Globular adiponectin protects H9c2 cells from palmitate-induced apoptosis via Akt and ERK1/2 signaling pathways

Lipids in Health and Disease

Volumn 11, Issue , 2012, Pages

  Wei, Chuan Dong ^a,b   Li, Yan ^a   Zheng, Hong Yun ^a   Sun, Kai Sheng ^a   Tong, Yong Qing ^a   Dai, Wen ^a   Wu, Wei ^a   Bao, An Yu ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b AFFILIATED HOSPITAL OF YOUJIANG MEDICAL UNIVERSITY FOR NATIONALITIES   (China)

Author keywords

Adiponectin; Apoptosis; ERK1 2; H9c2 cells; Palmitate; PI3K Akt

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ADIPONECTIN; CASPASE 3; GLOBULAR PROTEIN; HOE 33342; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PALMITIC ACID; PROTEIN KINASE B;

ANIMAL CELL; APOPTOSIS; ARTICLE; BIOCHEMISTRY; CARDIOMYOPATHY; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; EMBRYO; HEART MUSCLE CELL; LIPOTOXICITY; MOLECULAR INTERACTION; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ADIPONECTIN; ANIMALS; APOPTOSIS; CARDIOTONIC AGENTS; CHROMONES; HUMANS; MAP KINASE SIGNALING SYSTEM; MORPHOLINES; MYOCYTES, CARDIAC; ONCOGENE PROTEIN V-AKT; PALMITATES; RATS; SIGNAL TRANSDUCTION;

EID: 84867234753     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-11-135     Document Type: Article

References (42)

