Therapeutic angiogenesis using genetically engineered human endothelial cells

Journal of Controlled Release

Volumn 160, Issue 3, 2012, Pages 515-524

  Cho, Seung Woo ^a   Yang, Fan ^b,c   Son, Sun Mi ^d   Park, Hyun Ji ^a   Green, Jordan J ^d   Bogatyrev, Said ^d   Mei, Ying ^d   Park, Sohyun ^e   Langer, Robert ^d,e   Anderson, Daniel G ^d,e  

^a Yonsei University   (South Korea)

^b STANFORD UNIVERSITY   (United States)

^c Stanford University   (United States)

^d Massachusetts Institute of Technology Cambridge   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Angiogenesis; Endothelial cells; Genetic engineering; Ischemia; Polymer nanoparticles

Indexed keywords

AMINO ESTERS; ANGIOGENESIS; CELL SURVIVAL; CELL THERAPY; ENGRAFTMENT; HIND LIMBS; HUMAN ENDOTHELIAL CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; IN-VIVO; ISCHEMIA; ISCHEMIC CONDITIONS; ISCHEMIC LIMBS; ISCHEMIC TISSUES; MOUSE MODELS; NONVIRAL; POLYMER NANOPARTICLES; SURVIVAL FACTOR; THERAPEUTIC ANGIOGENESIS; TRANSFECTION REAGENTS; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR; VASCULATURE;

DISEASE CONTROL; ENDOTHELIAL CELLS; GENETIC ENGINEERING; MAMMALS; NANOPARTICLES; TISSUE;

CYTOLOGY;

NANOPARTICLE; POLY(BETA AMINO ESTER); POLYMER; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; CELL TRANSPLANTATION; CELL VIABILITY; ENGRAFTMENT; GENE THERAPY; GENETIC ENGINEERING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIMB ISCHEMIA; LIMB SALVAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL FACTOR; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION;

ANIMALS; FEMALE; HINDLIMB; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; ISCHEMIA; MICE; MICE, NUDE; MUSCLE, SKELETAL; NANOPARTICLES; NEOVASCULARIZATION, PHYSIOLOGIC; PLASMIDS; POLYMERS; TRANSFECTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84861979906     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.03.006     Document Type: Article

References (40)

