Elevated levels of RhoA in the optic nerve head of human eyes with glaucoma

Journal of Glaucoma

Volumn 21, Issue 8, 2012, Pages 530-538

  Goldhagen, Brian ^a   Proia, Alan D ^a   Epstein, David L ^a   Rao, Ponugoti Vasantha ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

glaucoma; optic nerve head; Rho GTPase; Rho kinase

Indexed keywords

POLYCLONAL ANTIBODY; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ADULT; AGED; ANTIBODY SPECIFICITY; AQUEOUS HUMOR OUTFLOW; CILIARY MUSCLE; CONTROLLED STUDY; FEMALE; GLAUCOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; OPTIC NERVE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVIEW; TRABECULAR MESHWORK;

AGED; AGED, 80 AND OVER; ANTERIOR EYE SEGMENT; AQUEOUS HUMOR; FEMALE; GLAUCOMA, OPEN-ANGLE; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; OPTIC DISK; OPTIC NERVE DISEASES; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; TISSUE DONORS;

EID: 84867229440     PISSN: 10570829     EISSN: 1536481X     Source Type: Journal    
DOI: 10.1097/IJG.0b013e318241b83c     Document Type: Review

References (25)

1. Weinreb RN, Khaw PT. Primary open-angle glaucoma. Lancet. 2004;363:1711-1720. (Pubitemid 38670330)
2. Gabelt BT, Kaufman PL. Changes in aqueous humor dynamics with age and glaucoma. Prog Retin Eye Res. 2005;24:612-637. (Pubitemid 40943663)
3. Jaffe AB, Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol. 2005;21:247-269.
4. Vittitow JL, Garg R, Rowlette LL, et al. Gene transfer of dominant-negative RhoA increases outflow facility in perfused human anterior segment cultures. Mol Vis. 2002;8:32-44. (Pubitemid 36153588)
5. Honjo M, Tanihara H, Inatani M, et al. Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility. Invest Ophthalmol Vis Sci. 2001;42:137-144. (Pubitemid 32059420)
6. Rao PV, Deng PF, Kumar J, et al. Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632. Invest Ophthalmol Vis Sci. 2001;42:1029-1037. (Pubitemid 32289800)
7. Zhang M, Maddala R, Rao PV. Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork. Am J Physiol Cell Physiol. 2008;295:C1057-C1070. (Pubitemid 352790316)
8. Mettu PS, Deng PF, Misra UK, et al. Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility. Invest Ophthalmol Vis Sci. 2004;45:2263-2271. (Pubitemid 38906709)
9. Pattabiraman PP, Rao PV. Mechanistic basis of Rho GTPaseinduced extracellular matrix synthesis in trabecular meshwork cells. Am J Physiol Cell Physiol. 2010;298:C749-C763.
10. Rao VP, Epstein DL. Rho GTPase/Rho kinase inhibition as a novel target for the treatment of glaucoma. BioDrugs. 2007;21:167-177. (Pubitemid 46827850)
11. Tanihara H, Inatani M, Honjo M, et al. Intraocular pressurelowering effects and safety of topical administration of a selective ROCK inhibitor, SNJ-1656, in healthy volunteers. Arch Ophthalmol. 2008;126:309-315. (Pubitemid 351398453)
12. Lukas TJ, Miao H, Chen L, et al. Susceptibility to glaucoma: differential comparison of the astrocyte transcriptome from glaucomatous African American and Caucasian American donors. Genome Biol. 2008;9:R111.
13. Bertrand J, Winton MJ, Rodriguez-Hernandez N, et al. Application of Rho antagonist to neuronal cell bodies promotes neurite growth in compartmented cultures and regeneration of retinal ganglion cell axons in the optic nerve of adult rats. J Neurosci. 2005;25:1113-1121. (Pubitemid 40268952)
14. Sagawa H, Terasaki H, Nakamura M, et al. A novel ROCK inhibitor, Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats. Exp Neurol. 2007;205:230-240. (Pubitemid 46617509)
15. Butnor KJ, Proia AD. Unexpected autopsy findings arising from postmortem ocular examination. Arch Pathol Lab Med. 2001;125:1193-1196. (Pubitemid 32845795)
16. Tian B, Gabelt BT, Geiger B, et al. The role of the actomyosin system in regulating trabecular fluid outflow. Exp Eye Res. 2009;88:713-717.
17. Nakajima E, Nakajima T, Minagawa Y, et al. Contribution of ROCK in contraction of trabecular meshwork: proposed mechanism for regulating aqueous outflow in monkey and human eyes. J Pharm Sci. 2005;94:701-708. (Pubitemid 40577304)
18. Kitaoka Y, Kumai T, Lam TT, et al. Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina. Brain Res. 2004;1018:111-118. (Pubitemid 38942868)
19. Tura A, Schuettauf F, Monnier PP, et al. Efficacy of Rhokinase inhibition in promoting cell survival and reducing reactive gliosis in the rodent retina. Invest Ophthalmol Vis Sci. 2009;50:452-461.
20. Balaratnasingam C, Morgan WH, Bass L, et al. Axonal transport and cytoskeletal changes in the laminar regions after elevated intraocular pressure. Invest Ophthalmol Vis Sci. 2007;48:3632-3644. (Pubitemid 351261099)
21. Hernandez MR, Pena JD. The optic nerve head in glaucomatous optic neuropathy. Arch Ophthalmol. 1997;115:389-395. (Pubitemid 27131307)
22. Morrison JC. Elevated intraocular pressure and optic nerve injury models in the rat. J Glaucoma. 2005;14:315-317. (Pubitemid 41023020)
23. Sheikh AM, Nagai A, Ryu JK, et al. Lysophosphatidylcholine induces glial cell activation: role of rho kinase. Glia. 2009;57:898-907.
24. Bertrand J, Di Polo A, McKerracher L. Enhanced survival and regeneration of axotomized retinal neurons by repeated delivery of cell-permeable C3-like Rho antagonists. Neurobiol Dis. 2007;25:65-72. (Pubitemid 44773793)
25. Hinton DR, Sadun AA, Blanks JC, et al. Optic-nerve degeneration in Alzheimer's disease. N Engl J Med. 1986; 315:485-487. (Pubitemid 16034149)