메뉴 건너뛰기




Volumn 75, Issue 2, 2012, Pages 217-222

Overexpression of the mammalian target of rapamycin (mTOR) and angioinvasion are poor prognostic factors in early stage NSCLC: A verification study

Author keywords

Angioinvasion; Early stage NSCLC; Immunohistochemistry (IHC); Mammalian target of rapamycin (mTOR); MTOR inhibitors; Poor prognostic factor

Indexed keywords

BIOCHEMICAL MARKER; EVEROLIMUS; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; RIDAFOROLIMUS; TEMSIROLIMUS;

EID: 84855449478     PISSN: 01695002     EISSN: 18728332     Source Type: Journal    
DOI: 10.1016/j.lungcan.2011.06.012     Document Type: Article
Times cited : (34)

References (46)
  • 1
    • 0035467993 scopus 로고    scopus 로고
    • Global cancer statistics in the year 2000
    • Parkin D.M. Global cancer statistics in the year 2000. Lancet Oncol 2001, 2:533-543.
    • (2001) Lancet Oncol , vol.2 , pp. 533-543
    • Parkin, D.M.1
  • 2
    • 33847387137 scopus 로고    scopus 로고
    • Prognostic assessment after surgical resection for non-small cell lung cancer: experiences in 2083 patients
    • Pfannschmidt J., Muley T., Bülzebruck H., Dienemann H. Prognostic assessment after surgical resection for non-small cell lung cancer: experiences in 2083 patients. Lung Cancer 2007, 55(March (3)):371-377.
    • (2007) Lung Cancer , vol.55 , Issue.MARCH 3 , pp. 371-377
    • Pfannschmidt, J.1    Muley, T.2    Bülzebruck, H.3    Dienemann, H.4
  • 3
    • 77958102568 scopus 로고    scopus 로고
    • Personalized medicine for non-small-cell lung cancer
    • Mok T.S., Zhou Q., Leung L., Loong H.H. Personalized medicine for non-small-cell lung cancer. Expert Rev Anticancer Ther 2010, 10(October (10)):1601-1611.
    • (2010) Expert Rev Anticancer Ther , vol.10 , Issue.OCTOBER 10 , pp. 1601-1611
    • Mok, T.S.1    Zhou, Q.2    Leung, L.3    Loong, H.H.4
  • 5
    • 0020803058 scopus 로고
    • Prognostic significance of parenchymal lymphatic vessel and blood vessel invasion in carcinoma of the lung
    • Shields T.W. Prognostic significance of parenchymal lymphatic vessel and blood vessel invasion in carcinoma of the lung. Surg Gynecol Obstet 1983, 157:185-190.
    • (1983) Surg Gynecol Obstet , vol.157 , pp. 185-190
    • Shields, T.W.1
  • 6
    • 0027326034 scopus 로고
    • Blood vessel invasion by tumor cells predicts recurrence in completely resected T1 N0 M0 non-small-cell lung cancer
    • Macchiarini P., Fontanini G., Hardin M.J., Chuanchieh H., Bigini D., Vignati S. Blood vessel invasion by tumor cells predicts recurrence in completely resected T1 N0 M0 non-small-cell lung cancer. J Thorac Cardiovasc Surg 1993, 106:80-89.
    • (1993) J Thorac Cardiovasc Surg , vol.106 , pp. 80-89
    • Macchiarini, P.1    Fontanini, G.2    Hardin, M.J.3    Chuanchieh, H.4    Bigini, D.5    Vignati, S.6
  • 7
    • 19644363793 scopus 로고    scopus 로고
    • Arterial invasion predicts early mortality in stage I non-small cell lung cancer
    • Pechet T.T.V., Carr S.R., Collins J.E., Cohn H.E., Farber J.L. Arterial invasion predicts early mortality in stage I non-small cell lung cancer. Ann Thorac Surg 2004, 78:1748-1754.