1. D.R. Enis, B.R. Shepherd, Y. Wang, A. Qasim, C.M. Shanahan, P.L. Weissberg, M. Kashgarian, J.S. Pober, J.S. Schechner, Induction, differentiation, and remodeling of blood vessels after transplantation of Bcl-2-transduced endothelial cells, Proc. Natl. Acad. Sci. U. S. A. 102 (2) (2005) 425-430. (Pubitemid 40116783)
2. S.W. Cho, S.H. Moon, S.H. Lee, S.W. Kang, J. Kim, J.M. Lim, H.S. Kim, B.S. Kim, H.M. Chung, Improvement of postnatal neovascularization by human embryonic stem cell derived endothelial-like cell transplantation in a mouse model of hindlimb ischemia, Circulation 116 (21) (2007) 2409-2419. (Pubitemid 350147820)
3. H. Kamihata, H. Matsubara, T. Nishiue, S. Fujiyama, Y. Tsutsumi, R. Ozono, H. Masaki, Y. Mori, O. Iba, E. Tateishi, A. Kosaki, S. Shintani, T. Murohara, T. Imaizumi, T. Iwasaka, Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines, Circulation 104 (9) (2001) 1046-1052. (Pubitemid 32803883)
4. A.A. Kocher, M.D. Schuster, M.J. Szabolcs, S. Takuma, D. Burkhoff, J. Wang, S. Homma, N.M. Edwards, S. Itescu, Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function, Nat. Med. 7 (4) (2001) 430-436. (Pubitemid 32298545)
5. Y.L. Tang, Y. Tang, Y.C. Zhang, K. Qian, L. Shen, M.I. Phillips, Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector, J. Am. Coll. Cardiol. 46 (7) (2005) 1339-1350. (Pubitemid 41615559)
6. C. Toma, M.F. Pittenger, K.S. Cahill, B.J. Byrne, P.D. Kessler, Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart, Circulation 105 (1) (2002) 93-98. (Pubitemid 34049148)
7. M. Zhang, D. Methot, V. Poppa, Y. Fujio, K. Walsh, C.E. Murry, Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies, J. Mol. Cell. Cardiol. 33 (5) (2001) 907-921. (Pubitemid 32545326)
8. B. Assmus, J. Honold, V. Schächinger, M.B. Britten, U. Fischer-Rasokat, R. Lehmann, C. Teupe, K. Pistorius, H. Martin, N.D. Abolmaali, T. Tonn, S. Dimmeler, A.M. Zeiher, Transcoronary transplantation of progenitor cells after myocardial infarction, N. Engl. J. Med. 355 (12) (2006) 1222-1232. (Pubitemid 44427446)
9. K. Lunde, S. Solheim, S. Aakhus, H. Arnesen, M. Abdelnoor, T. Egeland, K. Endresen, A. Ilebekk, A. Mangschau, J.G. Fjeld, H.J. Smith, E. Taraldsrud, H.K. Grøgaard, R. Bjørnerheim, M. Brekke, C. Müller, E. Hopp, A. Ragnarsson, J.E. Brinchmann, K. Forfang, Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction, N. Engl. J. Med. 355 (12) (2006) 1199-1209. (Pubitemid 44427444)
10. W. Li, N. Ma, L.L. Ong, C. Nesselmann, C. Klopsch, Y. Ladilov, D. Furlani, C. Piechaczek, J.M. Moebius, K. Lützow, A. Lendlein, C. Stamm, R.K. Li, G. Steinhoff, Bcl-2 engineered MSCs inhibited apoptosis and improved heart function, Stem Cells 25 (8) (2007) 2118-2127. (Pubitemid 47258191)
11. R. Matsumoto, T. Omura, M. Yoshiyama, T. Hayashi, S. Inamoto, K.R. Koh, K. Ohta, Y. Izumi, Y. Nakamura, K. Akioka, Y. Kitaura, K. Takeuchi, J. Yoshikawa, Vascular endothelial growth factor-expressing mesenchymal stem cell transplantation for the treatment of acute myocardial infarction, Arterioscler. Thromb. Vasc. Biol. 25 (6) (2005) 1168-1173. (Pubitemid 40776604)
12. C.E. Thomas, A. Ehrhardt, M.A. Kay, Progress and problems with the use of viral vectors for gene therapy, Nat. Rev. Genet. 4 (5) (2003) 346-358. (Pubitemid 36538359)
13. L. Ye, H.Kh. Haider, R. Tan, W. Toh, P.K. Law, W. Tan, L. Su, W. Zhang, R. Ge, Y. Zhang, Y. Lim, E.K. Sim, Transplantation of nanoparticle transfected skeletal myoblasts overexpressing vascular endothelial growth factor-165 for cardiac repair, Circulation 116 (11 Suppl) (2007) I113-I120. (Pubitemid 47480778)
