Simultaneous PET-MRI in oncology: A solution looking for a problem?

Magnetic Resonance Imaging

Volumn 30, Issue 9, 2012, Pages 1342-1356

  Yankeelov, Thomas E ^a,b,c   Peterson, Todd E ^a   Abramson, Richard G ^a   Garcia Izquierdo, David ^d   Arlinghaus, Lori R ^a   Li, Xia ^a   Atuegwu, Nkiruka C ^a   Catana, Ciprian ^e   Manning, H Charles ^a,b   Fayad, Zahi A ^d   Gore, John C ^a,b,c  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MOUNT SINAI MEDICAL CENTER   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

AIF; Attenuation; Motion; MRI; Multimodality; PET; Reconstruction

Indexed keywords

BIOLOGICAL MARKER; BISPHOSPHONIC ACID DERIVATIVE; CONTRAST MEDIUM; COPPER 64; DEXTRAN; DITHIOCARBAMIC ACID; GALLIUM 68; MACROGOL; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; TETRAXETAN; TRACER;

ARTICLE; CANCER THERAPY; CLINICAL RESEARCH; COST; DIAGNOSTIC IMAGING EQUIPMENT; DRUG DISTRIBUTION; HUMAN; IMAGE RECONSTRUCTION; INFORMATION PROCESSING; KINETICS; MEASUREMENT; MOLECULAR IMAGING; MOTION; NEOPLASM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; ONCOLOGY; POSITRON EMISSION TOMOGRAPHY; POSITRON EMISSION TOMOGRAPHY SCANNER; PRIORITY JOURNAL; TREATMENT RESPONSE;

BREAST NEOPLASMS; CONTRAST MEDIA; DIAGNOSTIC IMAGING; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; KINETICS; MAGNETIC RESONANCE IMAGING; MALE; MEDICAL ONCOLOGY; MOTION; NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; PROSTATIC NEOPLASMS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84867140164     PISSN: 0730725X     EISSN: 18735894     Source Type: Journal    
DOI: 10.1016/j.mri.2012.06.001     Document Type: Article

References (99)

1. Afaq A., Akin O. Imaging assessment of tumor response: past, present and future. Future Oncol 2011, 7(5):669-677.
2. Schnall M., Rosen M. Primer on imaging technologies for cancer. J Clin Oncol 2006, 24:3225-3233.
3. Levin C.S. Primer on molecular imaging technology. Eur J Nucl Med Mol Imaging 2005, 32:S325-S345.
4. Webb S. Physics of medical imaging 1988, Institute of Physics Publishing, London.
5. Correia J.A. Editorial: registration of nuclear medicine images. J Nucl Med 1990, 31:1227-1229.
6. Hasegawa B.H., Gingold E.L., Reilly S.M., et al. Description of a simultaneous emission-transmission CT system. In: Medical imaging IV: image formation. Proc SPIE 1990, 1231:50-60.
7. Hasegawa B.H., Iwata K., Wong K.H., Wu M.C., Da Silva A.J., Tang H.R., et al. Dual-modality imaging of function and physiology. Acad Radiol 2002, 9(11):1305-1321.
8. Beyer T., Townsend D.W., Brun T., et al. A combined PET/CT scanner for clinical oncology. J Nucl Med 2000, 41:1369-1379.
9. Horger M., Bares R. The role of single-photon emission computed tomography/computed tomography in benign and malignant bone disease. Semin Nucl Med 2006, 36(4):286-294.
10. Even-Sapir E., Keidar Z., Sachs J., Engel A., Bettman L., Gaitini D., et al. The new technology of combined transmission and emission tomography in evaluation of endocrine neoplasms. J Nucl Med 2001, 42(7):998-1004.
11. Pfannenberg A.C., Eschmann S.M., Horger M., Lamberts R., Vonthein R., Claussen C.D., et al. Benefit of anatomical-functional image fusion in the diagnostic work-up of neuroendocrine neoplasms. Eur J Nucl Med Mol Imaging 2003, 30(6):835-843.
