Sonic hedgehog intradermal gene therapy using a biodegradable poly(β-amino esters) nanoparticle to enhance wound healing

Biomaterials

Volumn 33, Issue 35, 2012, Pages 9148-9156

  Park, Hyun Ji ^a   Lee, Joan ^a   Kim, Mun Jung ^a   Kang, Taek Jin ^b   Jeong, Yongsu ^c   Um, Soong Ho ^d   Cho, Seung Woo ^a  

^a Yonsei University   (South Korea)

^b Dongguk University   (South Korea)

^c Kyung Hee University   (South Korea)

^d Sungkyunkwan University   (South Korea)

Author keywords

Angiogenesis; Intradermal delivery; Poly( amino esters); Sonic hedgehog; Wound healing

Indexed keywords

AMINO ESTERS; ANGIOGENESIS; INTRADERMAL DELIVERY; SONIC HEDGEHOGS; WOUND HEALING;

BLOOD VESSELS; ESTERIFICATION; ESTERS; GENE THERAPY; GENE TRANSFER; LIPOSOMES; MAMMALS; POLYMERASE CHAIN REACTION; TISSUE;

NANOPARTICLES;

ANGIOGENIC FACTOR; LIPOFECTAMINE; NANOPARTICLE; POLY(BETA AMINO ESTERS); SONIC HEDGEHOG PROTEIN; STROMAL CELL DERIVED FACTOR 1ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE THERAPY; GENETIC TRANSFECTION; IN VITRO STUDY; MOUSE; NERVE REGENERATION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKIN CULTURE; SKIN INJURY; TISSUE REGENERATION; WOUND HEALING;

ANIMALS; BETA-GALACTOSIDASE; BIODEGRADATION, ENVIRONMENTAL; CATIONS; CHEMOKINE CXCL12; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FEMALE; GENETIC THERAPY; HEDGEHOG PROTEINS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, ANIMAL; NANOPARTICLES; PLASMIDS; POLYMERS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SKIN; TRANSFECTION; VASCULAR ENDOTHELIAL GROWTH FACTORS; WOUND HEALING;

ANIMALIA; ERINACEIDAE; MUS;

EID: 84867138834     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.09.005     Document Type: Article

References (43)

