메뉴 건너뛰기




Volumn 4, Issue 6, 2012, Pages 1167-1170

RagD gene expression and NRF2 mutations in lung squamous cell carcinomas

Author keywords

Lung cancer; Mutation; NRF2; RagD; Squamous cell carcinoma

Indexed keywords

BETA ACTIN; GUANINE NUCLEOTIDE BINDING PROTEIN; MESSENGER RNA; RAGD PROTEIN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

EID: 84867256331     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2012.938     Document Type: Article
Times cited : (16)

References (23)
  • 1
    • 0002384775 scopus 로고
    • Cancer of the lung
    • In: Principles and Practice of Oncology. DeVita VT Jr, Hellman S and Rosenberg SA (eds), Lippincott, Philadelphia
    • Ginsberg RJ, Kris MK and Armstrong JG: Cancer of the lung. In: Principles and Practice of Oncology. DeVita VT Jr, Hellman S and Rosenberg SA (eds). 4th edition. Lippincott, Philadelphia, pp.673-682, 1993.
    • (1993) 4th Edition , pp. 673-682
    • Ginsberg, R.J.1    Kris, M.K.2    Armstrong, J.G.3
  • 3
    • 6044223545 scopus 로고    scopus 로고
    • Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers
    • Zhou X, Tan M, Stone Hawthorne V, et al: Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers. Clin Cancer Res 10: 6779-6788, 2004.
    • (2004) Clin Cancer Res , vol.10 , pp. 6779-6788
    • Zhou, X.1    Tan, M.2    Stone, H.V.3
  • 4
    • 2342559981 scopus 로고    scopus 로고
    • The TOR pathway: Target for cancer therapy
    • Bjornsti MA and Houghton PJ: The TOR pathway: target for cancer therapy. Nat Rev Cancer 4: 335-348, 2004.
    • (2004) Nat Rev Cancer , vol.4 , pp. 335-348
    • Bjornsti, M.A.1    Houghton, P.J.2
  • 5
    • 79952495236 scopus 로고    scopus 로고
    • Mammalian target of rapamycin: Biological function and target for novel anticancer agents
    • Borders EB, Bivona C and Medina PJ: Mammalian target of rapamycin: biological function and target for novel anticancer agents. Am J Health Syst Pharm 67: 2095-2106, 2010.
    • (2010) Am J Health Syst Pharm , vol.67 , pp. 2095-2106
    • Borders, E.B.1    Bivona, C.2    Medina, P.J.3
  • 6
    • 80051479542 scopus 로고    scopus 로고
    • Activation of mammalian target of rapamycin pathway confers adverse outcome in nonsmall cell lung carcinoma
    • Liu D, Huang Y, Chen B, et al: Activation of mammalian target of rapamycin pathway confers adverse outcome in nonsmall cell lung carcinoma. Cancer 117: 3763-3773, 2011.
    • (2011) Cancer , vol.117 , pp. 3763-3773
    • Liu, D.1    Huang, Y.2    Chen, B.3
  • 7
    • 84855449478 scopus 로고    scopus 로고
    • Overexpression of the mammalian target of rapamycin (mTOR) and angioinvasion are poor prognostic factors in early stage NSCLC: A verification study
    • Gately K, Al-Alao B, Dhillon T, et al: Overexpression of the mammalian target of rapamycin (mTOR) and angioinvasion are poor prognostic factors in early stage NSCLC: a verification study. Lung Cancer 75: 217-222, 2012.
    • (2012) Lung Cancer , vol.75 , pp. 217-222
    • Gately, K.1    Al-Alao, B.2    Dhillon, T.3
  • 8
    • 45849105156 scopus 로고    scopus 로고
    • The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
    • Sancak Y, Peterson TR, Shaul YD, et al: The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320: 1496-1501, 2008.
    • (2008) Science , vol.320 , pp. 1496-1501
    • Sancak, Y.1    Peterson, T.R.2    Shaul, Y.D.3
  • 9
    • 78549273400 scopus 로고    scopus 로고
    • Global downstream pathway analysis reveals a dependence of oncogenic NF-E2-related factor 2 mutation on the mTOR growth signaling pathway
    • Shibata T, Saito S, Kokubu A, et al: Global downstream pathway analysis reveals a dependence of oncogenic NF-E2-related factor 2 mutation on the mTOR growth signaling pathway. Cancer Res 70: 9095-9105, 2010.
    • (2010) Cancer Res , vol.70 , pp. 9095-9105
    • Shibata, T.1    Saito, S.2    Kokubu, A.3
  • 10
    • 77954695549 scopus 로고    scopus 로고
    • Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features
    • Solis LM, Behrens C, Dong W, et al: Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features. Clin Cancer Res 16: 3743-3753, 2010.
    • (2010) Clin Cancer Res , vol.16 , pp. 3743-3753
    • Solis, L.M.1    Behrens, C.2    Dong, W.3
  • 11
    • 77953139490 scopus 로고    scopus 로고
    • NFE2L2 gene mutation in male Japanese squamous cell carcinoma of the lung