12. von Schulthess G.K., Steinert H.C., Hany T.F. Integrated PET/CT: current applications and future directions. Radiology 2006, 238:405-422.
13. Catana C., Procissi D., Wu Y., Judenhofer M.S., Qi J., Pichler B.J., et al. Simultaneous in vivo positron emission tomography and magnetic resonance imaging. Proc Natl Acad Sci USA 2008, 105(10):3705-3710.
14. Judenhofer M.S., Wehrl H.F., Newport D.F., Catana C., Siegel S.B., Becker M., et al. Simultaneous PET-MRI: a new approach for functional and morphological imaging. Nat Med 2008, 14(4):459-465.
15. Mawlawi O., Pan T., Macapinlac H.A. PET/CT imaging techniques, considerations, and artifacts. J Thorac Imaging 2006, 21(2):99-110.
16. Osman M.M., Cohade C., Nakamoto Y., et al. Respiratory motion artifacts on PET emission images obtained using CT attenuation correction on PET-CT. Eur J Nucl Med Mol Imaging 2003, 30:603-606.
17. Goerres G.W., Kamel E., Heidelberg T.N., et al. PET-CT image coregistration in the thorax: influence of respiration. Eur J Nucl Med Mol Imaging 2002, 29:351-360.
18. Beyer T., Antoch G., Blodgett T., et al. Dual-modality PET/CT imaging: the effect of respiratory motion on combined image quality in clinical oncology. Eur J Nucl Med Mol Imaging 2003, 30:588-596.
19. Shao Y., Cherry S.R., Farahani K., Meadors K., Siegel S., et al. Simultaneous PET and MR imaging. Phys Med Biol 1997, 42:1965-1970.
20. Shao Y., Cherry S.R., Farahani K., Slates R., Silverman R.W., et al. Development of a PET detector system compatible with MRI/NMR systems. IEEE Trans Nucl Sci 1997, 44:1167-1171.
21. Slates R.B., Farahani K., Shao Y., Marsden P.K., Taylor J., et al. A study of artefacts in simultaneous PET and MR imaging using a prototype MR compatible PET scanner. Phys Med Biol 1999, 44:2015-2027.
22. Pichler B.J., Wehrl H.F., Kolb A., Judenhofer M.S. Positron emission tomography/magnetic resonance imaging: the next generation of multimodality imaging?. Semin Nucl Med 2008, 38(3):199-208.
23. Pichler B.J., Wehrl H.F., Judenhofer M.S. Latest advances in molecular imaging instrumentation. J Nucl Med 2008, 49(Suppl. 2):5S-23S.
24. Lucas A.J., Hawkes R.C., Ansorge R.E., Williams G.B., Nutt R.E., Clark J.C., et al. Development of a combined microPET-MR system. Technol Cancer Res Treat 2006, 5(4):337-341.
25. Pichler B.J., Judenhofer M.S., Catana C., Walton J.H., Kneilling M., Nutt R.E., et al. Performance test of an LSO-APD detector in a 7-T MRI scanner for simultaneous PET/MRI. J Nucl Med 2006, 47(4):639-647.
26. Maramraju S.H., Smith S.D., Junnarkar S.S., Schulz D., Stoll S., Ravindranath B., et al. Small animal simultaneous PET/MRI: initial experiences in a 9.4 T microMRI. Phys Med Biol 2011, 56(8):2459-2480.
27. Boss A., Bisdas S., Kolb A., Hofmann M., Ernemann U., Claussen C.D., et al. Hybrid PET/MRI of intracranial masses: initial experiences and comparison to PET/CT. J Nucl Med 2010, 51(8):1198-1205.
28. Boss A., Stegger L., Bisdas S., Kolb A., Schwenzer N., Pfister M., et al. Feasibility of simultaneous PET/MR imaging in the head and upper neck area. Eur Radiol 2011, 21(7):1439-1446.