    • (2004) Ann Thorac Surg , vol.78 , pp. 1748-1754
    • Pechet, T.T.V.1    Carr, S.R.2    Collins, J.E.3    Cohn, H.E.4    Farber, J.L.5
  • 8
    • 34247614402 scopus 로고    scopus 로고
    • Stage IA non-small cell lung cancer: vessel invasion is a poor prognostic factor and a new target of adjuvant chemotherapy
    • Tsuchiya T., Akamine S., Muraoka M., Kamohara R., Tsuji K., Urabe S., et al. Stage IA non-small cell lung cancer: vessel invasion is a poor prognostic factor and a new target of adjuvant chemotherapy. Lung Cancer 2007, 56:341-348.
    • (2007) Lung Cancer , vol.56 , pp. 341-348
    • Tsuchiya, T.1    Akamine, S.2    Muraoka, M.3    Kamohara, R.4    Tsuji, K.5    Urabe, S.6
  • 9
    • 79551526108 scopus 로고    scopus 로고
    • Significance of the presence of microscopic vascular invasion after complete resection of stage I-II pT1-T2N0 non-small cell lung cancer and its relation with T-size categories: did the 2009 7th edition of the TNM staging system miss something?
    • Ruffini E., Asioli S., Filosso P.L., Buffoni L., Bruna M.C., Mossetti C., et al. Significance of the presence of microscopic vascular invasion after complete resection of stage I-II pT1-T2N0 non-small cell lung cancer and its relation with T-size categories: did the 2009 7th edition of the TNM staging system miss something?. J Thorac Oncol 2011, 6(February (2)):319-326.
    • (2011) J Thorac Oncol , vol.6 , Issue.FEBRUARY 2 , pp. 319-326
    • Ruffini, E.1    Asioli, S.2    Filosso, P.L.3    Buffoni, L.4    Bruna, M.C.5    Mossetti, C.6
  • 10
    • 59149105815 scopus 로고    scopus 로고
    • Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: association with MMP-9
    • Chen J.S., Wang Q., Fu X.H., Huang X.H., Chen X.L., Cao L.Q., et al. Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: association with MMP-9. Hepatol Res 2009, 39(February (2)):177-186.
    • (2009) Hepatol Res , vol.39 , Issue.FEBRUARY 2 , pp. 177-186
    • Chen, J.S.1    Wang, Q.2    Fu, X.H.3    Huang, X.H.4    Chen, X.L.5    Cao, L.Q.6
  • 11
    • 63149143885 scopus 로고    scopus 로고
    • AKT/mTOR pathway activation and BCL-2 family proteins modulate the sensitivity of human small cell lung cancer cells to RAD001
    • Marinov M., Ziogas A., Pardo O.E., Tan L.T., Dhillon T., Mauri F.A., et al. AKT/mTOR pathway activation and BCL-2 family proteins modulate the sensitivity of human small cell lung cancer cells to RAD001. Clin Cancer Res 2009, 15:1277-1287.
    • (2009) Clin Cancer Res , vol.15 , pp. 1277-1287
    • Marinov, M.1    Ziogas, A.2    Pardo, O.E.3    Tan, L.T.4    Dhillon, T.5    Mauri, F.A.6
  • 12
    • 77649325976 scopus 로고    scopus 로고
    • Overexpression of the mammalian target of rapamycin a novel marker for poor survival in resected early stage non-small cell lung cancer
    • Dhillon T., Mauri F.A., Bellezza G., Cagini L., Barbareschi M., North B.V., et al. Overexpression of the mammalian target of rapamycin a novel marker for poor survival in resected early stage non-small cell lung cancer. J Thorac Oncol 2010, 5(3):314-319.
    • (2010) J Thorac Oncol , vol.5 , Issue.3 , pp. 314-319
    • Dhillon, T.1    Mauri, F.A.2    Bellezza, G.3    Cagini, L.4    Barbareschi, M.5    North, B.V.6
  • 13
    • 0028869086 scopus 로고
    • Rapamune (sirolimus, rapamycin): an overview and mechanism of action
    • Sehgal S.N. Rapamune (sirolimus, rapamycin): an overview and mechanism of action. Ther Drug Monit 1995, 17:660-665.