    • Sasaki H, Hikosaka Y, Okuda K, et al: NFE2L2 gene mutation in male Japanese squamous cell carcinoma of the lung. J Thorac Oncol 5: 786-789, 2010.
    • (2010) J Thorac Oncol , vol.5 , pp. 786-789
    • Sasaki, H.1    Hikosaka, Y.2    Okuda, K.3
  • 12
    • 51649130168 scopus 로고    scopus 로고
    • Cancer related mutations in Nrf2 impair its recognition by Keap1-Clu3 E3 ligase and promote malignancy
    • Shibata T, Ohta T, Tong KI, et al: Cancer related mutations in Nrf2 impair its recognition by Keap1-Clu3 E3 ligase and promote malignancy. Proc Natl Acad Sci USA 105: 13568-13573, 2008.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 13568-13573
    • Shibata, T.1    Ohta, T.2    Tong, K.I.3
  • 13
    • 84863091925 scopus 로고    scopus 로고
    • Mutation of the Nrf2 gene in non-small cell lung cancer
    • (Epub ahead of print)
    • Hu Y, Ju Y, Lin D, et al: Mutation of the Nrf2 gene in non-small cell lung cancer. Mol Biol Rep: Oct 1, 2011 (Epub ahead of print).
    • (2011) Mol Biol Rep: Oct , pp. 1
    • Hu, Y.1    Ju, Y.2    Lin, D.3
  • 14
    • 67349217986 scopus 로고    scopus 로고
    • Molecular mechanisms of mTOR-mediated translational control
    • Ma XM and Blenis J: Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol 10: 307-318, 2009.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 307-318
    • Ma, X.M.1    Blenis, J.2
  • 15
    • 48649085816 scopus 로고    scopus 로고
    • regulation of TORC1 by Rag GTPases in nutrient response
    • Kim E, Goraksha-Hicks P, Li L, et al. regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol 10: 935-945, 2008.
    • (2008) Nat Cell Biol , vol.10 , pp. 935-945
    • Kim, E.1    Goraksha-Hicks, P.2    Li, L.3
  • 16
    • 0031577292 scopus 로고    scopus 로고
    • An Nef2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
    • Itoh K, Chiba T, Takahashi S, et al: An Nef2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun 236: 313-322, 1997.
    • (1997) Biochem Biophys Res Commun , vol.236 , pp. 313-322
    • Itoh, K.1    Chiba, T.2    Takahashi, S.3
  • 17
    • 0036783335 scopus 로고    scopus 로고
    • Pharmacogenomics, regulation and signaling pathways of phase I and II detoxifying enzymes
    • Rushmore TH and Kong AN: Pharmacogenomics, regulation and signaling pathways of phase I and II detoxifying enzymes. Curr Drug Metab 3: 481-490, 2002.
    • (2002) Curr Drug Metab , vol.3 , pp. 481-490
    • Rushmore, T.H.1    Kong, A.N.2
  • 18
    • 3142570440 scopus 로고    scopus 로고
    • The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress
    • Ngyyen T, Yang CS and Pickett CB: The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress. Free Radic Biol Med 37: 433-441, 2004.
    • (2004) Free Radic Biol Med , vol.37 , pp. 433-441
    • Ngyyen, T.1    Yang, C.S.2    Pickett, C.B.3
  • 19
    • 54249087596 scopus 로고    scopus 로고
    • RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy
    • Singh A, Boldin-Adamsky S, Thimmulappa RK, et al: RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy. Cancer Res 68: 7975-7984, 2008.
    • (2008) Cancer Res , vol.68 , pp. 7975-7984
    • Singh, A.1    Boldin-Adamsky, S.2    Thimmulappa, R.K.3
  • 20
    • 44349189804 scopus 로고    scopus 로고
    • Nrf2 gene promoter polymorphism and gastric carcinogenesis
    • Arisawa T, Tahara T, Shibata T, et al: Nrf2 gene promoter polymorphism and gastric carcinogenesis. Hepatogastroenterology. 55: 750-754, 2008.
    • (2008) Hepatogastroenterology , vol.55 , pp. 750-754
    • Arisawa, T.1    Tahara, T.2    Shibata, T.3
  • 21
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL: Targeting HIF-1 for cancer therapy. Nat Rev Cancer. 3: 721-732, 2003.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 23
    • 84866629688 scopus 로고    scopus 로고
    • mTOR and PTEN expression in non-small cell lung cancer: Analysis by real-time fluorescence quantitative polymerase chain reaction and immunohistochemistry
    • Nov 30, (Epub ahead of print)
    • Wang L, Yue W, Zhang L, et al: mTOR and PTEN expression in non-small cell lung cancer: analysis by real-time fluorescence quantitative polymerase chain reaction and immunohistochemistry. Surg Today: Nov 30, 2011 (Epub ahead of print).
    • (2011) Surg Today
    • Wang, L.1    Yue, W.2    Zhang, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.