Transcriptional response of bronchial epithelial cells to Pseudomonas aeruginosa: Identification of early mediators of host defense

Physiological Genomics

Volumn 21, Issue , 2005, Pages 324-336

  Vos, Joost B ^a   Van Sterkenburg, Marianne A ^a   Rabe, Klaus F ^a   Schalkwijk, Joost ^b   Hiemstra, Pieter S ^a   Datson, Nicole A ^c  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Airway inflammation; Innate immunity; Primary bronchial epithelial cells; Secretory leukocyte proteinase inhibitor; Serial analysis of gene expression

Indexed keywords

CALCIUM BINDING PROTEIN; CYTOKINE; ELAFIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 1F9; KERATIN; PROTEIN S 100; PROTEIN S100 A8; PROTEIN S100 A9; PROTEINASE INHIBITOR; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AIRWAY; ANTIMICROBIAL ACTIVITY; ARTICLE; BRONCHUS MUCOSA; CALCIUM BINDING; CELL ACTIVITY; CELL CULTURE; CONTROLLED STUDY; CYTOSKELETON; EPITHELIUM CELL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HOST RESISTANCE; HUMAN; HUMAN CELL; INFLAMMATION; INNATE IMMUNITY; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; REAL TIME POLYMERASE CHAIN REACTION; SERIAL ANALYSIS OF GENE EXPRESSION; TRANSCRIPTION REGULATION;

BRONCHI; CELL CULTURE TECHNIQUES; CELLS, CULTURED; DATABASES, NUCLEIC ACID; DNA PRIMERS; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; INTERLEUKIN-1; POLYMERASE CHAIN REACTION; PSEUDOMONAS AERUGINOSA; RESPIRATORY MUCOSA; RNA; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

PSEUDOMONAS AERUGINOSA;

EID: 21244442629     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00289.2004     Document Type: Article

References (61)

