The Nuclear Receptor NR4A1 Induces a Form of Cell Death Dependent on Autophagy in Mammalian Cells

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Bouzas Rodríguez, Jimena ^a   Zárraga Granados, Gabriela ^a   de Sánchez Carbente, Marial Rayo ^a   Rodríguez Valentín, Rocío ^a   Gracida, Xicotencatl ^a   Anell Rendón, Dámaris ^a   Covarrubias, Luis ^a   Castro Obregón, Susana ^a  

^a INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

BECLIN 1; CASPASE INHIBITOR; CELL PROTEIN; NEUROKININ 1 RECEPTOR; NUCLEAR RECEPTOR NUR77; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN ATG7; PROTEIN P53; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL STRAIN HEK293; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; ELECTRON MICROSCOPY; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOELECTRON MICROSCOPY; IMMUNOFLUORESCENCE; MAMMAL CELL; NUCLEOTIDE SEQUENCE; PLASMID; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

AUTOPHAGY; CASPASE INHIBITORS; CELL DEATH; HEK293 CELLS; HUMANS; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 1; RECEPTOR, IGF TYPE 1;

MAMMALIA;

EID: 84867170076     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046422     Document Type: Article

References (51)

1. Wingate AD, Arthur JS, (2006) Post-translational control of Nur77. Biochem Soc Trans 34: 1107-1109.
2. Wu Q, Liu S, Ye XF, Huang ZW, Su WJ, (2002) Dual roles of Nur77 in selective regulation of apoptosis and cell cycle by TPA and ATRA in gastric cancer cells. Carcinogenesis 23: 1583-1592.
3. Winoto A, Littman DR, (2002) Nuclear hormone receptors in T lymphocytes. Cell 109 Suppl: S57-66.
4. Kim SO, Ono K, Tobias PS, Han J, (2003) Orphan nuclear receptor Nur77 is involved in caspase-independent macrophage cell death. J Exp Med 197: 1441-1452.
5. Liu W, Youn HD, Liu JO, (2001) Thapsigargin-induced apoptosis involves Cabin1-MEF2-mediated induction of Nur77. Eur J Immunol 31: 1757-1764.
6. Bras A, Albar JP, Leonardo E, de Buitrago GG, Martinez AC, (2000) Ceramide-induced cell death is independent of the Fas/Fas ligand pathway and is prevented by Nur77 overexpression in A20 B cells. Cell Death Differ 7: 262-271.
7. Suzuki S, Suzuki N, Mirtsos C, Horacek T, Lye E, et al. (2003) Nur77 as a survival factor in tumor necrosis factor signaling. Proc Natl Acad Sci U S A 100: 8276-8280.
8. Schweichel JU, Merker HJ, (1973) The morphology of various types of cell death in prenatal tissues. Teratology 7: 253-266.
9. Clarke PG, (1990) Developmental cell death: morphological diversity and multiple mechanisms. Anat Embryol 181: 195-213.
10. Bredesen DE, (2007) Key note lecture: toward a mechanistic taxonomy for cell death programs. Stroke 38: 652-660.
11. Honarpour N, Du C, Richardson JA, Hammer RE, Wang X, et al. (2000) Adult Apaf-1-deficient mice exhibit male infertility. Dev Biol 218: 248-258.
12. Blum ES, Abraham MC, Yoshimura S, Lu Y, Shaham S, (2012) Control of nonapoptotic developmental cell death in Caenorhabditis elegans by a polyglutamine-repeat protein. Science 335: 970-973.
13. Berry DL, Baehrecke EH, (2007) Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. Cell 131: 1137-1148.
14. Denton D, Shravage B, Simin R, Mills K, Berry DL, et al. (2009) Autophagy, not apoptosis, is essential for midgut cell death in Drosophila. Curr Biol 19: 1741-1746.
15. Mizushima N, Levine B, Cuervo AM, Klionsky DJ, (2008) Autophagy fights disease through cellular self-digestion. Nature 451: 1069-1075.
16. Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, et al. (2006) Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441: 880-884.
17. Yu L, Alva A, Su H, Dutt P, Freundt E, et al. (2004) Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 304: 1500-1502.
18. Castro-Obregon S, Del Rio G, Chen SF, Swanson RA, Frankowski H, et al. (2002) A ligand-receptor pair that triggers a non-apoptotic form of programmed cell death. Cell Death Differ 9: 807-817.
19. Quartara L, Maggi CA, (1998) The tachykinin NK1 receptor. Part II: Distribution and pathophysiological roles. Neuropeptides 32: 1-49.
20. Castro-Obregon S, Rao RV, del Rio G, Chen SF, Poksay KS, et al. (2004) Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77. J Biol Chem 279: 17543-17553.
21. Slagsvold HH, Ostvold AC, Fallgren AB, Paulsen RE, (2002) Nuclear receptor and apoptosis initiator NGFI-B is a substrate for kinase ERK2. Biochem Biophys Res Commun 291: 1146-1150.
22. Honkaniemi J, Sharp FR, (1999) Prolonged expression of zinc finger immediate-early gene mRNAs and decreased protein synthesis following kainic acid induced seizures. Eur J Neurosci 11: 10-17.