14. M. Aluigi, M. Fogli, A. Curti, A. Isidori, E. Gruppioni, C. Chiodoni, M.P. Colombo, P. Versura, A. D'Errico-Grigioni, E. Ferri, M. Baccarani, R.M. Lemoli, Nucleofection is an efficient nonviral transfection technique for human bone marrow-derived mesenchymal stem cells, Stem Cells 24 (2) (2006) 454-461. (Pubitemid 44464815)
15. I. Elmadbouh, H.Kh. Haider, S. Jiang, N.M. Idris, G. Lu, M. Ashraf, Ex vivo delivered stromal cell-derived factor-1alpha promotes stem cell homing and induces angiomyogenesis in the infarcted myocardium, J. Mol. Cell. Cardiol. 42 (4) (2007) 792-803. (Pubitemid 46527603)
16. J.J. Green, R. Langer, D.G. Anderson, A combinatorial polymer library approach yields insight into nonviral gene delivery, Acc. Chem. Res. 41 (6) (2008) 749-759.
17. D.G. Anderson, A. Akinc, N. Hossain, R. Langer, Structure/property studies of polymeric gene delivery using a library of poly(beta-amino esters), Mol. Ther. 11 (3) (2005) 426-434. (Pubitemid 40277319)
18. F. Yang, J.J. Green, T. Dinio, L. Keung, S.W. Cho, H. Park, R. Langer, D.G. Anderson, Gene delivery to human adult and embryonic cell-derived stem cells using biodegradable nanoparticulate polymeric vectors, Gene Ther. 16 (4) (2009) 533-546.
19. J.J. Green, B.Y. Zhou, M.M. Mitalipova, C. Beard, R. Langer, R. Jaenisch, D.G. Anderson, Nanoparticles for gene transfer to human embryonic stem cell colonies, Nano Lett. 8 (10) (2008) 3126-3130.
20. J.J. Green, G.T. Zugates, N.C. Tedford, Y.H. Huang, L.G. Griffith, D.A. Lauffenburger, J.A. Sawicki, R. Langer, D.G. Anderson, Combinatorial modification of degradable polymers enables transfection of human cells comparable to adenovirus, Adv. Mater. 19 (19) (2007) 2836-2842. (Pubitemid 47597872)
21. J.J. Green, J. Shi, E. Chiu, E.S. Leshchiner, R. Langer, D.G. Anderson, Biodegradable polymeric vectors for gene delivery to human endothelial cells, Bioconjug. Chem. 17 (5) (2006) 1162-1169. (Pubitemid 44455324)
22. F. Yang, S.W. Cho, S.M. Son, S.R. Bogatyrev, D. Singh, J.J. Green, Y. Mei, S. Park, S.H. Bhang, B.S. Kim, R. Langer, D.G. Anderson, Genetic engineering of human stem cells for enhanced angiogenesis using biodegradable polymeric nanoparticles, Proc. Natl. Acad. Sci. U. S. A. 107 (8) (2010) 3317-3322.
23. S.W. Cho, M. Goldberg, S.M. Son, Q. Xu, F. Yang, Y. Mei, S. Bogatyrev, R. Langer, D.G. Anderson, Lipid-like nanoparticles for small interfering RNA delivery to endothelial cells, Adv. Funct. Mater. 19 (19) (2009) 3112-3118.
24. S.H. Bhang, S.W. Cho, J.M. Lim, J.M. Kang, T.J. Lee, H.S. Yang, Y.S. Song, M.H. Park, H.S. Kim, K.J. Yoo, Y. Jang, R. Langer, D.G. Anderson, B.S. Kim, Locally delivered growth factor enhances the angiogenic efficacy of adipose-derived stromal cells transplanted to ischemic limbs, Stem Cells 27 (8) (2009) 1976-1986.
25. A.N. McGinn, H.Y. Nam, M. Ou, N. Hu, C.M. Straub, J.W. Yockman, D.A. Bull, S.W. Kim, Bioreducible polymer-transfected skeletal myoblasts for VEGF delivery to acutely ischemic myocardium, Biomaterials 32 (3) (2011) 942-949.
26. D.W. Pack, A.S. Hoffman, S. Pun, P.S. Stayton, Design and development of polymers for gene delivery, Nat. Rev. Drug Discov. 4 (7) (2005) 581-593. (Pubitemid 40975711)
27. T. Merdan, J. Kopecek, T. Kissel, Prospects for cationic polymers in gene and oligonucleotide therapy against cancer, Adv. Drug Deliv. Rev. 54 (5) (2002) 715-758. (Pubitemid 35247524)
28. M.R. Abid, S. Guo, T. Minami, K.C. Spokes, K. Ueki, C. Skurk, K. Walsh, W.C. Aird, Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells, Arterioscler. Thromb. Vasc. Biol. 24 (2) (2004) 294-300. (Pubitemid 38197581)
