Small animal simultaneous PET/MRI: Initial experiences in a 9.4 T microMRI

Physics in Medicine and Biology

Volumn 56, Issue 8, 2011, Pages 2459-2480

  Maramraju, Sri Harsha ^a   Smith, S David ^b   Junnarkar, Sachin S ^b   Schulz, Daniela ^b   Stoll, Sean ^b   Ravindranath, Bosky ^a   Purschke, Martin L ^b   Rescia, Sergio ^b   Southekal, Sudeepti ^c   Pratte, Jean François ^d   Vaska, Paul ^a,b   Woody, Craig L ^b   Schlyer, David J ^a,b  

^a St Francis Hospital The Heart Center   (United States)

^b BROOKHAVEN NATIONAL LABORATORY   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2-DEOXY-2; ACTIVITY CONCENTRATION; DETECTOR BLOCKS; DUTY CYCLES; EMISSION TOMOGRAPHY; FLUORO D GLUCOSE; GRADIENT ECHO; IN-VIVO; INNER DIAMETERS; LUTETIUM OXYORTHOSILICATE CRYSTALS; MICRO-MRI; MOUSE HEART; MR IMAGES; MRI SCANNERS; NONMAGNETICS; PET DATA; PET DETECTORS; RADIO FREQUENCY PULSE; RAT BRAIN; RAT CONSCIOUS ANIMAL PETS; RF PULSE; SIGNAL TO NOISE; SIMULTANEOUS OPERATION; SMALL-ANIMAL; SPIN ECHO; VISUAL ARTIFACTS;

ANIMALS; DETECTORS; GLUCOSE; POSITRON EMISSION TOMOGRAPHY; POSITRONS; RESONANCE; SCANNING; SIGNAL TO NOISE RATIO;

MAGNETIC RESONANCE IMAGING;

DIAGNOSTIC AGENT; FLUORODEOXYGLUCOSE F 18; LUTETIUM; RACLOPRIDE; RADIOISOTOPE; RADIOPHARMACEUTICAL AGENT; SILICATE;

ANIMAL; ARTICLE; BRAIN; CALIBRATION; COMPARATIVE STUDY; EVALUATION; FEMALE; HEART; IMAGE QUALITY; INSTRUMENTATION; MALE; METHODOLOGY; MOUSE; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; RAT; REPRODUCIBILITY; SCINTISCANNING; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN; CALIBRATION; FEMALE; FLUORODEOXYGLUCOSE F18; HEART; LUTETIUM; MAGNETIC RESONANCE IMAGING; MALE; MICE; PHANTOMS, IMAGING; POSITRON-EMISSION TOMOGRAPHY; RACLOPRIDE; RADIOISOTOPES; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SILICATES;

EID: 79953675997     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/56/8/009     Document Type: Article

References (56)