1. Arend WP. The balance between IL-1 and IL-1Ra in disease. Cytokine Growth Factor Rev 13: 323-340, 2002.
2. Ashcroft GS, Lei K, Jin W, Longenecker G, Kulkarni AB, Greenwell-Wild T, Hale-Donze H, McGrady G, Song XY, and Wahl SM. Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing. Nat Med 6: 1147-1153, 2000.
3. Bals R and Hiemstra PS. Innate immunity in the lung: how epithelial cells fight against respiratory pathogens. Eur Respir J 23: 327-333, 2004.
4. Bals R, Wang X, Wu Z, Freeman T, Bafna V, Zasloff M, and Wilson JM. Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J Clin Invest 102: 874-880, 1998.
5. Belcher CE, Drenkow J, Kehoe B, Gingeras TR, McNamara N, Lemjabbar H, Basbaum C, and Relman DA. The transcriptional responses of respiratory epithelial cells to Bordetella pertussis reveal host defensive and pathogen counter-defensive strategies. Proc Natl Acad Sci USA 91: 13847-13852, 2000.
6. Boon K, Osorio EC, Greenhut SF, Schaefer CF, Shoemaker J, Polyak K, Morin PJ, Buetow KH, Strausberg RL, De Souza SJ, and Riggins GJ. An anatomy of normal and malignant gene expression. Proc Natl Acad Sci USA 99: 11287-11292, 2002.
7. Breen EC and Tang K. Calcyclin (S100A6) regulates pulmonary fibroblast proliferation, morphology, and cytoskeletal organization in vitro. J Cell Biochem 88: 848-854, 2003.
8. 2+-binding S100 proteins. Histol Histopathol 16: 707-712, 2001.
9. Chen J, Lee S, Zhou G, and Wang SM. High-throughput GLGI procedure for converting a large number of serial analysis of gene expression tag sequences into 3′ complementary DNAs. Genes Chromosomes Cancer 33: 252-261, 2002.
10. Chen JJ, Rowley JD, and Wang SM. Generation of longer cDNA fragments from serial analysis of gene expression tags for gene identification. Proc Natl Acad Sci USA 97: 349-353, 2000.
11. Clohessy PA and Golden BE. Calprotectin-mediated zinc chelation as a biostatic mechanism in host defence. Scand J Immunol 42: 551-556, 1995.
12. Datson NA, van der Perk J, de Kloet ER, and Vreugdenhil E. Expression profile of 30,000 genes in rat hippocampus using SAGE. Hippocampus 11: 430-444, 2001.
13. Datson NA, van der Perk J, de Kloet ER, and Vreugdenhil E. Identification of corticosteroid-responsive genes in rat hippocampus using serial analysis of gene expression. Eur J Neurosci 14: 675-689, 2001.
14. Debets R, Timans JC, Homey B, Zurawski S, Sana TR, Lo S, Wagner J, Edwards G, Clifford T, Menon S, Bazan JF, and Kastelein RA. Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. J Immunol 167: 1440-1446, 2001.
15. Dinarello CA. Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist. Int Rev Immunol 16: 457-499, 1998.
16. Donato R. Intracellular and extracellular roles of S100 proteins. Microsc Res Tech 60: 540-551, 2003.
17. Edgar R, Domrachev M, and Lash AE. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 30: 207-210, 2002.
18. Feng G, Xu X, Youssef EM, and Lotan R. Diminished expression of S100A2, a putative tumor suppressor, at early stage of human lung carcinogenesis. Cancer Res 61: 7999-8004, 2001.
19. Ganz T. Antimicrobial polypeptides. J Leukoc Biol 75: 34-38, 2004.
20. Geiss GK, Bumgarner RE, An MC, Agy MB, van't Wout AB, Hammersmark E, Carter VS, Upchurch D, Mullins JI, and Katze MG. Large-scale monitoring of host cell gene expression during HIV-1 infection using cDNA microarrays. Virology 266: 8-16, 2000.
21. Hertz CJ, Wu Q, Porter EM, Zhang YJ, Weismuller KH, Godowski PJ, Ganz T, Randell SH, and Modlin RL. Activation of toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2. J Immunol 171: 6820-6826, 2003.
22. Hiemstra PS, van den Barselaar MT, Roest M, Nibbering PH, and van Furth R. Ubiquicidin, a novel murine microbicidal protein present in the cytosolic fraction of macrophages. J Leukoc Biol 66: 423-428, 1999.
23. Hough CD, Cho KR, Zonderman AB, Schwartz DR, and Morin PJ. Coordinately up-regulated genes in ovarian cancer. Cancer Res 61: 3869-3876, 2001.