    • (1995) Ther Drug Monit , vol.17 , pp. 660-665
    • Sehgal, S.N.1
  • 14
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin D.A., Sabatini D.M. Defining the role of mTOR in cancer. Cancer Cell 2007, 12:9-22.
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 15
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N., Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004, 18:1926-1945.
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 16
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle T., Hall M.N. TOR, a central controller of cell growth. Cell 2000, 103:253-262.
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 17
    • 33745307617 scopus 로고    scopus 로고
    • Ras PI(3)K, and mTOR signalling controls tumor cell growth
    • Shaw R.J., Cantley L.C. Ras PI(3)K, and mTOR signalling controls tumor cell growth. Nature 2006, 441:424-430.
    • (2006) Nature , vol.441 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 18
    • 8844222002 scopus 로고    scopus 로고
    • Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions
    • Balsara B.R., Pei J., Mitsuuchi Y., Page R., Klein-Szanto A., Wang H., et al. Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions. Carcinogenesis 2004, 25:2053-2059.
    • (2004) Carcinogenesis , vol.25 , pp. 2053-2059
    • Balsara, B.R.1    Pei, J.2    Mitsuuchi, Y.3    Page, R.4    Klein-Szanto, A.5    Wang, H.6
  • 19
    • 20244367301 scopus 로고    scopus 로고
    • Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras
    • Wislez M., Spencer M.L., Izzo J.G., Juroske D.M., Balhara K., Cody D.D., et al. Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras. Cancer Res 2005, 65:3226-3235.
    • (2005) Cancer Res , vol.65 , pp. 3226-3235
    • Wislez, M.1    Spencer, M.L.2    Izzo, J.G.3    Juroske, D.M.4    Balhara, K.5    Cody, D.D.6
  • 20
    • 34547130295 scopus 로고    scopus 로고
    • RAD001 inhibits human ovarian cancer cell proliferation, enhances cisplatin induced apoptosis, and prolongs survival in an ovarian cancer model
    • Mabuchi S., Altomare D.A., Cheung M., Zhang L., Poulikakos P.I., Hensley H.H., et al. RAD001 inhibits human ovarian cancer cell proliferation, enhances cisplatin induced apoptosis, and prolongs survival in an ovarian cancer model. Clin Cancer Res 2007, 13:4261-4270.
    • (2007) Clin Cancer Res , vol.13 , pp. 4261-4270
    • Mabuchi, S.1    Altomare, D.A.2    Cheung, M.3    Zhang, L.4    Poulikakos, P.I.5    Hensley, H.H.6
  • 21
    • 33750565745 scopus 로고    scopus 로고
    • Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells
    • Cao C., Subhawong T., Albert J.M., Kim K.W., Geng L., Sekhar K.R., et al. Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells. Cancer Res 2006, 66:10040-10047.
    • (2006) Cancer Res , vol.66 , pp. 10040-10047
    • Cao, C.1    Subhawong, T.2    Albert, J.M.3    Kim, K.W.4    Geng, L.5    Sekhar, K.R.6
  • 22
    • 33745095268 scopus 로고    scopus 로고
    • Targeting the Akt/mammalian target of rapamycin pathway for radiosensitization of breast cancer
    • Albert J.M., Kim K.W., Cao C., Lu B. Targeting the Akt/mammalian target of rapamycin pathway for radiosensitization of breast cancer. Mol Cancer Ther 2006, 5:1183-1189.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1183-1189
    • Albert, J.M.1    Kim, K.W.2    Cao, C.3    Lu, B.4
  • 23
    • 77956533358 scopus 로고    scopus 로고
    • Effect of rapamycin, an mTOR inhibitor, on radiation sensitivity of lung cancer cells having different p53 gene status
    • Nagata Y., Takahashi A., Ohnishi K., Ota I., Ohnishi T., Tojo T., et al. Effect of rapamycin, an mTOR inhibitor, on radiation sensitivity of lung cancer cells having different p53 gene status. Int J Oncol 2010, 37(4):1001-1010.
