Dysregulated immunophenotypic attributes of plasmacytoid but not myeloid dendritic cells in HIV-1 infected individuals in the absence of highly active anti-retroviral therapy

Clinical and Experimental Immunology

Volumn 170, Issue 2, 2012, Pages 212-221

  Benlahrech, A ^a   Yasmin, A ^a   Westrop, S J ^a   Coleman, A ^a   Herasimtschuk, A ^a   Page, E ^a   Kelleher, P ^a   Gotch, F ^a   Imami, N ^a   Patterson, S ^a  

^a CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

Author keywords

HIV 1; ILT 7; MDC; PD L1; PDC

Indexed keywords

ALPHA INTERFERON; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; B7 ANTIGEN; CD83 ANTIGEN; CD86 ANTIGEN; IMMUNOGLOBULIN LIKE TRANSCRIPT 3; IMMUNOGLOBULIN LIKE TRANSCRIPT 4; INFERON ALPHA INHIBITORY RECEPTOR 7; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 LIGAND 2; UNCLASSIFIED DRUG;

ADULT; APOPTOSIS; ARTICLE; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; DOWN REGULATION; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNOPHENOTYPING; IMMUNOREGULATION; MALE; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; VIREMIA; VIRUS LOAD;

ADULT; ANTIGENS, CD; ANTIGENS, CD274; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; COHORT STUDIES; DENDRITIC CELLS; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; IMMUNOPHENOTYPING; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MYELOID CELLS; PROGRAMMED CELL DEATH 1 RECEPTOR; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; VIREMIA; YOUNG ADULT;

EID: 84867212616     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2012.04647.x     Document Type: Article

References (49)