24. Ichikawa JK, Norris A, Bangera MG, Geiss GK, van't Wout AB, Bumgarner RE, and Lory S. Interaction of pseudomonas aeruginosa with epithelial cells: identification of differentially regulated genes by expression microarray analysis of human cDNAs. Proc Natl Acad Sci USA 97: 9659-9664, 2000.
25. Ingman M, Kaessmann H, Paabo S, and Gyllensten U. Mitochondrial genome variation and the origin of modern humans. Nature 408: 708-713, 2000.
26. Ishida-Yamamoto A, McGrath JA, Chapman SJ, Leigh IM, Lane EB, and Eady RA. Epidermolysis bullosa simplex (Dowling-Meara type) is a genetic disease characterized by an abnormal keratin-filament network involving keratins K5 and K14. J Invest Dermatol 97: 959-968, 1991.
27. Ishii M, Hashimoto S, Tsutsumi S, Wada Y, Matsushima K, Kodama T, and Aburatani H. Direct comparison of GeneChip and SAGE on the quantitative accuracy in transcript profiling analysis. Genomics 68: 136-143, 2000.
28. Jansen BJ, van Ruissen F, de Jongh G, Zeeuwen PL, and Schalkwijk J. Serial analysis of gene expression in differentiated cultures of human epidermal keratinocytes. J Invest Dermatol 116: 12-22, 2001.
29. Kirfel J, Magin TM, and Reichelt J. Keratins: a structural scaffold with emerging functions. Cell Mol Life Sci 60: 56-71, 2003.
30. Lash AE, Tolstoshev CM, Wagner L, Schuler GD, Strausberg RL, Riggins GJ, and Altschul SF. SAGEmap: a public gene expression resource. Genome Res 10: 1051-1060, 2000.
31. Liu D, Rudland PS, Sibson DR, Platt-Higgins A, and Barraclough R. Expression of calcium-binding protein S100A2 in breast lesions. Br J Cancer 83: 1473-1479, 2000.
32. Liu L, Roberts AA, and Ganz T. By IL-1 signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharide. J Immunol 170: 575-580, 2003.
33. Loomans HJ, Hahn BL, Li QQ, Phadnis SH, and Sohnle PG. Histidine-based zinc-binding sequences and the antimicrobial activity of calprotectin. J Infect Dis 177: 812-814, 1998.
34. Maelandsmo GM, Florenes VA, Mellingsaeter T, Hovig E, Kerbel RS, and Fodstad O. Differential expression patterns of S100A2, S100A4 and S100A6 during progression of human malignant melanoma. Int J Cancer 74: 464-469, 1997.
35. McGowan K and Coulombe PA. The wound repair-associated keratins 6, 16, and 17. Insights into the role of intermediate filaments in specifying keratinocyte cytoarchitecture. Subcell Biochem 31: 173-204, 1998.
36. Moll R, Franke WW, Schiller DL, Geiger B, and Krepler R. The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell 31: 11-24, 1982.
37. Nacht M, Dracheva T, Gao Y, Fujii T, Chen Y, Player A, Akmaev V, Cook B, Dufault M, Zhang M, Zhang W, Guo M, Curran J, Han S, Sidransky D, Buetow K, Madden SL, and Jen J. Molecular characteristics of non-small cell lung cancer. Proc Natl Acad Sci USA 98: 15203-15208, 2001.
38. Nacht M, Ferguson AT, Zhang W, Petroziello JM, Cook BP, Gao YH, Maguire S, Riley D, Coppola G, Landes GM, Madden SL, and Sukumar S. Combining serial analysis of gene expression and array technologies to identify genes differentially expressed in breast cancer. Cancer Res 59: 5464-5470, 1999.
39. Nacken W, Roth J, Sorg C, and Kerkhoff C. S100A9/S100A8: myeloid representatives of the S100 protein family as prominent players in innate immunity. Microsc Res Tech 60: 569-580, 2003.
40. Nagy N, Brenner C, Markadieu N, Chaboteaux C, Camby I, Schafer BW, Pochet R, Heizmann CW, Salmon I, Kiss R, and Decaestecker C. S100A2, a putative tumor suppressor gene, regulates in vitro squamous cell carcinoma migration. Lab Invest 81: 599-612, 2001.
41. Pfundt R, van Ruissen F, Vlijmen-Willems IM, Alkemade HA, Zeeuwen PL, Jap PH, Dijkman H, Fransen J, Croes H, van Erp PE, and Schalkwijk J. Constitutive and inducible expression of SKALP/elafin provides anti-elastase defense in human epithelia. J Clin Invest 98: 1389-1399, 1996.