    • (2010) Int J Oncol , vol.37 , Issue.4 , pp. 1001-1010
    • Nagata, Y.1    Takahashi, A.2    Ohnishi, K.3    Ota, I.4    Ohnishi, T.5    Tojo, T.6
  • 24
    • 33644623904 scopus 로고    scopus 로고
    • Current status of mammalian target of rapamycin inhibitors in lung cancer
    • Gomez-Martin C., Rubio-Viqueira B., Hidalgo M. Current status of mammalian target of rapamycin inhibitors in lung cancer. Clin Lung Cancer 2005, 7(Suppl. 1):S13-S18.
    • (2005) Clin Lung Cancer , vol.7 , Issue.SUPPL. 1
    • Gomez-Martin, C.1    Rubio-Viqueira, B.2    Hidalgo, M.3
  • 25
    • 0030912190 scopus 로고    scopus 로고
    • Revisions in the International System for Staging Lung Cancer
    • Mountain C.F. Revisions in the International System for Staging Lung Cancer. Chest 1997, 111(6):1710-1717.
    • (1997) Chest , vol.111 , Issue.6 , pp. 1710-1717
    • Mountain, C.F.1
  • 26
    • 15744362912 scopus 로고    scopus 로고
    • The 2004 World Health Organization classification of lung tumors
    • Beasley M.B., Brambilla E., Travis W.D. The 2004 World Health Organization classification of lung tumors. Semin Roentgenol 2005, 40(April (2)):90-97.
    • (2005) Semin Roentgenol , vol.40 , Issue.APRIL 2 , pp. 90-97
    • Beasley, M.B.1    Brambilla, E.2    Travis, W.D.3
  • 27
    • 0025829609 scopus 로고
    • Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections
    • Shi S.R., Key M.E., Kalra K.L. Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J Histochem Cytochem 1991, 39:741-748.
    • (1991) J Histochem Cytochem , vol.39 , pp. 741-748
    • Shi, S.R.1    Key, M.E.2    Kalra, K.L.3
  • 29
    • 77956890008 scopus 로고
    • Martingale-based residuals forsurvival models
    • Therneau T., Grambsch P., Fleming T. Martingale-based residuals forsurvival models. Biometrika 1990, 77:147-160.
    • (1990) Biometrika , vol.77 , pp. 147-160
    • Therneau, T.1    Grambsch, P.2    Fleming, T.3
  • 30
    • 67449138837 scopus 로고    scopus 로고
    • High expression of mammalian target of rapamycin is associated with better outcome for patients with early stage lung adenocarcinoma
    • Anagnostou V.K., Bepler G., Syrigos G.N., Tanoue L., Gettinger S., Homer R.J., et al. High expression of mammalian target of rapamycin is associated with better outcome for patients with early stage lung adenocarcinoma. Clin Cancer Res 2009, 12:4157-4164.
    • (2009) Clin Cancer Res , vol.12 , pp. 4157-4164
    • Anagnostou, V.K.1    Bepler, G.2    Syrigos, G.N.3    Tanoue, L.4    Gettinger, S.5    Homer, R.J.6
  • 31
    • 34548085100 scopus 로고    scopus 로고
    • Activated mammalian target of rapamycin is an adverse prognostic factor in patients with biliary tract adenocarcinoma
    • Herberger B., Puhalla H., Lehnert M., Wrba F., Novak S., Brandstetter A., et al. Activated mammalian target of rapamycin is an adverse prognostic factor in patients with biliary tract adenocarcinoma. Clin Cancer Res 2007, 13:4795-4799.
    • (2007) Clin Cancer Res , vol.13 , pp. 4795-4799
    • Herberger, B.1    Puhalla, H.2    Lehnert, M.3    Wrba, F.4    Novak, S.5    Brandstetter, A.6
  • 32
    • 6044223545 scopus 로고    scopus 로고
    • Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers
    • Zhou X., Tan M., Stone Hawthorne V., Klos K.S., Lan K.H., Yang Y., et al. Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers. Clin Cancer Res 2004, 10:6779-6788.