1. Chesnoy S., Lee P.Y., Huang L. Intradermal injection of transforming growth factor-beta1 gene enhances wound healing in genetically diabetic mice. Pharm Res 2003, 20:345-350.
2. Lee P.Y., Chesnoy S., Huang L. Electroporatic delivery of TGF-beta1 gene works synergistically with electric therapy to enhance diabetic wound healing in db/db mice. J Invest Dermatol 2004, 123:791-798.
3. Eriksson E., Yao F., Svensjo T., Winkler T., Slama J., Macklin M.D., et al. In vivo gene transfer to skin and wound by microseeding. J Surg Res 1998, 78:85-91.
4. Escamez M.J., Carretero M., Garcia M., Martinez-Santamaria L., Mirones I., Duarte B., et al. Assessment of optimal virus-mediated growth factor gene delivery for human cutaneous wound healing enhancement. J Invest Dermatol 2008, 128:1565-1575.
5. Margolis D.J., Morris L.M., Papadopoulos M., Weinberg L., Filip J.C., Lang S.A., et al. Phase I study of H5.020CMV.PDGF-beta to treat venous leg ulcer disease. Mol Ther 2009, 17:1822-1829.
6. Margolis D.J., Cromblehome T., Herlyn M., Cross P., Weinberg L., Filip J., et al. Clinical protocol. Phase I trial to evaluate the safety of H5.020CMV.PDGF-b and limb compression bandage for the treatment of venous leg ulcer: trial A. Hum Gene Ther 2004, 15:1003-1019.
7. Thomas C.E., Ehrhardt A., Kay M.A. Progress and problems with the use of viral vectors for gene therapy. Nat Rev Genet 2003, 4:346-358.
8. Geusens B., Strobbe T., Bracke S., Dynoodt P., Sanders N., Van Gele M., et al. Lipid-mediated gene delivery to the skin. Eur J Pharm Sci 2011, 43:199-211.
9. Raghavachari N., Fahl W.E. Targeted gene delivery to skin cells in vivo: a comparative study of liposomes and polymers as delivery vehicles. J Pharm Sci 2002, 91:615-622.
10. Guo X., Huang L. Recent advances in nonviral vectors for gene delivery. Acc Chem Res 2012, 45:971-979.
11. Zhou J., Liu J., Cheng C.J., Patel T.R., Weller C.E., Piepmeier J.M., et al. Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery. Nat Mater 2012, 11:82-90.
12. Green J.J., Langer R., Anderson D.G. A combinatorial polymer library approach yields insight into nonviral gene delivery. Acc Chem Res 2008, 41:749-759.
13. Park H.J., Yang F., Cho S.W. Nonviral delivery of genetic medicine for therapeutic angiogenesis. Adv Drug Deliv Rev 2012, 64:40-52.
14. Domashenko A., Gupta S., Cotsarelis G. Efficient delivery of transgenes to human hair follicle progenitor cells using topical lipoplex. Nat Biotechnol 2000, 18:420-423.
15. Lobovkina T., Jacobson G.B., Gonzalez-Gonzalez E., Hickerson R.P., Leake D., Kaspar R.L., et al. In vivo sustained release of siRNA from solid lipid nanoparticles. ACS Nano 2011, 5:9977-9983.
16. Pai Kasturi S., Qin H., Thomson K.S., El-Bereir S., Cha S.C., Neelapu S., et al. Prophylactic anti-tumor effects in a B cell lymphoma model with DNA vaccines delivered on polyethylenimine (PEI) functionalized PLGA microparticles. J Control Release 2006, 113:261-270.
17. Anderson D.G., Lynn D.M., Langer R. Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery. Angew Chem Int Ed Engl 2003, 42:3153-3158.
18. Akinc A., Lynn D.M., Anderson D.G., Langer R. Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery. J Am Chem Soc 2003, 125:5316-5323.
19. Anderson D.G., Akinc A., Hossain N., Langer R. Structure/property studies of polymeric gene delivery using a library of poly(beta-amino esters). Mol Ther 2005, 11:426-434.
20. Anderson D.G., Peng W., Akinc A., Hossain N., Kohn A., Padera R., et al. A polymer library approach to suicide gene therapy for cancer. Proc Natl Acad Sci U S A 2004, 101:16028-16033.
21. Green J.J., Shi J., Chiu E., Leshchiner E.S., Langer R., Anderson D.G. Biodegradable polymeric vectors for gene delivery to human endothelial cells. Bioconjug Chem 2006, 17:1162-1169.
22. Cho S.W., Yang F., Son S.M., Park H.J., Green J.J., Bogatyrev S., et al. Therapeutic angiogenesis using genetically engineered human endothelial cells. J Control Release 2012, 160:515-524.