42. Sallenave JM. Antimicrobial activity of antiproteinases. Biochem Soc Trans 30: 111-115, 2002.
43. 2+-binding S100 proteins in epithelial tumours of the skin. Virchows Arch 432: 53-59, 1998.
44. Silva AP, De Souza JE, Galante PA, Riggins GJ, De Souza SJ, and Camargo AA. The impact of SNPs on the interpretation of SAGE and MPSS experimental data. Nucleic Acids Res 32: 6104-6110, 2004.
45. Simpson AJ, Wallace WAH, Marsden ME, Govan JRW, Porteous DJ, Haslett C, and Sallenave JM. Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection. J Immunol 167: 1778-1786, 2001.
46. Simpson DA, Feeney S, Boyle C, and Stitt AW. Retinal VEGF mRNA measured by SYBR green I fluorescence: a versatile approach to quantitative PCR. Mol Vis 6:178-183: 178-183, 2000.
47. Stockley RA, Dale I, Hill SL, and Fagerhol MK. Relationship of neutrophil cytoplasmic protein (L1) to acute and chronic lung disease. Scand J Clin Lab Invest 44: 629-634, 1984.
48. Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu Rev Immunol 21: 335-376, 2003.
49. Tibble J, Teahon K, Thjodleifsson B, Roseth A, Sigthorsson G, Bridger S, Foster R, Sherwood R, Fagerhol M, and Bjarnason I. A simple method for assessing intestinal inflammation in Crohn's disease. Gut 47: 506-513, 2000.
50. Towne JE, Garka KE, Renshaw BR, Virca GD, and Sims JE. Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-κB and MAPKs. J Biol Chem 279: 13677-13688, 2004.
51. Travis SM, Singh PK, and Welsh MJ. Antimicrobial peptides and proteins in the innate defense of the airway surface. Curr Opin Immunol 13: 89-95, 2001.
52. Tsutsumi-Ishii Y and Nagaoka I. Modulation of human beta-defensin-2 transcription in pulmonary epithelial cells by lipopolysaccharide-stimulated mononuclear phagocytes via proinflammatory cytokine production. J Immunol 170: 4226-4236, 2003.
53. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, and Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3: RESEARCH0034, 2002.
54. van Wetering S, van der Linden AC, van Sterkenburg MA, de Boer WI, Kuijpers AL, Schalkwijk J, and Hiemstra PS. Regulation of SLPI and elafin release from bronchial epithelial cells by neutrophil defensins. Am J Physiol Lung Cell Mol Physiol 278: L51-L58, 2000.
55. Velculescu VE, Zhang L, Vogelstein B, and Kinzler KW. Serial analysis of gene expression. Science 270: 484-487, 1995.
56. Velculescu VE, Zhang L, Zhou W, Vogalstein J, Basrai MA, Bassett DE Jr, Hieter P, Vogelstein B, and Kinzler KW. Characterization of the yeast transcriptome. Cell 88: 243-251, 1937.
57. Wiedow O, Harder J, Bartels J, Streit V, and Christophers E. Antileukoprotease in human skin: an antibiotic peptide constitutively produced by keratinocytes. Biochem Biophys Res Commun 248: 904-909, 1998.
58. Zeeberg BR, Feng W, Wang G, Wang MD, Fojo AT, Sunshine M, Narasimhan S, Kane DW, Reinhold WC, Lababidi S, Bussey KJ, Riss J, Barrett JC, and Weinstein JN. GoMiner: a resource for biological interpretation of genomic and proteomic data. Genome Biol 4: R28, 2003.
59. Zeeuwen PL, Vlijmen-Willems IM, Jansen BJ, Sotiropoulou G, Curfs JH, Meis JF, Janssen JJ, van Ruissen F, and Schalkwijk J. Cystatin M/E expression is restricted to differentiated epidermal keratinocytes and sweat glands: a new skin-specific proteinase inhibitor that is a target for cross-linking by transglutaminase. J Invest Dermatol 116: 693-701, 2001.
60. Zeeuwen PL, Vlijmen-Willems IM, Olthuis D, Johansen HT, Hitomi K, Hara-Nishimura I, Powers JC, James KE, Op Den Camp HJ, Lemmens R, and Schalkwijk J. Evidence that unrestricted legumain activity is involved in disturbed epidermal cornification in cystatin M/E deficient mice. Hum Mol Genet 13: 1069-1079, 2004.
61. Zhang T, Woods TL, and Elder JT. Differential responses of S100A2 to oxidative stress and increased intracellular calcium in normal, immortalized, and malignant human keratinocytes. J Invest Dermatol 119: 1196-1201, 2002.