    • (2004) Clin Cancer Res , vol.10 , pp. 6779-6788
    • Zhou, X.1    Tan, M.2    Stone Hawthorne, V.3    Klos, K.S.4    Lan, K.H.5    Yang, Y.6
  • 33
    • 33750271928 scopus 로고    scopus 로고
    • Molecular correlates associated with a phase II study of temsirolimus (CCI-779) in patients with metastatic or recurrent endometrial cancer-NCIC IND 160
    • Oza A.M., Elit L., Biagi J., Chapman W., Tsao M., Hedley D. Molecular correlates associated with a phase II study of temsirolimus (CCI-779) in patients with metastatic or recurrent endometrial cancer-NCIC IND 160. Proc Am Soc Clin Oncol 2006, 24(18S):3003.
    • (2006) Proc Am Soc Clin Oncol , vol.24 , Issue.18 S , pp. 3003
    • Oza, A.M.1    Elit, L.2    Biagi, J.3    Chapman, W.4    Tsao, M.5    Hedley, D.6
  • 34
    • 53849125004 scopus 로고    scopus 로고
    • MTORC1 inhibitors: is temsirolimus in renal cancer telling us how they really work?
    • Le Tourneau C., Faivre S., Serova M., Raymond E. mTORC1 inhibitors: is temsirolimus in renal cancer telling us how they really work?. Br J Cancer 2008, 99:1197-1203.
    • (2008) Br J Cancer , vol.99 , pp. 1197-1203
    • Le Tourneau, C.1    Faivre, S.2    Serova, M.3    Raymond, E.4
  • 35
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo controlled phase III trial
    • Motzer R.J., Escudier B., Oudard S., Hutson T.E., Porta C., Bracarda S., et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo controlled phase III trial. Lancet 2008, 372:449-456.
    • (2008) Lancet , vol.372 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3    Hutson, T.E.4    Porta, C.5    Bracarda, S.6
  • 36
    • 43249086546 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors
    • O'Donnell A., Faivre S., Burris H.A., Rea D., Papadimitrakopoulou V., Shand N., et al. Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors. J Clin Oncol 2008, 26:1588-1595.
    • (2008) J Clin Oncol , vol.26 , pp. 1588-1595
    • O'Donnell, A.1    Faivre, S.2    Burris, H.A.3    Rea, D.4    Papadimitrakopoulou, V.5    Shand, N.6
  • 37
    • 38649140450 scopus 로고    scopus 로고
    • Phase I trial of the novel mammalian target of rapamycin inhibitor deforolimus (AP23573; MK-8669) administered intravenously daily for 5 days every 2 weeks to patients with advanced malignancies
    • Mita M.M., Mita A.C., Chu Q.S., Rowinsky E.K., Fetterly G.J., Goldston M., et al. Phase I trial of the novel mammalian target of rapamycin inhibitor deforolimus (AP23573; MK-8669) administered intravenously daily for 5 days every 2 weeks to patients with advanced malignancies. J Clin Oncol 2008, 26:361-367.
    • (2008) J Clin Oncol , vol.26 , pp. 361-367
    • Mita, M.M.1    Mita, A.C.2    Chu, Q.S.3    Rowinsky, E.K.4    Fetterly, G.J.5    Goldston, M.6
  • 39
    • 23844476134 scopus 로고    scopus 로고
    • CCI-779 in metastatic melanoma: a phase II trial of the California Cancer Consortium
    • Margolin K., Longmate J., Baratta T., Synold T., Christensen S., Weber J., et al. CCI-779 in metastatic melanoma: a phase II trial of the California Cancer Consortium. Cancer 2005, 104:1045-1048.
    • (2005) Cancer , vol.104 , pp. 1045-1048
    • Margolin, K.1    Longmate, J.2    Baratta, T.3    Synold, T.4    Christensen, S.5    Weber, J.6
  • 40
    • 32944457518 scopus 로고    scopus 로고
    • MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
    • O'Reilly K.E., Rojo F., She Q.B., Solit D., Mills G.B., Smith D., et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 2006, 66:1500-1508.