29. Cherry S.R., Dahlbom M. PET: physics, instrumentation, and scanners. PET molecular imaging and its biological applications 2004, 1-124. Springer, New York. M.E. Phelps (Ed.).
30. Bergström M., Litton J., Eriksson L., Bohm C., Blomqvist G. Determination of object contour from projections for attenuation correction in cranial positron emission tomography. J Comput Assist Tomogr 1982, 6(2):365-372.
31. Bailey D.L. Transmission scanning in emission tomography. Eur J Nucl Med 1998, 25(7):774-787.
32. Visvikis D., Costa D.C., Croasdale I., Lonn A.H., Bomanji J., Gacinovic S., et al. CT-based attenuation correction in the calculation of semi-quantitative indices of [18F]FDG uptake in PET. Eur J Nucl Med Mol Imaging 2003, 30:344-353.
33. Westerterp M., Pruim J., Oyen W., Hoekstra O., Paans A., Visser E., et al. Quantification of FDG PET studies using standardised uptake values in multi-centre trials: effects of image reconstruction, resolution and ROI definition parameters. Eur J Nucl Med Mol Imaging 2007, 34:392-404.
34. Keereman V., Holen R.V., Mollet P., Vandenberghe S. The effect of errors in segmented attenuation maps on PET quantification. Med Phys 2011, 38(11):6010-6019.
35. Catana C., van der Kouwe A., Benner T., Michel C.J., Hamm M., Fenchel M., et al. Toward implementing an MRI-based PET attenuation-correction method for neurologic studies on the MR-PET brain prototype. J Nucl Med 2010, 51(9):1431-1438.
36. Marshall H.R., Stodilka R.Z., Theberge J., Sabondjian E., Legros A., Deans L., et al. A comparison of MR-based attenuation correction in PET versus SPECT. Phys Med Biol 2011 Jul 21, 56(14):4613-4629.
37. Malone I.B., Ansorge R.E., Williams G.B., Nestor P.J., Carpenter T.A., Fryer T.D. Attenuation correction methods suitable for brain imaging with a PET/MRI scanner: a comparison of tissue atlas and template attenuation map approaches. J Nucl Med 2011 Jul, 52(7):1142-1149.
38. Hofmann M., Bezrukov I., Mantlik F., Aschoff P., Steinke F., Beyer T., et al. MRI-based attenuation correction for whole-body PET/MRI: quantitative evaluation of segmentation- and atlas-based methods. J Nucl Med 2011, 52(9):1392-1399.
39. Zaidi H., Montandon M.L., Slosman D.O. Magnetic resonance imaging-guided attenuation and scatter corrections in three-dimensional brain positron emission tomography. Med Phys 2003, 30(5):937-948.
40. Salomon A., Goedicke A., Schweizer B., Aach T., Schulz V. Simultaneous reconstruction of activity and attenuation for PET/MR. IEEE Trans Med Imaging 2011, 30(3):804-813.
41. Robson M.D., Gatehouse P.D., Bydder M., Bydder G.M. Magnetic resonance: an introduction to ultrashort TE (UTE) imaging. J Comput Assist Tomogr 2003, 27(6):825-846.
42. Dixon W.T. Simple proton spectroscopic imaging. Radiology 1984, 153:189-194.
43. Seo S.W., Kwon J.W., Jang S.W., Jang S.P., Park Y.S. Feasibility of whole-body MRI for detecting metastatic myxoid liposarcoma: a case series. Orthopedics 2011, 34(11):e748-e754.
44. Costelloe C.M., Kundra V., Ma J., Chasen B.A., Rohren E.M., Bassett R.L., et al. Fast Dixon whole-body MRI for detecting distant cancer metastasis: a preliminary clinical study. J Magn Reson Imaging 2012, 35(2):399-408.
45. Manenti G., Cicciò C., Squillaci E., Strigari L., Calabria F., Danieli R., et al. Role of combined DWIBS/3D-CE-T1w whole-body MRI in tumor staging: comparison with PET-CT. Eur J Radiol 2011, Sep 9. [Epub ahead of print].