23. Eltoukhy A.A., Siegwart D.J., Alabi C.A., Rajan J.S., Langer R., Anderson D.G. Effect of molecular weight of amine end-modified poly(beta-amino ester)s on gene delivery efficiency and toxicity. Biomaterials 2012, 33:3594-3603.
24. Green J.J., Zugates G.T., Tedford N.C., Huang Y.H., Griffith L.G., Lauffenburger D.A., et al. Combinatorial modification of degradable polymers enables transfection of human cells comparable to adenovirus. Adv Mater 2007, 19:2836-2842.
25. Yang F., Green J.J., Dinio T., Keung L., Cho S.W., Park H., et al. Gene delivery to human adult and embryonic cell-derived stem cells using biodegradable nanoparticulate polymeric vectors. Gene Ther 2009, 16:533-546.
26. Zugates G.T., Peng W., Zumbuehl A., Jhunjhunwala S., Huang Y.H., Langer R., et al. Rapid optimization of gene delivery by parallel end-modification of poly(beta-amino ester)s. Mol Ther 2007, 15:1306-1312.
27. Sunshine J., Green J.J., Mahon K.P., Yang F., Eltoukhy A.A., Nguyen D.N., et al. Small-molecule end-groups of linear polymer determine cell-type gene-delivery efficacy. Adv Mater 2009, 21:4947-4951.
28. Huang Y.H., Zugates G.T., Peng W., Holtz D., Dunton C., Green J.J., et al. Nanoparticle-delivered suicide gene therapy effectively reduces ovarian tumor burden in mice. Cancer Res 2009, 69:6184-6191.
29. Yang F., Cho S.W., Son S.M., Bogatyrev S.R., Singh D., Green J.J., et al. Genetic engineering of human stem cells for enhanced angiogenesis using biodegradable polymeric nanoparticles. Proc Natl Acad Sci U S A 2010, 107:3317-3322.
30. Asai J., Takenaka H., Kusano K.F., Ii M., Luedemann C., Curry C., et al. Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling. Circulation 2006, 113:2413-2424.
31. Le H., Kleinerman R., Lerman O.Z., Brown D., Galiano R., Gurtner G.C., et al. Hedgehog signaling is essential for normal wound healing. Wound Repair Regen 2008, 16:768-773.
32. Kusano K.F., Pola R., Murayama T., Curry C., Kawamoto A., Iwakura A., et al. Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling. Nat Med 2005, 11:1197-1204.
33. Palladino M., Gatto I., Neri V., Straino S., Silver M., Tritarelli A., et al. Pleiotropic beneficial effects of sonic hedgehog gene therapy in an experimental model of peripheral limb ischemia. Mol Ther 2011, 19:658-666.
34. Cho S.W., Goldberg M., Son S.M., Xu Q.B., Yang F., Mei Y., et al. Lipid-like nanoparticles for small interfering RNA delivery to endothelial cells. Adv Funct Mater 2009, 19:3112-3118.
35. Bai C.B., Auerbach W., Lee J.S., Stephen D., Joyner A.L. Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development 2002, 129:4753-4761.
36. Platt K.A., Michaud J., Joyner A.L. Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice. Mech Dev 1997, 62:121-135.
37. Yang H.S., Shin J., Bhang S.H., Shin J.Y., Park J., Im G.I., et al. Enhanced skin wound healing by a sustained release of growth factors contained in platelet-rich plasma. Exp Mol Med 2011, 43:622-629.
38. Barnett D.H., Huang H.Y., Wu X.R., Laciak R., Shapiro E., Bushman W. The human prostate expresses sonic hedgehog during fetal development. J Urol 2002, 168:2206-2210.
39. Kim B.S., Chen J., Weinstein T., Noiri E., Goligorsky M.S. VEGF expression in hypoxia and hyperglycemia: reciprocal effect on branching angiogenesis in epithelial-endothelial co-cultures. J Am Soc Nephrol 2002, 13:2027-2036.
40. Zhang H., Singh R.R., Talukder A.H., Kumar R. Metastatic tumor antigen 3 is a direct corepressor of the Wnt4 pathway. Genes Dev 2006, 20:2943-2948.
41. Peng W., Anderson D.G., Bao Y., Padera R.F., Langer R., Sawicki J.A. Nanoparticulate delivery of suicide DNA to murine prostate and prostate tumors. Prostate 2007, 67:855-862.
42. Harris T.J., Green J.J., Fung P.W., Langer R., Anderson D.G., Bhatia S.N. Tissue-specific gene delivery via nanoparticle coating. Biomaterials 2010, 31:998-1006.
43. Vuorimaa E., Ketola T.M., Green J.J., Hanzlikova M., Lemmetyinen H., Langer R., et al. Poly(beta-amino ester)-DNA complexes: time-resolved fluorescence and cellular transfection studies. J Control Release 2011, 154:171-176.