1. Banchereau J, Briere F, Caux C etal. Immunobiology of dendritic cells. Annu Rev Immunol 2000; 18:767-811.
2. Palucka K, Banchereau J, Mellman I. Designing vaccines based on biology of human dendritic cell subsets. Immunity 2010; 33:464-78.
3. Steinman RM. Lasker Basic Medical Research Award. Dendritic cells: versatile controllers of the immune system. Nat Med 2007; 13:1155-9.
4. Grouard G, Rissoan MC, Filgueira L etal. The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J Exp Med 1997; 185:1101-11.
5. Robinson SP, Patterson S, English N etal. Human peripheral blood contains two distinct lineages of dendritic cells. Eur J Immunol 1999; 29:2769-78.
6. Ito T, Inaba M, Inaba K etal. A CD1a+/CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells. J Immunol 1999; 163:1409-19.
7. Li Q, Estes JD, Schlievert PM etal. Glycerol monolaurate prevents mucosal SIV transmission. Nature 2009; 458:1034-8.
8. Cella M, Jarrossay D, Facchetti F etal. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat Med 1999; 5:919-23.
9. Fitzgerald-Bocarsly P, Jacobs ES. Plasmacytoid dendritic cells in HIV infection: striking a delicate balance. J Leukoc Biol 2010; 87:609-20.
10. Reizis B, Bunin A, Ghosh HS, Lewis KL, Sisirak V. Plasmacytoid dendritic cells: recent progress and open questions. Annu Rev Immunol 2011; 23:163-83.
11. Liu YJ, Kanzler H, Soumelis V, Gilliet M. Dendritic cell lineage, plasticity and cross-regulation. Nat Immunol 2001; 2:585-9.
12. Patterson S, Rae A, Hockey N, Gilmour J, Gotch F. Plasmacytoid dendritic cells are highly susceptible to human immunodeficiency virus type 1 infection and release infectious virus. J Virol 2001; 75:6710-3.
13. Lore K, Smed-Sorensen A, Vasudevan J, Mascola JR, Koup RA. Myeloid and plasmacytoid dendritic cells transfer HIV-1 preferentially to antigen-specific CD4+ T cells. J Exp Med 2005; 201:2023-33.
14. Barron MA, Blyveis N, Palmer BE, MaWhinney S, Wilson CC. Influence of plasma viremia on defects in number and immunophenotype of blood dendritic cell subsets in human immunodeficiency virus 1-infected individuals. J Infect Dis 2003; 187:26-37.
15. Benlahrech A, Gotch F, Kelleher P, Patterson S. Loss of NK stimulatory capacity by plasmacytoid and monocyte-derived DC but not myeloid DC in HIV-1 infected patients. PLoS ONE 2011; 6:e17525.
16. Chehimi J, Azzoni L, Farabaugh M etal. Baseline viral load and immune activation determine the extent of reconstitution of innate immune effectors in HIV-1-infected subjects undergoing antiretroviral treatment. J Immunol 2007; 179:2642-50.
17. Donaghy H, Pozniak A, Gazzard B etal. Loss of blood CD11c(+) myeloid and CD11c(-) plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load. Blood 2001; 98:2574-6.
18. Lichtner M, Rossi R, Rizza MC etal. Plasmacytoid dendritic cells count in antiretroviral-treated patients is predictive of HIV load control independent of CD4+ T-cell count. Curr HIV Res 2008; 6:19-27.
19. Brown KN, Trichel A, Barratt-Boyes SM. Parallel loss of myeloid and plasmacytoid dendritic cells from blood and lymphoid tissue in simian AIDS. J Immunol 2007; 178:6958-67.
20. Donaghy H, Gazzard B, Gotch F, Patterson S. Dysfunction and infection of freshly isolated blood myeloid and plasmacytoid dendritic cells in patients infected with HIV-1. Blood 2003; 101:4505-11.
21. Boasso A, Shearer GM. Chronic innate immune activation as a cause of HIV-1 immunopathogenesis. Clin Immunol 2008; 126:235-42.
22. Mojumdar K, Vajpayee M, Chauhan NK, Mendiratta S, Wig N. Defects in blood dendritic cell subsets in HIV-1 subtype c infected Indians. Indian J Med Res 2010; 132:318-27.
23. Wang X, Zhang Z, Zhang S etal. B7-H1 up-regulation impairs myeloid DC and correlates with disease progression in chronic HIV-1 infection. Eur J Immunol 2008; 38:3226-36.
24. Day CL, Kaufmann DE, Kiepiela P etal. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 2006; 443:350-4.
25. Rosignoli G, Lim CH, Bower M, Gotch F, Imami N. Programmed death (PD)-1 molecule and its ligand PD-L1 distribution among memory CD4 and CD8 T cell subsets in human immunodeficiency virus-1-infected individuals. Clin Exp Immunol 2009; 157:90-7.
26. Trautmann L, Janbazian L, Chomont N etal. Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nat Med 2006; 12:1198-202.
27. Keir ME, Butte MJ, Freeman GJ, Sharpe AH. PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol 2008; 26:677-704.
28. Krathwohl MD, Schacker TW, Anderson JL. Abnormal presence of semimature dendritic cells that induce regulatory T cells in HIV-infected subjects. J Infect Dis 2006; 193:494-504.
29. Lim A, Tan D, Price P etal. Proportions of circulating T cells with a regulatory cell phenotype increase with HIV-associated immune activation and remain high on antiretroviral therapy. AIDS 2007; 21:1525-34.
30. Tsunemi S, Iwasaki T, Imado T etal. Relationship of CD4+CD25+ regulatory T cells to immune status in HIV-infected patients. AIDS 2005; 19:879-86.
31. Chang CC, Ciubotariu R, Manavalan JS etal. Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. Nat Immunol 2002; 3:237-43.
32. Manavalan JS, Rossi PC, Vlad G etal. High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells. Transpl Immunol 2003; 11:245-58.
33. Vlad G, Chang CC, Colovai AI etal. Immunoglobulin-like transcript 3: a crucial regulator of dendritic cell function. Hum Immunol 2009; 70:340-4.
34. Cao W, Bover L, Cho M etal. Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. J Exp Med 2009; 206:1603-14.
35. Cao W, Bover L. Signaling and ligand interaction of ILT7: receptor-mediated regulatory mechanisms for plasmacytoid dendritic cells. Immunol Rev 2010; 234:163-76.
36. Imami N, Pires A, Hardy G etal. A balanced type 1/type 2 response is associated with long-term nonprogressive human immunodeficiency virus type 1 infection. J Virol 2002; 76:9011-23.
37. Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev 2010; 236:219-42.
38. Ju XS, Hacker C, Scherer B etal. Immunoglobulin-like transcripts ILT2, ILT3 and ILT7 are expressed by human dendritic cells and down-regulated following activation. Gene 2004; 28:159-64.
39. Cao W, Rosen DB, Ito T etal. Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production. J Exp Med 2006; 203:1399-405.
40. Gougeon ML, Lecoeur H, Dulioust A etal. Programmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression. J Immunol 1996; 156:3509-20.
41. Massanella M, Negredo E, Perez-Alvarez N etal. CD4 T-cell hyperactivation and susceptibility to cell death determine poor CD4 T-cell recovery during suppressive HAART. AIDS 2010; 24:959-68.
42. Pantaleo G, Fauci AS. New concepts in the immunopathogenesis of HIV infection. Annu Rev Immunol 1995; 13:487-512.
43. Trabattoni D, Saresella M, Biasin M etal. B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. Blood 2003; 101:2514-20.
44. Benedict CA, Loewendorf A, Garcia Z, Blazar BR, Janssen EM. Dendritic cell programming by cytomegalovirus stunts naive T cell responses via the PD-L1/PD-1 pathway. J Immunol 2008; 180:4836-47.
45. Goldberg MV, Maris CH, Hipkiss EL etal. Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells. Blood 2007; 110:186-92.
46. Boasso A, Royle CM, Doumazos S etal. Overactivation of plasmacytoid dendritic cells inhibits antiviral T-cell responses: a model for HIV immunopathogenesis. Blood 2011; 118:5152-62.
47. Youngnak P, Kozono Y, Kozono H etal. Differential binding properties of B7-H1 and B7-DC to programmed death-1. Biochem Biophys Res Commun 2003; 307:672-7.
48. Xu H, Wang X, Pahar B etal. Increased B7-H1 expression on dendritic cells correlates with programmed death 1 expression on T cells in simian immunodeficiency virus-infected macaques and may contribute to T cell dysfunction and disease progression. J Immunol 2010; 185:7340-8.
49. Lehmann C, Lafferty M, Garzino-Demo A etal. Plasmacytoid dendritic cells accumulate and secrete interferon alpha in lymph nodes of HIV-1 patients. PLoS ONE 2010; 5:e11110.