46. MacDonald L.R., Kohlmyer S., Liu C., Lewellen T.K., Kinahan P.E. Effects of MR surface coils on PET quantification. Med Phys 2011, 38(6):2948-2956.
47. Delso G., Martinez-Möller A., Bundschuh R.A., Ladebeck R., Candidus Y., Faul D., et al. Evaluation of the attenuation properties of MR equipment for its use in a whole-body PET/MR scanner. Phys Med Biol 2010, 55(15):4361-4374.
48. Tellmann L., Quick H.H., Bockisch A., Herzog H., Beyer T. The effect of MR surface coils on PET quantification in whole-body PET/MR: results from a pseudo-PET/MR phantom study. Med Phys 2011, 38(5):2795-2805.
49. Qi J., Leahy R.M. Iterative reconstruction techniques in emission computed tomography. Phys Med Biol 2006, 51(15):R541-R578.
50. Leahy R., Yan X. Incorporation of anatomical MR data for improved functional imaging with PET. Lect Notes Comput Sci 1991, 511:105-120.
51. Bowsher J.E., Johnson V.E., Turkington T.G., et al. Bayesian reconstruction and use of anatomical a priori information for emission tomography. IEEE Trans Med Imaging 1996, 15:673-686.
52. Wang C.H., Chen J.C., Kao C.M., Liu R.S. Incorporation of correlated MR images in MAP reconstruction of PET images. J Nucl Med 2003, 44(5):278.
53. Vriens D., Visser E.P., de Geus-Oei L.F., Oyen W.J. Methodological considerations in quantification of oncological FDG PET studies. Eur J Nucl Med Mol Imaging 2010, 37(7):1408-1425.
54. Tsoumpas C., Mackewn J.E., Halsted P., King A.P., Buerger C., Totman J.J., et al. Simultaneous PET-MR acquisition and MR-derived motion fields for correction of non-rigid motion in PET. Ann Nucl Med 2010, 24(10):745-750.
55. Picard Y., Thompson C.J. Motion correction of PET images using multiple acquisition frames. IEEE Trans Med Imaging 1997, 16(2):137-144.
56. Haacke E.M., Brown R.W., Thompson M.R., Venkatesan R. Magnetic resonance imaging: physical principles and sequence design 1999, Wiley-Liss, New York.
57. King A.P., Buerger C., Tsoumpas C., Marsden P.K., Schaeffter T. Thoracic respiratory motion estimation from MRI using a statistical model and a 2-D image navigator. Med Image Anal 2012, 16(1):252-264.
58. Guérin B., Cho S., Chun S.Y., Zhu X., Alpert N.M., El Fakhri G., et al. Nonrigid PET motion compensation in the lower abdomen using simultaneous tagged-MRI and PET imaging. Med Phys 2011, 38(6):3025-3038.
59. Gambhir S.S. Quantitative assay development for PET. PET molecular imaging and its biological applications 2004, 125-217. Springer, New York. M.E. Phelps (Ed.).
60. Adam L.E., Karp J.S., Daube-Witherspoon M.E., Smith R.J. Performance of a whole-body PET scanner using curve-plate NaI(Tl) detectors. J Nucl Med 2001, 42:1821-1830.
61. Zaidi H., Ojha N., Morich M., et al. Design and performance evaluation of a whole-body Ingenuity TF PET-MRI system. Phys Med Biol 2011, 56:3091-3106.
62. Hoffman E.J., Huang S.C., Phelps M.E. Quantitation in positron emission computed tomography: 1. Effect of object size. J Comput Assist Tomogr 1979, 3:299-308.
63. Mazziotta J.C., Phelps M.E., Plummer D., Kuhl D.E. Quantitation in positron emission computed tomography: 5. Physical-anatomical effects. J Comput Assist Tomogr 1981, 5:734-743.
64. Greuter H.N., Boellaard R., van Lingen A., Franssen E.J., Lammertsma A.A. Measurement of 18F-FDG concentrations in blood samples: comparison of direct calibration and standard solution methods. J Nucl Med Technol 2003, 31:206-209.