1. Bindseil G A, Gilbert K M, Scholl T J, Handler W B and Chronik B A 2011 First image from a combined positron emission tomography and field-cycled MRI system Magn. Reson. Med.
2. Boss A, Bisdas S, Kolb A, Hofmann M, Ernemann U, Claussen C D, Pfannenberg C, Pichler B J, Reimold M and Stegger L 2010a Hybrid PET/MRI of intracranial masses: initial experiences and comparison to PET/CT J. Nucl. Med. 51 1198-205
3. Boss A et al 2010b Diffusion tensor imaging in a human PET/MR hybrid system Invest. Radiol. 45 270-4
4. Buscher K, Judenhofer M S, Kuhlmann M T, Hermann S, Wehrl H F, Schafers K P, Schafers M, Pichler B J and Stegger L 2010 Isochronous assessment of cardiac metabolism and function in mice using hybrid PET/MRI J. Nucl. Med. 51 1277-84
5. Catana C, Procissi D, Wu Y, Judenhofer M S, Qi J, Pichler B J, Jacobs R E and Cherry S R 2008 Simultaneous in vivo positron emission tomography and magnetic resonance imaging Proc. Natl Acad. Sci. USA 105 3705-10 (Pubitemid 351723462)
6. Catana C, Wu Y, Judenhofer M S, Qi J, Pichler B J and Cherry S R 2006 Simultaneous acquisition of multislice PET and MR images: initial results with a MR-compatible PET scanner J. Nucl. Med. 47 1968-76 (Pubitemid 47544984)
7. Delso G, Martinez-Moller A, Bundschuh R A, Ladebeck R, Candidus Y, Faul D and Ziegler S I 2010 Evaluation of the attenuation properties of MR equipment for its use in a whole-body PET/MR scanner Phys. Med. Biol. 55 4361-74
8. Doty F D, Entzminger G, Kulkarni J, Pamarthy K and Staab J P 2007 Radio frequency coil technology for small-animal MRI NMR Biomed. 20 304-25 (Pubitemid 46824531)
9. Espãa S, Fraile L M, Herraiz J L, Udías J M, Desco M and Vaquero J J 2010 Performance evaluation of SiPM photodetectors for PET imaging in the presence of magnetic fields Nucl. Instrum. Methods Phys. Res. A 613 308-16
10. Garlick P B, Marsden P K, Cave A C, Parkes H G, Slates R, Shao Y, Silverman R W and Cherry S R 1997 PET and NMR dual acquisition (PANDA): applications to isolated, perfused rat hearts NMR Biomed. 10 138-42 (Pubitemid 27483825)
11. Gati J S, Menon R S, Ugurbil K and Rutt B K 1997 Experimental determination of the BOLD field strength dependence in vessels and tissue Magn. Reson. Med. 38 296-302 (Pubitemid 27328259)
12. Gilbert K M, Handler W B, Scholl T J, Odegaard J W and Chronik B A 2006 Design of field-cycled magnetic resonance systems for small animal imaging Phys. Med. Biol. 51 2825-41 (Pubitemid 43832939)
13. Grazioso R, Zhang N, Corbeil J, Schmand M, Ladebeck R, Vester M, Schnur G, Renz W and Fischer H 2006 APD-based PET detector for simultaneous PET/MR imaging Nucl. Instrum. Methods Phys. Res. A 569 301-5 (Pubitemid 44820442)
14. Hawkes R, Lucas A, Stevick J, Llosa G, Marcatili S, Piemonte C, Del Guerra A and Carpenter T A 2007 Silicon photomultiplier performance tests in magnetic resonance pulsed fields IEEE Nucl. Sci. Symp. Conf. Record, 2007, NSS '07 pp 3400-3
15. Huang B, Law M W and Khong P L 2009 Whole-body PET/CT scanning: estimation of radiation dose and cancer risk Radiology 251 166-74
16. Imaizumi M, Yamamoto S, Kawakami M, Aoki M, Sugiyama E, Kanai Y, Shimosegawa E and Hatazawa J 2009 Simultaneous imaging of magnetic resonance imaging and positron emission tomography by means of MRI-compatible optic fiber-based PET: a validation study in ex vivo rat brain Japan. J. Radiol. 27 252-6
17. Judenhofer M S, Catana C, Swann B K, Siegel S B, Jung W I, Nutt R E, Cherry S R, Claussen C D and Pichler B J 2007 PET/MR images acquired with a compact MR-compatible PET detector in a 7-T magnet Radiology 244 807-14 (Pubitemid 47292092)
18. Judenhofer M S et al 2008 Simultaneous PET-MRI: a new approach for functional and morphological imaging Nat. Med. 14 459-65 (Pubitemid 351499385)
