert Opin Drug Discov
, vol.1
, pp. 439-446
-
-
Andersson, K.1
Karlsson, R.2
Lofas, S.3
Franklin, G.4
Hamalainen, M.D.5
-
21
-
-
17444407490
-
Kinetic studies of small molecule interactions with protein kinases using biosensor technology
-
DOI 10.1016/j.ab.2005.02.027
-
Nordin H, Jungnelius M, Karlsson R, Karlsson OP: Kinetic studies of small molecule interactions with protein kinases using biosensor technology. Anal Biochem 2005;340:359-368. (Pubitemid 40544876)
-
(2005)
Analytical Biochemistry
, vol.340
, Issue.2
, pp. 359-368
-
-
Nordin, H.1
Jungnelius, M.2
Karlsson, R.3
Karlsson, O.P.4
-
22
-
-
70349633983
-
Development and applications of a broad-coverage, TR-FRET-based kinase binding assay platform
-
Lebakken CS, Riddle SM, Singh U, Frazee WJ, Eliason HC, Gao Y, et al.: Development and applications of a broad-coverage, TR-FRET-based kinase binding assay platform. J Biomol Screen 2009;14:924-935.
-
(2009)
J Biomol Screen
, vol.14
, pp. 924-935
-
-
Lebakken, C.S.1
Riddle, S.M.2
Singh, U.3
Frazee, W.J.4
Eliason, H.C.5
Gao, Y.6
-
23
-
-
0031848098
-
Extending the range of rate constants available from BIACORE: Interpreting mass transport-influenced binding data
-
Myszka DG, He X, Dembo M, Morton TA, Goldstein B: Extending the range of rate constants available from BIACORE: Interpreting mass transport-influenced binding data. Biophys J 1998;75:583-594. (Pubitemid 28357501)
-
(1998)
Biophysical Journal
, vol.75
, Issue.2
, pp. 583-594
-
-
Myszka, D.G.1
He, X.2
Dembo, M.3
Morton, T.A.4
Goldstein, B.5
-
24
-
-
0032752117
-
The influence of transport on the kinetics of binding to surface receptors: Application to cells and BIAcore
-
Goldstein B, Coombs D, He X, Pineda AR, Wofsy C: The influence of transport on the kinetics of binding to surface receptors: Application to cells and BIAcore. J Mol Recognit 1999;12:293-299. (Pubitemid 129708592)
-
(1999)
Journal of Molecular Recognition
, vol.12
, Issue.5 SPEC. ISSUE
, pp. 293-299
-
-
Goldstein, B.1
Coombs, D.2
He, X.3
Pineda, A.R.4
Wofsy, C.5
-
25
-
-
79952096135
-
Biochemical characterization of TAK-593, a novel VEGFR/PDGFR inhibitor with a two-step slow binding mechanism
-
Iwata H, Imamura S, Hori A, Hixon MS, Kimura H, Miki H: Biochemical characterization of TAK-593, a novel VEGFR/PDGFR inhibitor with a two-step slow binding mechanism. Biochemistry 2011;50:738-751.
-
(2011)
Biochemistry
, vol.50
, pp. 738-751
-
-
Iwata, H.1
Imamura, S.2
Hori, A.3
Hixon, M.S.4
Kimura, H.5
Miki, H.6
-
26
-
-
58449131873
-
The role of binding kinetics in therapeutically useful drug action
-
Swinney DC: The role of binding kinetics in therapeutically useful drug action. Curr Opin Drug Discov Devel 2009;12:31-39.
-
(2009)
Curr Opin Drug Discov Devel
, vol.12
, pp. 31-39
-
-
Swinney, D.C.1
-
27
-
-
77955329488
-
Drug-target residence time: Critical information for lead optimization
-
Lu H, Tonge PJ: Drug-target residence time: Critical information for lead optimization. Curr Opin Chem Biol 2010;14:467-474.
-
(2010)
Curr Opin Chem Biol
, vol.14
, pp. 467-474
-
-
Lu, H.1
Tonge, P.J.2
-
28
-
-
58049204094
-
Small-molecule inhibitors binding to protein kinase Part I: Exceptions from the traditional pharmacophore approach of type I inhibition
-
Backes AC, Zech B, Felber B, Muller G: Small-molecule inhibitors binding to protein kinase. Part I: exceptions from the traditional pharmacophore approach of type I inhibition. Expert Opin Drug Discov 2008;3:1409-1425.
-
(2008)
Expert Opin Drug Discov
, vol.3
, pp. 1409-1425
-
-
Backes, A.C.1
Zech, B.2
Felber, B.3
Muller, G.4
-
29
-
-
58049211592
-
Small-molecule inhibitors binding to protein kinase Part II: The novel pharmacophore approach of type II and type III inhibition
-
Backes AC, Zech B, Felber B, Muller G: Small-molecule inhibitors binding to protein kinase. Part II: The novel pharmacophore approach of type II and type III inhibition. Expert Opin Drug Discov 2008;3:1427-1449.