1. Lipotoxic heart disease in obese rats: implications for human obesity. Zhou YT, Grayburn P, Karim A, Shimabukuro M, Higa M, Baetens D, Orci L, Unger RH, Proc Natl Acad Sci USA 2000 97 1784 1789 10.1073/pnas.97.4.1784 10677535
2. Apoptosis in myocytes in end-stage heart failure. Narula J, Haider N, Virmani R, DiSalvo TG, Kolodgie FD, Hajjar RJ, Schmidt U, Semigran MJ, Dec GW, Khaw BA, N Engl J Med 1996 335 1182 1189 10.1056/NEJM199610173351603 8815940
3. Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes. De Vries JE, Vork MM, Roemen TH, De Jong YF, Cleutjens JP, van der Vusse GJ, Van Bilsen M, J Lipid Res 1997 38 1384 1394 9254064
4. Palmitate-induced apoptosis can occur through a ceramide-independent pathway. Listenberger LL, Ory DS, Schaffer JE, J Biol Chem 2001 276 14890 14895 10.1074/jbc.M010286200 11278654
5. Palmitate-induced apoptosis in cardiomyocytes is mediated through alterations in mitochondria: prevention by cyclosporin A. Kong JY, Rabkin SW, Biochim Biophys Acta 2000 1485 45 55 10.1016/S1388-1981(00)00028-7 10802248
6. Targeting apoptosis in the heart of streptozotocin-induced diabetic rats. Baraka A, AbdelGawad H, J Cardiovasc Pharmacol Ther 2010 15 175 181 10.1177/1074248409356557 20133494
7. A novel serum protein similar to C1q, produced exclusively in adipocytes. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF, J Biol Chem 1995 270 26746 26749 10.1074/jbc.270.45.26746 7592907
8. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K, Biochem Biophys Res Commun 1996 221 286 289 10.1006/bbrc.1996.0587 8619847
9. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Fruebis J, Tsao TS, Javorschi S, Ebbets-Reed D, Erickson MR, Yen FT, Bihain BE, Lodish HF, Proc Natl Acad Sci USA 2001 98 2005 2010 10.1073/pnas.98.4.2005 11172066
10. Globular adiponectin, acting via AdipoR1/APPL1, protects H9c2 cells from hypoxia/reoxygenation-induced apoptosis. Park M, Youn B, Zheng XL, Wu D, Xu A, Sweeney G, PLoS One 2011 6 19143 10.1371/journal.pone.0019143 21552570
11. Adiponectin is synthesized and secreted by human and murine cardiomyocytes. Pineiro R, Iglesias MJ, Gallego R, Raghay K, Eiras S, Rubio J, Dieguez C, Gualillo O, Gonzalez-Juanatey JR, Lago F, FEBS Lett 2005 579 5163 5169 10.1016/j.febslet.2005.07.098 16140297
12. Adiponectin accumulates in myocardial tissue that has been damaged by ischemia-reperfusion injury via leakage from the vascular compartment. Shibata R, Sato K, Kumada M, Izumiya Y, Sonoda M, Kihara S, Ouchi N, Walsh K, Cardiovasc Res 2007 74 471 479 10.1016/j.cardiores.2007.02.010 17362898
13. Impaired expression of cardiac adiponectin in leptin-deficient mice with viral myocarditis. Takahashi T, Yu F, Saegusa S, Sumino H, Nakahashi T, Iwai K, Morimoto S, Kurabayashi M, Kanda T, Int Heart J 2006 47 107 123 10.1536/ihj.47.107 16479046
14. Adiponectin: an indispensable molecule in rosiglitazone cardioprotection following myocardial infarction. Tao L, Wang Y, Gao E, Zhang H, Yuan Y, Lau WB, Chan L, Koch WJ, Ma XL, Circ Res 2010 106 409 417 10.1161/CIRCRESAHA.109.211797 19940263
15. Adiponectin protects against doxorubicin-induced cardiomyopathy by anti-apoptotic effects through AMPK up-regulation. Konishi M, Haraguchi G, Ohigashi H, Ishihara T, Saito K, Nakano Y, Isobe M, Cardiovasc Res 2011 89 309 319 10.1093/cvr/cvq335 20978005
16. Intranuclear 3'-phosphoinositide metabolism and Akt signaling: new mechanisms for tumorigenesis and protection against apoptosis? Martelli AM, Faenza I, Billi AM, Manzoli L, Evangelisti C, Fala F, Cocco L, Cell Signal 2006 18 1101 1107 10.1016/j.cellsig.2006.01.011 16516442
17. ERK1/2 MAP kinases in cell survival and apoptosis. Lu Z, Xu S, IUBMB Life 2006 58 621 631 10.1080/15216540600957438 17085381
18. Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Shibata R, Sato K, Pimentel DR, Takemura Y, Kihara S, Ohashi K, Funahashi T, Ouchi N, Walsh K, Nat Med 2005 11 1096 1103 10.1038/nm1295 16155579
19. Adiponectin upregulates prolyl-4-hydroxylase alpha1 expression in interleukin 6-stimulated human aortic smooth muscle cells by regulating ERK 1/2 and Sp1. Li L, Zhang K, Cai XJ, Feng M, Zhang Y, Zhang M, PLoS One 2011 6 22819 10.1371/journal.pone.0022819 21829524
20. Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1. Cousin SP, Hugl SR, Wrede CE, Kajio H, Myers MG Jr, Rhodes CJ, Endocrinology 2001 142 229 240 10.1210/en.142.1.229 11145586
21. Caspases: killer proteases. Nicholson DW, Thornberry NA, Trends Biochem Sci 1997 22 299 306 10.1016/S0968-0004(97)01085-2 9270303
22. Failure of poly(ADP-ribose) polymerase cleavage by caspases leads to induction of necrosis and enhanced apoptosis. Herceg Z, Wang ZQ, Mol Cell Biol 1999 19 5124 5133 10373561