19. Junnarkar S S et al 2008 Next generation of real time data acquisition, calibration and control system for the RatCAP scanner IEEE Trans. Nucl. Sci. 55 220-4 (Pubitemid 351239465)
20. Kang J, Choi Y, Hong K J, Jung J H, Hu W, Huh Y S, Lim H and Kim B-T 2010 A feasibility study of photosensor charge signal transmission to preamplifier using long cable for development of hybrid PET-MRI Med. Phys. 37 5655-64
21. Kriplani A, Stoll S P, Schlyer D J, Shokouhi S, Vaska P, Villanueva A Jr and Woody C L 2003 Light output measurements of LSO single crystals and 4 × 8 arrays: comparison of experiment with Monte Carlo simulations IEEE Nucl. Sci. Symp. Conf. Record, 2003 vol 5 pp 3036-40 (Pubitemid 40100044)
22. Lewellen T K, Harrison R L and Vannoy S 1998 Monte Carlo Calculations in Nuclear Medicine: Applications in Diagnostic Imaging (Bristol: Institute of Physics Publishing) pp 77-92
23. Lucas A J, Hawkes R C, Ansorge R E, Williams G B, Nutt R E, Clark J C, Fryer T D and Carpenter T A 2006 Development of a combined microPET-MR system [abstract] Technol. Cancer Res. Treat. 5 337-41 (Pubitemid 44300249)
24. Mackewn J E, Strul D, Hallett W A, Halsted P, Page R A, Keevil S F, Williams S C R, Cherry S R and Marsden P K 2005 Design and development of an MR-compatible PET scanner for imaging small animals IEEE Trans. Nucl. Sci. 52 1376-80 (Pubitemid 41810424)
25. Maramraju S H et al 2008a An MR compatible PET scanner based on RatCAP for small animal imaging at 9.4 T IEEE Nucl. Sci. Symp. Conf. Rec. pp 3679-82
26. Maramraju S H, Schlyer D, Vaska P, Woody C, Junnarkar S, Ravindranath B, Southekal S, Smith D, Tomasi D and Lenz W 2008b Acquisition of simultaneous PET-MRI images based on RatCAP PET detector in the 9.4T MRI J. Nucl. Med. 49 (Suppl.) 67P (abstract)
27. Mawlawi O, Pan T and Macapinlac H A 2006 PET/CT imaging techniques, considerations, and artifacts J. Thorac. Imaging 21 99-110 (Pubitemid 43904258)
28. McElroy D P, Saveliev V, Reznik A and Rowlands J A 2007 Evaluation of silicon photomultipliers: a promising new detector for MR compatible PET Nucl. Instrum. Methods Phys. Res. A 571 106-9 (Pubitemid 46136579)
29. Park S J, Southekal S, Purschke M, Junnarkar S S, Pratte J F, Stoll S P, Woody C L, Schlyer D J and Vaska P 2008 Digital coincidence processing for the RatCAP conscious rat brain PET scanner IEEE Trans. Nucl. Sci. 55 510-5 (Pubitemid 351239506)
30. Peng B J, Walton J H, Cherry S R and Willig-Onwuachi J 2010 Studies of the interactions of an MRI system with the shielding in a combined PET/MRI scanner Phys. Med. Biol. 55 265-80
31. Pichler B J, Judenhofer M S, Catana C, Walton J H, Kneilling M, Nutt R E, Siegel S B, Claussen C D and Cherry S R 2006 Performance test of an LSO-APD detector in a 7-T MRI scanner for simultaneous PET/MRI J. Nucl. Med. 47 639-47 (Pubitemid 46768465)
32. Poole M, Bowtell R, Green D, Pittard S, Lucas A, Hawkes R and Carpenter A 2009 Split gradient coils for simultaneous PET-MRI Magn. Reson. Med. 62 1106-11
33. Pratte J F et al 2008 The RatCAP front-end ASIC IEEE Trans. Nucl. Sci. 55 2727-35
34. Raylman R R, Majewski S, Lemieux S K, Velan S S, Kross B, Popov V, Smith M F, Weisenberger A G, Zorn C and Marano G D 2006 Simultaneous MRI and PET imaging of a rat brain Phys. Med. Biol. 51 6371-9 (Pubitemid 46217627)
35. Schaart D R, Seifert S, Vinke R, van Dam H T, Dendooven P, Lohner H and Beekman F J 2010 LaBr(3):Ce and SiPMs for time-of-flight PET: achieving 100 ps coincidence resolving time Phys. Med. Biol. 55 N179-89
36. Schick F 2005 Whole-body MRI at high field: technical limits and clinical potential Eur. Radiol. 15 946-59 (Pubitemid 41166727)