65. de Geus-Oei L.F., Visser E.P., Krabbe P.F., et al. Comparison of image-derived and arterial input functions for estimating the rate of glucose metabolism in therapy-monitoring 18F-FDG PET studies. J Nucl Med 2006, 47:945-949.
66. Muller-Gartner H.W., Links J.M., Prince J.L., et al. Measurement of radiotracer concentration in brain gray matter using positron emission tomography: MRI-based correction for partial volume effects. J Cereb Blood Flow Metab 1992, 12:571-583.
67. Rousset O.G., Ma Y., Evans A.C. Correction for partial volume effects in PET: principle and validation. J Nucl Med 1998, 39:904-911.
68. Boussion N., Hatt M., Lamare F., Bizais Y., Turzo A., Cheze-Le Rest C., et al. A multiresolution image based approach for correction of partial volume effects in emission tomography. Phys Med Biol 2006, 51(7):1857-1876.
69. Meltzer C.C., Kinahan P.E., Greer P.J., et al. Comparative evaluation of MR-based partial volume correction schemes for PET. J Nucl Med 1999, 40:2053-2065.
70. Shidahara M., Tsoumpas C., Hammers A., Boussion N., Visvikis D., Suhara T., et al. Functional and structural synergy for resolution recovery and partial volume correction in brain PET. Neuroimage 2009, 44(2):340-348.
71. Torres Martin de Rosales R., Tavaré R., Paul R.L., Jauregui-Osoro M., Protti A., Glaria A., et al. Synthesis of 64Cu(II)-bis(dithiocarbamatebisphosphonate) and its conjugation with superparamagnetic iron oxide nanoparticles: in vivo evaluation as dual-modality PET-MRI agent. Angew Chem Int Ed Engl 2011, 50(24):5509-5513.
72. Glaus C., Rossin R., Welch M.J., Bao G. In vivo evaluation of (64)Cu-labeled magnetic nanoparticles as a dual-modality PET/MR imaging agent. Bioconjug Chem 2010, 21(4):715-722.
73. Choi J.-S., Park J., Nah H., Woo S., Oh J., Kim K., et al. Hybrid nanoparticle probe for dual-modality positron emission tomography and magnetic resonance imaging. Angew Chem Int Ed 2008, 47:6259-6262.
74. Lee H.Y., Li Z., Chen K., Hsu A.R., Xu C., Xie J., et al. PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)-conjugated radiolabeled iron oxide nanoparticles. Nucl Med 2008, 49(8):1371-1379.
75. Gaertner F.C., Schwaiger M., Beer A.J. Molecular imaging of αvβ3 expression in cancer patients. Q J Nucl Med Mol Imaging 2010, 54(3):309-326.
76. Frullano L., Catana C., Benner T., Sherry A., Caravan P. Bimodal MR-PET agent for quantitative pH imaging. Angewandte Chemie 2010, 122:2432-2434.
77. Vees H., Senthamizhchelvan S., Miralbell R., Weber D., Ratib O., Zaidi H. Assessment of various strategies for 18F-FET PET-guided delineation of target volumes in high-grade glioma. Eur J Nucl Med Mol Imaging 2009, 36(2):182-193.
78. Thorwarth D., Henke G., Müller A.C., Reimold M., Beyer T., Boss A., et al. Simultaneous 68Ga-DOTATOC-PET/MRI for IMRT treatment planning for meningioma: first experience. Int J Radiat Oncol Biol Phys 2011, 81:277-283.
79. Huang S.H., Chien C.Y., Lin W.C., Fang F.M., Wang P.W., Lui C.C., et al. A comparative study of fused FDG PET/MRI, PET/CT, MRI, and CT imaging for assessing surrounding tissue invasion of advanced buccal squamous cell carcinoma. Clin Nucl Med 2011, 36:518-525.
80. Tatsumi M., Isohashi K., Onishi H., Hori M., Kim T., Higuchi I., et al. 18F-FDG PET/MRI fusion in characterizing pancreatic tumors: comparison to PET/CT. Int J Clin Oncol 2011, 16:408-415.