    • (2006) Cancer Res , vol.66 , pp. 1500-1508
    • O'Reilly, K.E.1    Rojo, F.2    She, Q.B.3    Solit, D.4    Mills, G.B.5    Smith, D.6
  • 41
    • 34547133008 scopus 로고    scopus 로고
    • Phase 1 trial of everolimus and gefitinib in patients with advanced non small-cell lung cancer
    • Milton D.T., Riely G.J., Azzoli C.G., Gomez J.E., Heelan R.T., Kris M.G., et al. Phase 1 trial of everolimus and gefitinib in patients with advanced non small-cell lung cancer. Cancer 2007, 110(3):599-605.
    • (2007) Cancer , vol.110 , Issue.3 , pp. 599-605
    • Milton, D.T.1    Riely, G.J.2    Azzoli, C.G.3    Gomez, J.E.4    Heelan, R.T.5    Kris, M.G.6
  • 42
    • 70349637311 scopus 로고    scopus 로고
    • Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitors
    • Soria J.C., Shepherd F.A., Douillard J.Y., Wolf J., Giaccone G., Crino L., et al. Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitors. Ann Oncol 2009, 20(10):1674-1681.
    • (2009) Ann Oncol , vol.20 , Issue.10 , pp. 1674-1681
    • Soria, J.C.1    Shepherd, F.A.2    Douillard, J.Y.3    Wolf, J.4    Giaccone, G.5    Crino, L.6
  • 43
    • 39749149266 scopus 로고    scopus 로고
    • Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib+chemotherapy - cancer and leukemia group B trial 30203
    • Edelman M.J., Watson D., Wang X., Morrison C., Kratzke R.A., Jewell S., et al. Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib+chemotherapy - cancer and leukemia group B trial 30203. J Clin Oncol 2008, 26(6):848-855.
    • (2008) J Clin Oncol , vol.26 , Issue.6 , pp. 848-855
    • Edelman, M.J.1    Watson, D.2    Wang, X.3    Morrison, C.4    Kratzke, R.A.5    Jewell, S.6
  • 44
    • 77956227862 scopus 로고    scopus 로고
    • Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC)
    • Jassem J., Langer C.J., Karp D.D., Mok T., Benner R.J., Green S.J., et al. Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC). J Clin Oncol 2010, 28:7500.
    • (2010) J Clin Oncol , vol.28 , pp. 7500
    • Jassem, J.1    Langer, C.J.2    Karp, D.D.3    Mok, T.4    Benner, R.J.5    Green, S.J.6
  • 45
    • 84855422391 scopus 로고    scopus 로고
    • Randomized multicenter double-blind placebo controlled phase II study evaluating MetMAb, an antibody to met receptor, in combination with erlotinib, in patients with advanced non-small-cell lung cancer
    • [Abstract LBA15]
    • Spigel D. Randomized multicenter double-blind placebo controlled phase II study evaluating MetMAb, an antibody to met receptor, in combination with erlotinib, in patients with advanced non-small-cell lung cancer. ESMO 2010, [Abstract LBA15].
    • (2010) ESMO
    • Spigel, D.1
  • 46
    • 40349100358 scopus 로고    scopus 로고
    • Combined expression of caveolin-1 and an activated AKT/mTOR pathway predicts reduced disease-free survival in clinically confined renal cell carcinoma
    • Campbell L., Jasani B., Edwards K., Gumbleton M., Griffiths D.F. Combined expression of caveolin-1 and an activated AKT/mTOR pathway predicts reduced disease-free survival in clinically confined renal cell carcinoma. Br J Cancer 2008, 98:931-940.
    • (2008) Br J Cancer , vol.98 , pp. 931-940
    • Campbell, L.1    Jasani, B.2    Edwards, K.3    Gumbleton, M.4    Griffiths, D.F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.