Involvement of tryptase and proteinase-activated receptor-2 in spontaneous itch-associated response in mice with atopy-like dermatitis

Journal of Pharmacological Sciences

Volumn 109, Issue 3, 2009, Pages 388-395

  Tsujii, Kenichiro ^a   Andoh, Tsugunobu ^a   Ui, Haruna ^a   Lee, Jung Bum ^a   Kuraishi, Yasushi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Atopic dermatitis; Itch; Proteinase activated receptor; Scratching; Tryptase

Indexed keywords

NAFAMSTAT MESILATE; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 3; PROTEINASE ACTIVATED RECEPTOR 4; TRYPTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOPIC DERMATITIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; ENZYME LOCALIZATION; IMMUNOREACTIVITY; MALE; MOUSE; NONHUMAN; PRURITUS;

ANIMALS; CHRONIC DISEASE; DERMATITIS, ATOPIC; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EPIDERMIS; GUANIDINES; KERATINOCYTES; MALE; MAST CELLS; MICE; OLIGOPEPTIDES; PROTEASE INHIBITORS; RECEPTOR, PAR-2; TRYPTASES;

EID: 67249103872     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.08332FP     Document Type: Article

References (30)

1. Hanifin JM. Atopic dermatitis. J Am Acad Dermatol. 1982;6:1-13.
2. Akdis CA, Akdis M, Bieber T, Bindslev-Jensen C, Boguniewicz M, Eigenmann P, et al. Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report. J Allergy Clin Immunol. 2006;118:152-169.
3. Wahlgren CF. Itch and atopic dermatitis: an overview. J Dermatol. 1999;26:770-779.
4. Steinhoff M, Neisius U, Ikoma A, Fartasch M, Heyer G, Skov PS, et al. Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin. J Neurosci. 2003;23:6176-6180. (Pubitemid 36875617)
5. Macfarlane SR, Seatter MJ, Kanke T, Hunter GD, Plevin R. Proteinase-activated receptor. Pharmacol Rev. 2001;53:363-400.
6. Ui H, Andoh T, Lee JB, Nojima H, Kuraishi Y. Potent prurito- genic action of tryptase mediated by PAR-2 receptor and itch involvement in anti-pruritic effect of nafamostat mesilate in mice. Eur J Pharmacol. 2006;530:172-178. (Pubitemid 43037138)
7. Shimada SG, Shimada KA, Collins JG. Scratching behavior in mice induced by the proteinase-activated receptor-2 agonist, SLIGRL-NH2. Eur J Pharmacol. 2006;530:281-283. (Pubitemid 43075500)
8. Tsujii K, Andoh T, Lee JB, Kuraishi Y. Activation of proteinase activated receptor induces itch-associated response through histamine-dependent and -independent pathway in mice. J Pharmacol Sci. 2008;108:385-388.
9. Matsuda H, Watanabe N, Geba GP, Sperl J, Tsudzuki M, Hiroi J, et al. Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice. Int Immunol. 1997;9:461-466. (Pubitemid 27113270)
10. Yamaguchi T, Maekawa T, Nishikawa Y, Nojima H, Kaneko M, Kawakita T, et al. Characterization of itch-associated responses of NC mice with mite-induced chronic dermatitis. J Dermatol Sci. 2001;25:20-28. (Pubitemid 32012642)
11. Kuraishi Y, Nagasawa T, Hayashi K, Satoh M. Scratching behavior induced by pruritogenic but not algesiogenic agents in mice. Eur J Pharmacol. 1995;275:229-233.
12. Andoh T, Al-Akeel A, Tsujii K, Nojima H, Kuraishi Y. Repeated treatment with the traditional medicine Unsei-in inhibits substance P-induced itch-associated responses through downregulation of the expression of nitric oxide synthase 1 in mice. J Pharmacol Sci. 2004;94:207-210. (Pubitemid 38405137)
13. Wolters PJ, Pham CTN, Muilenburg DJ, Ley TJ, Caughey GH. Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice. J Biol Chem. 2001;276:18551-18556. (Pubitemid 37411434)