81. Moy L., Noz M.E., Maguire G.Q., Melsaether A., Deans A.E., Murphy-Walcott A.D., et al. Role of fusion of prone FDG-PET and magnetic resonance imaging of the breasts in the evaluation of breast cancer. Breast J 2010, 16:369-376.
82. Jansen J.F., Schöder H., Lee N.Y., Wang Y., Pfister D.G., Fury M.G., et al. Noninvasive assessment of tumor microenvironment using dynamic contrast-enhanced magnetic resonance imaging and 18F-fluoromisonidazole positron emission tomography imaging in neck nodal metastases. Int J Radiat Oncol Biol Phys 2010, 77(5):1403-1410.
83. Cho H., Ackerstaff E., Carlin S., Lupu M.E., Wang Y., Rizwan A., et al. Noninvasive multimodality imaging of the tumor microenvironment: registered dynamic magnetic resonance imaging and positron emission tomography studies of a preclinical tumor model of tumor hypoxia. Neoplasia 2009, 11(3):247-259.
84. Zhang F., Zhu L., Liu G., Hida N., Lu G., Eden H.S., et al. Multimodality imaging of tumor response to Doxil. Theranostics. 2011, 1:302-309.
85. Atuegwu N.C., Gore J.C., Yankeelov T.E. The integration of quantitative multi-modality imaging data into mathematical models of tumors. Phys Med Biol 2010, 55(9):2429-2449.
86. Hricak H., Amparo E.G. Body MRI: alleviation of claustrophobia by prone positioning. Radiology 1984, 152:819.
87. Quirk M.E., Letendre A.J., Ciottone R.A., Lingley J.F. Evaluation of three psychologic interventions to reduce anxiety during MR imaging. Radiology 1989, 173:759-762.
88. Quirk M.E., Letendre A.J., Ciottone R.A., Lingley J.F. Anxiety in patients undergoing MR imaging. Radiology 1989, 170:463-466.
89. Flaherty J.A., Hoskinson K. Emotional distress during magnetic resonance imaging. N Engl J Med 1989, 320:467-468.
90. Meléndez J.C., McCrank E. Anxiety-related reactions associated with magnetic resonance imaging examinations. JAMA 1993, 270(6):745-747.
91. Katz R.C., Wilson L., Frazer N. Anxiety and its determinants in patients undergoing magnetic resonance imaging. J Behav Ther Exp Psychiatry 1994, 25(2):131-134.
92. Murphy K.J., Brunberg J.A. Adult claustrophobia, anxiety and sedation in MRI. Magn Reson Imaging 1997, 15(1):51-54.
93. Hamblen S.M., Lowe V.J. Clinical 18F-FDG oncology patient preparation techniques. J Nucl Med Technol 2003, 31(1):3-10.
94. Mawlawi O., Kappadath S.C., Pan T., Rohren E., Macapinlac H.A. Factors affecting quantification in PET/CT imaging. Curr Med Imaging Rev 2008, 4(1):34-45.
95. Cohade C., Osman M., Pannu H.K., Wahl R.L. Uptake in supraclavicular area fat ("USA-Fat"): description on 18F-FDG PET/CT. J Nucl Med 2003, 44:170-176.
96. Yeung H.W., Grewal R.K., Gonen M., Schoder H., Larson S.M. Patterns of [18]F FDG uptake in adipose tissue and muscle: a potential source of false-positives for PET. J Nucl Med 2003, 44:1789-1796.
97. McQuattie S. Pediatric PET/CT imaging: tips and techniques. J Nucl Med Technol 2008, 36:171-178.
98. Veitch T.A. Pediatric nuclear medicine, part I: developmental cues. J Nucl Med Technol 2000, 28:3-7.
99. Eisenhauer E.A., Therasse P., Bogaerts J., Schwartz L.H., Sargent D., Ford R., et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 2009, 45(2):228-247.