-
(2008)
Expert Opin Drug Discov
, vol.3
, pp. 1427-1449
-
-
Backes, A.C.1
Zech, B.2
Felber, B.3
Muller, G.4
-
30
-
-
33745298429
-
Rational design of inhibitors that bind to inactive kinase conformations
-
DOI 10.1038/nchembio799, PII N799
-
Liu Y, Gray NS: Rational design of inhibitors that bind to inactive kinase conformations. Nat Chem Biol 2006;2:358-364. (Pubitemid 43936934)
-
(2006)
Nature Chemical Biology
, vol.2
, Issue.7
, pp. 358-364
-
-
Liu, Y.1
Gray, N.S.2
-
31
-
-
58149102648
-
Type-II kinase inhibitor docking, screening, and profiling using modified structures of active kinase states
-
Kufareva I, Abagyan R: Type-II kinase inhibitor docking, screening, and profiling using modified structures of active kinase states. J Med Chem 2008;51:7924- 7932.
-
(2008)
J Med Chem
, vol.51
, pp. 7924-7932
-
-
Kufareva, I.1
Abagyan, R.2
-
32
-
-
0034665713
-
Structural mechanism for STI-571 inhibition of Abelson tyrosine kinase
-
Schindler T, Bornmann W, Pellicena P, Miller WT, Clarkson B, Kuriyan J: Structural mechanism for STI-571 inhibition of Abelson tyrosine kinase. Science 2000;289:1938-1942.
-
(2000)
Science
, vol.289
, pp. 1938-1942
-
-
Schindler, T.1
Bornmann, W.2
Pellicena, P.3
Miller, W.T.4
Clarkson, B.5
Kuriyan, J.6
-
33
-
-
19944429284
-
A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase
-
DOI 10.1074/jbc.M409792200
-
Atwell S, Adams JM, Badger J, Buchanan MD, Feil IK, Froning KJ, et al.: A novel mode of binding of Gleevec is revealed by the structure of spleen tyrosine kinase. J Biol Chem 2004;279:55827-55832. (Pubitemid 40066590)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.53
, pp. 55827-55832
-
-
Atwell, S.1
Adams, J.M.2
Badger, J.3
Buchanan, M.D.4
Feil, I.K.5
Froning, K.J.6
Gao, X.7
Hendle, J.8
Keegan, K.9
Leon, B.C.10
Muller-Dieckmann, H.J.11
Nienaber, V.L.12
Noland, B.W.13
Post, K.14
Rajashankar, K.R.15
Ramos, A.16
Russell, M.17
Burley, S.K.18
Buchanan, S.G.19
-
34
-
-
65749105992
-
Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design
-
Han S, Mistry A, Chang JS, Cunningham D, Griffor M, Bonnette PC, et al.: Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design. J Biol Chem 2009;284:13193-13201.
-
(2009)
J Biol Chem
, vol.284
, pp. 13193-13201
-
-
Han, S.1
Mistry, A.2
Chang, J.S.3
Cunningham, D.4
Griffor, M.5
Bonnette, P.C.6
-
35
-
-
1842848073
-
Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography
-
DOI 10.1016/S0969-2126(02)00907-3, PII S0969212602009073
-
Nowakowski J, Cronin CN, McRee DE, Knuth MW, Nelson CG, Sang B-C, et al.: Structures of the cancer-related Aurora-A, FAK and EphA protein kinases from nanovolume crystallography. Structure 2002;10:1659-1667. (Pubitemid 35452573)
-
(2002)
Structure
, vol.10
, Issue.12
, pp. 1659-1667
-
-
Nowakowski, J.1
Cronin, C.N.2
McRee, D.E.3
Knuth, M.W.4
Nelson, C.G.5
Pavletich, N.P.6
Rogers, J.7
Sang, B.-C.8
Scheibe, D.N.9
Swanson, R.V.10
Thompson, D.A.11
-
36
-
-
31144460354
-
Analyzing a kinetic titration series using affinity biosensors
-
DOI 10.1016/j.ab.2005.09.034, PII S0003269705006986
-
Karlsson R, Katsamba PS, Nordin H, Pol E, Myszka DG: Analyzing a kinetic titration series using affinity biosensors. Anal Biochem 2006;349:136-147. (Pubitemid 43129567)
-
(2006)
Analytical Biochemistry
, vol.349
, Issue.1
, pp. 136-147
-
-
Karlsson, R.1
Katsamba, P.S.2
Nordin, H.3
Pol, E.4
Myszka, D.G.5
-
37
-
-
57049091187
-
Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation
-
Lietha D, Eck MJ: Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation. PLoS One 2008;3:1-7.
-
(2008)
PLoS One
, vol.3
, pp. 1-7
-
-
Lietha, D.1
Eck, M.J.2
|