37. Schlemmer H P et al 2008 Simultaneous MR/PET imaging of the human brain: feasibility study Radiology 248 1028-35
38. Schlyer D, Rooney W, Woody C, Vaska P, Kriplani A and Stoll S 2004 Development of a simultaneous PET/MRI scanner IEEE Nucl. Sci. Symp. Conf. Rec. pp 3419-21 (Pubitemid 41147682)
39. Schlyer D et al 2007 A Simultaneous PET/MRI scanner based on RatCAP in small animals IEEE Nucl. Sci. Symp. Conf. Rec. vol 5 pp 3256-9
40. Seong Jong H, In Chan S, Ito M, Sun Il K, Geon Song L, Kwang-Souk S, Kwang Suk P, June Tak R and Jae Sung L 2008 An investigation into the use of Geiger-mode solid-state photomultipliers for simultaneous PET and MRI acquisition IEEE Trans. Nucl. Sci. 55 882-8
41. Shao Y, Cherry S R, Farahani K, Meadors K, Siegel S, Silverman R W and Marsden P K 1997 Simultaneous PET and MR imaging Phys. Med. Biol. 42 1965-70 (Pubitemid 27448997)
42. Slates R B, Farahani K, Shao Y, Marsden P K, Taylor J, Summers P E, Williams S, Beech J and Cherry S R 1999 A study of artefacts in simultaneous PET and MR imaging using a prototype MR compatible PET scanner Phys. Med. Biol. 44 2015-27 (Pubitemid 29387608)
43. Solis E, Tomasi D, Junnarkar S, Schlyer D, Vaska P, Woody C, Pratte J F, O'Connor P and Rodriguez A O 2008 Shielded transceiver RF coil array for simultaneous PET-MRI Braz. J. Phys. 38 287-91
44. Southekal S 2009 Strategies for quantitative neuroimaging with the rat conscious animal PET (RatCAP) PhD Dissertation Stony Brook University, NY
45. Southekal S, Purschke M, Woody C L, Schlyer D J and Vaska P 2007 Optimization of image reconstruction for the RatCAP (PET) tomograph: an analysis of the statistical quality of the system response matrix IEEE Nucl. Sci. Symp. Conf. Rec. vol 4 pp 3051-4
46. Sureshbabu W and Mawlawi O 2005 PET/CT imaging artifacts J. Nucl. Med. Technol. 33 156-61 (Pubitemid 44699267)
47. Tkac I, Henry P G, Andersen P, Keene C D, Low W C and Gruetter R 2004 Highly resolved in vivo 1H NMR spectroscopy of the mouse brain at 9.4 T Magn. Reson. Med. 52 478-84 (Pubitemid 39108958)
48. Toi V et al 2010 Challenges and opportunities of ultra-high field MRI The Third International Conference on the Development of Biomedical Engineering in Vietnam ed R Magjarevic (Berlin: Springer) pp 1-5
49. Vaska P et al 2004 RatCAP: miniaturized head-mounted PET for conscious rodent brain imaging IEEE Trans. Nucl. Sci. 51 2718-22
50. Vaska P et al 2007 The design and performance of the 2nd-generation RatCAP awake rat brain PET system IEEE Nucl. Sci. Symp. Conf. Rec. vol 6 pp 4181-4
51. Wehrl H F, Judenhofer M S, Thielscher A, Martirosian P, Schick F and Pichler B J 2010 Assessment of MR compatibility of a PET insert developed for simultaneous multiparametric PET/MR imaging on an animal system operating at 7 T Magn. Reson. Med. 65 269-79
52. Woody C et al 2004 The RatCAP conscious small animal PET tomograph IEEE Nucl. Sci. Symp. Conf. Rec., 2004 vol 4 pp 2334-8 (Pubitemid 41148043)
53. Woody C et al 2007a Preliminary studies of a simultaneous PET/MRI scanner based on the RatCAP small animal tomograph Nucl. Instrum. Methods Phys. Res. A 571 102-5 (Pubitemid 46136578)
54. Woody C et al 2007b Initial studies using the RatCAP conscious animal PET tomograph Nucl. Instrum. Methods Phys. Res. A 571 14-7 (Pubitemid 46136563)
55. Wu Y, Catana C, Farrell R, Dokhale P A, Shah K S, Jinyi Q and Cherry S R 2009 PET performance evaluation of an MR-compatible PET insert IEEE Trans. Nucl. Sci. 56 574-80
56. Yamamoto S, Imaizumi M, Kanai Y, Tatsumi M, Aoki M, Sugiyama E, Kawakami M, Shimosegawa E and Hatazawa J 2010 Design and performance from an integrated PET/MRI system for small animals Ann. Nucl. Med. 24 89-98