23. Globular and full-length forms of adiponectin mediate specific changes in glucose and fatty acid uptake and metabolism in cardiomyocytes. Palanivel R, Fang X, Park M, Eguchi M, Pallan S, De Girolamo S, Liu Y, Wang Y, Xu A, Sweeney G, Cardiovasc Res 2007 75 148 157 10.1016/j.cardiores.2007.04.011 17499232
24. Insulin activates epithelial sodium channel (ENaC) via phosphoinositide 3-kinase in mammalian taste receptor cells. Baquero AF, Gilbertson TA, Am J Physiol Cell Physiol 2011 300 860 C871 10.1152/ajpcell.00318.2010 21106690
25. Apoptosis induction by oxidized glycated LDL in human retinal capillary pericytes is independent of activation of MAPK signaling pathways. Diffley JM, Wu M, Sohn M, Song W, Hammad SM, Lyons TJ, Mol Vis 2009 15 135 145 19158958
26. Saturated with fat: new perspectives on lipotoxicity. Garbarino J, Sturley SL, Curr Opin Clin Nutr Metab Care 2009 12 110 116 10.1097/MCO. 0b013e32832182ee 19202381
27. A metabolic role for mitochondria in palmitate-induced cardiac myocyte apoptosis. Sparagna GC, Hickson-Bick DL, Buja LM, McMillin JB, Am J Physiol Heart Circ Physiol 2000 279 2124 H2132 11045945
28. Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update. Soldani C, Scovassi AI, Apoptosis 2002 7 321 328 10.1023/A:1016119328968 12101391
29. Inconsistent relation of MAPK activation to infarct size reduction by ischemic preconditioning in pigs. Behrends M, Schulz R, Post H, Alexandrov A, Belosjorow S, Michel MC, Heusch G, Am J Physiol Heart Circ Physiol 2000 279 1111 H1119 10993774
30. Usefulness of adiponectin to predict myocardial salvage following successful reperfusion in patients with acute myocardial infarction. Shibata R, Numaguchi Y, Matsushita K, Sone T, Kubota R, Ohashi T, Ishii M, Kihara S, Walsh K, Ouchi N, Murohara T, Am J Cardiol 2008 101 1712 1715 10.1016/j.amjcard.2008. 02.057 18549845
31. Plasma adiponectin levels and risk of myocardial infarction in men. Pischon T, Girman CJ, Hotamisligil GS, Rifai N, Hu FB, Rimm EB, JAMA 2004 291 1730 1737 10.1001/jama.291.14.1730 15082700
32. Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress. Tao L, Gao E, Jiao X, Yuan Y, Li S, Christopher TA, Lopez BL, Koch W, Chan L, Goldstein BJ, Ma XL, Circulation 2007 115 1408 1416 10.1161/CIRCULATIONAHA.106.666941 17339545
33. Adiponectin inhibits palmitate-induced apoptosis through suppression of reactive oxygen species in endothelial cells: involvement of cAMP/protein kinase A and AMP-activated protein kinase. Kim JE, Song SE, Kim YW, Kim JY, Park SC, Park YK, Baek SH, Lee IK, Park SY, J Endocrinol 2010 207 35 44 10.1677/JOE-10-0093 20675307
34. Full-length adiponectin protects hepatocytes from palmitate-induced apoptosis via inhibition of c-Jun NH2 terminal kinase. Jung TW, Lee YJ, Lee MW, Kim SM, FEBS J 2009 276 2278 2284 10.1111/j.1742-4658.2009.06955.x 19290887
35. Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion. Wijesekara N, Krishnamurthy M, Bhattacharjee A, Suhail A, Sweeney G, Wheeler MB, J Biol Chem 2010 285 33623 33631 10.1074/jbc.M109.085084 20709750
36. Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt. Matsui T, Rosenzweig A, J Mol Cell Cardiol 2005 38 63 71 10.1016/j.yjmcc.2004.11.005 15623422
37. Adiponectin protects against myocardial ischaemia-reperfusion injury via AMP-activated protein kinase, Akt, and nitric oxide. Gonon AT, Widegren U, Bulhak A, Salehzadeh F, Persson J, Sjoquist PO, Pernow J, Cardiovasc Res 2008 78 116 122 10.1093/cvr/cvn017 18222959
38. Adiponectin Ameliorates Doxorubicin-induced Cardiotoxicity through Akt Protein-dependent Mechanism. Maruyama S, Shibata R, Ohashi K, Ohashi T, Daida H, Walsh K, Murohara T, Ouchi N, J Biol Chem 2011 286 32790 32800 10.1074/jbc.M111.245985 21784858
39. ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes. Liu J, Mao W, Ding B, Liang CS, Am J Physiol Heart Circ Physiol 2008 295 1956 H1965 10.1152/ajpheart.00407.2008 18775851
40. Adiponectin-stimulated CXCL8 release in primary human hepatocytes is regulated by ERK1/ERK2, p38 MAPK, NF-kappaB, and STAT3 signaling pathways. Wanninger J, Neumeier M, Weigert J, Bauer S, Weiss TS, Schaffler A, Krempl C, Bleyl C, Aslanidis C, Scholmerich J, Buechler C, Am J Physiol Gastrointest Liver Physiol 2009 297 611 G618 10.1152/ajpgi.90644.2008 19608729
41. Adiponectin inhibits insulin-like growth factor-1-induced cell migration by the suppression of extracellular signal-regulated kinase 1/2 activation, but not Akt in vascular smooth muscle cells. Motobayashi Y, Izawa-Ishizawa Y, Ishizawa K, Orino S, Yamaguchi K, Kawazoe K, Hamano S, Tsuchiya K, Tomita S, Tamaki T, Hypertens Res 2009 32 188 193 10.1038/hr.2008.19 19262481
42. ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish. Ren B, Deng Y, Mukhopadhyay A, Lanahan AA, Zhuang ZW, Moodie KL, Mulligan-Kehoe MJ, Byzova TV, Peterson RT, Simons M, J Clin Invest 2010 120 1217 1228 10.1172/JCI39837 20237411