23. Walton M, Connor B, Lawlor P, Young D, Sirimanne E, et al. (1999) Neuronal death and survival in two models of hypoxic-ischemic brain damage. Brain Res Brain Res Rev 29: 137-168.
24. Liu H, Cao Y, Basbaum AI, Mazarati AM, Sankar R, et al. (1999) Resistance to excitotoxin-induced seizures and neuronal death in mice lacking the preprotachykinin A gene. Proc Natl Acad Sci U S A 96: 12096-12101.
25. Yu Z, Cheng G, Huang X, Li K, Cao X, (1997) Neurokinin-1 receptor antagonist SR140333: a novel type of drug to treat cerebral ischemia. Neuroreport 8: 2117-2119.
26. Zachrisson O, Lindefors N, Brene S, (1998) A tachykinin NK1 receptor antagonist, CP-122,721-1, attenuates kainic acid-induced seizure activity. Brain Res Mol Brain Res 60: 291-295.
27. Sperandio S, de Belle I, Bredesen DE, (2000) An alternative, non-apoptotic form of programmed cell death. Proc Natl Acad Sci U S A 97: 14376-14381.
28. Sperandio S, Poksay K, de Belle I, Lafuente MJ, Liu B, et al. (2004) Paraptosis: mediation by MAP kinases and inhibition by AIP-1/Alix. Cell Death Differ 11: 1066-1075.
29. Puglielli L, (2008) Aging of the brain, neurotrophin signaling, and Alzheimer's disease: is IGF1-R the common culprit? Neurobiol Aging 29: 795-811.
30. Sui X, Jin L, Huang X, Geng S, He C, et al. (2011) p53 signaling and autophagy in cancer: a revolutionary strategy could be developed for cancer treatment. Autophagy 7: 565-571.
31. Li H, Kolluri SK, Gu J, Dawson MI, Cao X, et al. (2000) Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science 289: 1159-1164.
32. Liang B, Song X, Liu G, Li R, Xie J, et al. (2007) Involvement of TR3/Nur77 translocation to the endoplasmic reticulum in ER stress-induced apoptosis. Exp Cell Res 313: 2833-2844.
33. Lin B, Kolluri SK, Lin F, Liu W, Han YH, et al. (2004) Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell 116: 527-540.
34. Gozuacik D, Kimchi A, (2007) Autophagy and cell death. Curr Top Dev Biol 78: 217-245.
35. Mizushima N, Yoshimori T, Levine B, (2010) Methods in mammalian autophagy research. Cell 140: 313-326.
36. Zoncu R, Efeyan A, Sabatini DM, (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12: 21-35.
37. Liu J, Xia H, Kim M, Xu L, Li Y, et al. (2011) Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 147: 223-234.
38. Maiuri MC, Le Toumelin G, Criollo A, Rain JC, Gautier F, et al. (2007) Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. Embo J 26: 2527-2539.
39. Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, et al. (2007) The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res 67: 3043-3053.
40. Crighton D, Wilkinson S, O'Prey J, Syed N, Smith P, et al. (2006) DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 126: 121-134.
41. Xu Y, Kim SO, Li Y, Han J, (2006) Autophagy contributes to caspase-independent macrophage cell death. J Biol Chem 281: 19179-19187.
42. Christofferson DE, Yuan J, (2010) Necroptosis as an alternative form of programmed cell death. Curr Opin Cell Biol 22: 263-268.
43. Yu L, Wan F, Dutta S, Welsh S, Liu Z, et al. (2006) Autophagic programmed cell death by selective catalase degradation. Proc Natl Acad Sci U S A 103: 4952-4957.
44. Gomes LC, Di Benedetto G, Scorrano L, (2011) During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nat Cell Biol 13: 589-598.
45. Gonzalez P, Mader I, Tchoghandjian A, Enzenmuller S, Cristofanon S, et al. (2012) Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process. Cell Death Differ 19: 1337-1346.
46. Wan G, Zhaorigetu S, Liu Z, Kaini R, Jiang Z, et al. (2008) Apolipoprotein l1, a novel BH3-only lipid binding protein, induces autophagic cell death. J Biol Chem.
47. Sun Y, Li C, Shu Y, Ju X, Zou Z, et al. (2012) Inhibition of Autophagy Ameliorates Acute Lung Injury Caused by Avian Influenza A H5N1 Infection. Sci Signal 5: ra16.
48. Wilson AJ, Arango D, Mariadason JM, Heerdt BG, Augenlicht LH, (2003) TR3/Nur77 in colon cancer cell apoptosis. Cancer Res 63: 5401-5407.
49. Li QX, Ke N, Sundaram R, Wong-Staal F, (2006) NR4A1, 2, 3-an orphan nuclear hormone receptor family involved in cell apoptosis and carcinogenesis. Histol Histopathol 21: 533-540.
50. Franken NA, Rodermond HM, Stap J, Haveman J, van Bree C, (2006) Clonogenic assay of cells in vitro. Nat Protoc 1: 2315-2319.
51. Gomez EO, Mendoza-Milla C, Ibarra-Sanchez MJ, Ventura-Gallegos JL, Zentella A, (1996) Ceramide reproduces late appearance of oxidative stress during TNF-mediated cell death in L929 cells. Biochem Biophys Res Commun 228: 505-509.