Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design

Journal of Biological Chemistry

Volumn 284, Issue 19, 2009, Pages 13193-13201

  Han, Seungil ^a   Mistry, Anil ^a   Chang, Jeanne S ^a   Cunningham, David ^a   Griffor, Matt ^a   Bonnette, Peter C ^a   Wang, Hong ^a   Chrunyk, Boris A ^a   Aspnes, Gary E ^a   Walker, Daniel P ^a   Brosius, Arthur D ^a   Buckbinder, Leonard ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROLIFERATION; ENZYME INHIBITION; HINGES;

HIGH-RESOLUTION STRUCTURES; LOOP CONFORMATION; NEGATIVE REGULATORS; PROLINE-RICH TYROSINE KINASE 2; PROTEIN KINASE INHIBITORS; RECEPTOR TYROSINE KINASE; SIGNALING PATHWAYS; STRUCTURAL CHARACTERIZATION;

AMINO ACIDS;

ADENOSINE TRIPHOSPHATE; DORAMAPIMOD; FOCAL ADHESION KINASE 1; FOCAL ADHESION KINASE 2; LEUCINE; METHIONINE; PF 4618433; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; BINDING KINETICS; BINDING SITE; BONE DEVELOPMENT; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME SPECIFICITY; HINGE REGION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN STRUCTURE;

PYRONIA TITHONUS;

EID: 65749105992     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M809038200     Document Type: Article

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