14. Inagaki N, Nagao M, Igeta K, Kawasaki H, Kim JF, Nagai H. Scratching behavior in various strains of mice. Skin Pharmacol Appl Skin Physiol. 2001;14:87-96.
15. Ohtsuka E, Kawai S, Ichikawa T, Nojima H, Kitagawa K, Shirai Y, et al. Roles of mast cells and histamine in mosquito bite- induced allergic itch-associated responses in mice. Jpn J Pharmacol. 2001;86:97-105. (Pubitemid 32529750)
16. Steinhoff M, Corvera CU, Thoma MS, Kong W, McAlpine BE, Caughey GH, et al. Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase. Exp Dermatol. 1999;8:282-294. (Pubitemid 29370853)
17. Andoh T, Katsube N, Maruyama M, Kuraishi Y. Involvement of leukotriene B4 in substance P-induced itch-associated response in mice. J Invest Dermatol. 2001;117:1621-1626. (Pubitemid 34032796)
18. Andoh T, Kuraishi Y. Nitric oxide enhances substance P- induced itch-associated responses in mice. Br J Pharmacol. 2003;138:202-208. (Pubitemid 36194221)
19. Andoh T, Nishikawa Y, Miyamoto-Yamaguchi T, Nojima H, Narumiya S, Kuraishi Y. Thromboxane A2 induces itch- associated responses through TP receptors in the skin in mice. J Invest Dermatol. 2007;127:2042-2047. (Pubitemid 47075367)
20. Steinhoff M, Vergnolle N, Young SH, Tognetto M, Amadesi S, Ennes HS, et al. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat Med. 2000;6:151-158. (Pubitemid 30082358)
21. Mori S, Itoh Y, Shinohata R, Sendo T, Oishi R, Nishibori M. Nafamostat mesilate is an extremely potent inhibitor of human tryptase. J Pharmacol Sci. 2003;92:420-423. (Pubitemid 37086724)
22. Komatsu N, Saijoh K, Toyama T, Ohka R, Otsuki N, Hussack G, et al. Multiple tissue kallikrein mRNA and protein expression in normal skin and skin diseases. Br J Dermatol. 2005;153:274-281. (Pubitemid 41228422)
23. Komatsu N, Saijoh K, Kuk C, Liu A, Khan S, Shirasaki F, et al. Human tissue kallikrein expression in the stratum corneum and serum of atopic dermatitis patients. Exp Dermatol. 2007;16:513-519. (Pubitemid 46845395)
24. Hansson L, Bäckmann A, Ny A, Edlund M, Ekholm E, Hammarström BE, et al. Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: A model for chronic itchy dermatitis. J Invest Dermatol. 2002;118:444-449.
25. Stefansson K, Brattsand M, Roosterman D, Kemples C, Bocheva G, Steinhoff M, et al. Activation of proteinase-activated receptor-2 by human kallikrein-related peptidases. J Invest Dermatol. 2008;128:18-25. (Pubitemid 350249381)
26. Fujii S, Hitomi Y. New synthetic inhibitors of C1r, C1 esterase, plasmin, kallikrein and trypsin. Biochim Biophys Acta. 1981; 661:342-345. (Pubitemid 12233442)
27. Boguniewicz M, Fiedler VC, Raimer S, Lawrence ID, Leung DY, Hanifin JM. A randomized, vehicle-controlled trial of tacrolimus ointment for treatment of atopic dermatitis in children. Pediatric Tacrolimus Study Group. J Allergy Clin Immunol. 1998;102:637-644.
28. Bekersky I, Fitzsimmons W, Tanase A, Maher RM, Hodosh E, Lawrence I. Nonclinical and early clinical development of tacrolimus ointment for the treatment of atopic dermatitis. J Am Acad Dermatol. 2001;44:S17-S27. (Pubitemid 32047910)
29. Nakano T, Andoh T, Tayama M, Kosaka M, Lee JB, Kuraishi Y. Effects of topical application of tacrolimus on acute itch- associated responses in mice. Biol Pharm Bull. 2008;31:752-754.
30. Nakano T, Andoh T, Lee JB, Kuraishi Y. Different dorsal horn neurons responding to histamine and allergic itch stimuli. Neuroreport. 2008;19:723-726.