The coffee diterpene kahweol prevents osteoclastogenesis via impairment of NFATc1 expression and blocking of Erk phosphorylation

Journal of Pharmacological Sciences

Volumn 118, Issue 4, 2012, Pages 479-486

  Fumimoto, Reiko ^a   Sakai, Eiko ^a   Yamaguchi, Yu ^a   Sakamoto, Hiroshi ^a   Fukuma, Yutaka ^a   Nishishita, Kazuhisa ^a   Okamoto, Kuniaki ^a   Tsukuba, Takayuki ^a  

^a NAGASAKI UNIVERSITY   (Japan)

Author keywords

Extracellular signal regulated kinase (Erk); Kahweol; Nuclear factor of activated T cells cytoplasmic 1 (NFATc1); Osteoclast; Receptor activator of nuclear factor kappa B ligand (RANKL)

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; KAHWEOL; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOCLAST DIFFERENTIATION FACTOR; OXYGENASE; OXYGENASE 1; PHOSPHATASE; PROTEIN NFATC1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL ACTIVITY; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; DRUG STRUCTURE; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 84867207752     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.11212FP     Document Type: Article

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