29. P. Kumar, A.I. Miller, P.J. Polverini, p38 MAPK mediates gamma-irradiationinduced endothelial cell apoptosis, and vascular endothelial growth factor protects endothelial cells through the phosphoinositide 3-kinase-Akt-Bcl-2 pathway, J. Biol. Chem. 279 (41) (2004) 43352-43360. (Pubitemid 39372230)
30. C.M. Findley, M.J. Cudmore, A. Ahmed, C.D. Kontos, VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway tomodulate Tie2 signaling, Arterioscler. Thromb. Vasc. Biol. 27 (12) (2007) 2619-2626. (Pubitemid 350158914)
31. H. Jia, A. Bagherzadeh, R. Bicknell, M.R. Duchen, D. Liu, I. Zachary, Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells, J. Biol. Chem. 279 (34) (2004) 36148-36157. (Pubitemid 39100623)
32. K. Hattori, S. Dias, B. Heissig, N.R. Hackett, D. Lyden, M. Tateno, D.J. Hicklin, Z. Zhu, L. Witte, R.G. Crystal, M.A. Moore, S. Rafii, Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis by recruitment of vasculogenic and hematopoietic stem cells, J. Exp. Med. 193 (9) (2001) 1005-1014. (Pubitemid 32436194)
33. C.H. Yoon, J. Hur, I.Y. Oh, K.W. Park, T.Y. Kim, J.H. Shin, J.H. Kim, C.S. Lee, J.K. Chung, Y.B. Park, H.S. Kim, Intercellular adhesion molecule-1 is upregulated in ischemic muscle, which mediates trafficking of endothelial progenitor cells, Arterioscler. Thromb. Vasc. Biol. 26 (5) (2006) 1066-1072. (Pubitemid 43732113)
34. K. Matsuura, A. Honda, T. Nagai, N. Fukushima, K. Iwanaga, M. Tokunaga, T. Shimizu, T. Okano, H. Kasanuki, N. Hagiwara, I. Komuro, Transplantation of cardiac progenitor cells ameliorates cardiac dysfunction after myocardial infarction in mice, J. Clin. Invest. 119 (8) (2009) 2204-2217.
35. Y. Nishiwaki, M. Yoshida, H. Iwaguro, H. Masuda, N. Nitta, T. Asahara, M. Isobe, Endothelial E-selectin potentiates neovascularization via endothelial progenitor cell-dependent and -independent mechanisms, Arterioscler. Thromb. Vasc. Biol. 27 (3) (2007) 512-518.
36. J.X. Yu, X.F. Huang, W.M. Lv, C.S. Ye, X.Z. Peng, H. Zhang, L.B. Xiao, S.M. Wang, Combination of stromal-derived factor-1α and vascular endothelial growth factor gene-modified endothelial progenitor cells is more effective for ischemic neovascularization, J. Vasc. Surg. 50 (3) (2009) 608-616.
37. T.M. Yau, C. Kim, G. Li, Y. Zhang, S. Fazel, D. Spiegelstein, R.D. Weisel, R.K. Li, Enhanced angiogenesis with multimodal cell-based gene therapy, Ann. Thorac. Surg. 83 (3) (2007) 1110-1119. (Pubitemid 46343534)
38. T.M. Yau, C. Kim, G. Li, Y. Zhang, R.D. Weisel, R.K. Li, Maximizing ventricular function with multimodal cell-based gene therapy, Circulation 112 (9 Suppl) (2005) I123-I128. (Pubitemid 41266663)
39. A. Kawamoto, M. Katayama, N. Handa, M. Kinoshita, H. Takano, M. Horii, K. Sadamoto, A. Yokoyama, T. Yamanaka, R. Onodera, A. Kuroda, R. Baba, Y. Kaneko, T. Tsukie, Y. Kurimoto, Y. Okada, Y. Kihara, S. Morioka, M. Fukushima, T. Asahara, Intramuscular transplantation of G-CSF-mobilized CD34(+) cells in patients with critical limb ischemia: a phase I/IIa, multicenter, single-blinded, dose-escalation clinical trial, Stem Cells 27 (11) (2009) 2857-2864.
40. J. Babin-Ebell, H.H. Sievers, E.I. Charitos, H.M. Klein, F. Jung, A.K. Hellberg, R. Depping, H.A. Sier, J. Marxsen, S. Stoelting, E.G. Kraatz, K.F. Wagner, Transmyocardial laser revascularization combined with intramyocardial endothelial progenitor cell transplantation in patients with intractable ischemic heart disease ineligible for conventional revascularization: preliminary results in a highly selected small patient cohort, Thorac. Cardiovasc. Surg. 58 (1) (2010) 11-16.